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Cell Cycle Volume 14, 2015 - Issue 19
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Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

Sara ChikerInstitut Curie; Centre de Recherche; Centre Universitaire; Orsay Cedex, France;Inserm; U612; Centre Universitaire; Orsay Cedex, France;Université Paris-XI; Faculté de Médecine; Le Kremlin Bicêtre, France
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Vincent PennaneachInstitut Curie; Centre de Recherche; Centre Universitaire; Orsay Cedex, France;Inserm; U612; Centre Universitaire; Orsay Cedex, France
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Damarys LoewInstitut Curie; Centre de Recherche; Laboratoire de Spectrométrie de Masse Protéomique; Paris, France
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Florent DingliInstitut Curie; Centre de Recherche; Laboratoire de Spectrométrie de Masse Protéomique; Paris, France
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Denis BiardCommissariat à l'Energie Atomique; DSV; iMETI; SEPIA; Team Cellular Engineering and Human Syndromes; Fontenay aux Roses, France
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Fabrice P CordelièresInstitut Curie; Centre de Recherche; Centre Universitaire; Orsay Cedex, France;CNRS; UMR3348; Centre Universitaire; Orsay Cedex, France;Plateforme IBiSA d'Imagerie Cellulaire et Tissulaire; Institut Curie; Centre Universitaire; Orsay, France
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Simon GembleInstitut Curie; Centre de Recherche; Centre Universitaire; Orsay Cedex, France;CNRS; UMR3348; Centre Universitaire; Orsay Cedex, France
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Sophie VacherPharmacogenetics Unit; Genetics Service; Department of Tumour Biology; Institut Curie; Paris, France
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Ivan BiechePharmacogenetics Unit; Genetics Service; Department of Tumour Biology; Institut Curie; Paris, France
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Janet HallInstitut Curie; Centre de Recherche; Centre Universitaire; Orsay Cedex, France;Inserm; U612; Centre Universitaire; Orsay Cedex, France;Centre de Recherche en Cancérologie de Lyon -UMR Inserm 1052 - CNRS 5286; Lyon, FranceCorrespondence[email protected]
&
Marie FernetInstitut Curie; Centre de Recherche; Centre Universitaire; Orsay Cedex, France;Inserm; U612; Centre Universitaire; Orsay Cedex, France
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Pages 3066-3078 | Received 10 Oct 2014, Accepted 26 Jul 2015, Published online: 23 Oct 2015

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Hang-xing Bao, Qing Bi, Yong Han, Chen Zhao & Hai Zou. (2017) Potential mechanisms underlying CDK5 related Osteosarcoma progression. Expert Opinion on Therapeutic Targets 21:5, pages 455-460.
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Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R. Gilbert, Harish Pant, Emeline Tabouret & Zhengping Zhuang. (2023) TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma. International Journal of Molecular Sciences 24:14, pages 11733.
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Wentao Tang, Congcong Lin, Quanwei Yu, Dan Zhang, Yun Liu, Lele Zhang, Zhilan Zhou, Jifa Zhang & Liang Ouyang. (2023) Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery. Journal of Medicinal Chemistry 66:11, pages 7140-7161.
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Xianglai Xu, Ying Wang, Zhaoyi Chen, Yanjun Zhu, Jiajun Wang & Jianming Guo. (2023) Favorable Immunotherapy Plus Tyrosine Kinase Inhibition Outcome of Renal Cell Carcinoma Patients with Low CDK5 Expression. Cancer Research and Treatment.
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Phuong Anh Do & Chang Hoon Lee. (2020) The Role of CDK5 in Tumours and Tumour Microenvironments. Cancers 13:1, pages 101.
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Mohd Amir, Taj Mohammad, Ravins Dohare, Asimul Islam, Faizan Ahmad & Md Imtaiyaz Hassan. (2020) Structure, function and therapeutic implications of OB-fold proteins: A lesson from past to present. Briefings in Functional Genomics 19:5-6, pages 377-389.
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Yuncheng Bei, Nan Cheng, Ting Chen, Yuxin Shu, Ye Yang, Nanfei Yang, Xinyu Zhou, Baorui Liu, Jia Wei, Qin Liu, Wei Zheng, Wenlong Zhang, Huifang Su, Wei‐Guo Zhu, Jianguo Ji & Pingping Shen. (2020) CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy. Advanced Science 7:22.
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Stewart G. Martin, Siwei Zhang, Song Yang, Behnaz Saidy, Suha Deen & Sarah J. Storr. (2020) Dopamine and cAMP‐regulated phosphoprotein 32kDa (DARPP‐32), protein phosphatase‐1 and cyclin‐dependent kinase 5 expression in ovarian cancer. Journal of Cellular and Molecular Medicine 24:16, pages 9165-9175.
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Emeline Tabouret, Herui Wang, Niranjana Amin, Jinkyu Jung, Romain Appay, Jing Cui, Qi Song, Antonio Cardone, Deric M. Park, Mark R. Gilbert, Harish Pant & Zhengping Zhuang. (2020) TP5, a Peptide Inhibitor of Aberrant and Hyperactive CDK5/p25: A Novel Therapeutic Approach against Glioblastoma. Cancers 12:7, pages 1935.
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Behnaz Saidy, Emad A. Rakha, Andrew R. Green, Ian O. Ellis, Stewart G. Martin & Sarah J. Storr. (2020) Retrospective assessment of cyclin‐dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer. Journal of Cellular and Molecular Medicine 24:11, pages 6263-6271.
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Samanta Sharma & Piotr Sicinski. (2020) A kinase of many talents: non-neuronal functions of CDK5 in development and disease. Open Biology 10:1, pages 190287.
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Landon J. Getz, Cameron S. Runte, Jan K. Rainey & Nikhil A. Thomas. (2019) Tyrosine Phosphorylation as a Widespread Regulatory Mechanism in Prokaryotes. Journal of Bacteriology 201:19.
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Xiao-Feng Zheng, Sanket S. Acharya, Katherine N. Choe, Kumar Nikhil, Guillaume Adelmant, Shakti Ranjan Satapathy, Samanta Sharma, Keith Viccaro, Sandeep Rana, Amarnath Natarajan, Peter Sicinski, Jarrod A. Marto, Kavita Shah & Dipanjan Chowdhury. (2019) A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nature Communications 10:1.
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Muhammet Oner, Eugene Lin, Mei-Chih Chen, Fu-Ning Hsu, G M Shazzad Hossain Prince, Kun-Yuan Chiu, Chieh-Lin Jerry Teng, Tsung-Ying Yang, Hsin-Yi Wang, Chia-Herng Yue, Ching-Han Yu, Chih-Ho Lai, Jer-Tsong Hsieh & Ho Lin. (2019) Future Aspects of CDK5 in Prostate Cancer: From Pathogenesis to Therapeutic Implications. International Journal of Molecular Sciences 20:16, pages 3881.
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Tabughang Chi, Tina Horbach, Claudia Götz, Thomas Kietzmann & Elitsa Dimova. (2019) Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis. Cancers 11:4, pages 523.
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Aleksandra Nowak & Piotr Dziegiel. (2018) Implications of nestin in breast cancer pathogenesis (Review). International Journal of Oncology.
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Jimma Likisa Lenjisa, Solomon Tadesse, Nishat Zareen Khair, Malika Kumarasiri, Mingfeng Yu, Hugo Albrecht, Robert Milne & Shudong Wang. (2017) CDK5 in oncology: recent advances and future prospects. Future Medicinal Chemistry 9:16, pages 1939-1962.
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Guliang Wang & Karen Vasquez. (2017) Effects of Replication and Transcription on DNA Structure-Related Genetic Instability. Genes 8:1, pages 17.
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Yu-Qin Sun, Jian-Wei Xie, Hong-Teng Xie, Peng-Chen Chen, Xiu-Li Zhang, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Long-Long Cao, Chang-Ming Huang & Yao Lin. (2017) Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer. World Journal of Gastroenterology 23:11, pages 2012.
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Ying-Qing Wang, Ping-Yuan Wang, Yu-Ting Wang, Guang-Fu Yang, Ao Zhang & Ze-Hong Miao. (2016) An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy. Journal of Medicinal Chemistry 59:21, pages 9575-9598.
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Karine Pozo & James A. Bibb. (2016) The Emerging Role of Cdk5 in Cancer. Trends in Cancer 2:10, pages 606-618.
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Aziz Ouach, Rajâa Boulahjar, Christine Vala, Stéphane Bourg, Pascal Bonnet, Christiane Guguen-Guillouzo, Myriam Ravache, Rémy Le Guevel, Olivier Lozach, Saïd Lazar, Yves Troin, Laurent Meijer, Sandrine Ruchaud, Mohamed Akssira, Gérald Guillaumet & Sylvain Routier. (2016) Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors. European Journal of Medicinal Chemistry 115, pages 311-325.
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Seong Ji Park, Sun Woo Yang & Byung-Chul Kim. (2016) Transforming growth factor-β1 induces cell cycle arrest by activating atypical cyclin-dependent kinase 5 through up-regulation of Smad3-dependent p35 expression in human MCF10A mammary epithelial cells. Biochemical and Biophysical Research Communications 472:3, pages 502-507.
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