Advanced search
Publication Cover
Autophagy Volume 11, 2015 - Issue 12
Submit an article Journal homepage
2,393
Views
49
CrossRef citations to date
0
Altmetric
Basic Brief Report

Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation

Meng-Meng JiState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China
,
Li WangState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China;Pôle de Recherches Sino-Français en Science du Vivant et Génomique; Laboratory of Molecular Pathology; Shanghai, China
,
Qin ZhanPôle de Recherches Sino-Français en Science du Vivant et Génomique; Laboratory of Molecular Pathology; Shanghai, China
,
Wen XueState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China
,
Yan ZhaoState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China
,
Xia ZhaoState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China;Pôle de Recherches Sino-Français en Science du Vivant et Génomique; Laboratory of Molecular Pathology; Shanghai, China
,
Peng-Peng XuState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China
,
Yang ShenState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China
,
Han LiuState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China
,
Anne JaninPôle de Recherches Sino-Français en Science du Vivant et Génomique; Laboratory of Molecular Pathology; Shanghai, China;U1165 Inserm/Université Paris 7; Hôpital Saint Louis; Paris, France
,
Shu ChengState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, ChinaCorrespondence[email protected] [email protected]
&
Wei-Li ZhaoState Key Laboratory of Medical Genomics; Shanghai Institute of Hematology; Shanghai Rui Jin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, China;Pôle de Recherches Sino-Français en Science du Vivant et Génomique; Laboratory of Molecular Pathology; Shanghai, ChinaCorrespondence[email protected] [email protected]
 show all
Pages 2160-2171 | Received 12 Jan 2015, Accepted 07 Aug 2015, Published online: 06 Jan 2016

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Susanna Ambrosio, Andrea Ballabio & Barbara Majello. (2019) Histone methyl-transferases and demethylases in the autophagy regulatory network: the emerging role of KDM1A/LSD1 demethylase. Autophagy 15:2, pages 187-196.
Read now

Articles from other publishers (48)

Wenbin Yuan, Wanyi Fang, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou & Jingfeng Tang. (2023) Therapeutic strategies targeting AMPK-dependent autophagy in cancer cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1870:7, pages 119537.
Crossref
Małgorzata Drzewiecka, Anna Gajos-Michniewicz, Grażyna Hoser, Dominika Jaśniak, Gabriela Barszczewska-Pietraszek, Przemysław Sitarek, Piotr Czarny, Janusz Piekarski, Maciej Radek, Małgorzata Czyż, Tomasz Skorski & Tomasz Śliwiński. (2023) Histone Deacetylases (HDAC) Inhibitor—Valproic Acid Sensitizes Human Melanoma Cells to Dacarbazine and PARP Inhibitor. Genes 14:6, pages 1295.
Crossref
Shipra Singhal, Priyal Maheshwari, Praveen Thaggikuppe Krishnamurthy & Vaishali M. Patil. (2022) Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics. Anti-Cancer Agents in Medicinal Chemistry 22:15, pages 2726-2756.
Crossref
Sheikh Tahir Majeed, Rabiya Majeed & Khurshid I. Andrabi. (2022) Expanding the view of the molecular mechanisms of autophagy pathway. Journal of Cellular Physiology 237:8, pages 3257-3277.
Crossref
Lianfang Liu, Tianya Liu, Weiwei Tao, Naikai Liao, Qiuying Yan, Liu Li, Jiani Tan, Weixing Shen, Haibo Cheng & Dongdong Sun. (2022) Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway. Phytomedicine 99, pages 154007.
Crossref
Amira Ebrahim Alsemeh, Marwa Mahmood Ahmed, Amal Fawzy, Walaa Samy, Marwa Tharwat & Samar Rezq. (2022) Vitamin E rescues valproic acid-induced testicular injury in rats: Role of autophagy. Life Sciences 296, pages 120434.
Crossref
Ling Gao, Qian Zhang, Shaoming Li, Jingjing Zheng, Wenhao Ren & Keqian Zhi. (2022) Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas. Cell Death & Disease 13:2.
Crossref
Dalyia N. Benjamin, Tracey R. O’Donovan, Kristian B. Laursen, Nina Orfali, Mary R. Cahill, Nigel P. Mongan, Lorraine J. Gudas & Sharon L. McKenna. (2022) All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism. Frontiers in Oncology 12.
Crossref
Praveen Kumar Singh, Poulomi Majumdar & Surya Prakash Singh. (2021) Advances in BODIPY photocleavable protecting groups. Coordination Chemistry Reviews 449, pages 214193.
Crossref
Diana Duarte, Armando Cardoso & Nuno Vale. (2021) Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs. International Journal of Molecular Sciences 22:14, pages 7408.
Crossref
Steven C. Mitini-Nkhoma, Elizabeth T. Chimbayo, David T. Mzinza, David V. Mhango, Aaron P. Chirambo, Christine Mandalasi, Agness E. Lakudzala, Dumizulu L. Tembo, Kondwani C. Jambo & Henry C. Mwandumba. (2021) Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents. Frontiers in Immunology 12.
Crossref
Yinan Xiao, Ling Jin, Chaolin Deng, Ye Guan, Eleftheria Kalogera, Upasana Ray, Prabhu Thirusangu, Julie Staub, Sayantani Sarkar Bhattacharya, Haotian Xu, Xiaoling Fang & Viji Shridhar. (2021) Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer. Oncogene 40:8, pages 1409-1424.
Crossref
ZAHRA NASRPOUR NAVAEI, GHAZALEH KHALILI-TANHA, AMIR SADRA ZANGOUEI, MOHAMMAD REZA ABBASZADEGAN & MEYSAM MOGHBELI. (2021) PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells. Oncology Research 29:4, pages 235-250.
Crossref
. (2021) Organelle-Specific Autophagy in Cellular Aging and Rejuvenation. Advances in Geriatric Medicine and Research.
Crossref
Ying Wang, Zhiwen Liu, Shaoqun Shu, Juan Cai, Chengyuan Tang & Zheng Dong. (2020) AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury. Frontiers in Physiology 11.
Crossref
Xiangxiang Zhou, Linquan Zhan, Kai Huang & Xin Wang. (2020) The functions and clinical significance of circRNAs in hematological malignancies. Journal of Hematology & Oncology 13:1.
Crossref
Yantao Bao, Lili Tong, Boyan Song, Ge Liu, Qian Zhu, Xiaopeng Lu, Jun Zhang, Ya-Fei Lu, He Wen, Yuan Tian, Yujie Sun & Wei-Guo Zhu. (2020) UNG2 deacetylation confers cancer cell resistance to hydrogen peroxide-induced cytotoxicity. Free Radical Biology and Medicine 160, pages 403-417.
Crossref
Lubna Therachiyil, Javeria Haroon, Fairooz Sahir, Kodappully S. Siveen, Shahab Uddin, Michal Kulinski, Joerg Buddenkotte, Martin Steinhoff & Roopesh Krishnankutty. (2020) Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin. Frontiers in Oncology 10.
Crossref
Zhilong Zheng, Yanqing Wu, Zhengmao Li, Luxia Ye, Qi Lu, Yajiao Zhou, Yuan Yuan, Ting Jiang, Ling Xie, Yanlong Liu, Daqing Chen, Junming Ye, Wutigri Nimlamool, Hongyu Zhang & Jian Xiao. (2019) Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury. Journal of Neurochemistry 154:3, pages 284-300.
Crossref
Paige M. Brooks, Kevin P. Rose, Meaghan L. MacRae, Katherine M. Rangoussis, Mansa Gurjar, Ronna Hertzano & Thomas M. Coate. (2020) Pou3f4‐expressing otic mesenchyme cells promote spiral ganglion neuron survival in the postnatal mouse cochlea. Journal of Comparative Neurology 528:12, pages 1967-1985.
Crossref
Jie Sun, Junjie Piao, Nan Li, Yang Yang, Ki‐Yeol Kim & Zhenhua Lin. (2019) Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer. The FEBS Journal 287:10, pages 2118-2133.
Crossref
Feifan Wang, Min Cao, Mengjing Fan, Hongshen Wu, Wei Huang, Yan Zhang, Zhenghui Hu & Xiaodong Jin. (2019) AMPK‐mTOR‐ULK1 axis activation‐dependent autophagy promotes hydroxycamptothecin‐induced apoptosis in human bladder cancer cells. Journal of Cellular Physiology 235:5, pages 4302-4315.
Crossref
Jiao Meng, Kaiyi Liu, Yang Shao, Xu Feng, Zhaodong Ji, Bin Chang, Yan Wang, Ling Xu & Gong Yang. (2020) ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death & Disease 11:2.
Crossref
Romina Armando, Diego Mengual G�mez & Daniel Gomez. (2020) New drugs are not enough‑drug repositioning in oncology: An update. International Journal of Oncology.
Crossref
Paul Peixoto, Céline Grandvallet, Jean-Paul Feugeas, Michaël Guittaut & Eric Hervouet. (2019) Epigenetic Control of Autophagy in Cancer Cells: A Key Process for Cancer-Related Phenotypes. Cells 8:12, pages 1656.
Crossref
Karthik Sambath, Tinghan Zhao, Zhaoxiong Wan & Yuanwei Zhang. (2019) Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells. Chemical Communications 55:94, pages 14162-14165.
Crossref
Fan Liang, Chunxia Ren, Jingshu Wang, Shuoer Wang, Lina Yang, Xianghui Han, Yaping Chen, Guoqing Tong & Gong Yang. (2019) The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy. Oncogenesis 8:10.
Crossref
Carlo Follo, Yao Cheng, William G. Richards, Raphael Bueno & V. Courtney Broaddus. (2019) Autophagy facilitates the release of immunogenic signals following chemotherapy in 3D models of mesothelioma. Molecular Carcinogenesis 58:10, pages 1754-1769.
Crossref
Xiaohui Shi, Yan Liu, Daquan Zhang & Dong Xiao. (2019) Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway. Life Sciences 232, pages 116613.
Crossref
Shouping Xu, Shiyao Sui, Xianyu Zhang, Boran Pang, Lin Wan & Da Pang. (2019) Modulation of autophagy in human diseases strategies to foster strengths and circumvent weaknesses. Medicinal Research Reviews 39:5, pages 1953-1999.
Crossref
Rekha Khandia, Maryam Dadar, Ashok Munjal, Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Mohd. Iqbal Yatoo, Hafiz M.N. Iqbal, Karam Pal Singh, Sunil K. Joshi & Wanpen Chaicumpa. (2019) A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy. Cells 8:7, pages 674.
Crossref
Polina A. Golubinskaya, Marina V. Sarycheva, Svetlana Y. Burda, Maksim V. Puzanov, Natalya A. Nadezhdina, Vladimir F. Kulikovskiy, Sergey V. Nadezhdin, Michail V. Korokin & Yuriy E. Burda. (2019) Pharmacological modulation of cell functional activity with valproic acid and erythropoietin. Research Results in Pharmacology 5:2, pages 89-99.
Crossref
Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu & Shun Li. (2018) Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. Journal of Neuroinflammation 15:1.
Crossref
Farnaz Barneh, Mona Salimi, Fatemeh Goshadrou, Minoo Ashtiani, Mehdi Mirzaie, Hakimeh Zali & Mohieddin Jafari. (2018) Valproic acid inhibits the protective effects of stromal cells against chemotherapy in breast cancer: Insights from proteomics and systems biology. Journal of Cellular Biochemistry 119:11, pages 9270-9283.
Crossref
Xiangrong Chen, Handong Wang, Mengliang Zhou, Xiang Li, Zhongning Fang, Hongzhi Gao, Yasong Li & Weipeng Hu. (2018) Valproic Acid Attenuates Traumatic Brain Injury-Induced Inflammation in Vivo: Involvement of Autophagy and the Nrf2/ARE Signaling Pathway. Frontiers in Molecular Neuroscience 11.
Crossref
Natalia Prevarskaya, Roman Skryma & Yaroslav Shuba. (2018) Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?. Physiological Reviews 98:2, pages 559-621.
Crossref
Martin D. Bootman, Tala Chehab, Geert Bultynck, Jan B. Parys & Katja Rietdorf. (2018) The regulation of autophagy by calcium signals: Do we have a consensus?. Cell Calcium 70, pages 32-46.
Crossref
Fei Hu, Yu Zhao, Yi Yu, Jue-min Fang, Ran Cui, Zhu-qing Liu, Xian-ling Guo & Qing Xu. (2018) Docetaxel-mediated autophagy promotes chemoresistance in castration-resistant prostate cancer cells by inhibiting STAT3. Cancer Letters 416, pages 24-30.
Crossref
Martijn Kerkhofs, Mart Bittremieux, Giampaolo Morciano, Carlotta Giorgi, Paolo Pinton, Jan B. Parys & Geert Bultynck. (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death & Disease 9:3.
Crossref
Veronica Cartocci, Martina Catallo, Massimo Tempestilli, Marco Segatto, Frank W. Pfrieger, Maria Rosanna Bronzuoli, Caterina Scuderi, Michela Servadio, Viviana Trezza & Valentina Pallottini. (2018) Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders. Neuroscience 372, pages 27-37.
Crossref
Peng-Peng Xu, Yi-Feng Sun, Ying Fang, Qi Song, Zi-Xun Yan, Yi Chen, Xu-Feng Jiang, Xiao-Chun Fei, Yan Zhao, Christophe Leboeuf, Biao Li, Chao-Fu Wang, Anne Janin, Li Wang & Wei-Li Zhao. (2017) JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide. Scientific Reports 7:1.
Crossref
Zhen Wang, Qiao-Yun Long, Lin Chen, Jia-Dong Fan, Zhao-Ning Wang, Lian-Yun Li, Min Wu & Xuefeng Chen. (2017) Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:12, pages 2428-2437.
Crossref
Yarong Song, Peng Zhang, Yadong Sun, Xuechao Li, Lifeng Chen, Yajun Xiao & Yifei Xing. (2017) AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells. Oncotarget 8:40, pages 67942-67954.
Crossref
Fei Hu, Xian-Ling Guo, Shan-Shan Zhang, Qiu-Dong Zhao, Rong Li, Qing Xu & Li-Xin Wei. (2017) Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy. Oncology Letters 14:2, pages 1959-1966.
Crossref
Jian-Hui Chen, Yu-Long Zheng, Chuan-Qin Xu, Li-Zhi Gu, Zong-Li Ding, Ling Qin, Yi Wang, Ran Fu, Yu-Feng Wan & Cheng-Ping Hu. (2017) Valproic acid (VPA) enhances cisplatin sensitivity of non-small cell lung cancer cells via HDAC2 mediated down regulation of ABCA1. Biological Chemistry 398:7, pages 785-792.
Crossref
Subbroto Saha, Yingfu Yin, Kyeongseok Kim, Gwang-Mo Yang, Ahmed Dayem, Hye Choi & Ssang-Goo Cho. (2017) Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells. International Journal of Molecular Sciences 18:5, pages 1048.
Crossref
Y. Zhang, J.Y. Wu, L.H. Weng, X.X. Li, L.J. Yu & Y. Xu. (2017) Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy. Neuroscience Letters 638, pages 60-68.
Crossref
Jason S. Rockel & Mohit Kapoor. (2016) Autophagy: controlling cell fate in rheumatic diseases. Nature Reviews Rheumatology 12:9, pages 517-531.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.