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Original Article

Surfactant Regulation of Host Defense Function in the Lung: A Question of Balance

Pages 269-292 | Published online: 16 Apr 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Mingyue Qiang & Ruili Zhang. (2023) Identification of potential immune-related ceRNA Regulatory Network in UVB-irradiated human skin. Biotechnology and Genetic Engineering Reviews 0:0, pages 1-24.
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Melissa Grageda, Patricia Silveyra, Neal J. Thomas, Susan L. DiAngelo & Joanna Floros. (2015) DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. Experimental Lung Research 41:2, pages 93-102.
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Davide Paleari, Giovanni A Rossi, Gabriele Nicolini & Dario Olivieri. (2011) Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood. Expert Opinion on Drug Discovery 6:11, pages 1203-1214.
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Todd M. Umstead, David S. Phelps, Guirong Wang, Joanna Floros & Brian K. Tarkington. (2002) In Vitro Exposure of Proteins to Ozone. Toxicology Mechanisms and Methods 12:1, pages 1-16.
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Articles from other publishers (54)

Nithyananda Thorenoor & Joanna Floros. (2022) The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0). Frontiers in Immunology 13.
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David S. Phelps, Vernon M. Chinchilli, Lili Yang, Debra Shearer, Judith Weisz, Xuesheng Zhang & Joanna Floros. (2022) The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue. Scientific Reports 12:1.
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Yoshitoshi Kasuya, Jun-Dal Kim, Masahiko Hatano, Koichiro Tatsumi & Shuichi Matsuda. (2021) Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis. International Journal of Molecular Sciences 22:11, pages 6041.
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Nagwan Yossery Saleh, Reda Abdel Latif Ibrahem, Amany Abdel hakim Saleh, Shimaa El shafey Soliman & Asmaa Abdel Sameea Mahmoud. (2021) Surfactant protein D: a predictor for severity of community-acquired pneumonia in children. Pediatric Research.
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David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Lili Yang, Debra Shearer, Xuesheng Zhang & Joanna Floros. (2020) Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice. JCI Insight 5:24.
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David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Debra Shearer, Xuesheng Zhang & Joanna Floros. (2020) Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1. Biomarker Research 8:1.
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Nithyananda Thorenoor, David S. Phelps & Joanna Floros. (2020) Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure. Antioxidants 9:12, pages 1190.
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Chintan K. Gandhi, Anatoly N. Mikerov, Faryal Durrani, Todd M. Umstead, Sanmei Hu, Guirong Wang, David S. Phelps & Joanna Floros. (2020) Impact of Ozone, Sex, and Gonadal Hormones on Bronchoalveolar Lavage Characteristics and Survival in SP-A KO Mice Infected with Klebsiella pneumoniae. Microorganisms 8:9, pages 1354.
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Nithyananda Thorenoor, David S. Phelps, Padma Kala, Radhika Ravi, Andreas Floros Phelps, Todd M. Umstead, Xuesheng Zhang & Joanna Floros. (2020) Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to Klebsiella pneumoniae Infection and Ozone: Serendipity in Action. Microorganisms 8:9, pages 1276.
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Nithyananda Thorenoor, Yuka Imamura Kawasawa, Chintan K. Gandhi & Joanna Floros. (2020) Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae. Frontiers in Immunology 11.
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Nithyananda Thorenoor, Yuka Imamura Kawasawa, Chintan K. Gandhi, Xuesheng Zhang & Joanna Floros. (2019) Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences. Frontiers in Immunology 10.
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George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani & Joanna Floros. (2019) Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome. Frontiers in Immunology 10.
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Beatrice Aramini, Patrick Geraghty, David J. Lederer, Joseph Costa, Susan L. DiAngelo, Joanna Floros & Frank D'Ovidio. (2019) Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs. The Journal of Thoracic and Cardiovascular Surgery 157:5, pages 2109-2117.
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Guirong Wang, Todd M. Umstead, Sanmei Hu, Anatoly N. Mikerov, David S. Phelps & Joanna Floros. (2019) Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure. Frontiers in Immunology 10.
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Colin MacNeill, Glendell S. de Guzman, Kate Lupo, Todd Umstead, David S. Phelps & Joanna Floros. (2019) Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa. Journal of Lower Genital Tract Disease 23:1, pages 71-74.
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Margaret Gilfillan & Vineet Bhandari. 2019. Hematology, Immunology and Genetics. Hematology, Immunology and Genetics 149 164 .
Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps & Joanna Floros. (2018) Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences. Respiratory Research 19:1.
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Zhenwu Lin, Nithyananda Thorenoor, Rongling Wu, Susan L. DiAngelo, Meixia Ye, Neal J. Thomas, Xiaojie Liao, Tony R. Lin, Stuart Warren & Joanna Floros. (2018) Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis. Frontiers in Immunology 9.
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Virgilio P. Carnielli & Paola E. Cogo. 2018. Neonatology. Neonatology 809 822 .
Virgilio P. Carnielli & Paola E. Cogo. 2018. Neonatology. Neonatology 1 14 .
George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani & Joanna Floros. (2017) SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved. Biology of Sex Differences 8:1.
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George T. Noutsios, Amanda L. Willis, Julie G. Ledford & Eugene H. Chang. (2017) Novel role of surfactant protein A in bacterial sinusitis. International Forum of Allergy & Rhinology 7:9, pages 897-903.
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Carole R. Mendelson, Alina P. Montalbano & Lu Gao. (2017) Fetal-to-maternal signaling in the timing of birth. The Journal of Steroid Biochemistry and Molecular Biology 170, pages 19-27.
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Virgilio P. Carnielli, Chiara Giorgetti, Manuela Simonato, Luca Vedovelli & Paola Cogo. (2016) Neonatal Respiratory Diseases in the Newborn Infant: Novel Insights from Stable Isotope Tracer Studies. Neonatology 109:4, pages 325-333.
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Georgios T. Noutsios, Paul Ghattas, Stephanie Bennett & Joanna Floros. (2015) 14-3-3 isoforms bind directly exon B of the 5′-UTR of human surfactant protein A2 mRNA. American Journal of Physiology-Lung Cellular and Molecular Physiology 309:2, pages L147-L157.
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N. A. Kovalkova, Yu. I. Ragino, N. I. Logvinenko, E. S. Merekina & M. I. Voevoda. (2015) Significance of surfactant proteins in the diagnosis of therapeutic diseases. Terapevticheskii arkhiv 87:1, pages 115.
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Patricia Silveyra, Susan L. DiAngeloJoanna Floros. (2014) An 11-nt sequence polymorphism at the 3′UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. American Journal of Physiology-Lung Cellular and Molecular Physiology 307:1, pages L106-L119.
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Adam Bohr, Christian A. Ruge & Moritz Beck-Broichsitter. 2014. Nanomaterial. Nanomaterial 183 206 .
B. Aramini, C. Kim, S. DiAngelo, E. Petersen, D.J. Lederer, L. Shah, H. Robbins, J. Floros, S.M. Arcasoy, J.R. Sonett & F. D’Ovidio. (2013) Donor Surfactant Protein D (SP-D) Polymorphisms Are Associated With Lung Transplant Outcome. American Journal of Transplantation 13:8, pages 2130-2136.
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Georgios T. Noutsios, Patricia Silveyra, Faizah Bhatti & Joanna Floros. (2013) Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis -elements and secondary structure . American Journal of Physiology-Lung Cellular and Molecular Physiology 304:11, pages L722-L735.
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David S Phelps, Todd M Umstead & Joanna Floros. (2012) Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A. Proteome Science 10:1.
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G. S. GuptaRajesh K. Gupta & Anita Gupta. 2012. Animal Lectins: Form, Function and Clinical Applications. Animal Lectins: Form, Function and Clinical Applications 527 550 .
Patricia Silveyra, Guirong Wang & Joanna Floros. (2010) Human SP-A1 (SFTPA1) variant-specific 3′ UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. American Journal of Physiology-Lung Cellular and Molecular Physiology 299:4, pages L523-L534.
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Wondwossen Abate, Abdulaziz A. Alghaithy, Joan Parton, Kenneth P. Jones & Simon K. Jackson. (2010) Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains. Journal of Lipid Research 51:2, pages 334-344.
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Carole R. Mendelson. (2009) Minireview: Fetal-Maternal Hormonal Signaling in Pregnancy and Labor. Molecular Endocrinology 23:7, pages 947-954.
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V P Carnielli, L J I Zimmermann, A Hamvas & P E Cogo. (2009) Pulmonary surfactant kinetics of the newborn infant: novel insights from studies with stable isotopes. Journal of Perinatology 29:S2, pages S29-S37.
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Guirong Wang, Xiaoxuan Guo, Patricia Silveyra, Scot R. Kimball & Joanna Floros. (2009) Cap-independent translation of human SP-A 5′-UTR variants: a double-loop structure and cis -element contribution . American Journal of Physiology-Lung Cellular and Molecular Physiology 296:4, pages L635-L647.
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Anatoly N Mikerov, Xiaozhuang Gan, Todd M Umstead, Laura Miller, Vernon M Chinchilli, David S Phelps & Joanna Floros. (2008) Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection. Respiratory Research 9:1.
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Beena Puthothu, Johannes Forster, Jessica Heinze, Andrea Heinzmann & Marcus Krueger. (2007) Surfactant protein Bpolymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. BMC Pulmonary Medicine 7:1.
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Guirong Wang, Svetla Taneva, Kevin M.W. Keough & Joanna Floros. (2007) Differential effects of human SP-A1 and SP-A2 variants on phospholipid monolayers containing surfactant protein B. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:9, pages 2060-2069.
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Guirong Wang, Xiaoxuan Guo & Joanna Floros. (2005) Differences in the translation efficiency and mRNA stability mediated by 5′-UTR splice variants of human SP-A1 and SP-A2 genes. American Journal of Physiology-Lung Cellular and Molecular Physiology 289:3, pages L497-L508.
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G??nseli Kln??Elif Altu?? Kolsuk. (2005) The role of bronchoalveolar lavage in diffuse parenchymal lung diseases. Current Opinion in Pulmonary Medicine 11:5, pages 417-421.
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C Seifart, H-M Lin, U Seifart, A Plagens, S DiAngelo, P Von Wichert & J Floros. (2005) Rare SP-A alleles and the SP-A1-6A4 allele associate with risk for lung carcinoma. Clinical Genetics 68:2, pages 128-136.
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Branislava Janic, Todd M. Umstead, David S. Phelps & Joanna Floros. (2005) Modulatory effects of ozone on THP-1 cells in response to SP-A stimulation. American Journal of Physiology-Lung Cellular and Molecular Physiology 288:2, pages L317-L325.
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Anatoly N. Mikerov, Todd M. Umstead, Weixiong Huang, Wenlei Liu, David S. Phelps & Joanna Floros. (2005) SP-A1 and SP-A2 variants differentially enhance association of Pseudomonas aeruginosa with rat alveolar macrophages . American Journal of Physiology-Lung Cellular and Molecular Physiology 288:1, pages L150-L158.
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Yu Bai, Dmitry Galetskiy, Eugen Damoc, Christian Paschen, Zhiqiang Liu, Mathias Griese, Shuying Liu & Michael Przybylski. (2004) High resolution mass spectrometric alveolar proteomics: Identification of surfactant protein SP‐A and SP‐D modifications in proteinosis and cystic fibrosis patients. PROTEOMICS 4:8, pages 2300-2309.
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Jennifer C. Condon, Pancharatnam Jeyasuria, Julie M. Faust & Carole R. Mendelson. (2004) Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition. Proceedings of the National Academy of Sciences 101:14, pages 4978-4983.
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David S. Phelps, Todd M. Umstead, Mayra Mejia, Guillermo Carrillo, Annie Pardo & Moises Selman. (2004) Increased Surfactant Protein-A Levels in Patients With Newly Diagnosed Idiopathic Pulmonary Fibrosis. Chest 125:2, pages 617-625.
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Wolfgang Bernhard, Patricia L. Haslam & Joanna Floros. (2004) From Birds to Humans. American Journal of Respiratory Cell and Molecular Biology 30:1, pages 6-11.
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Luis G. Vazquez de Lara, Todd M. Umstead, Sara E. Davis & David S. Phelps. (2003) Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 285:4, pages L899-L906.
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Guirong Wang, Xiaoxuan Guo & Joanna Floros. (2003) Human SP-A 3′-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone. American Journal of Physiology-Lung Cellular and Molecular Physiology 284:5, pages L738-L748.
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Zhenwu Lin & Joanna Floros. (2002) Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues . Physiological Genomics 11:3, pages 235-243.
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Weixiong HuangGuirong WangDavid S. Phelps, Hamid Al-Mondhiry & Joanna Floros. (2002) Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect. American Journal of Physiology-Lung Cellular and Molecular Physiology 283:1, pages L94-L102.
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Joanna Floros, Ruzong Fan, Susan Diangelo, Xiaoxuan Guo, John Wert & Junming Luo. (2001) Surfactant protein (SP) B associations and interactions with SP-A in white and black subjects with respiratory distress syndrome. Pediatrics International 43:6, pages 567-576.
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