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Cell Cycle Volume 18, 2019 - Issue 13
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Research Paper

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

Zhengmin MaKey Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Xinxin JinCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Zhuang QianCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Fang LiKey Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Mao XuCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Ying ZhangCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Xiaomin KangCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Huixia LiKey Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Xin GaoKey Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Liting ZhaoCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Zhuanmin ZhangKey Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Yan ZhangCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Shufang WuCenter for Translational Medicine, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi Province, People’s Republic of ChinaCorrespondence[email protected] Shufang Wu [email protected]
View further author information
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Hongzhi SunKey Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of ChinaView further author information
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Pages 1473-1489 | Received 06 Dec 2018, Accepted 07 Apr 2019, Published online: 26 May 2019

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Read on this site (2)

Zhuang Qian, Zhen Liu, Zhenhua Feng, Zhenning Cai, Yong Qiu & Zezhang Zhu. (2023) Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway. Cell Cycle 22:1, pages 73-84.
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Qian Zhou, Huina Hu, Yuta Yang, Yuxin Kang, Xianyong Lan, Xianfeng Wu, Zhengang Guo & Chuanying Pan. (2022) Insertion/deletion (Indel) variant of the goat RORA gene is associated with growth traits. Animal Biotechnology 0:0, pages 1-8.
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Articles from other publishers (19)

Guangjin Chen, Qingming Tang, Shaoling Yu, Yufeng Shen, Jiwei Sun, Jinfeng Peng, Ying Yin, Guangxia Feng, Xiaofeng Lu, Gang Mei, Yifan Zhang, Qian Wan, Luoying Zhang & Lili Chen. (2023) Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation. Cell Death & Differentiation 30:6, pages 1503-1516.
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Xin-An Zhang & Hui Kong. (2023) Mechanism of HIFs in osteoarthritis. Frontiers in Immunology 14.
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Zhuang Qian, Xin Gao, Xinxin Jin, Xiaomin Kang & Shufang Wu. (2023) Cartilage-specific deficiency of clock gene Bmal1 accelerated articular cartilage degeneration in osteoarthritis by up-regulation of mTORC1 signaling. International Immunopharmacology 115, pages 109692.
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Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li & Feng-Lai Yuan. (2023) Circadian clock genes as promising therapeutic targets for bone loss. Biomedicine & Pharmacotherapy 157, pages 114019.
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Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang & Li Gao. (2022) Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats. Arthritis Research & Therapy 24:1.
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Ze Du, Xuanhe You, Diwei Wu, Shishu Huang & Zongke Zhou. (2022) Rhythm disturbance in osteoarthritis. Cell Communication and Signaling 20:1.
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Guangxia Feng, Jiajia Zhao, Jinfeng Peng, Beibei Luo, Jiaqi Zhang, Lili Chen & Zhi Xu. (2022) Circadian clock—A promising scientific target in oral science. Frontiers in Physiology 13.
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Fan Yang, Weijian Liu, Yongcan Huang, Shuhua Yang, Zengwu Shao, Xianyi Cai & Liming Xiong. (2022) Regulated cell death: Implications for intervertebral disc degeneration and therapy. Journal of Orthopaedic Translation 37, pages 163-172.
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Yanli Zhu, Yanqing Liu, Germaine Escames, Zhi Yang, Huadong Zhao, Lu Qian, Chengxu Xue, Danni Xu, Darío Acuña-Castroviejo & Yang Yang. (2022) Deciphering clock genes as emerging targets against aging. Ageing Research Reviews 81, pages 101725.
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Rongping Fan, Xuemin Peng, Lei Xie, Kun Dong, Delin Ma, Weijie Xu, Xiaoli Shi, Shujun Zhang, Juan Chen, Xuefeng Yu & Yan Yang. (2022) Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions. Aging Cell 21:10.
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Qiuyue Qin, Yiping Liu, Zhen Yang, Maierhaba Aimaijiang, Rui Ma, Yixin Yang, Yidi Zhang & Yanmin Zhou. (2022) Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair. International Journal of Molecular Sciences 23:19, pages 11201.
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Xiaopeng Song, Tianwen Ma, Hailong Hu, Mingchao Zhao, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xuanbo Sheng, Xinyu Xu, Xinmin Zhang & Li Gao. (2021) Chronic Circadian Rhythm Disturbance Accelerates Knee Cartilage Degeneration in Rats Accompanied by the Activation of the Canonical Wnt/β-Catenin Signaling Pathway. Frontiers in Pharmacology 12.
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Xiaopeng Song, Hui Bai, Xinghua Meng, Jianhua Xiao & Li Gao. (2021) Drivers of phenotypic variation in cartilage: Circadian clock genes. Journal of Cellular and Molecular Medicine 25:16, pages 7593-7601.
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Raewyn C Poulsen, James I Hearn & Nicola Dalbeth. (2021) The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?. Rheumatology 60:7, pages 3048-3057.
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Francesco Dernie & Daniel Adeyoju. (2021) A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy. Experimental Gerontology 143, pages 111163.
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Demin Li, Ruixue Zhang, Qinyuan Sun & Xiaoying Guo. (2020) Involvement of Bmal1 and circadian clock signaling in chondrogenic differentiation of ATDC5 cells by fluoride. Ecotoxicology and Environmental Safety 204, pages 111058.
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Jun Lin, Lin Chen & Dou Dou. (2020) Progress of orthopaedic research in China over the last decade. Journal of Orthopaedic Translation 24, pages 131-137.
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Guangjin Chen, Qingming Tang, Shaoling Yu, Yanling Xie, Jiwei Sun, Shue Li & Lili Chen. (2020) The biological function of BMAL1 in skeleton development and disorders. Life Sciences 253, pages 117636.
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Lei Li, Meng Li, Yiqun Pang, Jun Wang, Yunpeng Wan, Chen Zhu & Zongsheng Yin. (2019) Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone. Life Sciences 239, pages 116975.
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