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Cell Cycle Volume 17, 2018 - Issue 8
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PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer

Prerna MalaneyDepartment of Pathology and Cell Biology, Morsani College of MedicineORCID Iconhttp://orcid.org/0000-0002-4667-4823View further author information
ORCID Icon,
Emily PalumboDepartment of Pathology and Cell Biology, Morsani College of MedicineView further author information
,
Jonathan Semidey-HurtadoDepartment of Pathology and Cell Biology, Morsani College of MedicineView further author information
,
Jamaal HardeeDepartment of Pathology and Cell Biology, Morsani College of MedicineORCID Iconhttp://orcid.org/0000-0002-8400-1160View further author information
ORCID Icon,
Katherine StanfordDepartment of Pathology and Cell Biology, Morsani College of MedicineView further author information
,
Jaymin J. KathiriyaDepartment of Pathology and Cell Biology, Morsani College of MedicineView further author information
,
Deepal PatelDepartment of Pathology and Cell Biology, Morsani College of MedicineView further author information
,
Zhi TianCollege of Pharmacy, University of South Florida, Tampa, FL33612, United StatesORCID Iconhttp://orcid.org/0000-0002-0724-0432View further author information
ORCID Icon,
Diane Allen-GipsonCollege of Pharmacy, University of South Florida, Tampa, FL33612, United StatesORCID Iconhttp://orcid.org/0000-0001-6976-3960View further author information
ORCID Icon &
Vrushank DavéDepartment of Pathology and Cell Biology, Morsani College of Medicine;Lung Cancer Center of Excellence, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida33612, United States.Correspondence[email protected]
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Pages 947-962 | Received 11 Nov 2016, Accepted 02 Oct 2017, Published online: 31 May 2018

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Wei Du, Xu Zhang & Zhen Wan. (2019) miR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN. OncoTargets and Therapy 12, pages 4897-4906.
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Articles from other publishers (26)

Tatyana F. Kovalenko, Bhupender Yadav, Ksenia S. Anufrieva, Tatyana D. Larionova, Tatiana E. Aksinina, Yaroslav A. Latyshev, Soniya Bastola, Michail I. Shakhparonov, Amit Kumar Pandey & Marat S. Pavlyukov. (2024) PTEN regulates expression of its pseudogene in glioblastoma cells in DNA methylation-dependent manner. Biochimie 219, pages 74-83.
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Xiaojie Xiong & Gang Jian. (2023) E2F1‑mediated RAB34 upregulation accelerates the proliferation and inhibits the cell cycle arrest and apoptosis of acute myeloid leukemia cells. Experimental and Therapeutic Medicine 26:2.
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Varadha Balaji Venkadakrishnan, Yasutaka Yamada, Kenny Weng, Osasenaga Idahor & Himisha Beltran. (2023) Significance of RB Loss in Unlocking Phenotypic Plasticity in Advanced Cancers. Molecular Cancer Research 21:6, pages 497-510.
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Pei Xu, Lei Wang, Bin Mo, Xiao Xie, Rui Hu, Lianyong Jiang, Fengqing Hu, Fangbao Ding & Haibo Xiao. (2023) Identification of NLE1/CDK1 axis as key regulator in the development and progression of non-small cell lung cancer. Frontiers in Oncology 12.
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Casey G. Langdon. (2023) Nuclear PTEN’s Functions in Suppressing Tumorigenesis: Implications for Rare Cancers. Biomolecules 13:2, pages 259.
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Guan-Ming Lu, Li-Yuan Jiang, Dong-Lin Huang, Yong-Xian Rong, Yang-Hong Li, Liu-Xing Wei, Yan Ning, Shan-Fu Huang, Steven Mo, Fu-Han Meng & Hong-Mian Li. (2023) Advanced Platelet-Rich Fibrin Extract Treatment Promotes the Proliferation and Differentiation of Human Adipose-Derived Mesenchymal Stem Cells through Activation of Tryptophan Metabolism. Current Stem Cell Research & Therapy 18:1, pages 127-142.
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Yanlin Yu, Meng Dai, Liping Huang, Weiping Chen, Ellen Yu, Arnulfo Mendoza, Helen Michael, Chand Khanna, Marcus Bosenberg, Martin McMahon & Glenn Merlino. (2023) PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6. iScience, pages 106070.
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Iris N. Smith, Jennifer E. Dawson, James Krieger, Stetson Thacker, Ivet Bahar & Charis Eng. (2022) Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation. Journal of Chemical Information and Modeling 62:17, pages 4175-4190.
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Rui Xin, Biao Shen, Ying-Jie Jiang, Ji-Bin Liu, Sha Li, Li-Kun Hou, Wei Wu, Cheng-You Jia, Chun-Yan Wu, Da Fu, Yu-Shui Ma & Geng-Xi Jiang. (2022) Comprehensive analysis to identify a novel PTEN-associated ceRNA regulatory network as a prognostic biomarker for lung adenocarcinoma. Frontiers in Oncology 12.
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Shihui Xia & Zengwang Zhang. (2022) Circular RNA hsa_circ_0000317 inhibits non-small cell lung cancer progression through regulating microRNA-494-3p/phosphatase and tensin homolog deleted on chromosome 10 axis. Clinics 77, pages 100086.
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Sandip Misra, Ginia Ghosh, Sougata Ghosh Chowdhury & Parimal Karmakar. (2021) Non-canonical function of nuclear PTEN and its implication on tumorigenesis. DNA Repair 107, pages 103197.
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Baijun Li, Hao Yang, Bin Shen, Jianwei Huang & Zhiqiang Qin. (2021) Procollagen‑lysine, 2‑oxoglutarate 5‑dioxygenase 1 increases cellular proliferation and colony formation capacity in lung cancer via activation of E2F transcription factor 1. Oncology Letters 22:6.
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Hongyu Zheng, Hui Tian, Xuejuan Yu, Peng Ren & Qiuan Yang. (2021) G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1. International Journal of Biological Macromolecules 182, pages 858-865.
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Huizhen Zhu, Yan Xu, Meng Li & Zhitao Chen. (2021) Inhibition Sequence of miR-205 Hinders the Cell Proliferation and Migration of Lung Cancer Cells by Regulating PETN-Mediated PI3K/AKT Signal Pathway. Molecular Biotechnology 63:7, pages 587-594.
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Ping Xie, Zhiqiang Peng, Yujiao Chen, Hongchang Li, Mengge Du, Yawen Tan, Xin Zhang, Zhe Lu, Chun-Ping Cui, Cui Hua Liu, Fuchu He & Lingqiang Zhang. (2020) Neddylation of PTEN regulates its nuclear import and promotes tumor development. Cell Research 31:3, pages 291-311.
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Wenrui Li, Xiaolu Guan & Li Sun. (2020) Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder—Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection. International Journal of Molecular Sciences 21:20, pages 7725.
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Shiyu Chen, Zhiwei He, Changhao Zhu, Yanqing Liu, Lin Li, Lu Deng, Jun Wang, Chao Yu & Chengyi Sun. (2020) TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway. Frontiers in Oncology 10.
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Shuqin Xing, Yafei Wang, Kaiwen Hu, Fen Wang, Tao Sun & Quanwang Li. (2020) WGCNA reveals key gene modules regulated by the combined treatment of colon cancer with PHY906 and CPT11. Bioscience Reports 40:9.
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Xinyi Fan, Jeffrey Kraynak, Jonathan P.S. Knisely, Silvia C. Formenti & Wen H. Shen. (2020) PTEN as a Guardian of the Genome: Pathways and Targets. Cold Spring Harbor Perspectives in Medicine 10:9, pages a036194.
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Nicola Fusco, Elham Sajjadi, Konstantinos Venetis, Gabriella Gaudioso, Gianluca Lopez, Chiara Corti, Elena Guerini Rocco, Carmen Criscitiello, Umberto Malapelle & Marco Invernizzi. (2020) PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?. Genes 11:7, pages 719.
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Abdulaziz A. Almotlak, Mariya Farooqui & Jill M. Siegfried. (2020) Inhibiting Pathways Predicted From a Steroid Hormone Gene Signature Yields Synergistic Antitumor Effects in NSCLC. Journal of Thoracic Oncology 15:1, pages 62-79.
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Dan Zhao, Xing-Ping Qin, Song-Feng Chen, Xin-Yu Liao, Jing Cheng, Rui Liu, Yang Lei, Zhi-Feng Zhang & Qi Wan. (2019) PTEN Inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury Through PTEN/E2F1/β-Catenin Pathway. Frontiers in Molecular Neuroscience 12.
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Shengqing Li & Hai Zou. (2019) The Diagnostic and Therapeutic Potential of the Epigenetic Modifications of Lung Cancer–Related Genes. Current Pharmacology Reports 5:6, pages 421-428.
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Xiaobin Guo, Zhuochang Chen, Limin Zhao, Dongjun Cheng, Wei Song & Xiaoju Zhang. (2019) Long non-coding RNA-HAGLR suppressed tumor growth of lung adenocarcinoma through epigenetically silencing E2F1. Experimental Cell Research 382:1, pages 111461.
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Anastasios Gkountakos, Giulia Sartori, Italia Falcone, Geny Piro, Ludovica Ciuffreda, Carmine Carbone, Giampaolo Tortora, Aldo Scarpa, Emilio Bria, Michele Milella, Rafael Rosell, Vincenzo Corbo & Sara Pilotto. (2019) PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around. Cancers 11:8, pages 1141.
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Guifen Wei, Yiting Yuan, Xinzhong He, Liming Jin & Di Jin. (2019) Enhanced plasma miR‑142‑5p promotes the progression of intrahepatic cholangiocarcinoma via targeting PTEN. Experimental and Therapeutic Medicine.
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