Advanced search
Publication Cover
Cell Cycle Volume 17, 2018 - Issue 15
Submit an article Journal homepage
1,200
Views
20
CrossRef citations to date
0
Altmetric
Research Paper

Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis

Olga Fedorovaa Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaView further author information
,
Alexandra Daksa Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaORCID Iconhttps://orcid.org/0000-0003-0495-1244View further author information
ORCID Icon,
Varvara Petrovab MRC Toxicology Unit, Leicester, UKView further author information
,
Alexey Petukhova Gene Expression Programme, Institute of Cytology, Saint-Petersburg, Russia;c Institute of Hematology, Almazov National Medical Research Centre, RussiaORCID Iconhttps://orcid.org/0000-0002-3675-0597View further author information
ORCID Icon,
Larissa Lezinaa Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaView further author information
,
Oleg Shuvalova Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaView further author information
,
Pavel Davidovichd Molecular Pharmacology, State Technological University, Saint-Petersburg, RussiaORCID Iconhttps://orcid.org/0000-0003-1938-297XView further author information
ORCID Icon,
Darya Krigera Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaView further author information
,
Ekaterina Lomerta Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaView further author information
,
Dmitry Tentlera Gene Expression Programme, Institute of Cytology, Saint-Petersburg, RussiaORCID Iconhttps://orcid.org/0000-0003-3976-1205View further author information
ORCID Icon,
Victor Kartseve Interbioscreen, Chernogolovka, RussiaView further author information
,
Burhan Uyanikf INSERM U866, University of Burgundy, Dijon, FranceView further author information
,
Vyacheslav Tribulovichd Molecular Pharmacology, State Technological University, Saint-Petersburg, RussiaView further author information
,
Oleg Demidovf INSERM U866, University of Burgundy, Dijon, FranceView further author information
,
Gerry Melinob MRC Toxicology Unit, Leicester, UKView further author information
&
Nickolai A. Barleva Gene Expression Programme, Institute of Cytology, Saint-Petersburg, Russia;g Intracellular Signalling Laboratory, Moscow Institute of Physics and Technology, Dolgoprudny, RussiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7111-2446View further author information
ORCID Icon show all
Pages 1917-1930 | Received 28 Mar 2018, Accepted 21 Jul 2018, Published online: 05 Sep 2018

Citations (20)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Caterina Lanna, Mara Mancini, Roberta Gaziano, Maria Vittoria Cannizzaro, Marco Galluzzo, Marina Talamonti, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Ying Wang, Yufang Shi, Elena Campione & Luca Bianchi. (2019) Skin immunity and its dysregulation in psoriasis. Cell Cycle 18:20, pages 2581-2589.
Read now

Articles from other publishers (19)

Anna A. Danilushkina, Charles C. Emene, Nicolai A. Barlev & Marina O. Gomzikova. (2023) Strategies for Engineering of Extracellular Vesicles. International Journal of Molecular Sciences 24:17, pages 13247.
Crossref
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev & Alexey G. Mittenberg. (2023) p53 Affects Zeb1 Interactome of Breast Cancer Stem Cells. International Journal of Molecular Sciences 24:12, pages 9806.
Crossref
Anna P. Loboda, Leonid S. Adonin, Svetlana D. Zvereva, Dmitri Y. Guschin, Tatyana V. Korneenko, Alexandra V. Telegina, Olga K. Kondratieva, Sofia E. Frolova, Nikolay B. Pestov & Nick A. Barlev. (2023) BRCA Mutations—The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers. International Journal of Molecular Sciences 24:5, pages 4982.
Crossref
Daria Kriger, Ksenia Novitskaya, Giomar Vasileva, Ekaterina Lomert, Nikolai D. Aksenov, Nikolai A. Barlev & Dmitri Tentler. (2022) Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells. Biology Direct 17:1.
Crossref
Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay B. Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko & Nikolai A. Barlev. (2022) Artificial genetic polymers against human pathologies. Biology Direct 17:1.
Crossref
Gheorghe Roman. (2022) Anticancer Activity of Mannich Bases: A Review of Recent Literature. ChemMedChem 17:16.
Crossref
Olga Fedorova, Sergey Parfenyev, Alexandra Daks, Oleg Shuvalov & Nickolai A. Barlev. (2022) The Role of PTEN in Epithelial–Mesenchymal Transition. Cancers 14:15, pages 3786.
Crossref
Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Ivan Nevzorov, Oleg Shuvalov & Nickolai A. Barlev. (2022) The Role of E3 Ligase Pirh2 in Disease. Cells 11:9, pages 1515.
Crossref
Alexandra Daks, Elena Vasileva, Olga Fedorova, Oleg Shuvalov & Nickolai A. Barlev. (2022) The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response. Life 12:3, pages 362.
Crossref
Zhenzhen Zhang, Xin Liu, Liyun Zhao, Yaru Zhou, Jianyou Shi, Weini Chen & Jinqi Li. (2022) A review on the treatment of multiple myeloma with small molecular agents in the past five years. European Journal of Medicinal Chemistry 229, pages 114053.
Crossref
Tatyana Grigoreva, Aleksandra Sagaidak, Angelina Romanova, Daria Novikova, Aleksander Garabadzhiu & Viacheslav Tribulovich. (2021) Establishment of drug-resistant cell lines under the treatment with chemicals acting through different mechanisms. Chemico-Biological Interactions 344, pages 109510.
Crossref
Daria S. Novikova, Tatyana A. Grigoreva, Gleb S. Ivanov, Gerry Melino, Nickolai A. Barlev & Vyacheslav G. Tribulovich. (2020) Activating Effect of 3‐Benzylidene Oxindoles on AMPK: From Computer Simulation to High‐Content Screening. ChemMedChem 15:24, pages 2521-2529.
Crossref
T. Grigoreva, A. Romanova, A. Sagaidak, S. Vorona, D. Novikova & V. Tribulovich. (2020) Mdm2 inhibitors as a platform for the design of P-glycoprotein inhibitors. Bioorganic & Medicinal Chemistry Letters 30:18, pages 127424.
Crossref
Rafał Rusiecki, Jakub Witkowski & Joanna Jaszczewska-Adamczak. (2020) MDM2-p53 Interaction Inhibitors: The Current State-of-Art and Updated Patent Review (2010-Present). Recent Patents on Anti-Cancer Drug Discovery 14:4, pages 324-369.
Crossref
Aleksandra Sagaidak, Milena Lvova, Aleksander Garabadzhiu & Angelina Romanova. (2020) Treatment of chemoresistant cell lines with indolinone-based small molecules. E3S Web of Conferences 215, pages 05005.
Crossref
Maxim Gureev, Daria Novikova, Tatyana Grigoreva, Svetlana Vorona, Alexander Garabadzhiu & Vyacheslav Tribulovich. (2019) Simulation of MDM2 N-terminal domain conformational lability in the presence of imidazoline based inhibitors of MDM2-p53 protein–protein interaction. Journal of Computer-Aided Molecular Design 34:1, pages 55-70.
Crossref
Dmitri Tentler, Ekaterina Lomert, Ksenia Novitskaya & Nikolai A. Barlev. (2019) Role of ACTN4 in Tumorigenesis, Metastasis, and EMT. Cells 8:11, pages 1427.
Crossref
S. E. Parfenyev, A. N. Smotrova, M. A. Shkliaeva & N. A. Barlev. (2019) Regulation of p53 Protein Function in Response to Heat Shock. Cell and Tissue Biology 13:4, pages 259-267.
Crossref
Andrey S. Smirnov, Luísa M. D. R. S. Martins, Dmitriy N. Nikolaev, Roman A. Manzhos, Vlad V. Gurzhiy, Alexander G. Krivenko, Kirill O. Nikolaenko, Alexander V. Belyakov, Alexander V. Garabadzhiu & Pavel B. Davidovich. (2019) Structure and catalytic properties of novel copper isatin Schiff base complexes. New Journal of Chemistry 43:1, pages 188-198.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.