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Cell Cycle Volume 16, 2017 - Issue 12
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Curcumin increases efficiency of γ-irradiation in gliomas by inhibiting Hedgehog signaling pathway

Xiangqi MengDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China
,
Jinquan CaiDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China;Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, China
,
Jichao LiuDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
,
Bo HanDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China
,
Fei GaoDepartment of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
,
Weida GaoDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China
,
Yao ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China
,
Jinwei ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China
,
Zhefeng ZhaoDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, ChinaCorrespondence[email protected] [email protected]
&
Chuanlu JiangDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Chinese Glioma Cooperative Group (CGCG), Beijing, China;Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, ChinaCorrespondence[email protected] [email protected]
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Pages 1181-1192 | Received 29 Nov 2016, Accepted 10 Apr 2017, Published online: 19 May 2017

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Katrin Sak. (2020) Radiosensitizing Potential of Curcumin in Different Cancer Models. Nutrition and Cancer 72:8, pages 1276-1289.
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Xin-zhou Deng, Shan-shan Geng, Ming Luo, Jing-jing Chai, Ying Xu, Chun-li Chen, Li Qiu, Qing Ke, Qi-wen Duan, Shi-mao Song, Li Shen & Zhi-guo Luo. (2020) Curcumin potentiates laryngeal squamous carcinoma radiosensitivity via NF-ΚB inhibition by suppressing IKKγ expression. Journal of Receptors and Signal Transduction 40:6, pages 541-549.
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Articles from other publishers (16)

Victor Chmykhalo, Anna Belanova, Tatyana Shkurat & Peter Zolotukhin. (2023) Effects of curcumin on Wnt/β-catenin, Hedgehog pathways and expression of EMT transcription factors in basal conditions and upon HIF1A and RELA knockdown in HeLa cells. Gene Reports 33, pages 101848.
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Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishayee, Alan Prem Kumar & Gautam Sethi. (2023) Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds. Medicinal Research Reviews 43:4, pages 1141-1200.
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Marziyeh Salami, Raziyeh Salami, Mohammad-Hossein Aarabi, Alireza Mafi, Seyedeh Sara Ghorbanhosseini, Rana Shafabakhsh & Zatollah Asemi. (2023) Targeting Glioma Cells with Nutraceuticals: Therapeutic Effects Based on Molecular Mechanisms, New Evidence and Perspectives. Mini-Reviews in Medicinal Chemistry 23:11, pages 1167-1192.
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Ozal Beylerli, Aferin Beilerli, Alina Shumadalova, Xiaoxiong Wang, Mingchun Yang, Hanran Sun & Lei Teng. (2022) Therapeutic effect of natural polyphenols against glioblastoma. Frontiers in Cell and Developmental Biology 10.
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Sabah Nisar, Tariq Masoodi, Kirti S. Prabhu, Shilpa Kuttikrishnan, Lubna Zarif, Summaiya Khatoon, Shahid Ali, Shahab Uddin, Ammira Al-Shabeeb Akil, Mayank Singh, Muzafar A. Macha & Ajaz A. Bhat. (2022) Natural products as chemo-radiation therapy sensitizers in cancers. Biomedicine & Pharmacotherapy 154, pages 113610.
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Hideya Onishi, Katsuya Nakamura, Kosuke Yanai, Shuntaro Nagai, Kazunori Nakayama, Yasuhiro Oyama, Akiko Fujimura, Keigo Ozono & Akio Yamasaki. (2022) Cancer therapy that targets the Hedgehog signaling pathway considering the cancer microenvironment (Review). Oncology Reports 47:5.
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Hitarth Patel, Jigna Joshi, Apexa Raval & Franky Shah. (2022) Identification of Natural Compounds to Inhibit Sonic Hedgehog Pathway in Oral Cancer. Anti-Cancer Agents in Medicinal Chemistry 22:5, pages 905-913.
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Vasiliki Zoi, Vasiliki Galani, Pericles Tsekeris, Athanasios P. Kyritsis & George A. Alexiou. (2022) Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers. Biomedicines 10:2, pages 312.
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Baris Kucukkaraduman, Ekin Gokce Cicek, Muhammad Waqas Akbar, Secil Demirkol Canli, Burcak Vural & Ali Osmay Gure. (2021) Epithelial-to-Mesenchymal Transition Is Not a Major Modulating Factor in the Cytotoxic Response to Natural Products in Cancer Cell Lines. Molecules 26:19, pages 5858.
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Farah Sanduk, Yiming Meng, Darius Widera, Radoslaw M. Kowalczyk, Nicholas Michael, Amanpreet Kaur, Vivian Yip, Sandra Zulu, Irene Zavrou, Lulu Hana, Muhammad Yaqoob & Hisham Al-Obaidi. (2020) Enhanced anti-inflammatory potential of degradation resistant curcumin/ferulic acid eutectics embedded in triglyceride-based microemulsions. Journal of Drug Delivery Science and Technology 60, pages 102067.
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T. I. Kushnir, N. E. Arnotskaya, I. A. Kudryavtsev & V. E. Shevchenko. (2020) The therapeutic potential of curcumin for the treatment of glioblastoma multiforme. Advances in Molecular Oncology 7:1, pages 8-16.
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Xinzhou Deng, Chunli Chen, Feng Wu, Li Qiu, Qing Ke, Renhuang Sun, Qiwen Duan, Ming Luo & Zhiguo Luo. (2020) Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression. Technology in Cancer Research & Treatment 19, pages 153303382094748.
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Chin-Yap Loh, Jian Chai, Ting Tang, Won Wong, Gautam Sethi, Muthu Shanmugam, Pei Chong & Chung Looi. (2019) The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells 8:10, pages 1118.
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Etienne Giroux-Leprieur, Adrien Costantini, Vivianne Ding & Biao He. (2018) Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance. International Journal of Molecular Sciences 19:9, pages 2835.
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Marina Mojena, María Pimentel-Santillana, Adrián Povo-Retana, Victoria Fernández-García, Silvia González-Ramos, Patricia Rada, Alberto Tejedor, Daniel Rico, Paloma Martín-Sanz, Angela M. Valverde & Lisardo Boscá. (2018) Protection against gamma-radiation injury by protein tyrosine phosphatase 1B. Redox Biology 17, pages 213-223.
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Cheng Bao, Pavel Kramata, Hong Jin Lee & Nanjoo Suh. (2018) Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds. Molecular Nutrition & Food Research 62:1, pages 1700621.
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