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Clinical Toxicology Volume 56, 2018 - Issue 9
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Clinical Research

Modified release paracetamol overdose: a prospective observational study (ATOM-3)

Angela L. ChiewClinical Toxicology Unit/Emergency Department, Prince of Wales Hospital, Randwick, NSW, Australia; ;Department of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia; ;New South Wales Poisons Information Centre, The Children’s Hospital at Westmead, Westmead, NSW, Australia; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-0079-5056View further author information
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Geoffrey K. IsbisterNew South Wales Poisons Information Centre, The Children’s Hospital at Westmead, Westmead, NSW, Australia; ;Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Clinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia; View further author information
,
Colin B. PageClinical Toxicology Unit, Princess Alexandra Hospital, Brisbane, QLD, Australia; ;Queensland Poisons Information Centre, Lady Cilento Children's Hospital, South Brisbane, QLD, AustraliaView further author information
,
Katharine A. KirbyDepartment of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia; View further author information
,
Betty S. H. ChanClinical Toxicology Unit/Emergency Department, Prince of Wales Hospital, Randwick, NSW, Australia; ;New South Wales Poisons Information Centre, The Children’s Hospital at Westmead, Westmead, NSW, Australia; View further author information
&
Nicholas A. BuckleyDepartment of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia; ;New South Wales Poisons Information Centre, The Children’s Hospital at Westmead, Westmead, NSW, Australia; ORCID Iconhttp://orcid.org/0000-0002-6326-4711View further author information
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Pages 810-819 | Received 22 Nov 2017, Accepted 07 Feb 2018, Published online: 16 Feb 2018

Citations (16)

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Read on this site (8)

Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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A. L. Chiew & N. A. Buckley. (2023) Comment on: “population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations”. Clinical Toxicology 61:2, pages 139-140.
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Slobodan M. Janković. (2022) Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. Expert Opinion on Drug Metabolism & Toxicology 18:11, pages 745-753.
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Daniel A. Spyker, Richard C. Dart, Luke Yip, Kate Reynolds, Scott Brittain & Mark Yarema. (2022) Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations. Clinical Toxicology 60:10, pages 1113-1121.
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Jingyun Li, Angela L. Chiew, Geoffrey K. Isbister & Stephen B. Duffull. (2022) Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. Clinical Toxicology 60:1, pages 25-32.
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Lotte C. G. Hoegberg, Greene Shepherd, David M. Wood, Jami Johnson, Robert S. Hoffman, E. Martin Caravati, Wui Ling Chan, Silas W. Smith, Kent R. Olson & Sophie Gosselin. (2021) Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose. Clinical Toxicology 59:12, pages 1196-1227.
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Yu Kwan Li, Ka Fung Lam, Cheung Lun William Wong & Anselm Wong. (2020) In vitro study of pharmacobezoar formation in simulated acetaminophen overdose. Clinical Toxicology 58:9, pages 900-906.
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Articles from other publishers (8)

Angela L. Chiew, Geoffrey K. Isbister, Paul Stathakis, Katherine Z. Isoardi, Colin Page, Kirsty Ress, Betty S.H. Chan & Nicholas A. Buckley. (2023) Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose ( ATOM ‐7) . Clinical Pharmacology & Therapeutics 113:6, pages 1304-1314.
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A. Yu. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, V. V. Kulabuhov, N. Y. Stolbova & A. E. Klyuev. (2022) On the Treatment of Acute Poisoning With Paracetamol. Russian Sklifosovsky Journal "Emergency Medical Care" 11:2, pages 249-257.
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Angela L. Chiew & Nicholas A. Buckley. (2021) Acetaminophen Poisoning. Critical Care Clinics 37:3, pages 543-561.
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Angela L Chiew, Nicholas A Buckley, Andis Graudins & Venita L Munir. (2020) Review article: Up (to) date for Australian Toxicology and Toxinology guidelines. Emergency Medicine Australasia 33:1, pages 6-8.
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Angela L Chiew, David Reith, Adam Pomerleau, Anselm Wong, Katherine Z Isoardi, Jessamine Soderstrom & Nicholas A Buckley. (2019) Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. Medical Journal of Australia 212:4, pages 175-183.
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Andis Graudins & Anselm Wong. (2019) Paracetamol overdose: limiting the potential for harm. Medical Journal of Australia 211:5, pages 211-212.
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Rose Cairns, Jared A Brown, Claire E Wylie, Andrew H Dawson, Geoffrey K Isbister & Nicholas A Buckley. (2019) Paracetamol poisoning‐related hospital admissions and deaths in Australia, 2004–2017. Medical Journal of Australia 211:5, pages 218-223.
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. (2018) Multiple drugs. Reactions Weekly 1721:1, pages 194-194.
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