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Cell Cycle Volume 19, 2020 - Issue 17
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Research paper

Low glucose enhanced metformin’s inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p

Minglei Maa Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaView further author information
,
Chifa Maa Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaView further author information
,
Pingping Lic Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing 100050, China;b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical, Sciences and Peking Union Medical College, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0003-0679-270XView further author information
ORCID Icon,
Chunxiao Mac Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing 100050, China;b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical, Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Fan Pinga Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaView further author information
,
Wei Lia Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaORCID Iconhttps://orcid.org/0000-0002-3332-1287View further author information
ORCID Icon,
Lingling Xua Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaView further author information
,
Huabing Zhanga Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaORCID Iconhttps://orcid.org/0000-0001-6259-7584View further author information
ORCID Icon,
Qi Suna Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaView further author information
&
Yuxiu Lia Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,ChinaCorrespondence[email protected]
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Pages 2168-2181 | Received 25 Mar 2020, Accepted 30 Jun 2020, Published online: 28 Jul 2020

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Zhong Zhang & Hai-Jun Zhang. (2021) Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential. Expert Opinion on Therapeutic Targets 25:12, pages 1077-1093.
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Articles from other publishers (17)

Anchisa Poonprasartporn, Jin Xiao & K.L. Andrew Chan. (2024) A study of WZB117 as a competitive inhibitor of glucose transporter in high glucose treated PANC-1 cells by live-cell FTIR spectroscopy. Talanta 266, pages 125031.
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Mutian Lian, Maria Mortoglou & Pinar Uysal-Onganer. (2023) Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer. Current Issues in Molecular Biology 45:12, pages 9778-9792.
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Peng Gao, Jiang Yi, Wenjun Chen, Jun Gu, Sheng Miao, Xiaowei Wang, Yifan Huang, Tao Jiang, Qingqing Li, Wei Zhou, Shujie Zhao, Mengyuan Wu, Guoyong Yin & Jian Chen. (2023) Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway. Journal of Nanobiotechnology 21:1.
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Ying Li, Qingqian Zhang, Jintao Yang, Weiping He, Yulan Jiang, Yu Chen & Yifan Wang. (2023) Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response. Biochemical and Biophysical Research Communications 675, pages 146-154.
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Emine Nedime KORUCU, Esma MENEVŞE, Dudu ERKOÇ KAYA, Fatma GOKTURK & Hilal ARİKOGLU. (2023) Effects of Curcumin Treatment on Cell Energy Status, Levels of Mitochondrial Enzymes, and Gene Expression of Glucose-related Mechanism in Panc-1 and BxPC-3 Cell Lines. Journal of Basic and Clinical Health Sciences.
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Luis Alberto Bravo-Vázquez, Natalia Frías-Reid, Ana Gabriela Ramos-Delgado, Sofía Madeline Osorio-Pérez, Hania Ruth Zlotnik-Chávez, Surajit Pathak, Antara Banerjee, Anindya Bandyopadhyay, Asim K. Duttaroy & Sujay Paul. (2023) MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications. Translational Oncology 27, pages 101579.
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Mohamed Abdelmoneim, Ibrahim Ragab Eissa, Mona Alhussein Aboalela, Yoshinori Naoe, Shigeru Matsumura, Patricia Angela Sibal, Itzel Bustos-Villalobos, Maki Tanaka, Yasuhiro Kodera & Hideki Kasuya. (2022) Metformin enhances the antitumor activity of oncolytic herpes simplex virus HF10 (canerpaturev) in a pancreatic cell cancer subcutaneous model. Scientific Reports 12:1.
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Qinzhi Yang, Gang Wang, Dan Fang, Xiaojun Gao, Yu Liang, Liqun Wang, Jianbo Wu, Min Zeng & Mao Luo. (2022) The role of MicroRNA networks in tissue-specific direct and indirect effects of metformin and its application. Biomedicine & Pharmacotherapy 151, pages 113130.
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Aiste Gulla, Urte Andriusaityte, Gabrielius Zdanys, Elena Babonaite, Kestutis Strupas & Helena Kelly. (2022) The Impact of Epithelial–Mesenchymal Transition and Metformin on Pancreatic Cancer Chemoresistance: A Pathway towards Individualized Therapy. Medicina 58:4, pages 467.
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Baoyu He, Hongli Pan, Fengque Zheng, Saiqiong Chen, Qingli Bie, Jinghe Cao, Rou Zhao, Jing Liang, Li Wei, Jianchao Zeng, Hui Li, Xing Cui, Yixuan Ding, Wei Chao, Tiantian Xiang, Yuhe Cheng, Gui Qiu, Shishun Huang, Libo Tang, Jiansheng Chang, Delan Luo, Jie Yang & Bin Zhang. (2022) Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma. Journal of Experimental & Clinical Cancer Research 41:1.
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Shan Liu, Jumpei Washio, Satoko Sato, Yuki Abiko, Yuta Shinohara, Yuri Kobayashi, Haruki Otani, Shiori Sasaki, Xiaoyi Wang & Nobuhiro Takahashi. (2022) Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions. International Journal of Molecular Sciences 23:2, pages 989.
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Xiaoye Duan, Weihao Wang, Qi Pan & Lixin Guo. (2021) Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development. Frontiers in Oncology 11.
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Grazielle Paz, Gisele De Amorim & Janaina Fernandes. (2021) Metformin restores cisplatin cytotoxicity reduced by allantoin in CML in vitro . World Academy of Sciences Journal 3:5.
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Martin A. Prusinkiewicz & Joe S. Mymryk. (2021) Metabolic Control by DNA Tumor Virus-Encoded Proteins. Pathogens 10:5, pages 560.
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Nahid Alimoradi, Negar Firouzabadi & Reihaneh Fatehi. (2021) How metformin affects various malignancies by means of microRNAs: a brief review. Cancer Cell International 21:1.
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Wei-long Xu, Su Liu, Nan Li, Li-fang Ye, Min Zha, Chang-yin Li, Yue Zhao, Qiang Pu, Jin-jing Bao, Xing-jie Chen, Jiang-yi Yu & Ying-hao Pei. (2021) Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1α/miR-210/ISCU/FeS Pathway. Frontiers in Medicine 8.
Crossref
Ipek Alpertunga, Rabail Sadiq, Deep Pandya, Tammy Lo, Maxim Dulgher, Sarah Evans, Bridget Bennett, Nancy Rennert & Richard C. Frank. (2021) Glycemic Control as an Early Prognostic Marker in Advanced Pancreatic Cancer. Frontiers in Oncology 11.
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