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Review

4E-BP1, a multifactor regulated multifunctional protein

, &
Pages 781-786 | Received 03 Aug 2015, Accepted 01 Feb 2016, Published online: 22 Feb 2016

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Mingliang Wang, Yida Lu, Huizhen Wang, Youliang Wu, Xin Xu & Yongxiang Li. (2021) High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer. Frontiers in Oncology 11.
Crossref
Katrina Woodward & Nikolay E. Shirokikh. (2021) Translational control in cell ageing: an update. Biochemical Society Transactions 49:6, pages 2853-2869.
Crossref
Divya Ramchandani, Mirela Berisa, Diamile A. Tavarez, Zhuoning Li, Matthew Miele, Yang Bai, Sharrell B. Lee, Yi Ban, Noah Dephoure, Ronald C. Hendrickson, Suzanne M. Cloonan, Dingcheng Gao, Justin R. Cross, Linda T. Vahdat & Vivek Mittal. (2021) Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis. Nature Communications 12:1.
Crossref
Moein Ala & Mahan Ala. (2021) Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?. ACS Pharmacology & Translational Science 4:6, pages 1747-1770.
Crossref
Valentina Conti, Manuela Cominelli, Valentina Pieri, Alberto L. Gallotti, Ilaria Pagano, Matteo Zanella, Stefania Mazzoleni, Flavia Pivetta, Monica Patanè, Giulia M. Scotti, Ignazio S. Piras, Bianca Pollo, Andrea Falini, Alessio Zippo, Antonella Castellano, Roberta Maestro, Pietro L. Poliani & Rossella Galli. (2021) mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma. JCI Insight 6:23.
Crossref
Sara Diana Lolansen, Nina Rostgaard, Søren Norge Andreassen, Anja Hviid Simonsen, Marianne Juhler, Steen Gregers Hasselbalch & Nanna MacAulay. (2021) Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus. Fluids and Barriers of the CNS 18:1.
Crossref
You Jiang, Shui-Yan Wu, Yan-Ling Chen, Zi-Mu Zhang, Yan-Fang Tao, Yi Xie, Xin-Mei Liao, Xiao-Lu Li, Gen Li, Di Wu, Hai-Rong Wang, Ran Zuo, Hai-Bo Cao, Jing-Jing Pan, Juan-Juan Yu, Si-Qi Jia, Zheng Zhang, Xin-Ran Chu, Yong-Ping Zhang, Chen-xi Feng, Jian-Wei Wang, Shao-Yan Hu, Zhi-Heng Li, Jian Pan, Fang Fang & Jun Lu. (2021) CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1. Cancer Cell International 21:1.
Crossref
Jing Cui, Yao Guo, Heshui Wu, Jiongxin Xiong & Tao Peng. (2021) Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling. Molecular Medicine 27:1.
Crossref
Brian A. Hain, Haifang Xu, Ashley M. VanCleave, Bradley S. Gordon, Scot R. Kimball & David L. Waning. (2021) REDD1 deletion attenuates cancer cachexia in mice. Journal of Applied Physiology 131:6, pages 1718-1730.
Crossref
Dionysia N. Zouki, Ioanna Giannopoulou, Paraskevi Th. Alexandrou, Eleni A. Karatrasoglou, Georgios Pilichos, Konstantinos Stamopoulos, Theodore Kanellis, Eirini Roupou, Angelica A. Saetta, Irini Thymara, Nikolaos Kavantzas & Andreas C. Lazaris. (2021) MTOR/4EBP1 signaling and MMR status in colorectal cancer: New correlations and arising perspectives. Pathology - Research and Practice 228, pages 153655.
Crossref
Cheng Li, Kang Li, Kunming Li, Kete Ai, Yu Zhang, Jiansong Zhang, Jiaqi Li, Xiumei Wei & Jialong Yang. (2021) Essential role of 4E-BP1 for lymphocyte activation and proliferation in the adaptive immune response of Nile tilapia. Fish and Shellfish Immunology Reports 2, pages 100006.
Crossref
Johany Peñailillo, Miriam Palacios, Constanza Mounieres, Rosana Muñoz, Paula G. Slater, Elena De Domenico, Ilya Patrushev, Mike Gilchrist & Juan Larraín. (2021) Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells. npj Regenerative Medicine 6:1.
Crossref
Marti Cadena Sandoval, Alexander Martin Heberle, Ulrike Rehbein, Cecilia Barile, José Miguel Ramos Pittol & Kathrin Thedieck. (2021) mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases. Frontiers in Aging 2.
Crossref
Jui-Ling Hsu, Wohn-Jenn Leu, Nan-Shan Zhong & Jih-Hwa Guh. (2021) Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer. Molecules 26:19, pages 5967.
Crossref
Lin Yin, Na Li, Weihua Jia, Nuoqi Wang, Meidai Liang, Xiuying Yang & Guanhua Du. (2021) Skeletal muscle atrophy: From mechanisms to treatments. Pharmacological Research 172, pages 105807.
Crossref
Danbi Seo, Jungwook Roh, Yeonsoo Chae & Wanyeon Kim. (2021) Gene expression profiling after LINC00472 overexpression in an NSCLC cell line1. Cancer Biomarkers 32:2, pages 175-188.
Crossref
Chao Fang, Haishen Xie, Jun Zhao, Weichen Wang, Hui Hou, Bin Zhang, Dachen Zhou & Xiaoping Geng. (2021) eIF4E-eIF4G complex inhibition synergistically enhances the effect of sorafenib in hepatocellular carcinoma. Anti-Cancer Drugs 32:8, pages 822-828.
Crossref
Angel Cayo, Raúl Segovia, Whitney Venturini, Rodrigo Moore-Carrasco, Claudio Valenzuela & Nelson Brown. (2021) mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership. International Journal of Molecular Sciences 22:15, pages 8149.
Crossref
Muttarin Lothong, Watchara Sakares, Pornchai Rojsitthisak, Chizu Tanikawa, Koichi Matsuda & Varalee Yodsurang. (2021) Collagen XVII inhibits breast cancer cell proliferation and growth through deactivation of the AKT/mTOR signaling pathway. PLOS ONE 16:7, pages e0255179.
Crossref
Zilan Zhu, Ziyi Zheng & Jian Liu. (2021) Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling. Frontiers in Oncology 11.
Crossref
Zeta Chow, Jeremy Johnson, Aman Chauhan, Tadahide Izumi, Michael Cavnar, Heidi Weiss, Courtney M. TownsendJr.Jr., Lowell Anthony, Carrigan Wasilchenko, Matthew L. Melton, Jörg Schrader, B. Mark Evers & Piotr Rychahou. (2021) PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors. Cells 10:5, pages 1261.
Crossref
John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill & Ing Swie Goping. (2021) BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models. Nature Communications 12:1.
Crossref
YoungJun Ju, Yaacov Ben-David, Daniela Rotin & Eldad Zacksenhaus. (2021) Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells. Scientific Reports 11:1.
Crossref
Chiara Borga, Gianluca Businello, Sabina Murgioni, Francesca Bergamo, Chiara Martini, Eugenio De Carlo, Elisabetta Trevellin, Roberto Vettor & Matteo Fassan. (2021) Treatment personalization in gastrointestinal neuroendocrine tumors. Current Treatment Options in Oncology 22:4.
Crossref
Marine Melixetian, Daniela Bossi, Marija Mihailovich, Simona Punzi, Iros Barozzi, Federica Marocchi, Alessandro Cuomo, Tiziana Bonaldi, Giuseppe Testa, Jean‐Christophe Marine, Eleonora Leucci, Saverio Minucci, Pier Giuseppe Pelicci & Luisa Lanfrancone. (2021) Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation. EMBO reports 22:3.
Crossref
Devin Kepchia, Antonio Currais, Richard Dargusch, Kim Finley, David Schubert & Pamela Maher. (2021) Geroprotective effects of Alzheimer’s disease drug candidates. Aging 13:3, pages 3269-3289.
Crossref
Ralph Francescone, Débora Barbosa Vendramini-Costa, Janusz Franco-Barraza, Jessica Wagner, Alexander Muir, Allison N. Lau, Linara Gabitova, Tatiana Pazina, Sapna Gupta, Tiffany Luong, Dustin Rollins, Ruchi Malik, Roshan J. Thapa, Diana Restifo, Yan Zhou, Kathy Q. Cai, Harvey H. Hensley, Yinfei Tan, Warren D. Kruger, Karthik Devarajan, Siddharth Balachandran, Andres J. Klein-Szanto, Huamin Wang, Wafik S. El-Deiry, Matthew G. Vander Heiden, Suraj Peri, Kerry S. Campbell, Igor Astsaturov & Edna Cukierman. (2021) Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression. Cancer Discovery 11:2, pages 446-479.
Crossref
Jia Liu, MengLu Li, LingHao Kong, MengWen Cao, MoLan Zhang, YanHong Wang, ChengChuang Song, XingTang Fang, Hong Chen & ChunLei Zhang. (2021) CircARID1A regulates mouse skeletal muscle regeneration by functioning as a sponge of miR‐6368. The FASEB Journal 35:2.
Crossref
Alex Pizzini, Hannes Bacher, Magdalena Aichner, Alexander Franchi, Kathrin Watzinger, Ivan Tancevski, Thomas Sonnweber, Birgit Mosheimer-Feistritzer, Christina Duftner, Bettina Zelger, Johannes Pallua, Susanne Sprung, Thomas Weichhart, Bernhard Zelger, Günter Weiss & Judith Löffler-Ragg. (2021) High expression of mTOR signaling in granulomatous lesions is not predictive for the clinical course of sarcoidosis. Respiratory Medicine 177, pages 106294.
Crossref
Kelli L. Goss, Stacia L. Koppenhafer, Torin Waters, William W. Terry, Kuo-Kuang Wen, Meng Wu, Jason Ostergaard, Peter M. Gordon & David J. Gordon. (2020) The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors. Oncogene 40:3, pages 564-577.
Crossref
Lily Keane, Ignazio Antignano, Sean-Patrick Riechers, Raphael Zollinger, Anaelle A. Dumas, Nina Offermann, Maria E. Bernis, Jenny Russ, Frederike Graelmann, Patrick Neil McCormick, Julia Esser, Dario Tejera, Ai Nagano, Jun Wang, Claude Chelala, Yvonne Biederbick, Annett Halle, Paolo Salomoni, Michael T. Heneka & Melania Capasso. (2021) mTOR-dependent translation amplifies microglia priming in aging mice. Journal of Clinical Investigation 131:1.
Crossref
Radu C. Zamfirescu, Margot L. Day & Michael B. Morris. (2021) mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition. American Journal of Physiology-Cell Physiology 320:1, pages C30-C44.
Crossref
Ioannis A. Voutsadakis. (2021) Amplification of 8p11.23 in cancers and the role of amplicon genes. Life Sciences 264, pages 118729.
Crossref
Lilian Hernández-Alvarez, Antonio B Oliveira Jr, Jorge Enrique Hernández-González, Jorge Chahine, Pedro Geraldo Pascutti, Alexandre Suman de Araujo & Fátima Pereira de Souza. (2021) Computational study on the allosteric mechanism of Leishmania major IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of m7GTP cap recognition. Computational and Structural Biotechnology Journal 19, pages 2027-2044.
Crossref
Giovanna Maldonado & Greco Hernández. (2021) Translational control in the naked mole-rat as a model highly resistant to cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:1, pages 188455.
Crossref
Marcos Custódio, Bruno Tavares Sedassari, Albina Altemani, Maria Fernanda Setúbal Destro Rodrigues, Fábio Daumas Nunes & Suzana Cantanhede Orsini Machado de Sousa. (2020) Expression of upstream and downstream targets of mTOR pathway in seven cases of secretory carcinoma of salivary gland origin. European Archives of Oto-Rhino-Laryngology 278:1, pages 279-283.
Crossref
Yuan‐Chin Lee, Yi‐Jun Shi, Liang‐Jun Wang, Jing‐Ting Chiou, Chia‐Hui Huang & Long‐Sen Chang. (2020) GSK3β suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells. Journal of Cellular Physiology 236:1, pages 570-586.
Crossref
Elif Burcu BALİ. (2020) Memantine activates LKB1-AMPK pathway in breast carcinoma cells. Cumhuriyet Science Journal 41:4, pages 775-783.
Crossref
Sandra M. Martín-Guerrero, Pedro Casado, Maruan HijaziVinothini RajeeveJulio Plaza-Díaz, Francisco Abadía-Molina, Julio Navascués, Miguel A. Cuadros, Pedro R. CutillasDavid Martín-Oliva. (2020) PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability. Biochemical Journal 477:23, pages 4491-4513.
Crossref
Hui Wang, Xiaoling Ma, Jinhui Liu, Yicong Wan, Yi Jiang, Yankai Xia & Wenjun Cheng. (2020) Prognostic value of an autophagy-related gene expression signature for endometrial cancer patients. Cancer Cell International 20:1.
Crossref
Ragnhild Haugse, Anika Langer, Elisa Thodesen Murvold, Daniela Elena Costea, Bjørn Tore Gjertsen, Odd Helge Gilja, Spiros Kotopoulis, Gorka Ruiz de Garibay & Emmet McCormack. (2020) Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. Pharmaceutics 12:11, pages 1058.
Crossref
Salihanur Darici, Hazem Alkhaldi, Gillian Horne, Heather G. Jørgensen, Sandra Marmiroli & Xu Huang. (2020) Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence. Journal of Clinical Medicine 9:9, pages 2934.
Crossref
Lindsay K. Klofas, Brittany P. Short, John P. Snow, Justine Sinnaeve, Gabrielle V. Rushing, Grant Westlake, Will Weinstein, Rebecca A. Ihrie, Kevin C. Ess & Robert P. Carson. (2020) DEPDC5 haploinsufficiency drives increased mTORC1 signaling and abnormal morphology in human iPSC-derived cortical neurons. Neurobiology of Disease 143, pages 104975.
Crossref
Tiffany J. Rios-Fuller, Melanie Mahe, Beth Walters, Dounia Abbadi, Sandra Pérez-Baos, Abhilash Gadi, John J. Andrews, Olga Katsara, C. Theresa Vincent & Robert J. Schneider. (2020) Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs). International Journal of Molecular Sciences 21:15, pages 5301.
Crossref
Zhenzhen Han, Qi Zhang, Yanbo Zhu, Jingcheng Chen & Wei Li. (2020) Ribosomes: An Exciting Avenue in Stem Cell Research. Stem Cells International 2020, pages 1-12.
Crossref
Valeria Pietropaolo, Carla Prezioso & Ugo Moens. (2020) Merkel Cell Polyomavirus and Merkel Cell Carcinoma. Cancers 12:7, pages 1774.
Crossref
Hyun Sook Hwang, Mi Hyun Lee & Hyun Ah Kim. (2020) TGF‐β1‐induced expression of collagen type II and ACAN is regulated by 4E‐BP1, a repressor of translation. The FASEB Journal 34:7, pages 9531-9546.
Crossref
Jaroslav Kalous, Denisa Jansová & Andrej Šušor. (2020) Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase. Cells 9:7, pages 1568.
Crossref
Kristina Drizyte-Miller, Jing Chen, Hong Cao, Micah B. Schott & Mark A. McNiven. (2020) The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling. Journal of Cell Science 133:11.
Crossref
Yumiko Hori, Michio Ozeki, Katsutoshi Hirose, Kentaro Matsuoka, Takahiro Matsui, Masaharu Kohara, Shinichiro Tahara, Satoru Toyosawa, Toshiyuki Fukao & Eiichi Morii. (2020) Analysis of mTOR pathway expression in lymphatic malformation and related diseases. Pathology International 70:6, pages 323-329.
Crossref
Jehoon Lee, Raine Lunde‐Young, Vishal Naik, Josue Ramirez, Marcus Orzabal & Jayanth Ramadoss. (2020) Chronic Binge Alcohol Exposure During Pregnancy Alters mTOR System in Rat Fetal Hippocampus. Alcoholism: Clinical and Experimental Research 44:6, pages 1329-1336.
Crossref
Debbie L. Cunningham, Adil R. Sarhan, Andrew J. Creese, Katherine P. B. Larkins, Hongyan Zhao, Harriet R. Ferguson, Katie Brookes, Anna A. Marusiak, Helen J. Cooper & John K. Heath. (2020) Differential responses to kinase inhibition in FGFR2-addicted triple negative breast cancer cells: a quantitative phosphoproteomics study. Scientific Reports 10:1.
Crossref
Zhong Li, Yuan Li, Yunhao Jia, Bo Ding & Jinsong Yu. (2020) Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway. Archives of Biochemistry and Biophysics 685, pages 108352.
Crossref
Arnab Ghosh & Natalia Shcherbik. (2020) Effects of Oxidative Stress on Protein Translation: Implications for Cardiovascular Diseases. International Journal of Molecular Sciences 21:8, pages 2661.
Crossref
Ellen S. Ando-Suguimoto, Manjunatha R. Benakanakere, Marcia P.A. Mayer & Denis F. Kinane. (2020) Distinct Signaling Pathways Between Human Macrophages and Primary Gingival Epithelial Cells by Aggregatibacter actinomycetemcomitans. Pathogens 9:4, pages 248.
Crossref
Pilar Sarah Acevo-Rodríguez, Giovanna Maldonado, Susana Castro-Obregón & Greco Hernández. (2020) Autophagy Regulation by the Translation Machinery and Its Implications in Cancer. Frontiers in Oncology 10.
Crossref
Tom Malone, Lea Schäfer, Nathalie Simon, Susan Heavey, Sinead Cuffe, Stephen Finn, Gillian Moore & Kathy Gately. (2020) Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer. Pharmacology & Therapeutics 207, pages 107454.
Crossref
Daniel Missailidis, Sarah J. Annesley, Claire Y. Allan, Oana Sanislav, Brett A. Lidbury, Donald P. Lewis & Paul R. Fisher. (2020) An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients. International Journal of Molecular Sciences 21:3, pages 1074.
Crossref
Sophie Laguesse & Dorit Ron. (2019) Protein Translation and Psychiatric Disorders. The Neuroscientist 26:1, pages 21-42.
Crossref
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Nadiem Nazir Bhat & Khurshid Iqbal Andrabi. (2019) Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1. Molecular and Cellular Biochemistry 465:1-2, pages 13-26.
Crossref
Sabina Luszczak, Christopher Kumar, Vignesh Krishna Sathyadevan, Benjamin S. Simpson, Kathy A. Gately, Hayley C. Whitaker & Susan Heavey. (2020) PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer. Signal Transduction and Targeted Therapy 5:1.
Crossref
Kathryn A Jacobs, Gwennan André‐Grégoire, Clément Maghe, An Thys, Ying Li, Elizabeth Harford‐Wright, Kilian Trillet, Tiphaine Douanne, Carolina Alves Nicolau, Jean‐Sébastien Frénel, Nicolas Bidère & Julie Gavard. (2019) Paracaspase MALT1 regulates glioma cell survival by controlling endo‐lysosome homeostasis. The EMBO Journal 39:1.
Crossref
Simone Leggeri & Navid Sobhani. (2020) Single nucleotide polymorphisms Rs1045642 C&gt;T genetic alteration in ATP Binding Cassette Subfamily B Member 1 role in increasing everolimus toxicity in metastatic breast cancer. AIMS Molecular Science 7:1, pages 1-11.
Crossref
Xiaohan Jin, Jiabao Wang, Shuang Zou, Ruicheng Xu, Jin Cao, Yan Zhang, Jia Guo, Xiaochang Wen, Sanmin Deng, Yupiao Zheng, Yu Zhu, Fengmei Wang & Zhongwei Xu. (2020) Cinobufagin Triggers Defects in Spindle Formation and Cap-Dependent Translation in Liver Cancer Cells by Inhibiting the AURKA-mTOR-eIF4E Axis. The American Journal of Chinese Medicine 48:03, pages 651-678.
Crossref
Noriko Yamano-Adachi, Norichika Ogata, Sho Tanaka, Masayoshi Onitsuka & Takeshi Omasa. (2020) Characterization of Chinese hamster ovary cells with disparate chromosome numbers: Reduction of the amount of mRNA relative to total protein. Journal of Bioscience and Bioengineering 129:1, pages 121-128.
Crossref
Xiang-zi Zhang, Mo-han Zhang, Xue-sen Fang, Xiang-shu Cui & Zheng Jin. (2019) Mechanism of AMPK-mediated apoptosis of rat gastric smooth muscle cells under high glucose condition. Bioscience Reports 39:12.
Crossref
Sara J Holditch, Carolyn N Brown, Daniel J Atwood, Deepak Pokhrel, Sara E Brown, Andrew M Lombardi, Khoa N Nguyen, Ryan C Hill, Miguel Lanaspa, Katharina Hopp, Mary C M Weiser-Evans & Charles L Edelstein. (2019) The consequences of increased 4E-BP1 in polycystic kidney disease. Human Molecular Genetics 28:24, pages 4132-4147.
Crossref
Cedric Magaway, Eugene Kim & Estela Jacinto. (2019) Targeting mTOR and Metabolism in Cancer: Lessons and Innovations. Cells 8:12, pages 1584.
Crossref
Zhi Dong Zhou, Thevapriya Selvaratnam, Ji Chao Tristan Lee, Yin Xia Chao & Eng-King Tan. (2019) Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease. Translational Neurodegeneration 8:1.
Crossref
Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca & Ciro Isidoro. (2019) Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR. Cell Communication and Signaling 17:1.
Crossref
Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson & Stephen P. Ethier. (2019) Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. BMC Cancer 19:1.
Crossref
De Stefanis, Scimè, Accomazzo, Catti, Occhipinti, Bertea & Costelli. (2019) Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines. Cancers 11:11, pages 1640.
Crossref
Yoshika Janapala, Thomas Preiss & Nikolay E. Shirokikh. (2019) Control of Translation at the Initiation Phase During Glucose Starvation in Yeast. International Journal of Molecular Sciences 20:16, pages 4043.
Crossref
Ugo Moens & Andrew Macdonald. (2019) Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways. International Journal of Molecular Sciences 20:16, pages 3914.
Crossref
David Danielpour, Zhaofeng Gao, Patrick M. Zmina, Eswar Shankar, Benjamin C. Shultes, Raul Jobava, Scott M. Welford & Maria Hatzoglou. (2019) Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK. Scientific Reports 9:1.
Crossref
Alia Ghoneum & Neveen Said. (2019) PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers 11:7, pages 949.
Crossref
Teemu P Miettinen, Joon Ho Kang, Lucy F Yang & Scott R Manalis. (2019) Mammalian cell growth dynamics in mitosis. eLife 8.
Crossref
Seung H. Choi, Thomas F. Martinez, Seongjae Kim, Cynthia Donaldson, Maxim N. Shokhirev, Alan Saghatelian & Katherine A. Jones. (2019) CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. Genes & Development 33:7-8, pages 418-435.
Crossref
Oleta T. Johnson, Tanpreet Kaur & Amanda L. Garner. (2018) A Conditionally Fluorescent Peptide Reporter of Secondary Structure Modulation. ChemBioChem 20:1, pages 40-45.
Crossref
Stacia L. Koppenhafer, Kelli L. Goss, William W. Terry & David J. Gordon. (2018) mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells. Molecular Cancer Therapeutics 17:12, pages 2676-2688.
Crossref
Toru Uchimura, Yoshitaka Oyama, Meng Deng, Haitao Guo, Justin E. Wilson, Elena Rampanelli, Kevin D. Cook, Ichiro Misumi, Xianming Tan, Liang Chen, Brandon Johnson, Jason Tam, Wei-Chun Chou, W. June Brickey, Alex Petrucelli, Jason K. Whitmire & Jenny P.Y. Ting. (2018) The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Immunity 49:6, pages 1049-1061.e6.
Crossref
Hunter C. Jonus, Bradley S. Hanberry, Shivani Khatu, Jaeah Kim, Hendrik Luesch, Long H. Dang, Michael G. Bartlett & Jason A. Zastre. (2018) The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions. Oncotarget 9:83, pages 35422-35438.
Crossref
Osamu Ichiyanagi, Sei Naito, Hiromi Ito, Takanobu Kabasawa, Takafumi Narisawa, Hidenori Kanno, Yuta Kurota, Masayuki Kurokawa, Hiroki Fukuhara, Toshihiko Sakurai, Hayato Nishida, Tomoyuki Kato, Mitsunori Yamakawa & Norihiko Tsuchiya. (2018) Levels of 4EBP1/eIF4E Activation in Renal Cell Carcinoma Could Differentially Predict Its Early and Late Recurrence. Clinical Genitourinary Cancer 16:5, pages e1029-e1058.
Crossref
Prashant Kaushik, Michael Henry, Martin Clynes & Paula Meleady. (2018) The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture. Biotechnology Journal 13:10, pages 1700221.
Crossref
Yuan-Chin Lee, Liang-Jun Wang, Chia-Hui Huang, Yi-Jun Shi & Long-Sen Chang. (2018) ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells. Cancer Letters 432, pages 191-204.
Crossref
Emilia Białopiotrowicz, Patryk Górniak, Monika Noyszewska‐Kania, Bartosz Puła, Hanna Makuch‐Łasica, Grażyna Nowak, Aleksandra Bluszcz, Maciej Szydłowski, Ewa Jabłonska, Karolina Piechna, Tomasz Sewastianik, Anna Polak, Ewa Lech‐Marańda, Bożena K. Budziszewska, Maja Wasylecka‐Juszczyńska, Katarzyna Borg, Krzysztof Warzocha, Wojciech Czardybon, Michał Gałęzowski, Renata Windak, Krzysztof Brzózka & Przemysław Juszczyński. (2018) Microenvironment‐induced PIM kinases promote CXCR 4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration . Journal of Cellular and Molecular Medicine 22:7, pages 3548-3559.
Crossref
Dóra Marosvári, Noémi Nagy, Csilla Kriston, Beáta Deák, Melinda Hajdu, Csaba Bödör, Irén Csala, Attila G Bagó, Zoltán Szállási, Anna Sebestyén & Lilla Reiniger. (2018) Discrepancy Between Low Levels of mTOR Activity and High Levels of P-S6 in Primary Central Nervous System Lymphoma May Be Explained by PAS Domain-Containing Serine/Threonine-Protein Kinase-Mediated Phosphorylation. Journal of Neuropathology & Experimental Neurology 77:4, pages 268-273.
Crossref
Giuseppe Lamberti, Nicole Brighi, Ilaria Maggio, Lisa Manuzzi, Chiara Peterle, Valentina Ambrosini, Claudio Ricci, Riccardo Casadei & Davide Campana. (2018) The Role of mTOR in Neuroendocrine Tumors: Future Cornerstone of a Winning Strategy?. International Journal of Molecular Sciences 19:3, pages 747.
Crossref
Zhao Yu, Wang Lin, Zhang Rui & Pan Jihong. (2017) Fibroblast-like synoviocyte migration is enhanced by IL-17-mediated overexpression of l-type amino acid transporter 1 (LAT1) via the mTOR/4E-BP1 pathway. Amino Acids 50:2, pages 331-340.
Crossref
Arianna Piserà, Adele Campo & Salvatore Campo. (2018) Structure and functions of the translation initiation factor eIF4E and its role in cancer development and treatment. Journal of Genetics and Genomics 45:1, pages 13-24.
Crossref
Winn Aung, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Yoshinori Ukai, Katsushi Kouda, Yoshikazu Kurosawa, Takako Furukawa, Tsuneo Saga & Tatsuya Higashi. (2017) Combined treatment of pancreatic cancer xenograft with 90 Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor . World Journal of Gastroenterology 23:42, pages 7551-7562.
Crossref
Janelle Tarum, Mattias Folkesson, Philip J. Atherton & Fawzi Kadi. (2017) Electrical pulse stimulation: an in vitro exercise model for the induction of human skeletal muscle cell hypertrophy. A proof-of-concept study . Experimental Physiology 102:11, pages 1405-1413.
Crossref
Stephane Esnault, Zhong-Jian Shen & James S. Malter. (2017) Protein Translation and Signaling in Human Eosinophils. Frontiers in Medicine 4.
Crossref
Ella Lineham, John Spencer & Simon J Morley. (2017) Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry 9:13, pages 1539-1555.
Crossref
Tao Peng & Q. Ping Dou. (2017) Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G 2 /M Arrest . Journal of Cellular Biochemistry 118:9, pages 2722-2730.
Crossref
Craig A. Goodman, Allison M. Coenen, John W. Frey, Jae-Sung You, Robert G. Barker, Barnaby P. Frankish, Robyn M. Murphy & Troy A. Hornberger. (2016) Insights into the role and regulation of TCTP in skeletal muscle. Oncotarget 8:12, pages 18754-18772.
Crossref
Sousuke ImamuraKeiko TakiKan Tanaka. (2017) Construction of a rapamycin-susceptible strain of the unicellular red alga <i>Cyanidioschyzon merolae</i> for analysis of the target of rapamycin (TOR) function. The Journal of General and Applied Microbiology 63:5, pages 305-309.
Crossref

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