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Cell Cycle Volume 20, 2021 - Issue 3
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Research Paper

Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a

Tao WenDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaView further author information
,
Hongshen WangDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaView further author information
,
Yongjin LiDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaView further author information
,
Yongpeng LinDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaView further author information
,
Shuai ZhaoDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaView further author information
,
Jinggong LiuDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaView further author information
&
Bolai ChenDepartment of Spine Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaCorrespondence[email protected]
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Pages 256-270 | Received 15 May 2020, Accepted 09 Dec 2020, Published online: 26 Jan 2021

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Xiaoliang Bai, Mingyan Yao, Xiaojuan Zhu, Yong Lian & Mingyuan Zhang. (2023) Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells. Immunopharmacology and Immunotoxicology 45:4, pages 433-442.
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Articles from other publishers (27)

Shengxu Zhu, Junlin Wang, Moran Suo, Huagui Huang, Xin Liu, Jinzuo Wang & Zhonghai Li. (2023) Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?. Ageing Research Reviews 92, pages 102094.
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Qing-Xiang Zhang & Min Cui. (2023) How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration. World Journal of Stem Cells 15:11, pages 989-998.
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Changbao Xu, Mingyong Xin, Yu Wang & Jipu Gao. (2023) An efficient YOLO v3-based method for the detection of transmission line defects. Frontiers in Energy Research 11.
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Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen & Danièle Noël. (2023) Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells. Nature Reviews Rheumatology 19:11, pages 682-694.
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ZhaoLiang Zhang, JianZhong Huo, XingHua Ji, LinDong Wei & Jinfeng Zhang. (2023) GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data. BMC Musculoskeletal Disorders 24:1.
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Guangtao Pan, Yanran Wu, Yuhan Liu, Fangyuan Zhou, Sen Li & Yang Shenglan. (2023) Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways. Journal of Traditional and Complementary Medicine.
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Ankita Samanta, Thomas Lufkin & Petra Kraus. (2023) Intervertebral disc degeneration—Current therapeutic options and challenges. Frontiers in Public Health 11.
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Junyu Wei, Zixuan Ou, Bide Tong, Zhiwei Liao & Cao Yang. (2023) Engineered extracellular vesicles as therapeutics of degenerative orthopedic diseases. Frontiers in Bioengineering and Biotechnology 11.
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Maimaitiaili Niyazi, Jie Dai, Xiaoyuan Wang & Aikeremujiang Muheremu. (2023) Overexpression of MicroRNA-182-5p Alleviates Pain in Rats with Lumbar Disc Herniation. Journal of Biomaterials and Tissue Engineering 13:5, pages 721-725.
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Zixiang Geng, Hailing Guo, Yifei Li, Ying Liu & Yongfang Zhao. (2023) Stem cell-derived extracellular vesicles: A novel and potential remedy for primary ovarian insufficiency. Frontiers in Cell and Developmental Biology 11.
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Christiane B. Lombello, Débora C. Ferraraz, Jackeline S. Katayose, Thiago M. Sheguti, Luciana P. Giorno & Arnaldo R. SantosJrJr. 2023. Handbook of Stem Cell Applications. Handbook of Stem Cell Applications 1 26 .
Y. Hao, G. Zhu, L. Yu, Z. Ren, P. Zhang, J. Zhu & S. Cao. (2022) Extracellular vesicles derived from mesenchymal stem cells confer protection against intervertebral disc degeneration through a microRNA-217-dependent mechanism. Osteoarthritis and Cartilage 30:11, pages 1455-1467.
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Yuanliang Xia, Ruohan Yang, Yulin Hou, Hengyi Wang, Yuehong Li, Jianshu Zhu & Changfeng Fu. (2022) Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration. Frontiers in Bioengineering and Biotechnology 10.
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Li-Wen Zheng, Chun-Na Lan, Ying Kong, Li-Hong Liu, Yong-Mei Fan & Chang-Jie Zhang. (2022) Exosomal miR-150 derived from BMSCs inhibits TNF-α-mediated osteoblast apoptosis in osteonecrosis of the femoral head by GREM1/NF-κB signaling. Regenerative Medicine 17:10, pages 739-753.
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Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu & Haipeng Xue. (2022) Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration. Frontiers in Pharmacology 13.
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Peng Ye, Zhanhu Mi, Daihao Wei, Pengcheng Gao, Mei Ma & Haibo Yang. (2022) miR-3960 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Inactivates SDC1/Wnt/β-Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by Targeting PHLDA2. Stem Cells International 2022, pages 1-18.
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Xiao-Jun Yu, Qi-Kun Liu, Rui Lu, Shan-Xi Wang, Hao-Ran Xu, Ying-Guang Wang, Yuan Bao, Yong-Qiao Jiang, Meng-Wei Li & Hao Kang. (2022) Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity 2022, pages 1-27.
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Basanta Bhujel, Hae-Eun Shin, Dong-Jun Choi & Inbo Han. (2022) Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review. International Journal of Molecular Sciences 23:13, pages 7306.
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Xiaojun Yu, Haoran Xu, Qikun Liu, Yingguang Wang, Shanxi Wang, Rui Lu, Yongqiao Jiang, Hao Kang & Weihua Hu. (2022) circ_0072464 Shuttled by Bone Mesenchymal Stem Cell-Secreted Extracellular Vesicles Inhibits Nucleus Pulposus Cell Ferroptosis to Relieve Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity 2022, pages 1-21.
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Shunlun Chen, Linchuan Lei, Zemin Li, Fan Chen, Yuming Huang, Guowei Jiang, Xingyu Guo, Zhuoyang Zhao, Hui Liu, Hua Wang, Caijun Liu, Zhaomin Zheng & Jianru Wang. (2022) Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation. Experimental & Molecular Medicine 54:4, pages 518-530.
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Cong ZhangXin PengFeng WangZhiyang Xie, Lu ChenXiaotao Wu. (2022) Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration. DNA and Cell Biology 41:3, pages 257-261.
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Tyler J. DiStefano, Keti Vaso, George Danias, Henry N. Chionuma, Jennifer R. Weiser & James C. Iatridis. (2021) Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations. Advanced Healthcare Materials 11:5.
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Lin Lu, Aoshuang Xu, Fei Gao, Chenjun Tian, Honglin Wang, Jiayao Zhang, Yi Xie, Pengran Liu, Songxiang Liu, Cao Yang, Zhewei Ye & Xinghuo Wu. (2022) Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration. Frontiers in Cell and Developmental Biology 9.
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Xinjie Wu & Wei Sun. (2022) Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration. Frontiers in Cell and Developmental Biology 9.
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Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Claudia Cicione, Giuseppina Di Giacomo, Rocco Papalia & Vincenzo Denaro. (2021) Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration. Applied Sciences 11:23, pages 11222.
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Haoyu Wang, Fei Li, Wenrui Ban, Jing Zhang & Guiqi Zhang. (2021) Human Bone Marrow Mesenchymal Stromal Cell-Derived Extracellular Vesicles Promote Proliferation of Degenerated Nucleus Pulposus Cells and the Synthesis of Extracellular Matrix Through the SOX4/Wnt/β-Catenin Axis. Frontiers in Physiology 12.
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Guangtao Pan, Yuexing Gu, Jingyi Yang, Yuhan Liu, Fangyuan Zhou, Yanran Wu & Sen Li. (2022) Dachengqi Decoction Ameliorated the Sepsis-Induced Liver Injury by Inhibiting the TGF-β1/Smad3 Pathways. SSRN Electronic Journal.
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