Advanced search
Publication Cover
Autophagy Volume 16, 2020 - Issue 10
Submit an article Journal homepage
2,787
Views
26
CrossRef citations to date
0
Altmetric
Research Paper

The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target

Si-Tu XueInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Ke LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Yang GaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Lu-Yao ZhaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Yan GaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Hong YiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Jian-Dong JiangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
&
Zhuo-Rong LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 1823-1837 | Received 02 Nov 2018, Accepted 19 Dec 2019, Published online: 27 Jan 2020

Citations (26)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Ting Duan, Xin Yang, Jingyu Kuang, Wenjie Sun, Jin Li, Juan Ge, Mohan Zhang, Xiaobo Cai, Peilin Yu, Jun Yang & Xinqiang Zhu. (2023) ULK1 Depletion Protects Mice from Diethylnitrosamine-Induced Hepatocarcinogenesis by Promoting Apoptosis and Inhibiting Autophagy. Journal of Hepatocellular Carcinoma 10, pages 315-325.
Read now

Articles from other publishers (25)

Trinh Van Le, Nhung Hai Truong & Ai Xuan L. Holterman. (2023) Autophagy modulates physiologic and adaptive response in the liver. Liver Research.
Crossref
Thi Ha Nguyen, Tuan Minh Nguyen, Dinh Thi Minh Ngoc, Taesik You, Mi Kyung Park & Chang Hoon Lee. (2023) Unraveling the Janus-Faced Role of Autophagy in Hepatocellular Carcinoma: Implications for Therapeutic Interventions. International Journal of Molecular Sciences 24:22, pages 16255.
Crossref
Fanbo Jing, Xiao Li, Hui Jiang, Jialin Sun & Qie Guo. (2023) Combating drug resistance in hepatocellular carcinoma: No awareness today, no action tomorrow. Biomedicine & Pharmacotherapy 167, pages 115561.
Crossref
Yuankai Wu, Hayden Weng Siong Tan, Jin-Yi Lin, Han-Ming Shen, Haihe Wang & Guang Lu. (2023) Molecular mechanisms of autophagy and implications in liver diseases. Liver Research 7:1, pages 56-70.
Crossref
Ujjwala Karmacharya & Jong-Wha Jung. (2023) Small Molecule Inhibitors for Unc-51-like Autophagy-Activating Kinase Targeting Autophagy in Cancer. International Journal of Molecular Sciences 24:2, pages 953.
Crossref
Kun Fan, Kaihua Zhu, Jiwen Wang, Xiaojian Ni, Sheng Shen, Zijun Gong, Xi Cheng, Cheng Zhang, Han Liu, Tao Suo, Xiaoling Ni & Houbao Liu. (2022) Inhibition of 14-3-3ε by K50 acetylation activates YAP1 to promote cholangiocarcinoma growth. Experimental Cell Research 421:2, pages 113404.
Crossref
Sana Raza, Sangam Rajak, Jyotika Srivastava, Archana Tewari, Pratima Gupta, Bandana Chakravarti, Sujoy Ghosh, Chandra P. Chaturvedi & Rohit A. Sinha. (2022) ULK1 inhibition attenuates telomerase activity in hepatic cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:12, pages 119355.
Crossref
Ze Rong, Kaifeng Zheng, Jun Chen & Xiaofeng Jin. (2022) Function and regulation of ULK1: From physiology to pathology. Gene 840, pages 146772.
Crossref
Ling Zou, Minru Liao, Yongqi Zhen, Shiou Zhu, Xiya Chen, Jin Zhang, Yue Hao & Bo Liu. (2022) Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Acta Pharmaceutica Sinica B 12:10, pages 3743-3782.
Crossref
Wenjia Chen, Zhaochen Ma, Lingxiang Yu, Xia MAO, Nan Ma, Xiaodong Guo, Xiaoli Yin, Funeng Jiang, Qian Wang, Jigang Wang, Mingliang Fang, Na Lin & Yanqiong Zhang. (2022) Preclinical investigation of artesunate as a therapeutic agent for hepatocellular carcinoma via impairment of glucosylceramidase-mediated autophagic degradation. Experimental & Molecular Medicine 54:9, pages 1536-1548.
Crossref
Pil Soo Sung. (2022) Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma. Clinical and Molecular Hepatology 28:3, pages 333-350.
Crossref
Yang Gao, Ziying Zhou, Tingting Zhang, Situ Xue, Ke Li & Jiandong Jiang. (2022) Structure-Based Virtual Screening towards the Discovery of Novel ULK1 Inhibitors with Anti-HCC Activities. Molecules 27:9, pages 2627.
Crossref
Jiahong Yu, Liujing Qu, Yan Xia, Xuan Zhang, Jinqiu Feng, Mengyuan Duan, Pengli guo, Yaxin Lou, Ping Lv, Wenping Lu & Yingyu Chen. (2022) TMEM189 negatively regulates the stability of ULK1 protein and cell autophagy. Cell Death & Disease 13:4.
Crossref
Sangam Rajak, Sana Raza & Rohit Anthony Sinha. (2022) ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions. Frontiers in Cell and Developmental Biology 10.
Crossref
Rahul Kumar Vempati & Rama Rao Malla. 2022. Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 3. Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 3 63 80 .
Pengyun Zhang, Ningxia Gu, Lixin Song, Wei-Hsiang Chen, Pingfan Du, Xin Yin & Jie Xiong. (2021) Bifunctional green cellulose derivatives employed for high efficiency and stable perovskite solar cells under ambient environment. Journal of Alloys and Compounds 886, pages 161247.
Crossref
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane & Lionel Hebbard. (2021) Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. Biomedicines 9:11, pages 1639.
Crossref
Jeong-Su Park, Hwan Ma & Yoon-Seok Roh. (2021) Ubiquitin pathways regulate the pathogenesis of chronic liver disease. Biochemical Pharmacology 193, pages 114764.
Crossref
Xiaonan Qiu, Lin Zheng, Xiuting Liu, Dan Hong, Mintong He, Zengqi Tang, Cuicui Tian, Guozhen Tan, Sam Hwang, Zhenrui Shi & Liangchun Wang. (2021) ULK1 Inhibition as a Targeted Therapeutic Strategy for Psoriasis by Regulating Keratinocytes and Their Crosstalk With Neutrophils. Frontiers in Immunology 12.
Crossref
Dexi Zhou, Jiajie Luan, Cheng Huang & Jun Li. (2021) Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?. Gut and Liver 15:4, pages 500-516.
Crossref
Yafei Wu, Jigang Zhang & Qin Li. (2021) Autophagy, an accomplice or antagonist of drug resistance in HCC?. Cell Death & Disease 12:3.
Crossref
Siyu He, Yang Liu, Qihang Li, Weiping Lyu, Feng Feng, Qinglong Guo, Li Zhao & Haopeng Sun. (2021) In silico approaches using pharmacophore model combined with molecular docking for discovery of novel ULK1 inhibitors . Future Medicinal Chemistry 13:4, pages 341-361.
Crossref
Jianzhou Cui, Han-Ming Shen & Lina Hsiu Kim Lim. (2020) The Role of Autophagy in Liver Cancer: Crosstalk in Signaling Pathways and Potential Therapeutic Targets. Pharmaceuticals 13:12, pages 432.
Crossref
Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich & Ravi K. Amaravadi. (2020) PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma. JCI Insight 5:17.
Crossref
Yuehui Liang, Qi Liang, Liang Qiao & Fang Xiao. (2020) MicroRNAs Modulate Drug Resistance-Related Mechanisms in Hepatocellular Carcinoma. Frontiers in Oncology 10.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.