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Structure of the human dimeric ATM kinase

Wilson C. Y. LauSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong;State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong KongCorrespondence[email protected]

Yinyin LiState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

Zhe LiuGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

Yuanzhu GaoState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

Qinfen ZhangState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

Michael S. Y. HuenSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong;State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong KongCorrespondence[email protected]

Pages 1117-1124 | Received 23 Nov 2015, Accepted 18 Feb 2016, Published online: 20 Apr 2016

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https://doi.org/10.1080/15384101.2016.1158362
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Alex Vogt, Yuan He & Susan P. Lees-Miller. (2023) How to fix DNA breaks: new insights into the mechanism of non-homologous end joining. Biochemical Society Transactions 51:5, pages 1789-1800.
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Alex Vogt & Yuan He. (2023) Structure and mechanism in non-homologous end joining. DNA Repair 130, pages 103547.
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Hoi Tong Wong, Adeline M. Luperchio, Sean Riley & Daniel J. Salamango. (2023) Inhibition of ATM-directed antiviral responses by HIV-1 Vif. PLOS Pathogens 19:9, pages e1011634.
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Chao Dong, Yong Wang, Zhenlin Tu, Jingxue Yan, Yiqing Jiang, Tao Lu, Yadong Chen & Haichun Liu. (2022) Recent advances in ATM inhibitors as potential therapeutic agents. Future Medicinal Chemistry 14:23, pages 1811-1830.
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Dongfang Lv, Yun Ji, Qian Zhang, Zhuozhuo Shi, Tengfei Chen, Chao Zhang, Xiangyun Wang, Taotao Ren, Zhaowang Gao & Chongfu Zhong. (2022) Mailuoshutong pill for varicocele-associated male infertility—Phytochemical characterisation and multitarget mechanism. Frontiers in Pharmacology 13.
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María E. Guerra García, David G. Kirsch & Zachary J. Reitman. (2022) Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients. Seminars in Radiation Oncology 32:1, pages 3-14.
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Ji-Hoon Lee & Tanya T. Paull. (2021) Cellular functions of the protein kinase ATM and their relevance to human disease. Nature Reviews Molecular Cell Biology 22:12, pages 796-814.
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Atsushi Shibata & Penny A. Jeggo. (2021) ATM’s Role in the Repair of DNA Double-Strand Breaks. Genes 12:9, pages 1370.
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Jianxiong Xiao, Qinhui Rao & Yanhui Xu. (2021) The activation mechanisms of master kinases in the DNA damage response. Genome Instability & Disease 2:4, pages 211-224.
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Morgan Hepburn, Daniel J. Saltzberg, Linda Lee, Shujuan Fang, Claire Atkinson, Natalie C.J. Strynadka, Andrej Sali, Susan P. Lees-Miller & David C. Schriemer. (2021) The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex. Structure 29:5, pages 467-478.e6.
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Qiurong Ye, Huiling Chen, Zonghua Wen, Wenwen Guo, Yongta Huang & Xianglan Mo. (2021) Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis. Journal of Clinical Pathology 74:4, pages 223-227.
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Thomas J. Weitering, Sanami Takada, Corry M.R. Weemaes, Pauline A. van Schouwenburg & Mirjam van der Burg. (2021) ATM: Translating the DNA Damage Response to Adaptive Immunity. Trends in Immunology 42:4, pages 350-365.
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Rashmi Panigrahi & J. N. Mark Glover. (2021) Structural insights into DNA double-strand break signaling. Biochemical Journal 478:1, pages 135-156.
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Lara Pizzamiglio, Elisa Focchi & Flavia Antonucci. (2020) ATM Protein Kinase: Old and New Implications in Neuronal Pathways and Brain Circuitry. Cells 9:9, pages 1969.
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Magdalena Szatkowska & Renata Krupa. (2020) Regulation of DNA Damage Response and Homologous Recombination Repair by microRNA in Human Cells Exposed to Ionizing Radiation. Cancers 12:7, pages 1838.
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Marijke Jansma, Christian Linke-Winnebeck, Sebastian Eustermann, Katja Lammens, Dirk Kostrewa, Kristina Stakyte, Claudia Litz, Brigitte Kessler & Karl-Peter Hopfner. (2020) Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure 28:1, pages 83-95.e5.
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Zhiming Li, Yongcan Chen, Ming Tang, Yinglu Li & Wei-Guo Zhu. (2019) Regulation of DNA damage-induced ATM activation by histone modifications. Genome Instability & Disease 1:1, pages 20-33.
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Yueru Sun, Thomas J. McCorvie, Luke A. Yates & Xiaodong Zhang. (2019) Structural basis of homologous recombination. Cellular and Molecular Life Sciences 77:1, pages 3-18.
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Samantha A. Armstrong, Christopher W. Schultz, Ariana Azimi-Sadjadi, Jonathan R. Brody & Michael J. Pishvaian. (2019) ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications. Molecular Cancer Therapeutics 18:11, pages 1899-1908.
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Mei Hua Jin & Do-Youn Oh. (2019) ATM in DNA repair in cancer. Pharmacology & Therapeutics 203, pages 107391.
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Aimen K. Aljoundi, Clement Agoni, Fisayo A. Olotu & Mahmoud E.S. Soliman. (2019) Turning to Computer-aided Drug Design in the Treatment of Diffuse Large B-cell Lymphoma: Has it been Helpful?. Anti-Cancer Agents in Medicinal Chemistry 19:11, pages 1325-1339.
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Sarem Hailemariam, Sandeep Kumar & Peter M. Burgers. (2019) Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends. Journal of Biological Chemistry 294:26, pages 10120-10130.
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Munirah S. Abd Rahim, Yevhen K. Cherniavskyi, D. Peter Tieleman & Sonja A. Dames. (2019) NMR– and MD simulation–based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated. Journal of Biological Chemistry 294:17, pages 7098-7112.
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Meixi Peng, Dan Yang, Yixuan Hou, Shuiqing Liu, Maojia Zhao, Yilu Qin, Rui Chen, Yong Teng & Manran Liu. (2019) Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis. Cell Death & Disease 10:3.
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Stefan Imseng, Christopher HS Aylett & Timm Maier. (2018) Architecture and activation of phosphatidylinositol 3-kinase related kinases. Current Opinion in Structural Biology 49, pages 177-189.
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Amjad Horani, Alessandro UstioneTao HuangAmy L. Firth, Jiehong PanSean P. GunstenJeffrey A. HaspelDavid W. PistonSteven L. Brody. (2018) Establishment of the early cilia preassembly protein complex during motile ciliogenesis. Proceedings of the National Academy of Sciences 115:6.
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Kay Rui Choy & Dianne J. Watters. (2018) Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis. Developmental Dynamics 247:1, pages 33-46.
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Luis Miguel Díaz-Santín, Natasha Lukoyanova, Emir Aciyan & Alan CM Cheung. (2017) Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution. eLife 6.
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Andrew N. Blackford & Stephen P. Jackson. (2017) ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response. Molecular Cell 66:6, pages 801-817.
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Domagoj Baretić, Hannah K. PollardDavid I. FisherChristopher M. JohnsonBalaji SanthanamCaroline M. TrumanTomas KoubaAlan R. FershtChristopher PhillipsRoger L. Williams. (2017) Structures of closed and open conformations of dimeric human ATM. Science Advances 3:5.
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Marta Sawicka, Paulina H. Wanrooij, Vidya C. Darbari, Elias Tannous, Sarem Hailemariam, Daniel Bose, Alena V. Makarova, Peter M. Burgers & Xiaodong Zhang. (2016) The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization. Journal of Biological Chemistry 291:26, pages 13436-13447.
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T. Pesaran, R. Karam, R. Huether, S. Li, S. Farber-Katz, A. Chamberlin, H. Chong, H. LaDuca & A. Elliott. (2016) Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes. International Journal of Breast Cancer 2016, pages 1-10.
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Structure of the human dimeric ATM kinase

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