Search in:

Autophagy Volume 17, 2021 - Issue 10

Submit an article Journal homepage

Open access

9,961

Views

CrossRef citations to date

Altmetric

Research Paper- Translational

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2^R1441G mice

Huifang Liua Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaView further author information

Philip Wing-Lok Hoa Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China

https://orcid.org/0000-0001-7794-0146 View further author information

Chi-Ting Leunga Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaView further author information

Shirley Yin-Yu Panga Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaView further author information

Eunice Eun Seo Changa Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaView further author information

Zoe Yuen-Kiu Choia Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaView further author information

Michelle Hiu-Wai Kunga Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaView further author information

David Boyer Ramsdenb Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

https://orcid.org/0000-0002-0927-1304 View further author information

Shu-Leong Hoa Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, ChinaCorrespondence[email protected]
View further author information

show all

Pages 3196-3220 | Received 22 Apr 2020, Accepted 09 Nov 2020, Published online: 10 Dec 2020

Cite this article
https://doi.org/10.1080/15548627.2020.1850008
CrossMark

Full Article
Figures & data
References
Supplemental
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF View EPUB EPUB

Citations (26)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (26)

Wenqi Wang, Yidi Qu, Siyu Li, Jinyu Chu, Hongxin Yang, Lirong Teng & Di Wang. (2023) Neuroprotective effects of curculigoside against Alzheimer’s disease via regulation oxidative stress mediated mitochondrial dysfunction in L-Glu-exposed HT22 cells and APP/PS1 mice. Food Science and Human Wellness 12:4, pages 1265-1278.
Crossref

Yuanyuan Chen, Chuan Yang, Mi Zou, Dan Wang, Ruilin Sheng, Meng Zhan, Qi Chen, Wenqin Yang, Xiao Liu & Shijun Xu. (2023) Inhibiting mitochondrial inflammation through Drp1/ HK1 / NLRP3 pathway: A mechanism of alpinetin attenuated aging‐associated cognitive impairment . Phytotherapy Research 37:6, pages 2454-2471.
Crossref

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen, Xiao Chen, Yanhao Chen, Yu Chen, Yutian Chen, Zhiyang Chen, Jagadish K. Chhetri, Yingjie Ding, Junlin Feng, Jun Guo, Mengmeng Guo, Chuting He, Yujuan Jia, Haiping Jiang, Ying Jing, Dingfeng Li, Jiaming Li, Jingyi Li, Qinhao Liang, Rui Liang, Feng Liu, Xiaoqian Liu, Zuojun Liu, Oscar Junhong Luo, Jianwei Lv, Jingyi Ma, Kehang Mao, Jiawei Nie, Xinhua Qiao, Xinpei Sun, Xiaoqiang Tang, Jianfang Wang, Qiaoran Wang, Siyuan Wang, Xuan Wang, Yaning Wang, Yuhan Wang, Rimo Wu, Kai Xia, Fu-Hui Xiao, Lingyan Xu, Yingying Xu, Haoteng Yan, Liang Yang, Ruici Yang, Yuanxin Yang, Yilin Ying, Le Zhang, Weiwei Zhang, Wenwan Zhang, Xing Zhang, Zhuo Zhang, Min Zhou, Rui Zhou, Qingchen Zhu, Zhengmao Zhu, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Weimin Ci, Bi-Sen Ding, Qiurong Ding, Feng Gao, Jing-Dong J. Han, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Xin Li, Baohua Liu, Feng Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Jie Ren, Ruibao Ren, Moshi Song, Zhou Songyang, Yi Eve Sun, Yu Sun, Mei Tian, Shusen Wang, Si Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C. L. Wong, Andy Peng Xiang, Yichuan Xiao, Zhengwei Xie, Daichao Xu, Jing Ye, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Weiqi Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Dahai Zhu, Weiguo Zou, Gang Pei & Guang-Hui Liu. (2023) Biomarkers of aging. Science China Life Sciences 66:5, pages 893-1066.
Crossref

Wenjia Shi, Cheng Tan, Can Liu & Dan Chen. (2023) Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases. Reviews in the Neurosciences 34:3, pages 275-294.
Crossref

Junwei Tang, Wen Peng, Jiangzhou Ji, Chaofan Peng, Tuo Wang, Peng Yang, Ji'ou Gu, Yifei Feng, Kangpeng Jin, Xiaowei Wang & Yueming Sun. (2023) GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. Advanced Science 10:12.
Crossref

João D. Magalhães & Sandra Morais Cardoso. (2023) Mitochondrial signaling on innate immunity activation in Parkinson disease. Current Opinion in Neurobiology 78, pages 102664.
Crossref

Tatou Iseki, Yuzuru Imai & Nobutaka Hattori. (2023) Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?. Biomolecules 13:1, pages 178.
Crossref

Zhan Liu, Wenxin Zhuang, Meiyun Cai, E. Lv, Yanqiang Wang, Zhengyan Wu, Hongyu Wang & Wenyu Fu. (2022) Kaemperfol Protects Dopaminergic Neurons by Promoting mTOR-Mediated Autophagy in Parkinson’s Disease Models. Neurochemical Research.
Crossref

Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Edouard C. Nice, Canhua Huang & Li Fu. (2022) Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management. Journal of Hematology & Oncology 15:1.
Crossref

Chutian Zhang, Shiya Chen, Xiyu Li, Qian Xu, Yao Lin, Fan Lin, Mingzhou Yuan, Yong Zi & Jing Cai. (2022) Progress in Parkinson's disease animal models of genetic defects: Characteristics and application. Biomedicine & Pharmacotherapy 155, pages 113768.
Crossref

Megan M. Braun & Luigi Puglielli. (2022) Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseases. Frontiers in Cellular Neuroscience 16.
Crossref

Bin Xiao, Joshua Kuruvilla & Eng-King Tan. (2022) Mitophagy and reactive oxygen species interplay in Parkinson’s disease. npj Parkinson's Disease 8:1.
Crossref

Ailyn Irvita Ravinther, Hemaniswarri Dewi Dewadas, Shi Ruo Tong, Chai Nien Foo, Yu-En Lin, Cheng-Ting Chien & Yang Mooi Lim. (2022) Molecular Pathways Involved in LRRK2-Linked Parkinson’s Disease: A Systematic Review. International Journal of Molecular Sciences 23:19, pages 11744.
Crossref

Philip Wing-Lok Ho, Eunice Eun-Seo Chang, Chi-Ting Leung, Huifang Liu, Yasine Malki, Shirley Yin-Yu Pang, Zoe Yuen-Kiu Choi, Yingmin Liang, Weng Seng Lai, Yuefei Ruan, Kenneth Mei-Yee Leung, Susan Yung, Judith Choi-Wo Mak, Michelle Hiu-Wai Kung, David B. Ramsden & Shu-Leong Ho. (2022) Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects. npj Parkinson's Disease 8:1.
Crossref

Somnath Mazumder, Samik Bindu, Rudranil De, Subhashis Debsharma, Saikat Pramanik & Uday Bandyopadhyay. (2022) Emerging role of mitochondrial DAMPs, aberrant mitochondrial dynamics and anomalous mitophagy in gut mucosal pathogenesis. Life Sciences 305, pages 120753.
Crossref

Junsha An, Huali Fan, Mingyu Han, Cheng Peng, Jie Xie & Fu Peng. (2022) Exploring the mechanisms of neurotoxicity caused by fuzi using network pharmacology and molecular docking. Frontiers in Pharmacology 13.
Crossref

Cass Dedert, Vandana Mishra, Geetika Aggarwal, Andrew D. Nguyen & Fenglian Xu. (2022) Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress. Frontiers in Cellular Neuroscience 16.
Crossref

Maria Bilen, Sara Benhammouda, Ruth S Slack & Marc Germain. (2022) The integrated stress response as a key pathway downstream of mitochondrial dysfunction. Current Opinion in Physiology 27, pages 100555.
Crossref

Federica Albanese, Chiara Domenicale, Mattia Volta & Michele Morari. (2022) Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway. Biochemical Society Transactions 50:1, pages 621-632.
Crossref

Jing Lv, Ying Yi, Yan Qi, Chenchao Yan, Wenwen Jin, Liming Meng, Donghui Zhang & Wei Jiang. (2022) Mitochondrial homeostasis regulates definitive endoderm differentiation of human pluripotent stem cells. Cell Death Discovery 8:1.
Crossref

Guang-Hui Chen, Chang-Chun Song, Tao Zhao, Christer Hogstrand, Xiao-Lei Wei, Wu-Hong Lv, Yu-Feng Song & Zhi Luo. (2022) Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish. Environmental Science & Technology 56:4, pages 2407-2420.
Crossref

Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden & Shu-Leong Ho. (2022) LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease. Translational Neurodegeneration 11:1.
Crossref

Chenyang Duan, Lei Kuang, Chen Hong, Xinming Xiang, Jiancang Liu, Qinghui Li, Xiaoyong Peng, Yuanqun Zhou, Hongchen Wang, Liangming Liu & Tao Li. (2021) Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2. Cell Death & Disease 12:11.
Crossref

Katharina E. Rosenbusch, Asmaa Oun, Oana Sanislav, Sui T. Lay, Ineke Keizer-Gunnink, Sarah J. Annesley, Paul R. Fisher, Amalia M. Dolga & Arjan Kortholt. (2021) A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity. Frontiers in Cell and Developmental Biology 9.
Crossref

Cheng-long Zhu, Ren-qi Yao, Lu-xi Li, Peng Li, Jian Xie, Jia-feng Wang & Xiao-ming Deng. (2021) Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review. Frontiers in Cell and Developmental Biology 9.
Crossref

Yue Wang, Zhihua Han, Zuojun Xu & Junfeng Zhang. (2021) Protective Effect of Optic Atrophy 1 on Cardiomyocyte Oxidative Stress: Roles of Mitophagy, Mitochondrial Fission, and MAPK/ERK Signaling. Oxidative Medicine and Cellular Longevity 2021, pages 1-15.
Crossref

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2^R1441G mice

Articles from other publishers (26)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice

Citations (26)

Articles from other publishers (26)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2^R1441G mice