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Autophagy Volume 17, 2021 - Issue 10
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Research Paper

A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation

Bat-Chen Tamim-Yecheskela Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelView further author information
,
Milana Fraiberga Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelView further author information
,
Kamilya Kokabia Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelView further author information
,
Saskia Freuda Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Oren Shatza Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Letizia Marvaldia Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelORCID Iconhttps://orcid.org/0000-0002-2021-3949View further author information
ORCID Icon,
Nemanja Subica Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Ori Brennerb Veterinary Recourses, The Weizmann Institute of Science, Rehovot, IsraelORCID Iconhttps://orcid.org/0000-0001-8221-7278View further author information
ORCID Icon,
Michael Tsooryb Veterinary Recourses, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Raya Eilam-Altstadterb Veterinary Recourses, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Inbal Bitonb Veterinary Recourses, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Alon Savidorc Chemical Research Support, The Weizmann Institute of Science, Rehovot, IsraelORCID Iconhttps://orcid.org/0000-0001-8884-6948View further author information
ORCID Icon,
Nili Dezorellad Irving and Cherna Moskowitz Center for Nano and Bio-Nano Imaging, The Weizmann Institute of Science, Rehovot, IsraelView further author information
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Gali Heimere Department of Pediatric Neurology Unit, Edmond and Lilly Safra Children Hospital, Chaim Sheba Medical Center, Ramat Gan, Israel;f Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelView further author information
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Christian Behrendsg Munich Cluster for Systems Neurology (Synergy), Ludwig-Maximilians-Universität München, München, GermanyORCID Iconhttps://orcid.org/0000-0002-9184-7607View further author information
ORCID Icon,
Bruria Ben-Zeeve Department of Pediatric Neurology Unit, Edmond and Lilly Safra Children Hospital, Chaim Sheba Medical Center, Ramat Gan, Israel;f Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelView further author information
&
Zvulun Elazara Departments of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, IsraelCorrespondence[email protected]
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Pages 3082-3095 | Received 09 Jun 2020, Accepted 13 Nov 2020, Published online: 10 Dec 2020

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Hye Ran Kim, Hye Jin Lee, Yewon Jeon, So Young Jang, Yoon Kyoung Shin, Jean Ho Yun, Hye Ji Park, Hyongjong Koh, Kyung Eun Lee, Jung Eun Shin & Hwan Tae Park. (2023) Targeting SARM1 improves autophagic stress-induced axonal neuropathy. Autophagy 0:0, pages 1-16.
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Xiaohui Ma, Yangkai Liu, Luyang Sun, Quratulain Hanif, Kaixing Qu, Jianyong Liu, Jicai Zhang, Bizhi Huang & Chuzhao Lei. (2023) A novel SNP of TECPR2 gene associated with heat tolerance in Chinese cattle. Animal Biotechnology 34:4, pages 1050-1057.
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Milana Fraiberg, Bat-Chen Tamim-Yecheskel, Kamilya Kokabi, Nemanja Subic, Gali Heimer, Franziska Eck, Karsten Nalbach, Christian Behrends, Bruria Ben-Zeev, Oren Shatz & Zvulun Elazar. (2021) Lysosomal targeting of autophagosomes by the TECPR domain of TECPR2. Autophagy 17:10, pages 3096-3108.
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Articles from other publishers (13)

Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar & Christian Behrends. (2023) Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. Nature Communications 14:1.
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Yalin Guan, Hui Lu, Wenchao Zuo, Xiaodan Wang, Shimin Wang, Xinping Wang, Feng Liu, Kun Jia, Rui Gao, Hao Wu, Zhihong Shi & Yong Ji. (2022) Novel detection of mutation in the TECPR2 gene in a Chinese hereditary spastic paraplegia 49 patient: a case report. BMC Neurology 22:1.
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Jerrold M. Ward, Peter Vogel & John P. Sundberg. (2022) Brain and spinal cord lesions in 28 inbred strains of aging mice. Veterinary Pathology 59:6, pages 1047-1055.
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Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati & Angelo Poletti. (2022) The role of autophagy-lysosomal pathway in motor neuron diseases. Biochemical Society Transactions 50:5, pages 1489-1503.
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Ido Shalev, Judith Somekh & Alal Eran. (2022) Multimodal bioinformatic analyses of the neurodegenerative disease-associated TECPR2 gene reveal its diverse roles . Journal of Medical Genetics 59:10, pages 1002-1009.
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Luis A. Williams, David J. Gerber, Amy Elder, Wei Chou Tseng, Valeriya Baru, Nathaniel Delaney-Busch, Christina Ambrosi, Gauri Mahimkar, Vaibhav Joshi, Himali Shah, Karthiayani Harikrishnan, Hansini Upadhyay, Sakthi H. Rajendran, Aishwarya Dhandapani, Joshua Meier, Steven J. Ryan, Caitlin Lewarch, Lauren Black, Julie Douville, Stefania Cinquino, Helen Legakis, Karsten Nalbach, Christian Behrends, Ai Sato, Lorenzo Galluzzi, Timothy W. Yu, Duncan Brown, Sudhir Agrawal, David Margulies, Alan Kopin & Graham T. Dempsey. (2022) Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models. Molecular Therapy - Nucleic Acids 29, pages 189-203.
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Marco Cascella, Maria Rosaria Muzio, Federica Monaco, Davide Nocerino, Alessandro Ottaiano, Francesco Perri & Massimo Antonio Innamorato. (2022) Pathophysiology of Nociception and Rare Genetic Disorders with Increased Pain Threshold or Pain Insensitivity. Pathophysiology 29:3, pages 435-452.
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Annette Lischka, Petra Lassuthova, Arman Çakar, Christopher J. Record, Jonas Van Lent, Jonathan Baets, Maike F. Dohrn, Jan Senderek, Angelika Lampert, David L. Bennett, John N. Wood, Vincent Timmerman, Thorsten Hornemann, Michaela Auer-Grumbach, Yesim Parman, Christian A. Hübner, Miriam Elbracht, Katja Eggermann, C. Geoffrey Woods, James J. Cox, Mary M. Reilly & Ingo Kurth. (2022) Genetic pain loss disorders. Nature Reviews Disease Primers 8:1.
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Keri Ramsey, Newell Belnap, Anna Bonfitto, Wayne Jepsen, Marcus Naymik, Meredith Sanchez‐Castillo, David W. Craig, Szabolcs Szelinger, Matthew J. Huentelman, Vinodh Narayanan & Sampath Rangasamy. (2022) Progressive cerebellar atrophy caused by heterozygous TECPR2 mutations . Molecular Genetics & Genomic Medicine 10:2.
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Daniel J Klionsky, Giulia Petroni, Ravi K Amaravadi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo‐San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M K Choi, Mary E Choi, Charleen T Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva‐Liisa Eskelinen, Gian Maria Fimia, David A Gewirtz, Douglas R Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T Ktistakis, Sharad Kumar, Carlos Lopez‐Otin, Kay F Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef M Penninger, Rushika M Perera, Mauro Piacentini, Fulvio Reggiori, David C Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans‐Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi & Federico Pietrocola. (2021) Autophagy in major human diseases. The EMBO Journal 40:19.
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Liriopé Toupenet Marchesi, Marion Leblanc & Giovanni Stevanin. (2021) Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia. Cells 10:7, pages 1678.
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Masoud Edizadeh, Negar Chegeninejad, Soheila Akbari, Maryam Salehirad, Rezvan Pakmanesh, Shokoufeh Ahmadipour, Kourosh Hayatigolkhatmi & Hamidreza Khodadadi. (2021) Two novel biallelic variants in TECPR2 and FA2H genes causing complicated hereditary spastic paraplegia in Iranian families from Lur ethnicity: Case series . Clinical Case Reports 9:6.
Crossref
Karsten Nalbach, Martina Schifferer, Stefan Lichtenthaler, Zvulun Elazar & Christian Behrends. (2022) Spatial Proteomics Reveals Disturbances in Trafficking and Interactions Along the Secretory Pathway Upon Loss of Neuropathy-Associated TECPR2. SSRN Electronic Journal.
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