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Journal of Immunotoxicology Volume 4, 2007 - Issue 4
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Research Article

Changes In Gene Expression Induced by Tienilic Acid and Sulfamethoxazole: Testing the Danger Hypothesis

Stephanie R. Pacitto Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Ontario, Canada
,
Jack P. Uetrecht Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Ontario, Canada
,
Paul C. Boutros Faculty of Medicine, University of Toronto, Ontario, Canada
&
Marija Popovic Department of Investigative Toxicology, Novartis, AG, Switzerland
Pages 253-266 | Received 07 May 2007, Accepted 27 Jun 2007, Published online: 09 Oct 2008

Citations (15)

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Read on this site (4)

Winnie Ng, Imir G. Metushi & Jack Uetrecht. (2015) Hepatic effects of aminoglutethimide: A model aromatic amine. Journal of Immunotoxicology 12:1, pages 24-32.
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Winnie Ng & Jack Uetrecht. (2013) Changes in gene expression induced by aromatic amine drugs: Testing the danger hypothesis. Journal of Immunotoxicology 10:2, pages 178-191.
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Yurong Lai. (2009) Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1175-1187.
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Michael J Rieder. (2009) Immune mediation of hypersensitivity adverse drug reactions: implications for therapy. Expert Opinion on Drug Safety 8:3, pages 331-343.
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Articles from other publishers (11)

Wei-Sheng Wu & Meng-Jhun Jhou. (2017) MVIAeval: a web tool for comprehensively evaluating the performance of a new missing value imputation algorithm. BMC Bioinformatics 18:1.
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Monday O. OgeseShaheda AhmedAna AlferivicCatherine J. BettsAnne DickinsonLee FaulknerNeil French, Andrew GibsonGideon M. HirschfieldMichael Kammüller, Xiaoli Meng, Stefan F. Martin, Philippe Musette, Alan NorrisMunir PirmohamedB. Kevin ParkAnthony W. Purcell, Colin F. SpraggsJessica Whritenour & Dean J. Naisbitt. (2016) New Approaches to Investigate Drug-Induced Hypersensitivity. Chemical Research in Toxicology 30:1, pages 239-259.
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Jack Uetrecht. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 175 193 .
Muireann Coen, Peter M. Rademacher, Wei Zou, Michael Scott, Patricia E. Ganey, Robert Roth & Sidney D. Nelson. (2012) Comparative NMR-Based Metabonomic Investigation of the Metabolic Phenotype Associated with Tienilic Acid and Tienilic Acid Isomer. Chemical Research in Toxicology 25:11, pages 2412-2422.
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Alexander V. LyubimovJack P. Uetrecht. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 51 .
Xiu-Ju Zhao, Fuhua Hao, Chongyang Huang, Mattias RantalainenHehua Lei, Huiru Tang & Yulan Wang. (2012) Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling. Journal of Proteome Research 11:9, pages 4712-4721.
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D. J. Snodin & A. Suitters. 2011. Stephens' Detection and Evaluation of Adverse Drug Reactions. Stephens' Detection and Evaluation of Adverse Drug Reactions 157 214 .
Céline Narjoz, Philippe Beaune & Isabelle de Waziers. (2010) Idiosyncratiques et « omiques » peuvent-ils rimer ?. médecine/sciences 26:6-7, pages 641-646.
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C. Johanet & E. Ballot. (2010) Autoanticorps en hépatologie. EMC - Hépatologie 5:2, pages 1-10.
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Jinze Li & Jack P. Uetrecht. 2010. Adverse Drug Reactions. Adverse Drug Reactions 493 509 .
Takayoshi Nishiya, Kazuhiko Mori, Chiharu Hattori, Kiyonori Kai, Hiroko Kataoka, Noriko Masubuchi, Toshimasa Jindo & Sunao Manabe. (2008) The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats. Toxicology and Applied Pharmacology 232:2, pages 280-291.
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