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The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2

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Pages 3173-3183 | Received 05 Jun 2015, Accepted 02 Aug 2015, Published online: 23 Oct 2015

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Anjasu Paul, Md. Belayet Hasan Limon, Md. Mobarok Hossain & Md. Thosif Raza. (2023) An integrated computational approach to screening of alkaloids inhibitors of TBX3 in breast cancer cell lines. Journal of Biomolecular Structure and Dynamics 41:7, pages 3025-3041.
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H. Matthew Berns, Dawn E. Watkins‐Chow, Sizhu Lu, Pakavarin Louphrasitthiphol, Tongwu Zhang, Kevin M. Brown, Pedro Moura‐Alves, Colin R. Goding & William J. Pavan. (2023) Single‐cell profiling of MC1R ‐inhibited melanocytes . Pigment Cell & Melanoma Research.
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Xiaoyu Li, Daniel C Moreira, Asim K Bag, Ibrahim Qaddoumi, Sahaja Acharya & Jason Chiang. (2023) The clinical and molecular characteristics of progressive hypothalamic/optic pathway pilocytic astrocytoma. Neuro-Oncology 25:4, pages 750-760.
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Saif F. Khan, Carly A. Burmeister, David J. Scott, Musalula Sinkala, Amsha Ramburan, Hue-Tsi Wu, Georgia Schäfer, Arieh A. Katz & Sharon Prince. (2023) TBX3 Promotes Cervical Cancer Proliferation and Migration via HPV E6 and E7 Signaling. Molecular Cancer Research 21:4, pages 345-358.
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Lifu Huang, Xianjun Zhang, Feiping Li & Xiaohong Wang. (2022) MicroRNA-143-3p/TBX3 Axis Represses Malignant Cell Behaviors in Bladder Cancer. Computational and Mathematical Methods in Medicine 2022, pages 1-10.
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Victoria Damerell, Melvin Anyasi Ambele, Shanel Salisbury, Alexis Neumann-Mufweba, Chrisna Durandt, Michael Sean Pepper & Sharon Prince. (2022) The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells. Frontiers in Oncology 11.
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Jade Peres, Victoria Damerell, Jagat Chauhan, Ana Popovic, Pierre-Yves Desprez, Marie-Dominique Galibert, Colin R. Goding & Sharon Prince. (2021) TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF. Journal of Investigative Dermatology 141:9, pages 2250-2260.e2.
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Victoria Damerell, Michael S. Pepper & Sharon Prince. (2021) Molecular mechanisms underpinning sarcomas and implications for current and future therapy. Signal Transduction and Targeted Therapy 6:1.
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Zhecun Wang, Yunling Qi, Rui Wang, Weibin Wu, Zilun Li, Mian Wang, Ruiming Liu, Chunxiang Zhang, Wen Li & Shenming Wang. (2020) IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E–CDK2. Journal of Cellular Physiology 235:12, pages 9538-9556.
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Danica Sims, Hapiloe Mabaruti Maranyane, Victoria Damerell, Dhirendra Govender, Ashwin W. Isaacs, Jade Peres & Sharon Prince. (2020) The c-Myc/AKT1/TBX3 Axis Is Important to Target in the Treatment of Embryonal Rhabdomyosarcoma. Cancers 12:2, pages 501.
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Saif F. Khan, Victoria Damerell, Rehana Omar, Michelle Du Toit, Mohsin Khan, Hapiloe Mabaruti Maranyane, Mihlali Mlaza, Jenna Bleloch, Claire Bellis, Bianca D.B. Sahm, Jade Peres, K.N. ArulJothi & Sharon Prince. (2020) The roles and regulation of TBX3 in development and disease. Gene 726, pages 144223.
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Yongjiu Huang, Hongmei Zhu, Xiaohui Ji, Yin Chen, Yanhui Zhang, Ruofei Huang, Jin Xie & Pin Dong. (2019) TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis. Oncology Letters.
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Saeb Aliwaini, Abdel Lubbad, Ahmed Shourfa, Hosam Hamada, Basim Ayesh, Husam Abu Tayem, Ayman Abu Mustafa, Fayek Abu Rouk, Moen Redwan & Mohamed Al‑Najjar. (2018) Overexpression of TBX3 transcription factor as a potential diagnostic marker for breast cancer. Molecular and Clinical Oncology.
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Xiaomeng Li, Xianhui Ruan, Peitao Zhang, Yang Yu, Ming Gao, Shukai Yuan, Zewei Zhao, Jie Yang & Li Zhao. (2018) TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression. Oncogene 37:21, pages 2773-2792.
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Jie Ji, Yin Yin, Huanyu Ju, Xiaoliang Xu, Wei Liu, Qiang Fu, Jiaojiao Hu, Xudong Zhang & Beicheng Sun. (2018) Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC. Cell Death & Disease 9:5.
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Minxia Ke, Quan He, Danping Hong, Ouyang Li, Mengyi� Zhu, Wen‑Bin Ou, Yulong He & Yuehong Wu. (2018) Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/‌Akt‑dependent Tbx‑3 activation pathway. International Journal of Molecular Medicine.
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Jade Peres, Eliza M. Kwesi-Maliepaard, Florian Rambow, Lionel Larue & Sharon Prince. (2017) The tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor. Cancer Letters 405, pages 111-119.
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Ryo Ichijo, Hiroki Kobayashi, Saori Yoneda, Yui Iizuka, Hirokazu Kubo, Shigeru Matsumura, Satsuki Kitano, Hitoshi Miyachi, Tetsuya Honda & Fumiko Toyoshima. (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nature Communications 8:1.
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Tarryn Willmer, Aretha Cooper, Jade Peres, Rehana Omar & Sharon Prince. (2017) The T-Box transcription factor 3 in development and cancer. BioScience Trends 11:3, pages 254-266.
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Tarryn Willmer, Shannagh Hare, Jade Peres & Sharon Prince. (2016) The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor. Cell Division 11:1.
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T Willmer, A Cooper, D Sims, D Govender & S Prince. (2016) The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes. Oncogenesis 5:2, pages e199-e199.
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