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Journal of Occupational and Environmental Hygiene Volume 8, 2011 - Issue 2
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Original Articles

Identification and Measurement of Diacetyl Substitutes in Dry Bakery Mix Production

Gregory Day Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
,
Ryan LeBouf Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
,
Ardith Grote Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio
,
Stephanie Pendergrass Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio
,
Kristin Cummings Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
,
Kathleen Kreiss Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
&
Greg Kullman Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
 show all
Pages 93-103 | Published online: 19 Jan 2011

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Andrew J. Ghio, Joleen M. Soukup, Lisa A. Dailey, Victor L. Roggli, Alvin L. Crumbliss & Scott M. Palmer. (2021) Diacetyl exposure disrupts iron homeostasis in animals and cells. Inhalation Toxicology 33:6-8, pages 268-274.
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Kristin J. Cummings, Doug O. Johns, Jacek M. Mazurek, Frank J. Hearl & David N. Weissman. (2019) NIOSH’s Respiratory Health Division: 50 years of science and service. Archives of Environmental & Occupational Health 74:1-2, pages 15-29.
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Pei-Ting Chang, Po-Chen Hung & Shih-Wei Tsai. (2018) Occupational exposures of flour dust and airborne chemicals at bakeries in Taiwan. Journal of Occupational and Environmental Hygiene 15:8, pages 580-587.
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Matthew G. Duling, Ryan F. LeBouf, Jean M. Cox-Ganser, Kathleen Kreiss, Stephen B. Martin$suffix/text()$suffix/text() & Rachel L. Bailey. (2016) Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers. Journal of Occupational and Environmental Hygiene 13:10, pages 770-781.
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Jennifer S. Pierce, Anders Abelmann, Lauren J. Spicer, Rebecca E. Adams & Brent L. Finley. (2014) Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers. Critical Reviews in Toxicology 44:5, pages 420-435.
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Eric J. Zaccone, Janet A. Thompson, Dovenia S. Ponnoth, Amy M. Cumpston, W. Travis Goldsmith, Mark C. Jackson, Michael L. Kashon, David G. Frazer, Ann F. Hubbs, Michael J. Shimko & Jeffrey S. Fedan. (2013) Popcorn Flavoring Effects on Reactivity of Rat Airways in Vivo and in Vitro. Journal of Toxicology and Environmental Health, Part A 76:11, pages 669-689.
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David S Egilman & John Henry Schilling. (2012) Bronchiolitis obliterans and consumer exposure to butter-flavored microwave popcorn: a case series. International Journal of Occupational and Environmental Health 18:1, pages 29-42.
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Randy Boylstein. (2012) Case Study. Journal of Occupational and Environmental Hygiene 9:2, pages D33-D34.
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Articles from other publishers (31)

M Westhoff, M Keßler & J I Baumbach. (2023) Alveolar gradients in breath analysis. A pilot study with comparison of room air and inhaled air by simultaneous measurements using ion mobility spectrometry. Journal of Breath Research 17:4, pages 046009.
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Suzanne E. Tomasi, Ethan D. Fechter-LeggettBarbara L. MaternaJonathan G. Meiman, Randall J. Nett & Kristin J. Cummings. (2023) Impact of Epidemic Intelligence Service Training in Occupational Respiratory Epidemiology. ATS Scholar.
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Stacey E. Anderson, Courtney E. W. Sulentic & Barbara L. F. Kaplan. 2003. Patty's Toxicology. Patty's Toxicology 1 55 .
Ryan F. LeBouf, Anand Ranpara, Elizabeth Fernandez, Dru A. Burns & Alyson R. Fortner. (2022) Model Predictions of Occupational Exposures to Diacetyl and 2,3-Pentanedione Emitted From Roasted Whole Bean and Ground Coffee: Influence of Roast Level and Physical Form on Specific Emission Rates. Frontiers in Public Health 10.
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Konstantinos Farsalinos. 2021. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 617 643 .
Ryan F. LeBouf, Brie Hawley Blackley, Alyson R. Fortner, Marcia Stanton, Stephen B. Martin, Caroline P. Groth, Tia L. McClelland, Matthew G. Duling, Dru A. Burns, Anand Ranpara, Nicole Edwards, Kathleen B. Fedan, Rachel L. Bailey, Kristin J. Cummings, Randall J. Nett, Jean M. Cox-Ganser & M. Abbas Virji. (2020) Exposures and Emissions in Coffee Roasting Facilities and Cafés: Diacetyl, 2,3-Pentanedione, and Other Volatile Organic Compounds. Frontiers in Public Health 8.
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Ann F. Hubbs, Kathleen Kreiss, Kristin J. Cummings, Kara L. Fluharty, Ryan O’ConnellAllison Cole, Tiana M. Dodd, Sidney M. ClingermanJordan R. FlesherRebecca LeeSamantha PagelLori A. Battelli, Amy Cumpston, Mark Jackson, Michael Kashon, Marlene S. Orandle, Jeffrey S. Fedan & Krishnan Sriram. (2019) Flavorings-Related Lung Disease: A Brief Review and New Mechanistic Data. Toxicologic Pathology 47:8, pages 1012-1026.
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Evan M. Beckett, William D. Cyrs, Anders Abelmann, Andrew D. Monnot, Shannon H. Gaffney & Brent L. Finley. (2019) Derivation of an occupational exposure limit for diacetyl using dose‐response data from a chronic animal inhalation exposure study. Journal of Applied Toxicology 39:5, pages 688-701.
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Ian Pengelly, Hannah O’Shea, Gordon Smith & Marie A Coggins. (2019) Measurement of Diacetyl and 2,3-Pentanedione in the Coffee Industry Using Thermal Desorption Tubes and Gas Chromatography–Mass Spectrometry. Annals of Work Exposures and Health 63:4, pages 415-425.
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Ryan F LeBouf, Brie Hawley & Kristin J Cummings. (2019) Potential Hazards Not Communicated in Safety Data Sheets of Flavoring Formulations, Including Diacetyl and 2,3-Pentanedione. Annals of Work Exposures and Health 63:1, pages 124-130.
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Gurjot Kaur, Thivanka Muthumalage & Irfan Rahman. (2018) Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products. Toxicology Letters 288, pages 143-155.
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Silpa D. Krefft, Carlyne D. Cool & Cecile S. Rose. (2018) The emerging spectrum of exposure-related bronchiolitis. Current Opinion in Allergy & Clinical Immunology 18:2, pages 87-95.
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S.E. Anderson & B.J. Meade. 2018. Comprehensive Toxicology. Comprehensive Toxicology 542 558 .
M.W. Anders. (2017) Diacetyl and related flavorant α-Diketones: Biotransformation, cellular interactions, and respiratory-tract toxicity. Toxicology 388, pages 21-29.
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Kathleen Kreiss. (2017) Recognizing occupational effects of diacetyl: What can we learn from this history?. Toxicology 388, pages 48-54.
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Paul Cullinan, Xavier Muñoz, Hille Suojalehto, Raymond Agius, Surinder Jindal, Torben Sigsgaard, Anders Blomberg, Denis Charpin, Isabella Annesi-Maesano, Mridu Gulati, Yangho Kim, Arthur L Frank, Metin Akgün, David Fishwick, Rafael E de la Hoz & Subhabrata Moitra. (2017) Occupational lung diseases: from old and novel exposures to effective preventive strategies. The Lancet Respiratory Medicine 5:5, pages 445-455.
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Andrea Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 135 160 .
K.E. Farsalinos. 2017. Analytical Assessment of E-Cigarettes. Analytical Assessment of E-Cigarettes 75 122 .
Daniel L. Morgan, Micheal P. Jokinen, Crystal L. Johnson, Herman C. Price, William M. Gwinn, Ronald W. Bousquet & Gordon P. Flake. (2016) Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents. Toxicologic Pathology 44:5, pages 763-783.
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Van K. Holden & Stella E. Hines. (2016) Update on flavoring-induced lung disease. Current Opinion in Pulmonary Medicine 22:2, pages 158-164.
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Eric J. Zaccone, W. Travis Goldsmith, Michael J. Shimko, J.R. Wells, Diane Schwegler-Berry, Patsy A. Willard, Shannon L. Case, Janet A. Thompson & Jeffrey S. Fedan. (2015) Diacetyl and 2,3-pentanedione exposure of human cultured airway epithelial cells: Ion transport effects and metabolism of butter flavoring agents. Toxicology and Applied Pharmacology 289:3, pages 542-549.
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Rachel L. Bailey, Jean M. Cox-Ganser, Matthew G. Duling, Ryan F. LeBouf, Stephen B. MartinJr.Jr., Toni A. Bledsoe, Brett J. Green & Kathleen Kreiss. (2015) Respiratory morbidity in a coffee processing workplace with sentinel obliterative bronchiolitis cases. American Journal of Industrial Medicine 58:12, pages 1235-1245.
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Brian D Curwin, Jim A Deddens & Lauralynn T McKernan. (2014) Flavoring exposure in food manufacturing. Journal of Exposure Science & Environmental Epidemiology 25:3, pages 324-333.
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Konstantinos E. Farsalinos, Kurt A. Kistler, Gene Gillman & Vassilis Voudris. (2015) Evaluation of Electronic Cigarette Liquids and Aerosol for the Presence of Selected Inhalation Toxins. Nicotine & Tobacco Research 17:2, pages 168-174.
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Kristin J Cummings, Randy J Boylstein, Marcia L Stanton, Chris A Piacitelli, Nicole T Edwards, Ryan F LeBouf & Kathleen Kreiss. (2014) Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility. Occupational and Environmental Medicine 71:8, pages 549-554.
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Stacey E. Anderson, Jennifer Franko, J.R. Wells, Ewa Lukomska & B. Jean Meade. (2013) Evaluation of the hypersensitivity potential of alternative butter flavorings. Food and Chemical Toxicology 62, pages 373-381.
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Kathleen Kreiss. (2013) Occupational causes of constrictive bronchiolitis. Current Opinion in Allergy & Clinical Immunology 13:2, pages 167-172.
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Ann F. Hubbs, Amy M. Cumpston, W. Travis Goldsmith, Lori A. Battelli, Michael L. Kashon, Mark C. Jackson, David G. Frazer, Jeffrey S. Fedan, Madhusudan P. Goravanahally, Vincent Castranova, Kathleen Kreiss, Patsy A. Willard, Sherri Friend, Diane Schwegler-Berry, Kara L. Fluharty & Krishnan Sriram. (2012) Respiratory and Olfactory Cytotoxicity of Inhaled 2,3-Pentanedione in Sprague-Dawley Rats. The American Journal of Pathology 181:3, pages 829-844.
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Kathleen Kreiss, Kathleen B. Fedan, Muazzam Nasrullah, Thomas J. Kim, Barbara L. Materna, Janice C. Prudhomme & Paul L. Enright. (2011) Longitudinal lung function declines among California flavoring manufacturing workers. American Journal of Industrial Medicine 55:8, pages 657-668.
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Kathleen Kreiss. (2012) Respiratory Disease Among Flavoring-exposed Workers in Food and Flavoring Manufacture. Clinical Pulmonary Medicine 19:4, pages 165-173.
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Daniel L. Morgan, Micheal P. Jokinen, Herman C. Price, William M. Gwinn, Scott M. Palmer & Gordon P. Flake. (2012) Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans. Toxicologic Pathology 40:3, pages 448-465.
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