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Sarah E. Paraghamian, Jianqing Qiu, Gabrielle M. Hawkins, Ziyi Zhao, Wenchuan Sun, Yali Fan, Xin Zhang, Hongyan Suo, Tianran Hao, Varun Vijay Prabhu, Joshua E. Allen, Chunxiao Zhou & Victoria Bae-Jump. (2023) A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer. Cancer Biology & Therapy 24:1.
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Marie D. Ralff & Wafik S. El-Deiry. (2018) TRAIL pathway targeting therapeutics. Expert Review of Precision Medicine and Drug Development 3:3, pages 197-204.
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Andrew S. Chi. (2017) Identification of more potent imipridones, a new class of anti-cancer agents. Cell Cycle 16:17, pages 1566-1567.
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Peter M. Anderson & Jacob Scott. (2017) Imipridone family on successful TRAIL. Cell Cycle 16:16, pages 1487-1488.
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Sabrina C. D. Daglish, Emily M. J. Fennell & Lee M. Graves. (2023) Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment. Biomedicines 11:6, pages 1598.
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Hannah M. Neuendorf, Jacinta L. Simmons & Glen M. Boyle. (2023) Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis. Frontiers in Cell and Developmental Biology 11.
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Emily M. J. Fennell, Lucas J. Aponte-Collazo, Wimal Pathmasiri, Blake R. Rushing, Natalie K. Barker, Megan C. Partridge, Yuan-Yuan Li, Cody A. White, Yoshimi E. Greer, Laura E. Herring, Stanley Lipkowitz, Susan C. J. Sumner, Edwin J. Iwanowicz & Lee M. Graves. (2023) Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer. Frontiers in Pharmacology 14.
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Rohan Wedam, Yoshimi Endo Greer, David J. Wisniewski, Sarah Weltz, Manjari Kundu, Donna Voeller & Stanley Lipkowitz. (2023) Targeting Mitochondria with ClpP Agonists as a Novel Therapeutic Opportunity in Breast Cancer. Cancers 15:7, pages 1936.
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Yoshimi Endo Greer, Lidia Hernandez, Emily M.J. Fennell, Manjari Kundu, Donna Voeller, Raj Chari, Samuel F. Gilbert, Thomas S.K. Gilbert, Shashikala Ratnayake, Binwu Tang, Markus Hafner, Qingrong Chen, Daoud Meerzaman, Edwin Iwanowicz, Christina M. Annunziata, Lee M. Graves & Stanley Lipkowitz. (2022) Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis. Cancer Research Communications 2:10, pages 1144-1161.
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Justyna M Przystal, Chiara Cianciolo Cosentino, Sridevi Yadavilli, Jie Zhang, Sandra Laternser, Erin R Bonner, Rachna Prasad, Adam A Dawood, Nina Lobeto, Wai Chin Chong, Matt C Biery, Carrie Myers, James M Olson, Eshini Panditharatna, Bettina Kritzer, Sulayman Mourabit, Nicholas A Vitanza, Mariella G Filbin, Geoffry N de Iuliis, Matthew D Dun, Carl Koschmann, Jason E Cain, Michael A Grotzer, Sebastian M Waszak, Sabine Mueller & Javad Nazarian. (2022) Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas. Neuro-Oncology 24:9, pages 1438-1451.
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Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz & Lee M. Graves. (2022)
Characterization of
TR
‐107, a novel chemical activator of the human mitochondrial protease
ClpP
. Pharmacology Research & Perspectives 10:4.
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Xinrong Xiang, Rui Bao, Yu Wu & Youfu Luo. (2022) Targeting mitochondrial proteases for therapy of acute myeloid leukaemia. British Journal of Pharmacology 179:13, pages 3268-3282.
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Peter M. AndersonMatteo M. TruccoRohinton S. TaraporeStacey Zahler, Stefanie ThomasJanette GortzOmar Mian, Martin StoignewVarun PrabhuSara MorrowJoshua E. Allen. (2022) Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor. Clinical Cancer Research 28:9, pages 1773-1782.
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Jennifer C. Goodell, Sara M. Zimmerman, Cody J. Peer, Varun Prabhu, Tyler Yin, William J. Richardson, Arya Azinfar, John A. Dunn, Mark Mullin, Brett J. Theeler, Mark Gilbert & William D. Figg. (2022) Quantitation of the next-generation imipridone ONC206 in human plasma by a simple and sensitive UPLC-MS/MS assay for clinical pharmacokinetic application. Journal of Pharmaceutical and Biomedical Analysis 213, pages 114685.
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Lara Dürr, Tanja Hell, Maciej Dobrzyński, Alberto Mattei, Anika John, Nathanja Augsburger, Gloria Bradanini, Jakob K. Reinhardt, Florian Rossberg, Milos Drobnjakovic, Mahabir P. Gupta, Matthias Hamburger, Olivier Pertz & Eliane Garo. (2022) High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma. Journal of Natural Products 85:4, pages 1006-1017.
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Tamás Czuczi, József Murányi, Péter Bárány, István Móra, Adina Borbély, Miklós Csala & Antal Csámpai. (2022) Synthesis and Antiproliferative Activity of Novel Imipridone–Ferrocene Hybrids with Triazole and Alkyne Linkers. Pharmaceuticals 15:4, pages 468.
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Yali Fan, Jiandong Wang, Ziwei Fang, Stuart R. Pierce, Lindsay West, Allison Staley, Katherine Tucker, Yajie Yin, Wenchuan Sun, Weimin Kong, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou & Victoria L. Bae-Jump. (2022) Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer. Frontiers in Oncology 12.
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Stuart R. Pierce, Ziwei Fang, Yajie Yin, Lindsay West, Majdouline Asher, Tianran Hao, Xin Zhang, Katherine Tucker, Allison Staley, Yali Fan, Wenchuan Sun, Dominic T. Moore, Chang Xu, Yi-Hsuan Tsai, Joel Parker, Varun Vijay Prabhu, Joshua E. Allen, Douglas Lee, Chunxiao Zhou & Victoria Bae-Jump. (2021) Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer. Journal of Experimental & Clinical Cancer Research 40:1.
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Alexander G. Raufi, Nicholas R. Liguori, Lindsey Carlsen, Cassandra Parker, Liz Hernandez Borrero, Shengliang Zhang, Xiaobing Tian, Anna Louie, Lanlan Zhou, Attila A. Seyhan & Wafik S. El-Deiry. (2021) Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma. Frontiers in Pharmacology 12.
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Eva Fuchs, David Alexander Christian Messerer, Georg Karpel-Massler, Michael Fauler, Thomas Zimmer, Bettina Jungwirth & Karl Josef Föhr. (2021) Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10. Frontiers in Pharmacology 12.
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Isacco Ferrarini, Anna Louie, Lanlan Zhou & Wafik S. El-Deiry. (2021) ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer. Molecular Cancer Therapeutics 20:9, pages 1572-1583.
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Sarra El-Soussi, Reine Hanna, Hanna Semaan, Amanda-Rose Khater, Jad Abdallah, Wassim Abou-Kheir & Tamara Abou-Antoun. (2021) A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins. Frontiers in Pediatrics 9.
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Maria Grazia Perrone, Antonio Ruggiero, Antonella Centonze, Antonio Carrieri, Savina Ferorelli & Antonio Scilimati. (2021) Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective. Current Medicinal Chemistry 28:17, pages 3287-3317.
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Erin R Bonner, Sebastian M Waszak, Michael A Grotzer, Sabine Mueller & Javad Nazarian. (2021) Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells. Neuro-Oncology 23:4, pages 542-556.
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Baozhu Luo, Yu Ma, YuanZheng Zhou, Nannan Zhang & Youfu Luo. (2021) Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction. Drug Discovery Today 26:4, pages 968-981.
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Francesca Amoroso, Kimberley Glass, Reema Singh, Francisco Liberal, Rebecca E. Steele, Sarah Maguire, Rohinton Tarapore, Joshua E. Allen, Sandra Van Schaeybroeck, Karl T. Butterworth, Kevin Prise, Joe M. O’Sullivan, Suneil Jain, David J. Waugh & Ian G. Mills. (2021) Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells. Scientific Reports 11:1.
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Jenna L. Carter, Katie Hege, Jay Yang, Hasini A. Kalpage, Yongwei Su, Holly Edwards, Maik Hüttemann, Jeffrey W. Taub & Yubin Ge. (2020) Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy. Signal Transduction and Targeted Therapy 5:1.
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Varun Vijay Prabhu, Sara Morrow, Abed Rahman Kawakibi, Lanlan Zhou, Marie Ralff, Jocelyn Ray, Aakash Jhaveri, Isacco Ferrarini, Young Lee, Cassandra Parker, Yiqun Zhang, Robyn Borsuk, Wen-I Chang, Joshua N. Honeyman, Fabio Tavora, Benedito Carneiro, Alexander Raufi, Kelsey Huntington, Lindsey Carlsen, Anna Louie, Howard Safran, Attila A. Seyhan, Rohinton S. Tarapore, Lee Schalop, Martin Stogniew, Joshua E. Allen, Wolfgang Oster & Wafik S. El-Deiry. (2020) ONC201 and imipridones: Anti-cancer compounds with clinical efficacy. Neoplasia 22:12, pages 725-744.
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Jenna L. Carter, Katie Hege, Hasini A. Kalpage, Holly Edwards, Maik Hüttemann, Jeffrey W. Taub & Yubin Ge. (2020) Targeting mitochondrial respiration for the treatment of acute myeloid leukemia. Biochemical Pharmacology 182, pages 114253.
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Yingao Zhang, Yu Huang, Yajie Yin, Yali Fan, Wenchuan Sun, Xiaoling Zhao, Katherine Tucker, Allison Staley, Sarah Paraghamian, Gabrielle Hawkins, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou & Victoria Bae-Jump. (2020) ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro. Frontiers in Oncology 10.
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Sepideh Aminzadeh-Gohari, Daniela D. Weber, Luca Catalano, René G. Feichtinger, Barbara Kofler & Roland Lang. (2020) Targeting Mitochondria in Melanoma. Biomolecules 10:10, pages 1395.
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Wen Hu, Li Zhang, Sammy Ferri-Borgogno, Suet-Ying Kwan, Kelsey E. Lewis, Han T. Cun, Tsz-Lun Yeung, Pamela T. Soliman, Rohinton S. Tarapore, Joshua E. Allen, Xinyuan Guan, Karen H. Lu, Samuel C. Mok & Chi-Lam Au-Yeung. (2020) Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype. Cancers 12:9, pages 2436.
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Samuel Jacques, Almer M van der Sloot, Caroline C. Huard, Jasmin Coulombe-Huntington, Sarah Tsao, Sylvain Tollis, Thierry Bertomeu, Elizabeth J Culp, Daniel Pallant, Michael A Cook, Eric Bonneil, Pierre Thibault, Gerard D Wright & Mike Tyers. (2020) Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. Genetics 214:4, pages 1103-1120.
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Takenobu Nii, Varun V. Prabhu, Vivian Ruvolo, Neel Madhukar, Ran Zhao, Hong Mu, Lauren Heese, Yuki Nishida, Kensuke Kojima, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Neil Charter, Sean Deacon, Olivier Elemento, Joshua E. Allen, Wolfgang Oster, Martin Stogniew, Jo Ishizawa & Michael Andreeff. (2019) Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia. Leukemia 33:12, pages 2805-2816.
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George Nicolae Daniel Ion, George Mihai Nitulescu & Costin Ioan Popescu. (2019) Targeting TRAIL. Bioorganic & Medicinal Chemistry Letters 29:18, pages 2527-2534.
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Runze Zhao, Yuju Li, Santhi Gorantla, Larisa Y. Poluektova, Hai Lin, Fengtong Gao, Hongyun Wang, Jeffrey Zhao, Jialin C. Zheng & Yunlong Huang. (2019) Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL. Antiviral Research 168, pages 134-145.
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Paul R. Graves, Lucas J. Aponte-Collazo, Emily M. J. Fennell, Adam C. Graves, Andrew E. Hale, Nedyalka Dicheva, Laura E. Herring, Thomas S. K. Gilbert, Michael P. East, Ian M. McDonald, Matthew R. Lockett, Hani Ashamalla, Nathaniel J. Moorman, Donald S. Karanewsky, Edwin J. Iwanowicz, Ekhson Holmuhamedov & Lee M. Graves. (2019) Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues. ACS Chemical Biology 14:5, pages 1020-1029.
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Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St-Germain, Lauren E. Heese, Grace Egan, Vivian R. Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, Man Chun John Ma, Andrew B. Leber, Mark D. Minden, Walid Houry, Hagop Kantarjian, Martin Stogniew, Brian Raught, Emil F. Pai, Aaron D. Schimmer & Michael Andreeff. (2019) Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell 35:5, pages 721-737.e9.
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Varun V. Prabhu, Neel S. Madhukar, Coryandar Gilvary, C. Leah B. Kline, Sophie Oster, Wafik S. El-Deiry, Olivier Elemento, Faye Doherty, Alexander VanEngelenburg, Jessica Durrant, Rohinton S. Tarapore, Sean Deacon, Neil Charter, Jinkyu Jung, Deric M. Park, Mark R. Gilbert, Jessica Rusert, Robert Wechsler-Reya, Isabel Arrillaga-Romany, Tracy T. Batchelor, Patrick Y. Wen, Wolfgang Oster & Joshua E. Allen. (2019) Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. Clinical Cancer Research 25:7, pages 2305-2313.
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Chiaki T. Ishida, Yiru Zhang, Elena Bianchetti, Chang Shu, Trang T.T. Nguyen, Giulio Kleiner, Maria J. Sanchez-Quintero, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Varun V. Prabhu, Joshua E. Allen & Markus D. Siegelin. (2018) Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma. Clinical Cancer Research 24:21, pages 5392-5406.
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Péter Bárány, Rita Szabó Oláh, Imre Kovács, Tamás Czuczi, Csenge Lilla Szabó, Angéla Takács, Eszter Lajkó, Orsolya Láng, László Kőhidai, Gitta Schlosser, Szilvia Bősze, Gábor Mező, Ferenc Hudecz & Antal Csámpai. (2018) Ferrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure–Activity Relationships. Molecules 23:9, pages 2248.
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Avital Lev, Amriti R. Lulla, Brian C. Ross, Marie D. Ralff, Petr B. Makhov, David T. Dicker & Wafik S. El-Deiry. (2018) ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer. Molecular Cancer Research 16:5, pages 754-766.
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