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Autophagy Volume 16, 2020 - Issue 9
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Research Paper

Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism

Xing Zhanga Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
,
Dandan Wua Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
,
Chunqing Wanga Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
,
Yan Luoa Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
,
Xiaofeng Dinga Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
,
Xin Yanga Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAORCID Iconhttps://orcid.org/0000-0001-7020-8905View further author information
ORCID Icon,
Floyd Silvaa Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
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Sara Arenasa Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
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John Michael Weaverb Autophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAORCID Iconhttps://orcid.org/0000-0003-3304-001XView further author information
ORCID Icon,
Michael Mandellb Autophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA;c Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAView further author information
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Vojo Dereticb Autophagy Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA;c Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USAORCID Iconhttps://orcid.org/0000-0002-3624-5208View further author information
ORCID Icon &
Meilian Liua Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USACorrespondence[email protected]
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Pages 1668-1682 | Received 26 Feb 2019, Accepted 04 Dec 2019, Published online: 18 Dec 2019

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Yasmina Filali-Mouncef, Catherine Hunter, Federica Roccio, Stavroula Zagkou, Nicolas Dupont, Charlotte Primard, Tassula Proikas-Cezanne & Fulvio Reggiori. (2022) The ménage à trois of autophagy, lipid droplets and liver disease. Autophagy 18:1, pages 50-72.
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Articles from other publishers (24)

Haorui Qin, Zhiqiang Han, Wenkai Zhang, Rongquan He, Shuhua Zeng, Chunhui Qi, Shuting Zhou & Yingchun Chen. (2024) CTCF modulates adipocyte lipolysis via directly regulating the expression of Beclin 1 with the cooperation of PPARγ. Cellular Signalling 113, pages 110968.
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Haiying Cui, Yao Wang, Tong Zhou, Limei Qu, Xiaoling Zhang, Yingdi Wang, Mingyue Han, Shuo Yang, Xinhua Ren, Guixia Wang & Xiaokun Gang. (2023) Targeting DGAT1 inhibits prostate cancer cells growth by inducing autophagy flux blockage via oxidative stress. Oncogene.
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Asie Sadeghi, Maryam Niknam, Mohammad Amin Momeni-Moghaddam, Maryam Shabani, Hamid Aria, Alireza Bastin, Maryam Teimouri, Reza Meshkani & Hamed Akbari. (2023) Crosstalk between autophagy and insulin resistance: evidence from different tissues. European Journal of Medical Research 28:1.
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Mengxia FuSongren Shu, Zhiming PengXiaorui LiuXiao ChenZhiwei Zeng, Yicheng YangHao Cui, Ruojin ZhaoXiaohu Wang, Leilei DuMin WuWei Feng & Jiangping Song. (2023) Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies SPP1 + Macrophage Subpopulation as a Target for Alleviating Fibrosis . Arteriosclerosis, Thrombosis, and Vascular Biology.
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Yangmian Yuan, Yu Fan, Yihao Zhou, Rong Qiu, Wei Kang, Yu Liu, Yuchen Chen, Chenyu Wang, Jiajian Shi, Chengyu Liu, Yangkai Li, Min Wu, Kun Huang, Yong Liu & Ling Zheng. (2023) Linker histone variant H1.2 is a brake on white adipose tissue browning. Nature Communications 14:1.
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Zhuo-qing Lan, Zi-yi Ge, Shu-kai Lv, Bing Zhao & Cai-xia Li. (2023) The regulatory role of lipophagy in central nervous system diseases. Cell Death Discovery 9:1.
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Jeong Choi, Hyeok Choi, Gwang Ryu, Jae Lee & Jin Jeong. (2023) Inhibition of lipid droplet accumulation by Solanum nigrum by suppressing adipogenesis and inducing lipolysis, thermogenesis and autophagy in 3T3‑L1 cells . Experimental and Therapeutic Medicine 26:1.
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Siyao Cheng, Xintao Ni, Yanjing Yao, Yunxia Sun, Xiaofeng Yu, Daozong Xia, Zhenggang Yang, Miaofen G. Hu & Xiaoli Hou. (2023) Hyperoside prevents high-fat diet-induced obesity by increasing white fat browning and lipophagy via CDK6-TFEB pathway. Journal of Ethnopharmacology 307, pages 116259.
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Xue-Long Yan, Yue-Hua Pan, Run-Zhu Fan, Qin-Qin Song, Shen Li, Jia-Luo Huang, Wei Li, Dong Huang, Fang-Yu Yuan, Gui-Hua Tang, Yong Rao, Zhi-Shu Huang & Sheng Yin. (2023) Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent. Journal of Medicinal Chemistry 66:8, pages 5839-5858.
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Xingtao Zhao, Felix Kwame Amevor, Zhifu Cui, Yan Wan, Xinyan Xue, Cheng Peng & Yunxia Li. (2023) Steatosis in metabolic diseases: A focus on lipolysis and lipophagy. Biomedicine & Pharmacotherapy 160, pages 114311.
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Felix Clemens Richter, Matthias Friedrich, Nadja Kampschulte, Klara Piletic, Ghada Alsaleh, Ramona Zummach, Julia Hecker, Mathilde Pohin, Nicholas Ilott, Irina Guschina, Sarah Karin Wideman, Errin Johnson, Mariana Borsa, Paula Hahn, Christophe Morriseau, Bruce D Hammock, Henk Simon Schipper, Claire M Edwards, Rudolf Zechner, Britta Siegmund, Carl Weidinger, Nils Helge Schebb, Fiona Powrie & Anna Katharina Simon. (2023) Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL‐10 . The EMBO Journal 42:6.
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Karolina Ciesielska & Małgorzata Gajewska. (2023) Fatty Acids as Potent Modulators of Autophagy Activity in White Adipose Tissue. Biomolecules 13:2, pages 255.
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Jinke Xiong, Jingjing Bao, Wenping Hu, Mingyu Shang & Li Zhang. (2023) Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat. Frontiers in Genetics 13.
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Inmaculada Navarro-Lérida, Anna M. Aragay, Alejandro Asensio & Catalina Ribas. (2022) Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues. Antioxidants 11:8, pages 1599.
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Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Dandan Wu, Dianna Spilca, Que Le, Xin Yang, Katelyn Alvarez, William Curtis Hines, Xuexian O. Yang & Meilian Liu. (2022) COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity. Cells 11:11, pages 1819.
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Zhipeng Tao, Hiba Aslam, Jane Parke, Marcel Sanchez & Zhiyong Cheng. (2022) Mechanisms of autophagic responses to altered nutritional status. The Journal of Nutritional Biochemistry 103, pages 108955.
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Yongguo Li, Zhen Li, Devi Anggraini Ngandiri, Mireia Llerins Perez, Alexander Wolf & Yuanyuan Wang. (2022) The Molecular Brakes of Adipose Tissue Lipolysis. Frontiers in Physiology 13.
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Jihong Dong, Kaiming Yue, Juan J. Loor, Ahmad Aboragah, Guojin Li, Linfang Chen, Yuxiang Song, Xiliang Du, Guowen Liu, Zhe Wang, Xiaobing Li & Xinwei Li. (2022) Increased adipose tissue lipolysis in dairy cows with fatty liver is associated with enhanced autophagy activity. Journal of Dairy Science 105:2, pages 1731-1742.
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Gernot F. Grabner, Hao Xie, Martina Schweiger & Rudolf Zechner. (2021) Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nature Metabolism 3:11, pages 1445-1465.
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Irmgard Tegeder & Donat Kögel. (2021) When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy. Matrix Biology 100-101, pages 99-117.
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Winifred W. Yau, Kiraely Adam Wong, Jin Zhou, Nivetha Kanakaram Thimmukonda, Yajun Wu, Boon-Huat Bay, Brijesh Kumar Singh & Paul Michael Yen. (2021) Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue. iScience 24:5, pages 102434.
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Bulbul Ahmed, Rifat Sultana & Michael W. Greene. (2021) Adipose tissue and insulin resistance in obese. Biomedicine & Pharmacotherapy 137, pages 111315.
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Fengxing Li, Kai Zou & Ning Chen. 2021. Exercise, Autophagy and Chronic Diseases. Exercise, Autophagy and Chronic Diseases 81 101 .
Mercedes Clemente-Postigo, Alberto Tinahones, Rajaa El Bekay, María M. Malagón & Francisco J. Tinahones. (2020) The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health. Metabolites 10:5, pages 179.
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