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Clinical Toxicology Volume 57, 2019 - Issue 3
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Clinical Research

Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk

Vincent R. LeeDepartment of Emergency Medicine, Morristown Medical Center, Morristown, NJ, USA; Correspondence[email protected]
,
Ariel VeraDepartment of Emergency Medicine, Morristown Medical Center, Morristown, NJ, USA;
,
Andreia AlexanderDepartment of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA;
,
Bruce RuckDepartment of Emergency Medicine, New Jersey Poison Information and Education System, Rutgers New Jersey Medical School, Newark, NJ, USA;
,
Lewis S. NelsonDepartment of Emergency Medicine, New Jersey Poison Information and Education System, Rutgers New Jersey Medical School, Newark, NJ, USA;
,
Paul WaxUT Southwestern Medical School, Dallas, TX, USA; ;American College of Medical Toxicology, Phoenix, AZ, USA;
,
Sharan CamplemanAmerican College of Medical Toxicology, Phoenix, AZ, USA;
,
Jeffrey BrentAmerican College of Medical Toxicology, Phoenix, AZ, USA; ;School of Medicine, University of Colorado, Aurora, CO, USA
&
Diane P. CalelloDepartment of Emergency Medicine, New Jersey Poison Information and Education System, Rutgers New Jersey Medical School, Newark, NJ, USA;
show all
Pages 175-180 | Received 17 May 2018, Accepted 06 Aug 2018, Published online: 26 Dec 2018

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Mohammad Algarni, Muhammad Abdul Hadi, Asma Yahyouche, Sajid Mahmood & Zahraa Jalal. (2021) A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults. Journal of Pharmaceutical Policy and Practice 14:1.
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William Eggleston, Robert Palmer, Pierre-André Dubé, Stephen Thornton, Andrew Stolbach, Diane P Calello & Jeanna M Marraffa. (2020) Loperamide toxicity: recommendations for patient monitoring and management. Clinical Toxicology 58:5, pages 355-359.
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Articles from other publishers (13)

Muna Barakat, Amal Akour, Diana Malaeb, Sarah Cherri, Wala’a Al.Safadi, Ala’a Al.Safadi & Mayyada Wazaify. (2023) Perspectives of and Experience toward the Abuse of Antidiarrheal Drug (Loperamide) among Community Pharmacists: A Cross-Sectional Study. International Journal of Environmental Research and Public Health 20:14, pages 6400.
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Bruna Cremonezi Lammoglia, Gabriela Hasselmann, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Fernando Sabia Tallo, Murched Omar Taha, Rildo Yamaguti Lima, Afonso Caricati-Neto & Francisco Sandro Menezes-Rodrigues. (2022) Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review. Journal of Cardiovascular Development and Disease 9:12, pages 431.
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K Aaron Geno, Adina Badea, Kara L Lynch, Paul Jannetto, Jacqueline A Hubbard, Robert D Nerenz & Mark A Cervinski. (2022) An Opioid Hiding in Plain Sight: Loperamide-Induced False-Positive Fentanyl and Buprenorphine Immunoassay Results. The Journal of Applied Laboratory Medicine 7:6, pages 1318-1328.
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Peter E. Wu & David N. Juurlink. (2022) Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management. Canadian Journal of Cardiology 38:9, pages 1378-1383.
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Ashley Mason, Gavin Lockard, Vance Cantrell, Snow Pinxue Li, Kirtan Patel, Sierra Klein, Andre Elder, Melissa Sur & Charles Preuss. 2022. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology 285 301 .
Cori A. Malinky, Craig W. Lindsley & Changho Han. (2021) DARK Classics in Chemical Neuroscience: Loperamide. ACS Chemical Neuroscience 12:16, pages 2964-2973.
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David Vearrier & Oliver Grundmann. (2021) Clinical Pharmacology, Toxicity, and Abuse Potential of Opioids. The Journal of Clinical Pharmacology 61:S2.
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Jerome De Vera, Hyungjin Ben Kim & Antoine E. Sakr. (2021) A Case Report of Loperamide-Induced Ventricular Storm. Journal of Investigative Medicine High Impact Case Reports 9, pages 232470962199076.
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F. Schifano, F. Napoletano, S. Chiappini, A. Guirguis, J. M. Corkery, S. Bonaccorso, A. Ricciardi, N. Scherbaum & A. Vento. (2019) New/emerging psychoactive substances and associated psychopathological consequences. Psychological Medicine 51:1, pages 30-42.
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Ryan Feldman & Erik Everton. (2020) National assessment of pharmacist awareness of loperamide abuse and ability to restrict sale if abuse is suspected. Journal of the American Pharmacists Association 60:6, pages 868-873.
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Feng Sheng & Michael C Milone. (2019) Commentary. Clinical Chemistry 65:11, pages 1361-1361.
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Monica R Hill, Mark R Hopkins & Claire E Knezevic. (2019) Emerging Toxidromes: A 25-Year-Old Woman with Syncope and ECG Changes. Clinical Chemistry 65:11, pages 1357-1360.
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. (2019) Loperamide. Reactions Weekly 1749:1, pages 242-242.
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