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Original Articles

A Spreadsheet-Based Method for Estimating the Skin Disposition of Volatile Compounds: Application to N,N-Diethyl-m-Toluamide (DEET)

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Pages 633-644 | Received 01 Jul 2010, Published online: 04 Aug 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Koko Lear & Laurent Simon. (2022) A method to assess dermal absorption dynamics of chemical warfare agents: Finite doses of volatile compounds. Journal of Occupational and Environmental Hygiene 19:10-11, pages 603-614.
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Matthew A. Miller & Gerald B. Kasting. (2009) Toward a Better Understanding of Pesticide Dermal Absorption: Diffusion Model Analysis of Parathion Absorption in Vitro and in Vivo . Journal of Toxicology and Environmental Health, Part A 73:4, pages 284-300.
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Articles from other publishers (38)

Kevin Tonnis, Joanna Jaworska & Gerald B. Kasting. (2024) Modeling the percutaneous absorption of solvent-deposited solids over a wide dose range: II. Weak electrolytes. Journal of Controlled Release 365, pages 435-447.
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Abdullah Hamadeh, JF. Nash, Heidi Bialk, Peter Styczynski, John Troutman & Andrea Edginton. (2023) Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application. Journal of Pharmaceutical Sciences.
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Christian Wennberg, Magnus Lundborg, Erik Lindahl & Lars Norlén. (2023) Understanding Drug Skin Permeation Enhancers Using Molecular Dynamics Simulations. Journal of Chemical Information and Modeling 63:15, pages 4900-4911.
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Abdullah Hamadeh & Andrea Edginton. (2023) Efficient large-scale mechanism-based computation of skin permeability. Computational Toxicology 26, pages 100263.
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Laurent Simon. (2022) Analysis of the absorption kinetics following dermal exposure to large doses of volatile organic compounds. Mathematical Biosciences 351, pages 108889.
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Matthew A. Miller & Gerald B. Kasting. (2022) Absorption of solvent-deposited weak electrolytes and their salts through human skin in vitro. International Journal of Pharmaceutics 620, pages 121753.
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Gerald B. Kasting, Matthew A. Miller, Lijing Xu, Fang Yu & Joanna Jaworska. (2022) In Vitro Human Skin Absorption of Solvent-deposited Solids: Niacinamide and Methyl Nicotinate. Journal of Pharmaceutical Sciences 111:3, pages 727-733.
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Sébastien Grégoire, Ian Sorrell, Daniela Lange, Abdulkarim Najjar, Andreas Schepky, Corie Ellison, John Troutman, Eric Fabian, Hélène Duplan, Camille Genies, Carine Jacques-Jamin, Martina Klaric & Nicola J. Hewitt. (2021) Cosmetics Europe evaluation of 6 in silico skin penetration models. Computational Toxicology 19, pages 100177.
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Abdullah Hamadeh, John Troutman & Andrea N. Edginton. (2021) Assessment of Vehicle Volatility and Deposition Layer Thickness in Skin Penetration Models. Pharmaceutics 13:6, pages 807.
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John Jenner, Christopher H. Dalton & Stuart J. Graham. (2021) A simple mathematical model of skin diffusion of nerve agent VX in vitro. Computational Toxicology 17, pages 100137.
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J.C. Kissel, A.L. Bunge, H.F. Frasch & G.B. Kasting. 2018. Comprehensive Toxicology. Comprehensive Toxicology 112 127 .
D.A. Basketter, I. Kimber & S.N.E. Kolle. 2018. Comprehensive Toxicology. Comprehensive Toxicology 582 598 .
Carsten Goebel, Kirstin Kosemund-Meynen, Emanuele Marco Gargano, Valerie Politano, Gábor von Bölcshazy, Kimberly Zupko, Neelam Jaiswal, Jin Zhang, Sheppard Martin, Daniel Neumann & Helga Rothe. (2017) Non-animal skin sensitization safety assessments for cosmetic ingredients – What is possible today?. Current Opinion in Toxicology 5, pages 46-54.
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Neha Goyal, Purva Thatai & Bharti Sapra. (2017) Surging footprints of mathematical modeling for prediction of transdermal permeability. Asian Journal of Pharmaceutical Sciences 12:4, pages 299-325.
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Lei Huang, Alexi Ernstoff, Peter Fantke, Susan A. Csiszar & Olivier Jolliet. (2017) A review of models for near-field exposure pathways of chemicals in consumer products. Science of The Total Environment 574, pages 1182-1208.
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Jason T. Chittenden & Jim E. Riviere. (2015) Quantification of vehicle mixture effects on in vitro transdermal chemical flux using a random process diffusion model. Journal of Controlled Release 217, pages 74-81.
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Tatsiana Dudzina, Elena Garcia Hidalgo, Natalie von Goetz, Christian Bogdal & Konrad Hungerbuehler. (2015) Evaporation of decamethylcyclopentasiloxane (D5) from selected cosmetic products: Implications for consumer exposure modeling. Environment International 84, pages 55-63.
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Matthew A. Miller & Gerald B. Kasting. (2015) A Spreadsheet-Based Method for Simultaneously Estimating the Disposition of Multiple Ingredients Applied to Skin. Journal of Pharmaceutical Sciences 104:6, pages 2047-2055.
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Rachna M. Gajjar & Gerald B. Kasting. (2014) Absorption of ethanol, acetone, benzene and 1,2-dichloroethane through human skin in vitro: a test of diffusion model predictions. Toxicology and Applied Pharmacology 281:1, pages 109-117.
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Bernard QuerleuxGerald Kasting & Johannes Nitsche. 2014. Computational Biophysics of the Skin. Computational Biophysics of the Skin 187 216 .
Jordan Wade Moran & Suzanne Bell. (2014) Skin Permeation of Organic Gunshot Residue: Implications for Sampling and Analysis. Analytical Chemistry 86:12, pages 6071-6079.
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Jason T. Chittenden, James D. Brooks & Jim E. Riviere. (2014) Development of a Mixed-Effect Pharmacokinetic Model for Vehicle Modulated In Vitro Transdermal Flux of Topically Applied Penetrants. Journal of Pharmaceutical Sciences 103:3, pages 1002-1012.
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. (2013) Evaporation of Volatile Organic Compounds from Human Skin <italic>In Vitro</italic>. The Annals of Occupational Hygiene.
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Kenneth T. Bogen. (2013) Dermal Uptake of 18 Dilute Aqueous Chemicals: In Vivo Disappearance-Method Measures Greatly Exceed In Vitro -Based Predictions . Risk Analysis 33:7, pages 1334-1352.
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Anthony P. Raphael, Stefano C. Meliga, Xianfeng Chen, Germain J.P. Fernando, Christopher Flaim & Mark A.F. Kendall. (2013) Depth-resolved characterization of diffusion properties within and across minimally-perturbed skin layers. Journal of Controlled Release 166:2, pages 87-94.
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Arne Naegel, Michael Heisig & Gabriel Wittum. (2013) Detailed modeling of skin penetration—An overview. Advanced Drug Delivery Reviews 65:2, pages 191-207.
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Yuri Dancik, Matthew A. Miller, Joanna Jaworska & Gerald B. Kasting. (2013) Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure. Advanced Drug Delivery Reviews 65:2, pages 221-236.
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D. Selzer, T. Hahn, A. Naegel, M. Heisig, K.H. Kostka, C.M. Lehr, D. Neumann, U.F. Schaefer & G. Wittum. (2013) Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models. Journal of Controlled Release 165:2, pages 119-128.
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Jennifer I. Karr, Tycho J. Speaker & Gerald B. Kasting. (2012) A novel encapsulation of N,N-diethyl-3-methylbenzamide (DEET) favorably modifies skin absorption while maintaining effective evaporation rates. Journal of Controlled Release 160:3, pages 502-508.
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Rania Ibrahim, Johannes M. Nitsche & Gerald B. Kasting. (2012) Dermal Clearance Model for Epidermal Bioavailability Calculations. Journal of Pharmaceutical Sciences 101:6, pages 2094-2108.
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Samir Mitragotri, Yuri G. Anissimov, Annette L. Bunge, H. Frederick Frasch, Richard H. Guy, Jonathan Hadgraft, Gerald B. Kasting, Majella E. Lane & Michael S. Roberts. (2011) Mathematical models of skin permeability: An overview. International Journal of Pharmaceutics 418:1, pages 115-129.
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Arne Naegel, Tsambika Hahn, Ulrich F. Schaefer, Claus-Michael Lehr, Michael Heisig & Gabriel Wittum. (2012) Finite dose skin penetration: a comparison of concentration-depth profiles from experiment and simulation. Computing and Visualization in Science 14:7, pages 327-339.
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Michael Davies, Ruth U. Pendlington, Leanne Page, Clive S. Roper, David J. Sanders, Clare Bourner, Camilla K. Pease & Cameron MacKay. (2011) Determining Epidermal Disposition Kinetics for Use in an Integrated Nonanimal Approach to Skin Sensitization Risk Assessment. Toxicological Sciences 119:2, pages 308-318.
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Rania Ibrahim & Gerald B. Kasting. (2010) Improved Method for Determining Partition and Diffusion Coefficients in Human Dermis. Journal of Pharmaceutical Sciences 99:12, pages 4928-4939.
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D.A. Basketter & I. Kimber. 2010. Comprehensive Toxicology. Comprehensive Toxicology 397 411 .
David A. Basketter & Ian Kimber. (2009) Updating the skin sensitization in vitro data assessment paradigm in 2009 . Journal of Applied Toxicology 29:6, pages 545-550.
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Siladitya Ray Chaudhuri, Rachna M. Gajjar, William B. Krantz & Gerald B. Kasting. (2009) Percutaneous absorption of volatile solvents following transient liquid exposures II. Ethanol. Chemical Engineering Science 64:8, pages 1665-1672.
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Siladitya Ray Chaudhuri, Gerald B. Kasting & William B. Krantz. (2009) Percutaneous absorption of volatile solvents following transient liquid exposures: I. Model development. Chemical Engineering Science 64:5, pages 1027-1035.
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