1,993
Views
41
CrossRef citations to date
0
Altmetric
Report

Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics

, , , , , , , , & show all
Pages 1252-1259 | Received 12 Dec 2014, Accepted 27 Jan 2014, Published online: 18 Apr 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Siqing Fu, Yudong Wang, Khandan Keyomarsi & Funda Meric-Bernstein. (2018) Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy. Expert Opinion on Investigational Drugs 27:9, pages 741-751.
Read now

Articles from other publishers (40)

Jian Xu, Yao Zhou, Ke Dong, Jun Gong, Wei Xiong, Xu Wang, Chun Gu, Xiang-yu Lu, De-pei Huang, Xu-dong Shen, Xue-ke She, Xiao-chen Zhao, Xiao-jiong Yu & Hao Zhang. (2023) Gene variation profile and its potential correlation with clinical characteristics in HBV-associated HCC patients of Sichuan Han nationality in China. Asian Journal of Surgery 46:10, pages 4371-4377.
Crossref
Akash Bararia, Amlan Das, Sangeeta Mitra, Sudeep Banerjee, Aniruddha Chatterjee & Nilabja Sikdar. (2023) Deoxyribonucleic acid methylation driven aberrations in pancreatic cancer-related pathways. World Journal of Gastrointestinal Oncology 15:9, pages 1505-1519.
Crossref
Denis L F Jardim, Sherri Z Millis, Jeffrey S Ross, Scott Lippman, Siraj M Ali & Razelle Kurzrock. (2023) Comprehensive Landscape of Cyclin Pathway Gene Alterations and Co-occurrence with FGF/FGFR Aberrations Across Urinary Tract Tumors . The Oncologist 28:2, pages e82-e91.
Crossref
Hina Qayoom, Umar Mehraj, Shazia Sofi, Shariqa Aisha, Abdullah Almilaibary, Mustfa Alkhanani & Manzoor Ahmad Mir. (2022) Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study. Medical Oncology 39:10.
Crossref
Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S. Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Katherine A. Donovan, Marta Palafox, Jorge S. Reis-Filho, Elisa de Stanchina, Eric S. Fischer, Neal Rosen, Violeta Serra, Andrew Koff, John D. Chodera, Nathanael S. Gray & Sarat Chandarlapaty. (2022) INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors. Cancer Discovery 12:2, pages 356-371.
Crossref
Jianguo Lai, Bo Chen, Yingzi Li, Xiaoyi Lin, Min Li, Jing Liu & Ning Liao. (2021) Integrated analysis of cell cycle-related genes in HR+/HER2− breast cancer. Breast Cancer 29:1, pages 121-130.
Crossref
Akhmad Madaminov, Akbar Khasanov, Shuhrat Khatamov, Otabek Abdurakhmonov, Anvar Amonov, Zohir Shukurov, Murod Khudayorov, Rahim Bekmirzaev & Latif Nishonboev. (2021) Cancer - dysregulation of the cell cycle and transduction of cascade signals. Romanian Journal of Rhinology 11:43, pages 90-100.
Crossref
Betzaira G. Childers, Divya Sood, Rohini Patel, Evangeline S. Mose, Mojgan Hosseini, Shumei Kato, Joel M. Baumgartner & Andrew M. Lowy. (2021) Palbociclib as a Novel Therapy for Low-Grade Mucinous Carcinomatosis Peritonei of Appendiceal Origin. JCO Precision Oncology:5, pages 1069-1072.
Crossref
Shumei Kato, Jacob J. Adashek, Justin Shaya, Ryosuke Okamura, Rebecca E. Jimenez, Suzanna Lee, Jason K. Sicklick & Razelle Kurzrock. (2021) Concomitant MEK and Cyclin Gene Alterations: Implications for Response to Targeted Therapeutics. Clinical Cancer Research 27:10, pages 2792-2797.
Crossref
Shumei Kato, Ryosuke Okamura, Jacob J. Adashek, Noor Khalid, Suzanna Lee, Van Nguyen, Jason K. Sicklick & Razelle Kurzrock. (2021) Targeting G1/S phase cell-cycle genomic alterations and accompanying co-alterations with individualized CDK4/6 inhibitor–based regimens. JCI Insight 6:1.
Crossref
Denis L. Jardim, Sherri Z. Millis, Jeffrey S. Ross, Michelle Sue-Ann Woo, Siraj M. Ali & Razelle Kurzrock. (2021) Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large-Scale Data to Inform Therapeutic Directions. The Oncologist 26:1, pages e78-e89.
Crossref
Yuan Chen, Bo Ren, Jinshou Yang, Huanyu Wang, Gang Yang, Ruiyuan Xu, Lei You & Yupei Zhao. (2020) The role of histone methylation in the development of digestive cancers: a potential direction for cancer management. Signal Transduction and Targeted Therapy 5:1.
Crossref
Jun Ye, Mei Lin, Chuanmeng Zhang, Xiaowei Zhu, Sumeng Li, Hui Liu, Jianfeng Yin, Hong Yu & Kuichun Zhu. (2020) Tissue gene mutation profiles in patients with colorectal cancer and their clinical implications. Biomedical Reports 13:1, pages 43-48.
Crossref
Queenie Fernandes, Ishita Gupta, Semir Vranic & Ala-Eddin Al Moustafa. (2020) Human Papillomaviruses and Epstein–Barr Virus Interactions in Colorectal Cancer: A Brief Review. Pathogens 9:4, pages 300.
Crossref
Duo Xu, Shun-Qing Liang, Haitang Yang, Rémy Bruggmann, Sabina Berezowska, Zhang Yang, Thomas Michael Marti, Sean Ralph Robert Hall, Yanyun Gao, Gregor J. Kocher, Ralph A. Schmid & Ren-Wang Peng. (2020) CRISPR Screening Identifies WEE1 as a Combination Target for Standard Chemotherapy in Malignant Pleural Mesothelioma. Molecular Cancer Therapeutics 19:2, pages 661-672.
Crossref
Julio Peguero, Davendra P. S. Sohal, Bert H. O’Neil, Howard Safran, Karen Kelly, Juneko E. Grilley-Olson, Vivek Subbiah, Lincoln Nadauld, Das Purkayastha, Erica Stealey, Alejandro D. Ricart, Barinder P. Kang & Joseph Paul Eder. (2019) Tissue/Site-Agnostic Study of Ribociclib for Tumors With Cyclin D–CDK4/6 Pathway Genomic Alterations: A Phase II, Open-Label, Single-Arm Basket Study. JCO Precision Oncology:3, pages 1-10.
Crossref
Jaana Oikkonen, Kaiyang Zhang, Liina Salminen, Ingrid Schulman, Kari Lavikka, Noora Andersson, Erika Ojanperä, Sakari Hietanen, Seija Grénman, Rainer Lehtonen, Kaisa Huhtinen, Olli Carpén, Johanna Hynninen, Anniina Färkkilä & Sampsa Hautaniemi. (2019) Prospective Longitudinal ctDNA Workflow Reveals Clinically Actionable Alterations in Ovarian Cancer. JCO Precision Oncology:3, pages 1-12.
Crossref
Giovanny Soca-Chafre, Angelica Montiel-Dávalos, Inti Alberto De La Rosa-Velázquez, Claudia Haydeé Saraí Caro-Sánchez, Adriana Peña-Nieves & Oscar Arrieta. (2019) Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer. International Journal of Genomics 2019, pages 1-8.
Crossref
Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Maria Schwaederle, Michael E. Hahn, Casey B. Williams, Pradip De, Amy Krie, David E. Piccioni, Vincent A. Miller, Jeffrey S. Ross, Adam Benson, Jennifer Webster, Philip J. Stephens, J. Jack Lee, Paul T. Fanta, Scott M. Lippman, Brian Leyland-Jones & Razelle Kurzrock. (2019) Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study. Nature Medicine 25:5, pages 744-750.
Crossref
Jennifer L. Green, Eric S. Okerberg, Josilyn Sejd, Marta Palafox, Laia Monserrat, Senait Alemayehu, Jiangyue Wu, Maria Sykes, Arwin Aban, Violeta Serra & Tyzoon Nomanbhoy. (2019) Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs. Molecular Cancer Therapeutics 18:4, pages 771-779.
Crossref
Daniel A. Morgenstern & Meredith S. Irwin. 2019. Neuroblastoma. Neuroblastoma 263 281 .
Xian Chen, Kwang-Huei Low, Angela Alexander, Yufeng Jiang, Cansu Karakas, Kenneth R. Hess, Jason P.W. Carey, Tuyen N. Bui, Smruthi Vijayaraghavan, Kurt W. Evans, Min Yi, D. Christian Ellis, Kwok-Leung Cheung, Ian O. Ellis, Siqing Fu, Funda Meric-Bernstam, Kelly K. Hunt & Khandan Keyomarsi. (2018) Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition. Clinical Cancer Research 24:24, pages 6594-6610.
Crossref
Rui Zhang, Jibin Li, Xiaofei Yan, Keer Jin, Wenya Li, Xin Liu, Jianfeng Zhao, Wen Shang & Xiang Zhao. (2018) Long non‑coding RNA MLK7‑AS1 promotes proliferation in human colorectal cancer via downregulation of p21 expression. Molecular Medicine Reports.
Crossref
Yubing Zhou, Jacson K. Shen, Zujiang Yu, Francis J. Hornicek, Quancheng Kan & Zhenfeng Duan. (2018) Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:5, pages 1573-1582.
Crossref
Andrew N. Hesse, William Fabricius, Christian A. Thomas, Ramesh Gaindh, Robert Christman, Pavalan Selvam, Matthew Prego, Gregory Lewis, Jasmina Uvalic, Daniel Bergeron, Shelbi Burns, Bridgette Sisson, Kevin Kelly, Jens Rueter & Honey V. Reddi. (2018) Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease. Case Reports in Oncology 11:1, pages 196-205.
Crossref
Maria Schwaederle, Nithya Krishnamurthy, Gregory A. Daniels, David E. Piccioni, Santosh Kesari, Paul T. Fanta, Richard B. Schwab, Sandip P. Patel, Barbara A. Parker & Razelle Kurzrock. (2018) Telomerase reverse transcriptase promoter alterations across cancer types as detected by next-generation sequencing: A clinical and molecular analysis of 423 patients. Cancer 124:6, pages 1288-1296.
Crossref
Elena V. Demidova, Waleed Iqbal & Sanjeevani Arora. 2018. Molecular Determinants of Head and Neck Cancer. Molecular Determinants of Head and Neck Cancer 185 227 .
Zhonghua Ma, Hesuyuan Huang, Jirong Wang, Yan Zhou, Fuxing Pu, Qinghong Zhao, Peng Peng, Bingqing Hui, Hao Ji & Keming Wang. (2017) Long non-coding RNA SNHG15 inhibits P15 and KLF2 expression to promote pancreatic cancer proliferation through EZH2-mediated H3K27me3. Oncotarget 8:48, pages 84153-84167.
Crossref
Jill J.J. Geenen & Jan H.M. Schellens. (2017) Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer. Clinical Cancer Research 23:16, pages 4540-4544.
Crossref
Kai Wang, Jeffery S. Russell, Jessica D. McDermott, Julia A. Elvin, Depinder Khaira, Adrienne Johnson, Timothy A. Jennings, Siraj M. Ali, Molly Murray, Carrie Marshall, Dwight S. Oldham, Donna Washburn, Stuart J. Wong, Juliann Chmielecki, Roman Yelensky, Doron Lipson, Vincent A. Miller, Philip J. Stephens, Hilary S. Serracino, Jeffrey S. Ross & Daniel W. Bowles. (2016) Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations. Clinical Cancer Research 22:24, pages 6061-6068.
Crossref
Yayoi Takahashi, Tamotsu Sugai, Wataru Habano, Kazuyuki Ishida, Makoto Eizuka, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Takanori Morikawa, Michiaki Unno & Hiromu Suzuki. (2016) Molecular differences in the microsatellite stable phenotype between left‐sided and right‐sided colorectal cancer. International Journal of Cancer 139:11, pages 2493-2501.
Crossref
Shumei Kato, Brett N. Tomson, Timon P.H. Buys, Sheryl K. Elkin, Jennifer L. Carter & Razelle Kurzrock. (2016) Genomic Landscape of Malignant Mesotheliomas. Molecular Cancer Therapeutics 15:10, pages 2498-2507.
Crossref
Shumei Kato, Scott M. Lippman, Keith T. Flaherty & Razelle Kurzrock. (2016) The Conundrum of Genetic “Drivers” in Benign Conditions. Journal of the National Cancer Institute 108:8, pages djw036.
Crossref
Qian Zhang, Hai-Bo Yan, Jie Wang, Shu-Jian Cui, Xiao-Qing Wang, Ying-Hua Jiang, Li Feng, Peng-Yuan Yang & Feng Liu. (2016) Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1 . Oncotarget 7:29, pages 46127-46141.
Crossref
Teresa Helsten, Shumei Kato, Maria Schwaederle, Brett N. Tomson, Timon P.H. Buys, Sheryl K. Elkin, Jennifer L. Carter & Razelle Kurzrock. (2016) Cell-Cycle Gene Alterations in 4,864 Tumors Analyzed by Next-Generation Sequencing: Implications for Targeted Therapeutics. Molecular Cancer Therapeutics 15:7, pages 1682-1690.
Crossref
Philip R. Cohen, Brett N. Tomson, Sheryl K. Elkin, Erica Marchlik, Jennifer L. Carter & Razelle Kurzrock. (2016) Genomic portfolio of Merkel cell carcinoma as determined by comprehensive genomic profiling: implications for targeted therapeutics. Oncotarget 7:17, pages 23454-23467.
Crossref
Xiyin Wang, Shikha Khatri, Russell Broaddus, Zhong Wang & Shannon M. Hawkins. (2016) Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice1. Biology of Reproduction 94:4.
Crossref
Petra Minarikova, Lucie Benesova, Tereza Halkova, Barbora Belsanova, Inna Tuckova, Frantisek Belina, Ladislav Dusek, Miroslav Zavoral & Marek Minarik. (2016) Prognostic Importance of Cell Cycle Regulators Cyclin D1 ( CCND1 ) and Cyclin-Dependent Kinase Inhibitor 1B ( CDKN1B /p27) in Sporadic Gastric Cancers . Gastroenterology Research and Practice 2016, pages 1-8.
Crossref
Sabine Mueller & Daphne A. Haas-Kogan. (2015) WEE1 Kinase As a Target for Cancer Therapy. Journal of Clinical Oncology 33:30, pages 3485-3487.
Crossref
Shumei Kato, Sheryl K. Elkin, Maria Schwaederle, Brett N. Tomson, Teresa Helsten, Jennifer L. Carter & Razelle Kurzrock. (2015) Genomic landscape of salivary gland tumors. Oncotarget 6:28, pages 25631-25645.
Crossref