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Poison Centre Research

The standard treatment protocol for paracetamol poisoning may be inadequate following overdose with modified release formulation: a pharmacokinetic and clinical analysis of 53 cases

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Pages 63-68 | Received 22 Feb 2017, Accepted 31 May 2017, Published online: 23 Jun 2017

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Slobodan M. Janković. (2022) Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. Expert Opinion on Drug Metabolism & Toxicology 18:11, pages 745-753.
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Daniel A. Spyker, Richard C. Dart, Luke Yip, Kate Reynolds, Scott Brittain & Mark Yarema. (2022) Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations. Clinical Toxicology 60:10, pages 1113-1121.
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Jingyun Li, Angela L. Chiew, Geoffrey K. Isbister & Stephen B. Duffull. (2022) Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. Clinical Toxicology 60:1, pages 25-32.
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Robert G. Hendrickson. (2019) What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?. Clinical Toxicology 57:8, pages 686-691.
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Lotte Christine Groth Hoegberg, Frank Refsgaard, Steen Hauge Pedersen, Mark Personne, Shahid Ullah, Georgios Panagiotidis, Tonny Studsgaard Petersen & Anita Annas. (2019) Potential pharmacobezoar formation of large size extended-release tablets and their dissolution – an in vitro study. Clinical Toxicology 57:4, pages 271-281.
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Angela L. Chiew, Geoffrey K. Isbister, Colin B. Page, Katharine A. Kirby, Betty S. H. Chan & Nicholas A. Buckley. (2018) Modified release paracetamol overdose: a prospective observational study (ATOM-3). Clinical Toxicology 56:9, pages 810-819.
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Articles from other publishers (11)

Richard C. Dart, Michael E. Mullins, Theresa Matoushek, Anne-Michelle Ruha, Michele M. Burns, Karen Simone, Michael C. Beuhler, Kennon J. Heard, Maryann Mazer-Amirshahi, Christine M. Stork, Shawn M. Varney, Alexandra R. Funk, Lee F. Cantrell, Jon B. Cole, William Banner, Andrew I. Stolbach, Robert G. Hendrickson, Scott N. Lucyk, Marco L. A. Sivilotti, Mark K. Su, Lewis S. Nelson & Barry H. Rumack. (2023) Management of Acetaminophen Poisoning in the US and Canada. JAMA Network Open 6:8, pages e2327739.
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Pavlína Nosková. (2023) Treatment of chronic pain-up to date. Medicína pro praxi 20:3, pages 171-178.
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Pavlína Nosková. (2022) New fixed combination of analgesics. Medicína pro praxi 19:2, pages 115-118.
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Avery Michienzi, Natasha Tobarran & Michelle A. Hieger. (2022) Extended Release Acetaminophen Overdose With Delayed Peak Concentrations. American Journal of Therapeutics 29:6, pages e655-e656.
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Angela L. Chiew & Nicholas A. Buckley. (2021) Acetaminophen Poisoning. Critical Care Clinics 37:3, pages 543-561.
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Pavlína Nosková. (2021) Fixed combination of paracetamol and tramadol in the practice: a case report. Neurologie pro praxi 22:1, pages 68-71.
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Emrah Akgun, Murat Boyacioglu & Sadiye Kum. (2021) The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats. Experimental Animals 70:1, pages 54-62.
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Scott McLachlan, Evangelia Kyrimi, Kudakwashe Dube, Graham Hitman, Jennifer Simmonds & Norman Fenton. (2020) Towards standardisation of evidence-based clinical care process specifications. Health Informatics Journal 26:4, pages 2512-2537.
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A. Min Kang, Angela Padilla-Jones, Erik S. Fisher, Jephte Y. Akakpo, Hartmut Jaeschke, Barry H. Rumack, Richard D. Gerkin & Steven C. Curry. (2019) The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers. Journal of Medical Toxicology 16:2, pages 169-176.
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Angela L Chiew, David Reith, Adam Pomerleau, Anselm Wong, Katherine Z Isoardi, Jessamine Soderstrom & Nicholas A Buckley. (2019) Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. Medical Journal of Australia 212:4, pages 175-183.
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Scott McLachlan, Evangelia Kyrimi, Kudakwashe Dube & Norman Fenton. 2020. Biomedical Engineering Systems and Technologies. Biomedical Engineering Systems and Technologies 429 452 .

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