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Cell Cycle Volume 16, 2017 - Issue 11
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Metformin inhibits RANKL and sensitizes cancer stem cells to denosumab

Elisabet CuyàsProgram Against Cancer Therapeutic Resistance(ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Catalonia, Spain;Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Spain
,
Begoña Martin-CastilloUnit of Clinical Research, Catalan Institute of Oncology, Girona, Catalonia, Spain
,
Joaquim Bosch-BarreraDeparment of Medical Oncology, Catalan Institute of Oncology, Girona, Catalonia, Spain;Department of Medical Sciences, Medical School, University of Girona, Girona, SpainORCID Iconhttp://orcid.org/0000-0002-0893-7821
ORCID Icon &
Javier A. MenendezProgram Against Cancer Therapeutic Resistance(ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Catalonia, Spain;Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, SpainCorrespondence[email protected] [email protected]
Pages 1022-1028 | Received 06 Mar 2017, Accepted 17 Mar 2017, Published online: 04 May 2017

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Maria V. Deligiorgi, Mihalis I. Panayiotidis & Dimitrios T. Trafalis. (2020) Repurposing denosumab in breast cancer beyond prevention of skeletal related events: Could nonclinical data be translated into clinical practice?. Expert Review of Clinical Pharmacology 13:11, pages 1235-1252.
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Articles from other publishers (18)

Bolin Ren, Xiaolei Ren, Lu Wang, Chao Tu, Wenchao Zhang, Zhongyue Liu, Lin Qi, Lu Wan, Ke Pang, Cheng Tao & Zhihong Li. (2022) A bibliometric research based on hotspots and frontier trends of denosumab. Frontiers in Pharmacology 13.
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Yuanchun Fan, Huimin Cheng, Yueping Liu, Shihao Liu, Scott Lowe, Yaru Li, Rachel Bentley, Bethany King, John Pocholo W. Tuason, Qin Zhou, Chenyu Sun & Hui Zhang. (2022) Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells. Frontiers in Pharmacology 13.
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Haipeng Yao, Zhen Sun, Guangyao Zang, Lili Zhang, Lina Hou, Chen Shao & Zhongqun Wang. (2021) Epidemiological Research Advances in Vascular Calcification in Diabetes. Journal of Diabetes Research 2021, pages 1-15.
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Elisabet Cuyàs, Juan Gumuzio, Jesús Lozano-Sánchez, Antonio Segura-Carretero, Sara Verdura, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Alfons Nonell-Canals, Amadeu Llebaria, Silvia Cabello, Carme Serra, Melchor Sanchez-Martinez, Ángel G. Martin & Javier A. Menendez. (2020) Mimetics of extra virgin olive oil phenols with anti-cancer stem cell activity. Aging 12:21, pages 21057-21075.
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Bi Chen, Peng Ye, Yeh Chen, Tong Liu, Jong-Ho Cha, Xiuwen Yan & Wen-Hao Yang. (2020) Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance. Frontiers in Oncology 10.
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Samson Mathews Samuel, Elizabeth Varghese, Lenka Koklesová, Alena Líšková, Peter Kubatka & Dietrich Büsselberg. (2020) Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells. Cancers 12:9, pages 2482.
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Sounak Ghosh, Dongling Luo, Wanbing He, Jie Chen, Xiaoyan Su & Hui Huang. (2020) Diabetes and calcification: The potential role of anti-diabetic drugs on vascular calcification regression. Pharmacological Research 158, pages 104861.
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Kerstin Tiedemann, Osama Hussein & Svetlana V. Komarova. (2020) Role of Altered Metabolic Microenvironment in Osteolytic Metastasis. Frontiers in Cell and Developmental Biology 8.
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Solène FortunAndreea R. Schmitzer. (2020) The chemistry of biguanides: from synthetic routes to applications in organic chemistry. Canadian Journal of Chemistry 98:6, pages 251-260.
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Anindita De & Gowthamarajan Kuppusamy. (2020) Metformin in breast cancer: preclinical and clinical evidence. Current Problems in Cancer 44:1, pages 100488.
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Yuanchao Gong, Caihong Wang, Yi Jiang, Shaosen Zhang, Shi Feng, Yan Fu & Yongzhang Luo. (2020) Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner. Cells 9:1, pages 144.
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Harras J. Khan, Sagar O. Rohondia, Zainab Sabry Othman Ahmed, Nirav Zalavadiya & Q. Ping Dou. 2020. Drug Repurposing in Cancer Therapy. Drug Repurposing in Cancer Therapy 121 172 .
Samson Samuel, Elizabeth Varghese, Peter Kubatka, Chris Triggle & Dietrich Büsselberg. (2019) Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer. Biomolecules 9:12, pages 846.
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Federica Barbieri, Ivan Verduci, Valentina Carlini, Gianluigi Zona, Aldo Pagano, Michele Mazzanti & Tullio Florio. (2019) Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity. Frontiers in Oncology 9.
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Ramesh Butti, Vinoth Prasanna Gunasekaran, Totakura V.S. Kumar, Pinaki Banerjee & Gopal C. Kundu. (2019) Breast cancer stem cells: Biology and therapeutic implications. The International Journal of Biochemistry & Cell Biology 107, pages 38-52.
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Mingzhu Bai, Linlin Yang, Hong Liao, Xiaoyan Liang, Bingying Xie, Ji Xiong, Xiang Tao, Xiong Chen, Yali Cheng, Xiaojun Chen, Youji Feng, Zhenbo Zhang & Wenxin Zheng. (2018) Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism. Oncogene 37:42, pages 5666-5681.
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Marion M. Chan, Rensa Chen & Dunne Fong. (2018) Targeting cancer stem cells with dietary phytochemical - Repositioned drug combinations. Cancer Letters 433, pages 53-64.
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Solène Fortun & Andreea R. Schmitzer. (2018) Synthesis and Characterization of Biguanide and Biguanidium Surfactants for Efficient and Recyclable Application in the Suzuki–Miyaura Reaction. ACS Omega 3:2, pages 1889-1896.
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