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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 3, 2006 - Issue 1
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ORIGINAL RESEARCH

Multi-Center Study: The Biochemical Efficacy, Safety and Tolerability of a New α1-Proteinase Inhibitor, Zemaira

James M. Stocks The University of Texas Health Center at Tyler, Tyler, Texas, USA
,
Mark Brantly Department of Pulmonary Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
,
David Pollock Department of Pulmonary Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
,
Alan Barker Pulmonary & Critical Care, Oregon Health and Science University, PortlandUSA
,
Friedrich Kueppers The Lung Center at Temple University Hospital, Philadelphia, Pennsylvania, USA
,
Charlie Strange Medical University of South Carolina, Charleston, South Carolina, USA
,
James F. Donohue Division of Pulmonary Disease & Critical Care, University of NC at Chapel Hill, Chapel Hill, North Carolina, USA
&
Robert Sandhaus National Jewish Medical and Research Center, Denver, Colorado, USA
 show all
Pages 17-23 | Published online: 02 Jul 2009

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Kenneth R Chapman, Joanna Chorostowska-Wynimko, A Rembert Koczulla, Ilaria Ferrarotti & Noel G McElvaney. (2018) Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 419-432.
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David G Parr & Beatriz Lara. (2017) Clinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature. Drug Design, Development and Therapy 11, pages 2149-2162.
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Ross G Edgar, Mitesh Patel, Susan Bayliss, Diana Crossley, Elizabeth Sapey & Alice M Turner. (2017) Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1295-1308.
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Killian Hurley, Emer P. Reeves, Tomás P. Carroll & Noel G. McElvaney. (2016) Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment. Expert Review of Respiratory Medicine 10:2, pages 207-222.
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Leock Y Ngo, Adam Haeberle, Jacqueline Dyck-Jones, David Gelmont & Leman Yel. (2014) Safety and tolerability of an intravenously administered alpha1-proteinase inhibitor at an increased infusion rate: a novel, randomized, placebo-masked, infusion rate-controlled, crossover study in healthy adults. Open Access Journal of Clinical Trials 6, pages 55-61.
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Robert A. Sandhaus, James Stocks, Farshid N. Rouhani, Mark Brantly & Pnina Strauss. (2014) Biochemical Efficacy and Safety of a New, Ready-to-Use, Liquid Alpha-1-Proteinase Inhibitor, GLASSIA (Alpha1-Proteinase Inhibitor (Human), Intravenous). COPD: Journal of Chronic Obstructive Pulmonary Disease 11:1, pages 17-25.
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Manish Mohanka, Danai Khemasuwan & James K Stoller. (2012) A review of augmentation therapy for alpha-1 antitrypsin deficiency. Expert Opinion on Biological Therapy 12:6, pages 685-700.
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F. Kueppers. (2011) The role of augmentation therapy in alpha-1 antitrypsin deficiency. Current Medical Research and Opinion 27:3, pages 579-588.
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Ariel Modrykamien & James K Stoller. (2009) Alpha-1 antitrypsin (AAT) deficiency - what are the treatment options?. Expert Opinion on Pharmacotherapy 10:16, pages 2653-2661.
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Gustavo A Heresi & James K Stoller. (2008) Augmentation therapy in α-1 antitrypsin deficiency. Expert Opinion on Biological Therapy 8:4, pages 515-526.
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Articles from other publishers (31)

Zhaoyang Li, Mitali Gaurav & Leman Yel. (2023) Evaluation of body weight–based dosing, alternative dosing regimens, and treatment interruptions for α1-proteinase inhibitors and implications on biochemical efficacy in patients with α1-antitrypsin deficiency. Pulmonary Pharmacology & Therapeutics 83, pages 102265.
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J.-F. Mornex, M. Balduyck, M. Bouchecareilh, A. Cuvelier, R. Epaud, M. Kerjouan, O. Le Rouzic, C. Pison, L. Plantier, M.-C. Pujazon, M. Reynaud-Gaubert, A. Toutain, B. Trumbic, M.-C. Willemin, M. Zysman, O. Brun, M. Campana, F. Chabot, V. Chamouard, M. Dechomet, J. Fauve, B. Girerd, C. Gnakamene, S. Lefrançois, J.-N. Lombard, B. Maitre, C. Maynié-François, A. Moerman, A. Payancé, P. Reix, D. Revel, M.-P. Revel, M. Schuers, P. Terrioux, D. Theron, F. Willersinn, V. Cottin & H. Mal. (2022) Atteinte pulmonaire du déficit en alpha-1 antitrypsine. Recommandations pratiques pour le diagnostic et la prise en charge. Revue des Maladies Respiratoires 39:7, pages 633-656.
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Zhaoyang Li, Ryan M. Franke, Denise N. Morris & Leman Yel. (2022) Pharmacokinetics and Biochemical Efficacy of an α1-Proteinase Inhibitor (Aralast NP) in α1-Antitrypsin Deficiency: a Cross-Product Retrospective Comparability Analysis. Pulmonary Therapy 8:3, pages 311-326.
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Matthew J. McNulty, David Z. Silberstein, Brooks T. Kuhn, Hal S. Padgett, Somen Nandi, Karen A. McDonald & Carroll E. Cross. (2021) Alpha-1 antitrypsin deficiency and recombinant protein sources with focus on plant sources: Updates, challenges and perspectives. Free Radical Biology and Medicine 163, pages 10-30.
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Igor Barjaktarevic & Michael Campos. (2021) Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know. Therapeutic Advances in Chronic Disease 12_suppl, pages 204062232110101.
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Paul Ellis, Asger Dirksen & Alice M. Turner. 2019. α 1 -Antitrypsin Deficiency . α 1 -Antitrypsin Deficiency 78 92 .
Bari, Ferrarotti, Di Silvestre, Grisoli, Barzon, Balderacchi, Torre, Rossi, Mauri, Corsico & Perteghella. (2019) Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration. Cells 8:9, pages 965.
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Pius Ochieng, Sridesh Nath, Reane Macarulay, Edward Eden, Abdoulaye Dabo, Michael Campos, Xian-Cheng Jiang, Robert F. Foronjy & Patrick Geraghty. (2018) Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation. Scientific Reports 8:1.
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Cristina Esquinas & Marc Miravitlles. (2018) ¿Existen diferencias entre los tratamientos disponibles para el enfisema pulmonar por déficit de alfa-1 antitripsina?. Archivos de Bronconeumología 54:9, pages 451-452.
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Cristina Esquinas & Marc Miravitlles. (2018) Are There Differences Between the Available Treatments for Emphysema Associated With Alpha-1 Antitrypsin Deficiency?. Archivos de Bronconeumología (English Edition) 54:9, pages 451-452.
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Article Editorial. (2018) Diagnosis and treatment of pulmonarydisease in α1-antitrypsin deficiency: a statement of European Respiratory Society. Russian Pulmonology 28:3, pages 273-295.
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John M. MagenauSteven C. GoldsteinDan PeltierRobert J. SoifferThomas BraunAttaphol PawarodeMary M. RiwesMaggi KennelJoseph H. AntinCorey S. CutlerVincent T. HoEdwin P. AlyeaIIIIIIBrian L. ParkinGregory A. YanikSung Won ChoiEli C. Lewis, Charles A. Dinarello, John KorethPavan Reddy. (2018) α1-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease. Blood 131:12, pages 1372-1379.
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Marc Miravitlles, Asger Dirksen, Ilaria Ferrarotti, Vladimir Koblizek, Peter Lange, Ravi Mahadeva, Noel G. McElvaney, David Parr, Eeva Piitulainen, Nicolas Roche, Jan Stolk, Gabriel Thabut, Alice Turner, Claus Vogelmeier & Robert A. Stockley. (2017) European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α 1 -antitrypsin deficiency . European Respiratory Journal 50:5, pages 1700610.
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Michael A. Tortorici, James A. Rogers, Oliver Vit, Martin Bexon, Robert A. Sandhaus, Jonathan Burdon, Joanna Chorostowska-Wynimko, Philip Thompson, James Stocks, Noel G. McElvaney, Kenneth R. Chapman & Jonathan M. Edelman. (2017) Quantitative disease progression model of α-1 proteinase inhibitor therapy on computed tomography lung density in patients with α-1 antitrypsin deficiency. British Journal of Clinical Pharmacology 83:11, pages 2386-2397.
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Scott Kee, David Weber, Birgit Popp, Thomas Nowak, Wolfram Schäfer, Albrecht Gröner & Nathan J. Roth. (2017) Pathogen safety and characterisation of a highly purified human alpha 1 -proteinase inhibitor preparation. Biologicals 47, pages 25-32.
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Ignacio Blanco. 2017. Blanco's Overview of Alpha-1 Antitrypsin Deficiency. Blanco's Overview of Alpha-1 Antitrypsin Deficiency 175 191 .
Kate McKeage & Katherine A. Lyseng-Williamson. (2016) Human α1-proteinase inhibitor (Respreeza®) in α1-antitrypsin deficiency emphysema: a guide to its use in the EU. Drugs & Therapy Perspectives 32:10, pages 422-427.
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Cormac McCarthy, Emer P. Reeves & Noel G. McElvaney. (2016) The Role of Neutrophils in Alpha-1 Antitrypsin Deficiency. Annals of the American Thoracic Society 13:Supplement_4, pages S297-S304.
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Ciara A. O’Dwyer, M. Emmet O’Brien, Mark R. Wormald, Michelle M. White, Nessa Banville, Killian Hurley, Cormac McCarthy, Noel G. McElvaney & Emer P. Reeves. (2015) The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling. The Journal of Immunology 195:8, pages 3628-3641.
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Susan Sorrells, Sandra Camprubi, Rhonda Griffin, Junliang Chen & Jaume Ayguasanosa. (2015) SPARTA clinical trial design: Exploring the efficacy and safety of two dose regimens of alpha1-proteinase inhibitor augmentation therapy in alpha1-antitrypsin deficiency. Respiratory Medicine 109:4, pages 490-499.
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Francisco Casas, Ignacio Blanco, María Teresa Martínez, Ana Bustamante, Marc Miravitlles, Sergio Cadenas, José M. Hernández, Lourdes Lázaro, Esther Rodríguez, Francisco Rodríguez-Frías, María Torres & Beatriz Lara. (2015) Actualización sobre indicaciones de búsqueda activa de casos y tratamiento con alfa-1 antitripsina por vía intravenosa en pacientes con enfermedad pulmonar obstructiva crónica asociada a déficit de alfa-1 antitripsina. Archivos de Bronconeumología 51:4, pages 185-192.
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Francisco Casas, Ignacio Blanco, María Teresa Martínez, Ana Bustamante, Marc Miravitlles, Sergio Cadenas, José M. Hernández, Lourdes Lázaro, Esther Rodríguez, Francisco Rodríguez-Frías, María Torres & Beatriz Lara. (2015) Indications for Active Case Searches and Intravenous Alpha-1 Antitrypsin Treatment for Patients With Alpha-1 Antitrypsin Deficiency Chronic Pulmonary Obstructive Disease: An Update. Archivos de Bronconeumología (English Edition) 51:4, pages 185-192.
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Adriano R. Tonelli & Mark L. Brantly. (2010) Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies. Therapeutic Advances in Respiratory Disease 4:5, pages 289-312.
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