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Cell Cycle Volume 14, 2015 - Issue 15
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Sumoylation regulates EXO1 stability and processing of DNA damage

Serena BolognaInstitute of Molecular Cancer Research; University of Zurich; Zurich, Switzerland
,
Veronika AltmannovaDepartment of Biology; Masaryk University; Brno, Czech Republic
,
Emanuele ValtortaDepartment of Hematology and Oncology; Niguarda Cancer Center; Milan, Italy
,
Christiane KoenigInstitute of Molecular Cancer Research; University of Zurich; Zurich, Switzerland
,
Prisca LiberaliInstitute of Molecular Life Sciences; University of Zurich; Zurich, Switzerland
,
Christian GentiliInstitute of Molecular Cancer Research; University of Zurich; Zurich, Switzerland
,
Dorothea AnratherDepartment of Biochemistry and Cell Biology; Max F. Perutz Laboratories; University of Vienna; Vienna, Austria
,
Gustav AmmererDepartment of Biochemistry and Cell Biology; Max F. Perutz Laboratories; University of Vienna; Vienna, Austria
,
Lucas PelkmansInstitute of Molecular Life Sciences; University of Zurich; Zurich, Switzerland
,
Lumir KrejciDepartment of Biology; Masaryk University; Brno, Czech Republic;National Center for Biomolecular Research; Masaryk University; Brno, Czech Republic;International Clinical Research Center; St. Anne's University Hospital in Brno; Brno, Czech Republic
&
Stefano FerrariInstitute of Molecular Cancer Research; University of Zurich; Zurich, SwitzerlandCorrespondence[email protected]
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Pages 2439-2450 | Received 20 Jan 2015, Accepted 03 Jun 2015, Published online: 17 Jul 2015

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Yaoyao Dai, Zuxiong Tang, Zongguo Yang, Lan Zhang, Qing Deng, Xiaofeng Zhang, Yongchun Yu, Xing Liu & Junfeng Zhu. (2018) EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients. Cell Cycle 17:19-20, pages 2386-2397.
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Guido Keijzers, Dekang Liu & Lene Juel Rasmussen. (2016) Exonuclease 1 and its versatile roles in DNA repair. Critical Reviews in Biochemistry and Molecular Biology 51:6, pages 440-451.
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Hanspeter Naegeli. (2015) Exonuclease containment by SUMO plus ubiquitin. Cell Cycle 14:18, pages 2873-2874.
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Articles from other publishers (34)

Laura A. Claessens, Matty Verlaan-de Vries, Ilona J. de Graaf & Alfred C. O. Vertegaal. (2023) SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation. Nature Communications 14:1.
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Yao Lu, Panpan Huang, Yanli Li, Wenyu Liu, Jing Li, Rui Zhao, Haihua Feng, Ce Shi & Gaolu Cao. (2023) The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression. Acta Biochimica et Biophysica Sinica.
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Wenli Sun, Hui Liu, Wenhao Yin, Jie Qiao, Xueke Zhao & Yi Liu. (2022) Strategies for Enhancing the Homology-Directed Repair Efficiency of CRISPR-Cas Systems. The CRISPR Journal 5:1, pages 7-18.
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Shuang Yan, Shanshan Gao & Pingkun Zhou. (2021) Multi-functions of exonuclease 1 in DNA damage response and cancer susceptibility. Radiation Medicine and Protection 2:4, pages 146-154.
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Johannes Gebert, Ozkan Gelincik, Mine Oezcan-Wahlbrink, Jason D. Marshall, Alejandro Hernandez-Sanchez, Katharina Urban, Mark Long, Eduardo Cortes, Elena Tosti, Eva-Maria Katzenmaier, Yurong Song, Ali Elsaadi, Nan Deng, Eduardo Vilar, Vera Fuchs, Nina Nelius, Yan P. Yuan, Aysel Ahadova, Shizuko Sei, Robert H. Shoemaker, Asad Umar, Lei Wei, Song Liu, Peer Bork, Winfried Edelmann, Magnus von Knebel Doeberitz, Steven M. Lipkin & Matthias Kloor. (2021) Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model. Gastroenterology 161:4, pages 1288-1302.e13.
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Paulina Tokarz & Katarzyna Woźniak. (2021) SENP Proteases as Potential Targets for Cancer Therapy. Cancers 13:9, pages 2059.
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Andrew J Locke, Lazina Hossain, Glynnis McCrostie, Daryl A Ronato, Amira Fitieh, Tanzeem Ahmed Rafique, Fatemeh Mashayekhi, Mobina Motamedi, Jean-Yves Masson & Ismail Hassan Ismail. (2021) SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection. Nucleic Acids Research 49:2, pages 928-953.
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Yilun Sun, Liton Kumar Saha, Sourav Saha, Ukhyun Jo & Yves Pommier. (2020) Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways. DNA Repair 94, pages 102926.
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Sarah Sertic, Roberto Quadri, Federico Lazzaro & Marco Muzi-Falconi. (2020) EXO1: A tightly regulated nuclease. DNA Repair 93, pages 102929.
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Jenna M. Whalen & Catherine H. Freudenreich. (2020) Location, Location, Location: The Role of Nuclear Positioning in the Repair of Collapsed Forks and Protection of Genome Stability. Genes 11:6, pages 635.
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Esther C Morafraile, Alberto Bugallo, Raquel Carreira, María Fernández, Cristina Martín-Castellanos, Miguel G Blanco & Mónica Segurado. (2020) Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins. Nucleic Acids Research 48:6, pages 3053-3070.
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Yaping Liang, Yu Zhang & Liangwei Liu. (2020) Intra-Molecular Homologous Recombination of Scarless Plasmid. International Journal of Molecular Sciences 21:5, pages 1697.
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Alexander J. Garvin. (2019) Beyond reversal: ubiquitin and ubiquitin-like proteases and the orchestration of the DNA double strand break repair response. Biochemical Society Transactions 47:6, pages 1881-1893.
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Nagaraja Chappidi, Giuseppe De Gregorio & Stefano Ferrari. (2019) Replication stress-induced Exo1 phosphorylation is mediated by Rad53/Pph3 and Exo1 nuclear localization is controlled by 14-3-3 proteins. Cell Division 14:1.
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Nalini Dhingra & Xiaolan Zhao. (2019) Intricate SUMO-based control of the homologous recombination machinery. Genes & Development 33:19-20, pages 1346-1354.
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Shan Li, Zeno Lavagnino, Delphine Lemacon, Lingzhen Kong, Alessandro Ustione, Xuewen Ng, Yuanya Zhang, Yingchun Wang, Bin Zheng, Helen Piwnica-Worms, Alessandro Vindigni, David W. Piston & Zhongsheng You. (2019) Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Molecular Cell 74:6, pages 1123-1137.e6.
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Lepakshi Ranjha, Maryna Levikova, Veronika Altmannova, Lumir Krejci & Petr Cejka. (2019) Sumoylation regulates the stability and nuclease activity of Saccharomyces cerevisiae Dna2. Communications Biology 2:1.
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Alexander J. Garvin, Alexandra K. Walker, Ruth M. Densham, Anoop Singh Chauhan, Helen R. Stone, Hannah L. Mackay, Mohammed Jamshad, Katarzyna Starowicz, Manuel Daza-Martin, George E. Ronson, Alexander J. Lanz, James F. Beesley & Joanna R. Morris. (2019) The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms. Genes & Development 33:5-6, pages 333-347.
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Paul G. Barghouth, Manish Thiruvalluvan, Melanie LeGro & Néstor J. Oviedo. (2019) DNA damage and tissue repair: What we can learn from planaria. Seminars in Cell & Developmental Biology 87, pages 145-159.
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Sara Espinoza-Corona, Ma Luisa Bazán-Tejeda, Ulises Omar García-Lepe & Rosa Ma Bermúdez-Cruz. 2018. Ubiquitination Governing DNA Repair - Implications in Health and Disease. Ubiquitination Governing DNA Repair - Implications in Health and Disease.
Brian L. Lee, Anamika Singh, J.N. Mark Glover, Michael J. Hendzel & Leo Spyracopoulos. (2017) Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics. Journal of Molecular Biology 429:22, pages 3409-3429.
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Joanna R. Morris & Alexander J. Garvin. (2017) SUMO in the DNA Double-Stranded Break Response: Similarities, Differences, and Cooperation with Ubiquitin. Journal of Molecular Biology 429:22, pages 3376-3387.
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Alexander J. Garvin & Joanna R. Morris. (2017) SUMO, a small, but powerful, regulator of double-strand break repair. Philosophical Transactions of the Royal Society B: Biological Sciences 372:1731, pages 20160281.
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Nozomi Tomimatsu, Bipasha Mukherjee, Janelle Louise Harris, Francesca Ludovica Boffo, Molly Catherine Hardebeck, Patrick Ryan Potts, Kum Kum Khanna & Sandeep Burma. (2017) DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair. Journal of Biological Chemistry 292:26, pages 10779-10790.
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Minghua Nie, Bettina A. Moser, Toru M. Nakamura & Michael N. Boddy. (2017) SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion. PLOS Genetics 13:5, pages e1006776.
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Anna V. Gaponova, Alexander Y. Deneka, Tim N. Beck, Hanqing Liu, Gregory Andrianov, Anna S. Nikonova, Emmanuelle Nicolas, Margret B. Einarson, Erica A. Golemis & Ilya G. Serebriiskii. (2016) Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin. Oncotarget 8:12, pages 19156-19171.
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Deena Jalal, Jisha Chalissery & Ahmed H. Hassan. (2017) Genome maintenance in Saccharomyces cerevisiae : the role of SUMO and SUMO-targeted ubiquitin ligases . Nucleic Acids Research, pages gkw1369.
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Stephen GrayPaula E. Cohen. (2016) Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation. Annual Review of Genetics 50:1, pages 175-210.
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Wassim Eid & Wafaa Abdel-Rehim. (2016) Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A. Biological Chemistry 397:11, pages 1205-1213.
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Mahmoud El-Shemerly, Wassim Eid, Daniel Hess, Serena Bologna, Christian Gentili & Stefano Ferrari. (2016) Exonuclease-1 interacts with the transcriptional co-repressor KAP1. Matters.
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Sarah-Felicitas Himmels & Alessandro A. Sartori. (2016) Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO. Frontiers in Genetics 7.
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Sharad C. Paudyal & Zhongsheng You. (2016) Sharpening the ends for repair: mechanisms and regulation of DNA resection. Acta Biochimica et Biophysica Sinica 48:7, pages 647-657.
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Jayabal Panneerselvam, Hong Wang, Jun Zhang, Raymond Che, Herbert Yu & Peiwen Fei. (2016) BLM promotes the activation of Fanconi Anemia signaling pathway. Oncotarget 7:22, pages 32351-32361.
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Stefania Pellegrino & Matthias Altmeyer. (2016) Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress. Frontiers in Genetics 7.
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