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Clinical Toxicology Volume 55, 2017 - Issue 2
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Review

What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning?

Betty S. ChanClinical Toxicology Unit & Emergency Department, Prince of Wales Hospital, Sydney, Australia; ;New South Wales Poisons Information Centre, Sydney, Australia; Correspondence[email protected]
,
Andrew H. DawsonNew South Wales Poisons Information Centre, Sydney, Australia; ;Drug Health, Royal Prince Alfred Hospital, Sydney, Australia;
&
Nicholas A. BuckleyNew South Wales Poisons Information Centre, Sydney, Australia; ;Clinical Pharmacology Department, University of Sydney, Sydney, Australia
Pages 88-96 | Received 15 Jul 2016, Accepted 05 Dec 2016, Published online: 13 Jan 2017

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Emma Davey & Geoffrey K. Isbister. (2023) Repeated daily dosing of weekly methotrexate therapy causing multiorgan toxicity: a case report. Toxicology Communications 7:1.
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Katherine Z. Isoardi, Keith Harris, Kate E. Carmichael, Goce Dimeski, Betty S. H. Chan & Colin B. Page. (2018) Acute bone marrow suppression and gastrointestinal toxicity following acute oral methotrexate overdose. Clinical Toxicology 56:12, pages 1204-1206.
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Hannah Hays, Michael C. Beuhler & Henry A. Spiller. (2018) Adverse outcomes after single acute methotrexate exposures in pediatric patients are rare. Clinical Toxicology 56:9, pages 870-871.
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Hannah Hays, Michael C. Beuhler, Henry A. Spiller, Julie Weber, James B. Mowry, Mark L. Ryan, Natalie E. Spiller & Ashley Webb. (2018) Evaluation of toxicity after acute accidental methotrexate ingestions in children under 6 years old: a 16-year multi-center review. Clinical Toxicology 56:2, pages 120-125.
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Betty S. Chan, Andrew H. Dawson & Nicholas A. Buckley. (2017) Response to the letter regarding “Is it really safe to withhold folinic acid when less than 1000 mg/m2 methotrexate is ingested?”. Clinical Toxicology 55:9, pages 1020-1020.
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Arjen Koppen, Marieke A. Dijkman, Claudine C. Hunault, Dylan W. de Lange & Irma de Vries. (2017) Is it really safe to withhold folinic acid when less than 1000 mg/m2 methotrexate is ingested?. Clinical Toxicology 55:9, pages 1018-1018.
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Katherine A. Janeway, Luis Gros, Stefan Schwartz, Claire Daugherty, Eva Gallardo, Christon Hill, Emma Thomas, Suzanne Ward & Carmelo Rizzari. (2023) A pooled subgroup analysis of glucarpidase treatment in 86 pediatric, adolescent, and young adult patients receiving high‐dose methotrexate therapy in open‐label trials. Pediatric Blood & Cancer 70:9.
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Chen Fu, Lifeng Yu, Yuxi Miao, Xinli Liu, Zhaojin Yu & Minjie Wei. (2023) Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?. Acta Pharmaceutica Sinica B 13:2, pages 498-516.
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Sam Ontiveros, Brenna Hogue, Allyson Kreshak, Christopher Coyne, Lee Cantrell & Alicia Minns. (2023) Oral Chemotherapeutic Ingestions Reported to a Poison Control Center Treated in a Health Care Facility. American Journal of Therapeutics Publish Ahead of Print.
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Mahdi H Alsugoor. (2022) Availability of Antidotes for Management of Acute Toxicity Cases at Emergency Departments in Qassim Hospitals: A Retrospective Study. Cureus.
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Maria Manuel Silva, Carla Campinho Ferreira, Maria Afonso Garcia & Edite Pereira. (2022) Methotrexate Pneumonitis After a Low-Dose Medication Error: A Case Report. Cureus.
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Azzurra Schicchi, Giulia Scaravaggi, Valeria M. Petrolini, Alberto Malovini, Davide Lonati, Marta Crevani, Eleonora Buscaglia & Carlo A. Locatelli. (2020) Poisoning related to therapeutic error in prolonged low‐dose methotrexate treatment. British Journal of Clinical Pharmacology 87:5, pages 2385-2391.
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Rachael Westover, Andrew F. Micciche, Carin King Malley & Anthony F. Pizon. (2020) A Rational, Evidence-Based Approach to Methotrexate Poisoning. Current Emergency and Hospital Medicine Reports 8:4, pages 160-167.
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Arman Ahmadzadeh, Nasim Zamani, Hossein Hassanian-Moghaddam, Seyed Kaveh Hadeiy & Parinaz Parhizgar. (2019) Acute versus chronic methotrexate poisoning; a cross-sectional study. BMC Pharmacology and Toxicology 20:1.
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Ashok Kumar Pannu. (2019) Methotrexate overdose in clinical practice. Current Drug Metabolism 20:9, pages 714-719.
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Thierry Vial, Anne Marie Patat, David Boels, Delphine Castellan, Antoine Villa, Hélène Theophile, Romain Torrents & Behrouz Kassai. (2019) Risque des erreurs médicamenteuses liées au méthotrexate à faible dose : données des centres antipoison et de pharmacovigilance français. Revue du Rhumatisme 86:5, pages 471-475.
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Lisa J. Herrinton, Tiffany S. Woodworth, Efe Eworuke, Laura B. Amsden, Liyan Liu, Jo Wyeth, Andrew Petrone, Talia J. Menzin, James Williams, Robert Goldfien & Michael Nguyen. (2019) Development of an algorithm to detect methotrexate wrong frequency error using computerized health care data. Pharmacoepidemiology and Drug Safety 28:10, pages 1361-1368.
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Sophie Lalevée, Bénédicte Lebrun-Vignes, Corinne Simon, Delphine Laugier & Laurence Fardet. (2019) Cytopenia induced by low-dose methotrexate: An analysis of 433 cases from the French pharmacovigilance database. European Journal of Internal Medicine 67, pages 97-101.
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Dong-Dong Zhang, Jing-Min Liu, Shi-Ming Sun, Chang Liu, Guo-Zhen Fang & Shuo Wang. (2019) Construction of Persistent Luminescence-Plastic Antibody Hybrid Nanoprobe for In Vivo Recognition and Clearance of Pesticide Using Background-Free Nanobioimaging. Journal of Agricultural and Food Chemistry 67:24, pages 6874-6883.
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Thierry Vial, Anne Marie Patat, David Boels, Delphine Castellan, Antoine Villa, Hélène Theophile, Romain Torrents & Behrouz Kassai. (2019) Adverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers. Joint Bone Spine 86:3, pages 351-355.
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Rais Vohra, Stacy Sawtelle Vohra, Andrew Grock & Jessica Mason. (2018) Working Through the Paradox of Methotrexate Toxicity. Annals of Emergency Medicine 72:2, pages 129-132.
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