Advanced search
Publication Cover
Autophagy Volume 15, 2019 - Issue 2
Submit an article Journal homepage
3,698
Views
24
CrossRef citations to date
0
Altmetric
Commentary

Spermidine reduces cancer-related mortality in humans

Federico PietrocolaInstitute for Research in Biomedicine, Barcelona, Spain;INSERM, U1138, Paris, FranceView further author information
,
Francesca CastoldiINSERM, U1138, Paris, France;Gustave Roussy Cancer Campus, Villejuif, France;Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France;Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;Université Pierre et Marie Curie, Paris, France;Faculté de Medecine; Kremlin-Bicetre, Université Paris-Sud/Paris-Saclay, Kremlin Bicêtre, FranceView further author information
,
Oliver KeppINSERM, U1138, Paris, France;Gustave Roussy Cancer Campus, Villejuif, France;Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France;Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;Université Pierre et Marie Curie, Paris, France;Faculté de Medecine; Kremlin-Bicetre, Université Paris-Sud/Paris-Saclay, Kremlin Bicêtre, FranceORCID Iconhttp://orcid.org/0000-0002-6081-9558View further author information
ORCID Icon,
Didac Carmona-GutierrezInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria;BioTechMed Graz, Graz, AustriaView further author information
,
Frank MadeoInstitute of Molecular Biosciences, University of Graz, NAWI Graz, Graz, Austria;BioTechMed Graz, Graz, AustriaView further author information
&
Guido KroemerINSERM, U1138, Paris, France;Gustave Roussy Cancer Campus, Villejuif, France;Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France;Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;Université Pierre et Marie Curie, Paris, France;Faculté de Medecine; Kremlin-Bicetre, Université Paris-Sud/Paris-Saclay, Kremlin Bicêtre, France;Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-9334-4405View further author information
ORCID Icon
Pages 362-365 | Received 11 Sep 2018, Accepted 17 Oct 2018, Published online: 29 Oct 2018

Citations (24)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Lingyan Ma, Yinhua Ni, Zhe Wang, Wenqing Tu, Liyang Ni, Fen Zhuge, Aqian Zheng, Luting Hu, Yufeng Zhao, Liujie Zheng & Zhengwei Fu. (2020) Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice. Gut Microbes 12:1.
Read now

Articles from other publishers (23)

Aleksandar Ž. Kostić, Danijel D. Milinčić, Bojana Špirović Trifunović, Nebojša Nedić, Uroš M. Gašić, Živoslav Lj. Tešić, Sladjana P. Stanojević & Mirjana B. Pešić. (2023) Monofloral Corn Poppy Bee-Collected Pollen—A Detailed Insight into Its Phytochemical Composition and Antioxidant Properties. Antioxidants 12:7, pages 1424.
Crossref
Tianqi Nie, Hengyu Liu, Zhengwen Fang, Yilu Zheng, Ruhe Zhang, Xiaojun Xu, Sixi Liu & Jun Wu. (2023) Tumor Microenvironment Mediated Spermidine-Metal-Immunopeptide Nanocomplex for Boosting Ferroptotic Immunotherapy of Lymphoma. ACS Nano 17:11, pages 10925-10937.
Crossref
Xiaohui Ma, Xiaonan Jia, Yahui Peng, Xueting Li, Changsong Wang & Kaijiang Yu. (2023) Gut microbiota disruption during sepsis and the influence of innate metabolites on sepsis prognosis. International Microbiology 26:4, pages 929-938.
Crossref
Sebastian J. Hofer, Anna Katharina Simon, Martina Bergmann, Tobias Eisenberg, Guido Kroemer & Frank Madeo. (2022) Mechanisms of spermidine-induced autophagy and geroprotection. Nature Aging 2:12, pages 1112-1129.
Crossref
Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Karina Standahl Olsen, Torkjel Manning Sandanger, Therese Haugdahl Nøst, J. Ramón Quirós, Catalina Bonet, Miguel Rodríguez Barranco, María-Dolores Chirlaque, Eva Ardanaz, Malte Sandsveden, Jonas Manjer, Linda Vidman, Matilda Rentoft, David Muller, Kostas Tsilidis, Alicia K. Heath, Hector Keun, Jerzy Adamski, Pekka Keski-Rahkonen, Augustin Scalbert, Marc J. Gunter & Vivian Viallon. (2022) Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition. BMC Medicine 20:1.
Crossref
Dian Zou, Ziyue Zhao, Lu Li, Yu Min, Daiyuan Zhang, Anying Ji, Cong Jiang, Xuetuan Wei & Xian Wu. (2022) A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and bioprocessing. Comprehensive Reviews in Food Science and Food Safety 21:3, pages 2820-2842.
Crossref
Srimanta Patra, Soumya R. Mishra, Bishnu P. Behera, Kewal K. Mahapatra, Debasna P. Panigrahi, Chandra S. Bhol, Prakash P. Praharaj, Gautam Sethi, Samir K. Patra & Sujit K. Bhutia. (2022) Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives. Seminars in Cancer Biology 80, pages 205-217.
Crossref
Hong Min Choi, Se-Gun Kim, Hyo Young Kim, Soon Ok Woo, Seonmi Kim, Hyo-Jung Moon & Sang Mi Han. (2022) Determination of Spermidine in Freeze-dried Royal Jelly using Ultra Performance Liquid Chromatography. Journal of Apiculture 37:1, pages 51-57.
Crossref
Chiara Vidoni, Alessandra Ferraresi, Andrea Esposito, Chinmay Maheshwari, Danny N. Dhanasekaran, Vincenzo Mollace & Ciro Isidoro. (2021) Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy. Journal of Cancer Prevention 26:4, pages 224-236.
Crossref
Yudy V. Cardona‐Cardona, Ignacio Regla, Javier Andrés Juárez‐Díaz, Javier Carrillo‐Campos, Manuel López‐Ortiz, Alejandro Aguilera‐Cruz, Carlos Mújica‐Jiménez & Rosario A. Muñoz‐Clares. (2021) The critical role of the aldehyde dehydrogenase PauC in spermine, spermidine, and diaminopropane toxicity in Pseudomonas aeruginosa : Its possible use as a drug target . The FEBS Journal.
Crossref
Mélanie Bourgin, Lisa Derosa, Carolina Alves Costa Silva, Anne-Gaëlle Goubet, Agathe Dubuisson, François-Xavier Danlos, Claudia Grajeda-Iglesias, Luigi Cerbone, Arthur Geraud, Ariane Laparra, Fanny Aprahamian, Nitharsshini Nirmalathasan, Frank Madeo, Laurence Zitvogel, Guido Kroemer & Sylvère Durand. (2021) Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients. Aging 13:17, pages 20860-20885.
Crossref
M. Fidelle, L. Derosa, B. Routy & L. Zitvogel. (2021) Contourner la résistance à l’immunothérapie des cancers : interventions centrées sur le microbiome intestinal. Bulletin de l'Académie Nationale de Médecine 205:4, pages 364-382.
Crossref
Erwan Eriau, Juliette Paillet, Guido Kroemer & Jonathan G. Pol. (2021) Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy. Cancers 13:6, pages 1260.
Crossref
Mark F McCarty & Aaron Lerner. (2021) Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin. Advances in Nutrition 12:2, pages 355-362.
Crossref
Ji-Xia Wang, Yao-Peng Zhao, Na-Na Du, Yang Han, Hao Li, Rong Wang, Yang Xu, Yan-Fang Liu & Xin-Miao Liang. (2020) Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica . Organic Letters 22:21, pages 8240-8244.
Crossref
Yang Ouyang, Qi Wu, Juanjuan Li, Si Sun & Shengrong Sun. (2020) S‐adenosylmethionine: A metabolite critical to the regulation of autophagy. Cell Proliferation 53:11.
Crossref
Louis P. Conway, Veronica Rendo, Mário S. P. Correia, Ingvar A. Bergdahl, Tobias Sjöblom & Daniel Globisch. (2020) Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N ‐Acetyltransferase NAT2 . Angewandte Chemie International Edition 59:34, pages 14342-14346.
Crossref
Louis P. Conway, Veronica Rendo, Mário S. P. Correia, Ingvar A. Bergdahl, Tobias Sjöblom & Daniel Globisch. (2020) Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N ‐Acetyltransferase NAT2 . Angewandte Chemie 132:34, pages 14448-14452.
Crossref
Mark F. McCarty & Aaron Lerner. (2020) Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson’s Disease. International Journal of Molecular Sciences 21:10, pages 3624.
Crossref
Guo Chen, Wei Xie, Jihoon Nah, Allan Sauvat, Peng Liu, Federico Pietrocola, Valentina Sica, Didac Carmona‐Gutierrez, Andreas Zimmermann, Tobias Pendl, Jelena Tadic, Martina Bergmann, Sebastian J Hofer, Lana Domuz, Sylvie Lachkar, Maria Markaki, Nektarios Tavernarakis, Junichi Sadoshima, Frank Madeo, Oliver Kepp & Guido Kroemer. (2019) 3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE 3 and TFEB . EMBO Molecular Medicine 11:11.
Crossref
Mélanie Viltard, Sylvère Durand, Maria Pérez-Lanzón, Fanny Aprahamian, Deborah Lefevre, Christine Leroy, Frank Madeo, Guido Kroemer & Gérard Friedlander. (2019) The metabolomic signature of extreme longevity: naked mole rats versus mice. Aging 11:14, pages 4783-4800.
Crossref
David R. Zhou, Rawan Eid, Katie A. Miller, Eric Boucher, Craig A. Mandato & Michael T. Greenwood. (2019) Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:5, pages 773-792.
Crossref
Maria Chiara Maiuri & Guido Kroemer. (2019) Therapeutic modulation of autophagy: which disease comes first?. Cell Death & Differentiation 26:4, pages 680-689.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.