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Review

Risk prediction of hepatotoxicity in paracetamol poisoning

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Pages 879-892 | Received 27 Oct 2016, Accepted 04 Apr 2017, Published online: 27 Apr 2017

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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Charlotte Uggerhøj Andersen, Steffen Hansen, Kim Peder Dalhoff, Lars Peter Nielsen, Jørn Munkhof Møller & Anne Estrup Olesen. (2023) Clinical characteristics of hospitalized patients with paracetamol poisoning before and after restrictions of over-the-counter sale of paracetamol. Clinical Toxicology 61:4, pages 228-233.
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D. Nicholas Bateman, James W. Dear, Michael Eddleston & J. Allister Vale. (2022) Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:5, pages 666-667.
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Brandon J. Sonn, Kennon J. Heard, Susan M. Heard, Angelo D’Alessandro, Kate M. Reynolds, Richard C. Dart, Barry H. Rumack & Andrew A. Monte. (2022) Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen. Clinical Toxicology 60:2, pages 221-230.
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Anselm Wong, Natalie Homer, James W. Dear, Kay Weng Choy, James Doery & Andis Graudins. (2019) Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion. Clinical Toxicology 57:5, pages 312-317.
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Anselm Wong, Naren Gunja, Richard McNulty & Andis Graudins. (2018) Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol. Clinical Toxicology 56:3, pages 199-203.
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Anselm Wong, Marco L. A. Sivilotti, Naren Gunja, Richard McNulty & Andis Graudins. (2018) Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen. Clinical Toxicology 56:3, pages 182-188.
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Francisco J. Enguita, Sofia Pereira & Ana Lúcia Leitão. (2023) Transcriptomic Analysis of Acetaminophen Biodegradation by Penicillium chrysogenum var. halophenolicum and Insights into Energy and Stress Response Pathways. Journal of Fungi 9:4, pages 408.
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Liesbeth Geelen, Koen Verbeke, Jietse Ryckeboer, Rogier Nieuwendijk & Peter Rogiers. (2019) Survival After Methemoglobinemia Associated with Massive Paracetamol Ingestion: A Case Report and Review of the Literature. Annals of Anesthesiology and Critical Care In Press:In Press.
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Anselm Wong, Richard McNulty, David Taylor, Marco Sivilotti, Shaun Greene, Naren Gunja, Zeff Koutsogiannis & Andis Graudins. (2019) The NACSTOP Trial: A Multicenter, Cluster‐Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose. Hepatology 69:2, pages 774-784.
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C. Gade, K. Dalhoff, T. S. Petersen, T. Riis, C. Schmeltz, E. Chabanova, H. R. Christensen, G. Mikus, J. Burhenne, J. C. Holm & H. Holst. (2018) Higher chlorzoxazone clearance in obese children compared with nonobese peers. British Journal of Clinical Pharmacology 84:8, pages 1738-1747.
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Ka Wu, Jinlian Fan, Xiaoying Huang, Xinmou Wu & Chao Guo. (2018) Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice. International Journal of Biological Macromolecules 114, pages 137-142.
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H. Willem, D. Castanares-Zapatero, V. Dinant, P.-F. Laterre & P. Hantson. (2018) Intoxication accidentelle ou volontaire au paracétamol traitée tardivement : devenir des patients admis en réanimation. Toxicologie Analytique et Clinique 30:2, pages S25.
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Anselm Wong, Cornelia B. Landersdorfer & Andis Graudins. (2017) In reply. European Journal of Clinical Pharmacology 74:2, pages 253-253.
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