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RNA Biology Volume 18, 2021 - Issue 2: La-related proteins
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Research Paper

The isolated La-module of LARP1 mediates 3’ poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1

Sandy Mattijssena Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United StatesORCID Iconhttps://orcid.org/0000-0002-4285-7438View further author information
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Guennadi Kozlovb Department of Biochemistry & Centre for Structural Biology, McGill University, Montreal, CanadaORCID Iconhttps://orcid.org/0000-0002-7742-6558View further author information
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Sergei Gaidamakova Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United StatesView further author information
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Amitabh Ranjana Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United StatesView further author information
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Bruno D. Fonsecac PrimerGen Ltd, Viseu, PortugalView further author information
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Kalle Gehringb Department of Biochemistry & Centre for Structural Biology, McGill University, Montreal, CanadaORCID Iconhttps://orcid.org/0000-0001-6500-1184View further author information
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Richard J. Maraiaa Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States;d Commissioned Corps, U.S. Public Health Service, Rockville, MD, USACorrespondence[email protected]
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Pages 275-289 | Received 10 Apr 2020, Accepted 01 Dec 2020, Published online: 23 Dec 2020

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Sandy Mattijssen, Guennadi Kozlov, Bruno D. Fonseca, Kalle Gehring & Richard J. Maraia. (2021) LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization. RNA Biology 18:2, pages 259-274.
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Articles from other publishers (13)

Tobias Hochstoeger & Jeffrey A. Chao. (2024) Towards a molecular understanding of the 5′TOP motif in regulating translation of ribosomal mRNAs. Seminars in Cell & Developmental Biology 154, pages 99-104.
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Farnaz Mansouri-Noori, Andreas Pircher, Danielle Bilodeau, Lidia Siniavskaia, Jörg Grigull, Olivia S. Rissland & Mark A. Bayfield. (2023) The LARP1 homolog Slr1p controls the stability and expression of proto-5′TOP mRNAs in fission yeast. Cell Reports 42:10, pages 113226.
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Marine Baptissart, Brian N. Papas, Ru-pin Alicia Chi, Yin Li, Dongwon Lee, Bhairavy Puviindran & Marcos Morgan. (2023) A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation. iScience 26:9, pages 107511.
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D. Joe Millward. (2023) Post-natal muscle growth and protein turnover: a narrative review of current understanding. Nutrition Research Reviews, pages 1-28.
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Weijie Yao, Yanrong Yao, Wen He, Chengsi Zhao, Di Liu, Genwang Wang & Zuozheng Wang. (2023) PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression. Immunity, Inflammation and Disease 11:7.
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Martin Turner. (2023) Regulation and function of poised mRNAs in lymphocytes. BioEssays 45:5.
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Zhongqi Cui, Jiangtu He, Jiabei Zhu, Wenxuan Ni, Li Liu, Zhixuan Bian, Siwei Mao, Song Gu, Yuhua Shan, Zhexuan Chu, Qi Wu, Jiayi Lu, Ya Liu, Fenyong Sun, Qiuhui Pan, Yue Zhang, Nan Huang & Ji Ma. (2023) O ‐GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β‐catenin signalling . Clinical and Translational Medicine 13:4.
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Joha Park, Myeonghwan Kim, Hyerim Yi, Kyungmin Baeg, Yongkuk Choi, Young-suk Lee, Jaechul Lim & V. Narry Kim. (2023) Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex. Nature Structural & Molecular Biology 30:3, pages 330-338.
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Ya Qi, Min Wang & Qi Jiang. (2022) PABPC1——mRNA stability, protein translation and tumorigenesis. Frontiers in Oncology 12.
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Koichi Ogami, Yuka Oishi, Kentaro Sakamoto, Mayu Okumura, Ryota Yamagishi, Takumi Inoue, Masaya Hibino, Takuto Nogimori, Natsumi Yamaguchi, Kazuya Furutachi, Nao Hosoda, Hiroto Inagaki & Shin-ichi Hoshino. (2022) mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading. Cell Reports 41:4, pages 111548.
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Guennadi Kozlov, Sandy Mattijssen, Jianning Jiang, Samuel Nyandwi, Tara Sprules, James R Iben, Steven L Coon, Sergei Gaidamakov, Anne M Noronha, Christopher J Wilds, Richard J Maraia & Kalle Gehring. (2022) Structural basis of 3′-end poly(A) RNA recognition by LARP1. Nucleic Acids Research 50:16, pages 9534-9547.
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Jinbu Jia, Wenqin Lu, Bo Liu, Huihui Fang, Yiming Yu, Weipeng Mo, Hong Zhang, Xianhao Jin, Yi Shu, Yanping Long, Yanxi Pei & Jixian Zhai. (2022) An atlas of plant full-length RNA reveals tissue-specific and monocots–dicots conserved regulation of poly(A) tail length. Nature Plants 8:9, pages 1118-1126.
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Azman Embarc-Buh, Rosario Francisco-Velilla & Encarnacion Martinez-Salas. (2021) RNA-Binding Proteins at the Host-Pathogen Interface Targeting Viral Regulatory Elements. Viruses 13:6, pages 952.
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