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CLINICAL REVIEW

Combination of Formoterol and Tiotropium in the Treatment of COPD: Effects on Lung Function

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Pages 404-415 | Published online: 08 Oct 2009

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Corrado Pelaia, Anna Ferrante Bannera, Fioramante Lello Rotundo, Francesco Giuseppe Tropea, Giuseppe Armentaro, Angelantonio Maglio, Angela Sciacqua, Alessandro Vatrella & Girolamo Pelaia. (2023) Clinical and Functional Effects of Inhaled Dual Therapy Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease: A Real-Life Study. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 995-1002.
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Cristoforo Incorvaia, Bruna L. Gritti & Erminia Ridolo. (2020) Is there any further advance in bronchodilator combination therapy for COPD?. Current Medical Research and Opinion 36:1, pages 125-126.
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Fabiano Di Marco, Piero Balbo, Francesco de Blasio, Vittorio Cardaci, Nunzio Crimi, Giuseppe Girbino, Girolamo Pelaia, Pietro Pirina, Pietro Roversi, Pierachille Santus, Nicola Scichilone, Alessandro Vatrella, Patrizio Pasqualetti & Mauro Carone. (2019) Early management of COPD: where are we now and where do we go from here? A Delphi consensus project. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 353-360.
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Mario Malerba, Alessandro Radaeli, Paolo Montuschi, Kesavan S. Babu & Jaymin B Morjaria. (2017) Investigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Investigational Drugs 26:3, pages 319-329.
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Maria Gabriella Matera, Alessandro Sanduzzi & Mario Cazzola. (2016) Specific role of combination aclidinium: formoterol in the treatment of chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 73-79.
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Reynold A Panettieri Jr. (2015) Bronchodilators, receptors and cross-talk: Together is better?. Postgraduate Medicine 127:7, pages 771-780.
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Tony D’Urzo, James F Donohue, David Price, Marc Miravitlles & Edward Kerwin. (2015) Dual bronchodilator therapy with aclidinium bromide/formoterol fumarate for chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 9:5, pages 519-532.
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James F Davidson, James F Donohue & Jill A Ohar. (2015) Umeclidinium/vilanterol combination inhaler efficacy and potential impact on current chronic obstructive pulmonary disease management guidelines. Expert Opinion on Drug Safety 14:2, pages 317-324.
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Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2014) Muscarinic receptor antagonists for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 15:7, pages 961-977.
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Annette J Theron, Helen C Steel, Gregory R Tintinger, Charles Feldman & Ronald Anderson. (2013) Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?. Drug Design, Development and Therapy 7, pages 1387-1398.
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Mario Cazzola, Andrea Segreti & Maria Gabriella Matera. (2013) New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol. Drug Design, Development and Therapy 7, pages 1201-1208.
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Ronald Dahl, Dalal Jadayel, Vijay KT Alagappan, Hungta Chen & Donald Banerji. (2013) Efficacy and safety of QVA149 compared to the concurrent administration of its monocomponents indacaterol and glycopyrronium: the BEACON study. International Journal of Chronic Obstructive Pulmonary Disease 8, pages 501-508.
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Mario Cazzola, Paola Rogliani & Maria Gabriella Matera. (2013) Aclidinium bromide/formoterol fumarate fixed-dose combination for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 14:6, pages 775-781.
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Vandana Gupta & Dave Singh. (2012) Aclidinium bromide for the treatment of chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 6:6, pages 581-588.
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Jutta Beier, Jan van Noord, Amanda Deans, Jean Brooks, Claire Maden, Suus Baggen, Rashmi Mehta & Anthony Cahn. (2012) Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients. International Journal of Chronic Obstructive Pulmonary Disease 7, pages 153-164.
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Donald P Tashkin. (2010) Indacaterol maleate for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 11:12, pages 2077-2085.
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Donald P Tashkin. (2010) Preventing and managing exacerbations in COPD – critical appraisal of the role of tiotropium. International Journal of Chronic Obstructive Pulmonary Disease 5, pages 41-53.
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Nicholas J Gross & James F Donohue. (2010) Nebulized formoterol: a review of clinical efficacy and safety in COPD. International Journal of Chronic Obstructive Pulmonary Disease 5, pages 223-232.
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Mario Cazzola, Nicola A Hanania & Maria G Matera. (2010) Arformoterol tartrate in the treatment of COPD. Expert Review of Respiratory Medicine 4:2, pages 155-162.
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Corrado Pelaia, Giada Procopio, Fioramante Lello Rotundo, Maria Rosaria Deodato, Anna Ferrante Bannera, Francesco Giuseppe Tropea, Anna Cancelliere, Alessandro Vatrella & Girolamo Pelaia. (2023) Real-life therapeutic effects of beclomethasone dipropionate/formoterol fumarate/glycopyrronium combined triple therapy in patients with chronic obstructive pulmonary disease. Therapeutic Advances in Respiratory Disease 17, pages 175346662311557.
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Elena Menchi, Charaf El Khattabi, Stéphanie Pochet, Olivier Denis, Karim Amighi & Nathalie Wauthoz. (2022) Optimization of Long-Acting Bronchodilator Dose Ratios Using Isolated Guinea Pig Tracheal Rings for Synergistic Combination Therapy in Asthma and COPD. Pharmaceuticals 15:8, pages 963.
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Sahar Zayed, Fatma Fouad & Fathalla Belal. (2020) A simple and economic chromatographic method for simultaneous determination of six bronchodilator drugs in pharmaceutical dosage forms. Journal of the Iranian Chemical Society 18:6, pages 1251-1259.
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Ilaria Aredano, Francesca De Blasio, Paola Berchialla, Luisa Brussino, Caterina Bucca & Paolo Solidoro. (2020) <b>RETRACTED:</b> Determinants of self-reported adherence to inhaler therapy in patients with chronic obstructive pulmonary disease. Multidisciplinary Respiratory Medicine 15.
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Bartolome R. Celli. (2018) Pharmacological Therapy of COPD. Chest 154:6, pages 1404-1415.
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Anthony D'Urzo, Stephen Rennard, Edward Kerwin, James F. Donohue, Alejhandra Lei, Eduard Molins & Anne Leselbaum. (2017) A randomised double-blind, placebo-controlled, long-term extension study of the efficacy, safety and tolerability of fixed-dose combinations of aclidinium/formoterol or monotherapy in the treatment of chronic obstructive pulmonary disease. Respiratory Medicine 125, pages 39-48.
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Dave Singh, Marc Miravitlles & Claus Vogelmeier. (2016) Chronic Obstructive Pulmonary Disease Individualized Therapy: Tailored Approach to Symptom Management. Advances in Therapy 34:2, pages 281-299.
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Takashige Kuraki. 2017. Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease 211 243 .
Donald P. Tashkin, Fernando J. Martinez, Roberto Rodriguez-Roisin, Charles Fogarty, Mark Gotfried, Michael Denenberg, Gregory Gottschlich, James F. Donohue, Chad Orevillo, Patrick Darken, Earl St Rose, Shannon Strom, Tracy Fischer, Michael Golden & Colin Reisner. (2016) A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocomponents and open-label tiotropium dry powder inhaler in patients with moderate-to-severe COPD. Respiratory Medicine 120, pages 16-24.
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Alexander I. Sinopal’nikov, I. V. Leshenko & K. Kostikas. (2016) The possibilities and limits of modern bronchodilating therapy for COPD. Clinical Medicine (Russian Journal) 94:6, pages 418-427.
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Eva Rahman Kabir & Nabila Morshed. (2015) Different approaches in the treatment of obstructive pulmonary diseases. European Journal of Pharmacology 764, pages 306-317.
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Mario Cazzola, Luigino Calzetta, Clive P. Page, Paola Rogliani, Francesco Facciolo, Amadeu Gavaldà & Maria Gabriella Matera. (2014) Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi. European Journal of Pharmacology 745, pages 135-143.
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Philippa R Dale, Hana Cernecka, Martina Schmidt, Mark R Dowling, Steven J Charlton, Michael P Pieper & Martin C Michel. (2014) The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease. Current Opinion in Pharmacology 16, pages 31-42.
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Makoto Hoshino & Junichi Ohtawa. (2014) Computed tomography assessment of airway dimensions with combined tiotropium and indacaterol therapy in COPD patients. Respirology 19:3, pages 403-410.
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Sundeep Salvi, Bill Brashier, Dipti Gothi, Vinaya Karkhanis, Sapna Madas, Jaideep Gogtay & Jyotsna Joshi. (2014) Bronchodilator efficacy of tiotropium–formoterol via single pressurized meter dose inhaler (pMDI) versus tiotropium alone in COPD. Pulmonary Pharmacology & Therapeutics 27:1, pages 90-95.
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Gregory J. Feldman & Anton Edin. (2013) The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Therapeutic Advances in Respiratory Disease 7:6, pages 311-319.
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Mario Cazzola, Jose-Luis Lopez-Campos & Luis Puente-Maestu. (2013) The MABA approach: a new option to improve bronchodilator therapy. European Respiratory Journal 42:4, pages 885-887.
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Donald P Tashkin & Gary T Ferguson. (2013) Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respiratory Research 14:1, pages 49.
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Stephane Jouneau, Arnaud Boché, Graziella Brinchault, Kristina Fekete, Stephanie Guillot, Sahar Bayat & Benoit Desrues. (2011) On-site screening of farming-induced chronic obstructive pulmonary disease with the use of an electronic mini-spirometer: results of a pilot study in Brittany, France. International Archives of Occupational and Environmental Health 85:6, pages 623-630.
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Mario Cazzola, Clive P. Page, Luigino Calzetta & M. Gabriella Matera. (2012) Pharmacology and Therapeutics of Bronchodilators. Pharmacological Reviews 64:3, pages 450-504.
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Wen‐Hui Zhang, Yong Zhang, Yong‐Yao Cui, Wei‐Fang Rong, Carole Cambier, Philippe Devillier, Fabrice Bureau, Charles Advenier & Pascal Gustin. (2011) Can β 2 ‐adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD? . Fundamental & Clinical Pharmacology 26:1, pages 118-134.
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Michael Roth. (2011) Is There a Regulatory Role of Immunoglobulins on Tissue Forming Cells Relevant in Chronic Inflammatory Lung Diseases?. Journal of Allergy 2011, pages 1-9.
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Maria Gabriella Matera, Clive P. Page & Mario Cazzola. (2011) Novel bronchodilators for the treatment of chronic obstructive pulmonary disease. Trends in Pharmacological Sciences 32:8, pages 495-506.
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Mario Cazzola, Luigino Calzetta & Maria Gabriella Matera. (2011) β2-adrenoceptor agonists: current and future direction. British Journal of Pharmacology 163:1, pages 4-17.
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Mario Cazzola & Mathieu Molimard. (2010) The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD. Pulmonary Pharmacology & Therapeutics 23:4, pages 257-267.
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Donald P Tashkin. (2010) Long-acting anticholinergic use in chronic obstructive pulmonary disease: efficacy and safety. Current Opinion in Pulmonary Medicine 16:2, pages 97-105.
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