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The emerging role and clinical implication of human exonic circular RNA

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Pages 1000-1006 | Received 28 Jun 2016, Accepted 19 Aug 2016, Published online: 01 Nov 2016

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Jiani Liu, Xinyu Peng, Yinfeng Liu, Ran Hao, Rumeng Zhao, Lei Zhang, Fuqing Zhao, Qi Liu, Yunjiang Liu & Yixin Qi. (2021) The Diagnostic Value of Serum Exosomal Has_circ_0000615 for Breast Cancer Patients. International Journal of General Medicine 14, pages 4545-4554.
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Wei Zeng, Mengmeng Guo, Lin Yao & Zhang Deng. (2021) Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis. Bioengineered 12:1, pages 4111-4122.
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Ming Liu, Qian Wang, Jian Shen, Burton B. Yang & Xiangming Ding. (2019) Circbank: a comprehensive database for circRNA with standard nomenclature. RNA Biology 16:7, pages 899-905.
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Articles from other publishers (71)

Zichun Wei, Jixian Liu, Gang Hui & Xinyu Luan. (2023) Circ_0020123 promotes non‐small cell lung cancer progression via miR ‐146a‐5p mediated regulation of EIF4G2 expression . Thoracic Cancer.
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Dan Song, Ziqi Ye, Fangyu Chen, Liangliang Zhan & Xinchen Sun. (2023) circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p. BMC Cancer 23:1.
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Chengyao Jiang, Jianjun Zhang, Wentao Wang, Zexing Shan, Fan Sun, Yuen Tan, Yilin Tong & Yue Qiu. (2023) Extracellular vesicles in gastric cancer: role of exosomal lncRNA and microRNA as diagnostic and therapeutic targets. Frontiers in Physiology 14.
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Mohamed Maarouf, Lulu Wang, Yiming Wang, Kul Raj Rai, Yuhai Chen, Min Fang & Ji-Long Chen. (2023) Functional Involvement of circRNAs in the Innate Immune Responses to Viral Infection. Viruses 15:8, pages 1697.
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Yu Deng, Liu Xu & Yuqiang Li. (2023) Knockdown of circEXOC6 inhibits cell progression and glycolysis by sponging miR-433-3p and mediating FZD6 in glioma. Translational Neuroscience 14:1.
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Sulieman Ibraheem Shelash Al-Hawary, Waqas Asghar, Aaima Amin, Yasser Fakri Mustafa, Ahmed Hjazi, Abbas F. Almulla, Sana Abdul-Jabbar Ali, Sally Saad Ali, Rosario Mireya Romero-Parra, Adeeb Abdulally Abdulhussien alazbjee, Reza Mahmoudi & Seyed Reza Hosseini Fard. (2023) Circ_0067934 as a novel therapeutic target in cancer: From mechanistic to clinical perspectives. Pathology - Research and Practice 245, pages 154469.
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Jianxia Wei, Mengna Li, Changning Xue, Shipeng Chen, Lemei Zheng, Hongyu Deng, Faqing Tang, Guiyuan Li, Wei Xiong, Zhaoyang Zeng & Ming Zhou. (2023) Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression. Journal of Experimental & Clinical Cancer Research 42:1.
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Mingming Jin, Yan Wang, Dawei Zhou, Wanchao Liu, Ruodong Han & Yongbin Chi. (2023) Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p–HMGB1 axis. Respiratory Research 24:1.
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Dan Liu, Haitao Xiao, Jinxing Liu, Yixin Zhang, Jialiang Li, Tingyu Zhang & Honglin Chen. (2023) Circ_0000566 contributes oxygen–glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis. Metabolic Brain Disease 38:4, pages 1273-1284.
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Konii Takenaka, Ellen M. Olzomer, Kyle L. Hoehn, Ashton Curry-Hyde, Bei Jun Chen, Rhonda Farrell, Frances L. Byrne & Michael Janitz. (2023) Investigation of circular RNA transcriptome in obesity-related endometrial cancer. Gene 855, pages 147125.
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NaiHeng Hei, Peng Liu, Linyu Jin, Shixiong Peng & Yang Bao. (2023) Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression. Functional & Integrative Genomics 23:1.
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Quanjin Zhang, Feng Ding, Congcong Zhang, Xu Han & Hui Cheng. (2023) Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5. Biochemical Genetics.
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Verma Nishita-Hiresha, Raghavan Varsha, Ravichandran Jayasuriya & Kunka Mohanram Ramkumar. (2023) The role of circRNA-miRNA-mRNA interaction network in endothelial dysfunction. Gene 851, pages 146950.
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Jingbin Xu, Lanyi Huang, Tuya Bao, Kaiqian Duan, Yu Cheng, Haimin Zhang, Yong Zhang, Jing Li, Qiujuan Li & Fasheng Li. (2023) CircCDR1as mediates PM2.5-induced lung cancer progression by binding to SRSF1. Ecotoxicology and Environmental Safety 249, pages 114367.
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Shilin Xu, Wen Luo, Mengxin Li, Quanchao Li, Wanxin Hong, Yun Gao, Jin Yang, Hongchang Song, li Chen, Yuanxia Yang & Chao Yang. (2023) Circ_0001667 Promotes Adriamycin Resistance and Malignant Progression via Targeting the miR-193a-5p/Rap2A Molecular Axis in Breast Cancer. Clinical Breast Cancer 23:1, pages 71-83.
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Tao Cheng, Feifei Huang, Yin Zhang & Zhen Zhou. (2022) Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR ‐145‐5p/lysine demethylase 2A ( KDM2A ) axis in oral squamous cell carcinoma . Head & Neck 45:1, pages 225-236.
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Long Pei, Xianqiang Lv, Gaopei Jia, Xiangdong Liang, Xiaosen Song & Aili Zhang. (2022) CircSCNN1A is a tumor suppressor in renal cell carcinoma via inducing the upregulation of MPP7 by the sponge effect on miR-421. Transplant Immunology 75, pages 101736.
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Xiao Han, Ruxian Tian, Cai Wang, Yumei Li & Xicheng Song. (2022) CircRNAs: Roles in regulating head and neck squamous cell carcinoma. Frontiers in Oncology 12.
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Xinyi Zhou & Juan Du. (2022) CircRNAs: novel therapeutic targets in multiple myeloma. Molecular Biology Reports 49:11, pages 10667-10676.
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Shan Gao, Tianjun Zhao, Fangchi Meng, Yinzhou Luo, Yan Li & Yong Wang. (2022) Circular RNAs in endometrial carcinoma (Review). Oncology Reports 48:6.
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Min Zhu, Yaping Dai, Xinyu Tong, Yaxin Zhang, Yang Zhou, Jiali Cheng, Yiting Jiang, Ruolin Yang, Xiangyu Wang, Guangli Cao, Renyu Xue, Xiaolong Hu & Chengliang Gong. (2022) Circ-Udg Derived from Cyprinid Herpesvirus 2 Promotes Viral Replication. Microbiology Spectrum 10:4.
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Yuanyuan Sun, Wenhui Wu, Qinhua Zhao, Rong Jiang, Jinling Li, Lan Wang, Shijin Xia, Mingjie Liu, Sugang Gong, Jinming Liu & Ping Yuan. (2022) CircGSAP regulates the cell cycle of pulmonary microvascular endothelial cells via the miR-942-5p sponge in pulmonary hypertension. Frontiers in Cell and Developmental Biology 10.
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Martina Dori, Jimmy Caroli & Mattia Forcato. (2022) Circr, a Computational Tool to Identify miRNA:circRNA Associations. Frontiers in Bioinformatics 2.
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Sepideh Mirzaei, Mohammad Hossein Gholami, Kiavash Hushmandi, Farid Hashemi, Amirhossein Zabolian, Israel Canadas, Ali Zarrabi, Noushin Nabavi, Amir Reza Aref, Francesco Crea, Yuzhuo Wang, Milad Ashrafizadeh & Alan Prem Kumar. (2022) The long and short non-coding RNAs modulating EZH2 signaling in cancer. Journal of Hematology & Oncology 15:1.
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Hengqian He, Juntao Zhang, Weikun Gong, Mengyun Liu, Hao Liu, Xiaoyong Li, Yufei Wu & Qinkang Lu. (2022) Involvement of CircRNA Expression Profile in Diabetic Retinopathy and Its Potential Diagnostic Value. Frontiers in Genetics 13.
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Qiyang Shen, Xingyu Liu, Wei Li, Xu Zhao, Tao Li, Kai Zhou & Jianfeng Zhou. (2022) Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors. Frontiers in Genetics 12.
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Junhong Chen, Jie Gu, Mengtian Tang, Zhiqiang Liao, Rui Tang, Lianqing Zhou, Min Su, Jiarui Jiang, Yingbin Hu, Yongyi Chen, Yujuan Zhou, Qianjin Liao, Wei Xiong, Jumei Zhou, Yanyan Tang & Shaolin Nie. (2021) Regulation of cancer progression by circRNA and functional proteins. Journal of Cellular Physiology 237:1, pages 373-388.
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Liang Luo, Lei-Lei Zhang, Wen Tao, Tao-Lin Xia & Liao-Yuan Li. (2021) Prediction of potential prognostic biomarkers in metastatic prostate cancer based on a circular RNA-mediated competing endogenous RNA regulatory network. PLOS ONE 16:12, pages e0260983.
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Junshuang Zhao, Yang Jiang, Haiying Zhang, Jinpeng Zhou, Lian Chen, Hao Li, Jinkun Xu, Guoqing Zhang & Zhitao Jing. (2021) The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway. Journal of Experimental & Clinical Cancer Research 40:1.
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Zhenchuan Liu, Tingting Wang, Yunlang She, Kaiqing Wu, Shaorui Gu, Lei Li, Chenglai Dong, Chang Chen & Yongxin Zhou. (2021) N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Molecular Cancer 20:1.
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Kuangzheng Li, Xiaosheng Fan, Ziyi Yan, Jia Zhan, Fangyun Cao & Yixia Jiang. (2021) Circ_0000745 strengthens the expression of CCND1 by functioning as miR-488 sponge and interacting with HuR binding protein to facilitate the development of oral squamous cell carcinoma. Cancer Cell International 21:1.
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Dongxue Li, Zhe Zhang, Chengyu Xia, Chaoshi Niu & Wenchao Zhou. (2021) Non-Coding RNAs in Glioma Microenvironment and Angiogenesis. Frontiers in Molecular Neuroscience 14.
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Yanfei Liang, Kaiyi Meng & Rui Qiu. (2021) Circular RNA Circ_0013958 Functions as a Tumor Promoter in Ovarian Cancer by Regulating miR-637/PLXNB2 Axis. Frontiers in Genetics 12.
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Yang Jiang, Zhenlin Wang, Chenting Ying, Jiangfeng Hu, Tao Zeng & Liang Gao. (2021) FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs. Oncogene 40:24, pages 4094-4110.
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Wenhui Zou, Yalei Cao, Kai Cheng, Changyu Li, Fu Zhu, Shumao Yang, Maolin Jin & Shaojun Song. (2021) Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis. Open Life Sciences 16:1, pages 442-454.
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Liqiang Zhi, Jingqi Liang, Wei Huang, Jianbing Ma, Zhong Qing & Xi Wang. (2021) Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis. Experimental and Molecular Pathology 119, pages 104617.
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Lu Han, Dandan Li, Yanwen Hang, Xiaojuan Zong, Jiashun Lv, Xiaolu Bai, Yi Lu, Peng Zhang, Meiling Zhou, Zhaodi Wu & Wei Hu. (2021) Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis. Frontiers in Genetics 12.
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Ning Shi, Shu Zhang, Yidi Guo, Xiuhua Yu, Weizheng Zhao, Maolin Zhang, Zhenhong Guan & Ming Duan. (2021) CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1. Veterinary Microbiology 254, pages 108995.
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Qingqing Miao, Bing Ni & Jun Tang. (2021) Coding potential of circRNAs: new discoveries and challenges. PeerJ 9, pages e10718.
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Xuejun Wang, Zijie Cheng, Jia Xu, Mengwen Feng, Hao Zhang, Li Zhang & Lingmei Qian. (2021) Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p. Life Sciences 265, pages 118788.
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Yang Jiang, Jinpeng Zhou, Junshuang Zhao, Haiying Zhang, Long Li, Hao Li, Lian Chen, Jiangfeng Hu, Wei Zheng & Zhitao Jing. (2020) The U2AF2 /circRNA ARF1/miR-342–3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells. Journal of Experimental & Clinical Cancer Research 39:1.
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Qingyuan Li, Wei Wang, Min Zhang, Wenguo Sun, Wei Shi & Feng Li. (2020) Circular RNA circ-0016068 Promotes the Growth, Migration, and Invasion of Prostate Cancer Cells by Regulating the miR-330-3p/BMI-1 Axis as a Competing Endogenous RNA. Frontiers in Cell and Developmental Biology 8.
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Dwayne Tucker, Wei Zheng, Da-Hong Zhang & Xuesen Dong. (2020) Circular RNA and its potential as prostate cancer biomarkers. World Journal of Clinical Oncology 11:8, pages 563-572.
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Qian Liu, Qi Zhou & Peng Zhong. (2020) circ_0067934 increases bladder cancer cell proliferation, migration and invasion through suppressing miR‑1304 expression and increasing Myc expression levels. Experimental and Therapeutic Medicine.
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