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Clinical Toxicology Volume 55, 2017 - Issue 5
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Clinical Research

Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose

Anselm WongVictorian Poisons Information Centre and Austin Toxicology Service, Heidelberg, Australia; ;School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia; Correspondence[email protected]
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,
Marco L. A. SivilottiDepartments of Emergency Medicine and of Biomedical & Molecular Sciences, Queen’s University, Kingston, Canada; View further author information
&
Andis GraudinsSchool of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia; ;Emergency Medicine and Toxicology Research, Monash Health, Victoria, AustraliaView further author information
Pages 346-351 | Received 08 Dec 2016, Accepted 29 Jan 2017, Published online: 15 Feb 2017

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Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Chun En Yau, Haoyang Chen, Bryant Po-Yuen Lim, Mingwei Ng, R. Ponampalam, Daniel Yan Zheng Lim, Yip Han Chin & Andrew Fu Wah Ho. (2023) Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis. Clinical Toxicology 61:1, pages 1-11.
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Yu Kwan Li, Ka Fung Lam, Cheung Lun William Wong & Anselm Wong. (2020) In vitro study of pharmacobezoar formation in simulated acetaminophen overdose. Clinical Toxicology 58:9, pages 900-906.
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Yvonne Gloor, Domitille Schvartz & Caroline F.Samer. (2019) Old problem, new solutions: biomarker discovery for acetaminophen liver toxicity. Expert Opinion on Drug Metabolism & Toxicology 15:8, pages 659-669.
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Harry Egan, Geoffrey K. Isbister, Jennifer Robinson, Michael Downes, Betty S. Chan, Elia Vecellio & Angela L. Chiew. (2019) Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol. Clinical Toxicology 57:8, pages 703-711.
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Anselm Wong, Marco L. A. Sivilotti, Naren Gunja, Richard McNulty & Andis Graudins. (2018) Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen. Clinical Toxicology 56:3, pages 182-188.
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Articles from other publishers (8)

Nataliya Khomin, Taras Hroshovyi, Marjana Vasenda & Yuliya Plaskonis. (2023) Justification of the choice of excipients for obtaining tablets based on thiotriazoline and paracetamol. Ukrainian Scientific Medical Youth Journal 139:2, pages 121-127.
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Ari B. Filip & Michael E. Mullins. (2022) Fomepizole should be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 594-598.
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Iwona Popiolek & Grzegorz Porebski. 2022. Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics. Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics 309 317 .
Iwona Popiolek, Piotr Hydzik, Pawel Jagielski, Monika Zrodlowska, Karol Mystek & Grzegorz Porebski. (2021) Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults. Medicina 57:8, pages 752.
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Mark Real, Michele S. Barnhill, Cory Higley, Jessica Rosenberg & James H. Lewis. (2018) Drug-Induced Liver Injury: Highlights of the Recent Literature. Drug Safety 42:3, pages 365-387.
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Anselm Wong, Richard McNulty, David Taylor, Marco Sivilotti, Shaun Greene, Naren Gunja, Zeff Koutsogiannis & Andis Graudins. (2019) The NACSTOP Trial: A Multicenter, Cluster‐Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose. Hepatology 69:2, pages 774-784.
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Anselm Wong, Cornelia Landersdorfer & Andis Graudins. (2017) Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. European Journal of Clinical Pharmacology 73:9, pages 1103-1110.
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. (2017) Paracetamol overdose. Reactions Weekly 1653:1, pages 252-252.
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