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Journal of Immunotoxicology Volume 4, 2007 - Issue 2
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Research Article

Immuno- and Hepato-Toxicity of Dichloroacetic Acid in MRL+/+ and B6C3F1 Mice

Ping Cai Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
,
Paul J. Boor Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
,
M. Firoze Khan Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
,
Bhupendra S. Kaphalia Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
,
G. A. S. Ansari Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
&
Rolf König Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA
Pages 107-115 | Received 02 Oct 2006, Accepted 09 Dec 2006, Published online: 09 Oct 2008

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Matthew J. Smith, Dori R. Germolec, Robert W. Luebke, Christopher M. Sheth, Wimolnut Auttachoat, Tai L. Guo & Kimber L. White$suffix/text()$suffix/text(). (2010) Immunotoxicity of dibromoacetic acid administered via drinking water to female B6C3F1 mice. Journal of Immunotoxicology 7:4, pages 333-343.
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Yue Wang, Wenbo Jiang, Qiuying Dong, Yue Zhao, Yingying Chen, Changhao Sun & Guoli Sun. (2020) Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood. Brain and Behavior 10:10.
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Yao Pan, Xiaohong Hou, Qinghe Meng, Xiaohua Yang, Lanqin Shang, Xuetao Wei & Weidong Hao. (2019) The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro. Toxicology and Applied Pharmacology 380, pages 114705.
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Hui Wang, Gangduo Wang, G. A. Shakeel Ansari & M. Firoze Khan. (2018) Trichloroethene metabolite dichloroacetyl chloride induces apoptosis and compromises phagocytosis in Kupffer Cells: Activation of inflammasome and MAPKs. PLOS ONE 13:12, pages e0210200.
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Theodoros Eleftheriadis, Georgios Pissas, Athanasios Mavropoulos, Vassilios Liakopoulos & Ioannis Stefanidis. (2017) Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity. Biomedical Reports 7:5, pages 439-444.
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Jaromir Michałowicz, Wojciech Wróblewski, Katarzyna Mokra, Aneta Maćczak & Marta Kwiatkowska. (2015) Comparative study of the effect of chloro-, dichloro-, bromo-, and dibromoacetic acid on necrotic, apoptotic and morphological changes in human peripheral blood mononuclear cells (in vitro study). Toxicology in Vitro 29:7, pages 1416-1424.
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Yao Pan, Xuetao Wei & Weidong Hao. (2015) Trichloroethylene and Its Oxidative Metabolites Enhance the Activated State and Th1 Cytokine Gene Expression in Jurkat Cells. International Journal of Environmental Research and Public Health 12:9, pages 10575-10586.
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Ashutosh Pandey, Divya Vimal, Swati Chandra, Sanjay Saini, Gopeshwar Narayan & Debapratim Kar Chowdhuri. (2014) Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster. AGE 36:3.
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Mithilesh Kumar JhaKyoungho Suk. (2013) Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas. Brain Tumor Research and Treatment 1:2, pages 57.
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Ilia Brondz & Anton Brondz. (2011) Suppression of immunity by some pesticides, xenobiotics, and industrial chemicals. <i>In vitro</i> model. Journal of Biophysical Chemistry 02:03, pages 226-232.
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Stephen J. Ralph, Sara Rodríguez-Enríquez, Jiri Neuzil & Rafael Moreno-Sánchez. (2010) Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. Molecular Aspects of Medicine 31:1, pages 29-59.
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Rolf König, Ping Cai, Xin Guo & G. A. S. Ansari. (2008) Transcriptomic Analysis Reveals Early Signs of Liver Toxicity in Female MRL +/+ Mice Exposed to the Acylating Chemicals Dichloroacetyl Chloride and Dichloroacetic Anhydride. Chemical Research in Toxicology 21:3, pages 572-582.
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