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Autophagy Volume 17, 2021 - Issue 11
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Research Paper

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

Nina Meyera Experimental Neurosurgery, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
,
Lisa Henkela Experimental Neurosurgery, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
,
Benedikt Lindera Experimental Neurosurgery, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
,
Svenja Zielkeb Experimental Cancer Research in Pediatrics, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
,
Georg Tascherc Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
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Sandra Trautmannd Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
,
Gerd Geisslingerd Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
,
Christian Münchc Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyORCID Iconhttps://orcid.org/0000-0003-3832-090XView further author information
ORCID Icon,
Simone Fuldab Experimental Cancer Research in Pediatrics, Goethe University Hospital Frankfurt/Main, Frankfurt, Germany;e German Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt, GermanyView further author information
,
Irmgard Tegederd Institute of Clinical Pharmacology, Goethe University Hospital Frankfurt/Main, Frankfurt, GermanyView further author information
&
Donat Kögela Experimental Neurosurgery, Goethe University Hospital Frankfurt/Main, Frankfurt, Germany;e German Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt, GermanyCorrespondence[email protected]
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Pages 3424-3443 | Received 27 Aug 2019, Accepted 06 Jan 2021, Published online: 19 Jan 2021

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Wenjie Sun, Junqiang Yan, Hongxia Ma, Jiannan Wu & Yongjiang Zhang. (2022) Autophagy-Dependent Ferroptosis-Related Signature is Closely Associated with the Prognosis and Tumor Immune Escape of Patients with Glioma. International Journal of General Medicine 15, pages 253-270.
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Articles from other publishers (27)

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Matthew J. Sydor, Rebekah L. Kendall & Andrij Holian. (2023) Cholesterol content regulates silica-induced lysosomal membrane permeability. Frontiers in Toxicology 5.
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Harshit Shah, Metodi Stankov, Diana Panayotova-Dimitrova, Amir Yazdi, Ramachandramouli Budida, Jan-Henning Klusmann & Georg M. N. Behrens. (2023) Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death. Frontiers in Oncology 13.
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Meng Zhang, Qian Lei, Xiaobo Huang & Yi Wang. (2022) Molecular mechanisms of ferroptosis and the potential therapeutic targets of ferroptosis signaling pathways for glioblastoma. Frontiers in Pharmacology 13.
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Haksoo Lee, Dahye Kim & BuHyun Youn. (2022) Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment. International Journal of Molecular Sciences 23:22, pages 13818.
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James S. Brown. (2022) Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer. Neuroscience & Biobehavioral Reviews 141, pages 104809.
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Adonis Sfera, Sabine Hazan, Jonathan J. Anton, Dan O. Sfera, Christina V. Andronescu, Sarvin Sasannia, Leah Rahman & Zisis Kozlakidis. (2022) Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics. Frontiers in Pharmacology 13.
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Hao Liu, Wenling Zhou, Lan Guo, Heng Zhang, Lingling Guan, Xu Yan, Yuanyuan Zhai, Yuan Qiao, Zai Wang, Junhua Zhao, Kangbo Lyu, Ping Li, Haitao Wang & Liang Peng. (2022) Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux. The Journal of Nutritional Biochemistry 107, pages 109060.
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Debasna Pritimanjari Panigrahi, Srimanta Patra, Bishnu Prasad Behera, Pradyota Kumar Behera, Shankargouda Patil, Birija Sankar Patro, Laxmidhar Rout, Itisam Sarangi & Sujit Kumar Bhutia. (2022) MTP18 inhibition triggers mitochondrial hyperfusion to induce apoptosis through ROS-mediated lysosomal membrane permeabilization-dependent pathway in oral cancer. Free Radical Biology and Medicine 190, pages 307-319.
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Guang Lu, Yu Wang, Yin Shi, Zhe Zhang, Canhua Huang, Weifeng He, Chuang Wang & Han‐Ming Shen. (2022) Autophagy in health and disease: From molecular mechanisms to therapeutic target. MedComm 3:3.
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Jiahui Fu, Lifeng Wu, Gaoyong Hu, Qiqi Shi, Ruodi Wang, Lingjuan Zhu, Haiyang Yu & Leilei Fu. (2022) AMTDB: A comprehensive database of autophagic modulators for anti-tumor drug discovery. Frontiers in Pharmacology 13.
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Shiyu Liu, Lihua Dong, Weiyan Shi, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Ying Xin & Xin Jiang. (2022) Potential targets and treatments affect oxidative stress in gliomas: An overview of molecular mechanisms. Frontiers in Pharmacology 13.
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Kaikai Wang, Junjie Wang, Jiahao Zhang, Anke Zhang, Yibo Liu, Jingyi Zhou, Xiaoyu Wang & Jianmin Zhang. (2022) Ferroptosis in Glioma Immune Microenvironment: Opportunity and Challenge. Frontiers in Oncology 12.
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Jiao Li, Peng Qu, Xing-Zhi Zhou, Yun-Xia Ji, Shuo Yuan, Shuang-Ping Liu & Qing-Gao Zhang. (2022) Pimozide inhibits the growth of breast cancer cells by alleviating the Warburg effect through the P53 signaling pathway. Biomedicine & Pharmacotherapy 150, pages 113063.
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Guiyun Zhang, Ping Zheng, Yisong Lv, Zhonghua Shi & Fei Shi. (2022) m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction. Frontiers in Genetics 13.
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Janina Remy, Benedikt Linder, Ulrike Weirauch, Bryan W. Day, Brett W. Stringer, Christel Herold-Mende, Achim Aigner, Knut Krohn & Donat Kögel. (2022) STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Cancers 14:2, pages 339.
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Martina L. Hernandez, Michael Marone, Karen M. Gorse & Audrey D. Lafrenaye. (2022) Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats. ASN Neuro 14, pages 175909142210991.
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