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Clinical Toxicology Volume 46, 2008 - Issue 2
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Case Report

Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction

Pat Audia Beth Israel Medical Center, Nephrology and Hypertension, New York, New York, USA
, M.D.,
Donald A. Feinfeld Beth Israel Medical Center, Nephrology and Hypertension, New York, New York, USA
, F.A.S.N. , M.D. , F.A.C.P,
Alan Dubrow Beth Israel Medical Center, Nephrology and Hypertension, New York, New York, USA
, M.D. &
James F. Winchester Beth Israel Medical Center, Nephrology and Hypertension, New York, New York, USA
, F.A.C.P. , M.D. , F.R.C.P. (Glas)
Pages 164-166 | Received 28 Dec 2006, Accepted 21 Mar 2007, Published online: 20 Jan 2009

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Claudiu T. Supuran. (2016) Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 423-431.
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Sadeem Alsubaie & Mussa H. Almalki. (2013) Metformin induced acute pancreatitis. Dermato-Endocrinology 5:2, pages 317-318.
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Articles from other publishers (25)

Myrem Jesame F Sarno, Dan Philip F Hernandez & Melgar O Matulac. (2023) "Normal but Catastrophic” Euglycemic Diabetic Ketoacidosis Precipitated by Sodium-Glucose Cotransporter-2 Inhibitor Use: A Case Report. Cureus.
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Jennifer L. Wilson, Ethan Steinberg, Rebecca Racz, Russ B. Altman, Nigam Shah & Kevin Grimes. (2022) A network paradigm predicts drug synergistic effects using downstream protein–protein interactions. CPT: Pharmacometrics & Systems Pharmacology 11:11, pages 1527-1538.
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Sheikh S. Abdullah, Neda Rostamzadeh, Kamran Sedig, Daniel J. Lizotte, Amit X. Garg & Eric McArthur. (2020) Machine Learning for Identifying Medication-Associated Acute Kidney Injury. Informatics 7:2, pages 18.
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Isabelle H. S. Kuan, Ruth L. Savage, Stephen B. Duffull, Robert J. Walker & Daniel F. B. Wright. (2019) The Association between Metformin Therapy and Lactic Acidosis. Drug Safety 42:12, pages 1449-1469.
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Nopporn Thangthaeng, Margaret Rutledge, Jessica M. Wong, Philip H. Vann, Michael J. Forster & Nathalie Sumien. (2017) Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice. Aging and Disease 8:1, pages 17.
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Ryan M. Rivosecchi, John A. Kellum, Joseph F. Dasta, Michael J. Armahizer, Scott Bolesta, Mitchell S. Buckley, Amy L. Dzierba, Erin N. Frazee, Heather J. Johnson, Catherine Kim, Raghavan Murugan, Pamela L. Smithburger, Adrian Wong & Sandra L. Kane Gill. (2016) Drug Class Combination–Associated Acute Kidney Injury. Annals of Pharmacotherapy 50:11, pages 953-972.
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Chieh-Hua Lu, Yi-Jen Hung & Po-Shiuan Hsieh. (2016) Additional effect of metformin and celecoxib against lipid dysregulation and adipose tissue inflammation in high-fat fed rats with insulin resistance and fatty liver. European Journal of Pharmacology 789, pages 60-67.
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Diane P. Calello, Kathleen D. Liu, Timothy J. Wiegand, Darren M. Roberts, Valéry Lavergne, Sophie Gosselin, Robert S. Hoffman, Thomas D. Nolin & Marc Ghannoum. (2015) Extracorporeal Treatment for Metformin Poisoning. Critical Care Medicine 43:8, pages 1716-1730.
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Amy Quynh Trang Pham, Li Hao Richie Xu & Orson W. Moe. (2015) Drug-Induced Metabolic Acidosis. F1000Research 4, pages 1460.
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C. B. Giorda, E. Nada, B. Tartaglino, L. Marafetti & R. Gnavi. (2014) A systematic review of acute pancreatitis as an adverse event of type 2 diabetes drugs: from hard facts to a balanced position. Diabetes, Obesity and Metabolism 16:11, pages 1041-1047.
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Juan Villa, Alejandra Cano, David Franco, Mauricio Monsalve, Jaime Hincapié & Pedro Amariles. (2014) Relevancia clínica de las interacciones medicamentosas entre antiinflamatorios no esteroideos y antihipertensivos. Atención Primaria 46:9, pages 464-474.
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Mariko SueAya YoshiharaKoji KubokiNaoki HiroiGen Yoshino. (2013) A Case of Severe Acute Necrotizing Pancreatitis after Administration of Sitagliptin. Clinical Medicine Insights: Case Reports 6, pages CCRep.S10856.
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Marina Borges, Alessandra Melchert, Rivaldo Marini Filho, Cec?lia Braga Laposy, Beatriz Cristina Concei??o Porto Alegre & Karine Ramires Silva. (2012) Fun??o renal, hep?tica e card?aca de c?es h?gidos sob terapia prolongada com celecoxibe. Ci?ncia Rural 42:10, pages 1844-1850.
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Thomas G Wadsworth, Jo Kiester & E Gregory Thompson. (2012) Metformin-Associated Exacerbation of Chronic Pancreatitis: A Possible Adverse Drug-Disease Interaction. Journal of Pharmacy Technology 28:5, pages 208-210.
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S. Cigarran, M. L. Rodriguez, M. Pousa, H. Menendez & M. J. Mendez. (2011) Transient vision loss in a patient with severe metformin-associated lactic acidosis. QJM 105:8, pages 781-783.
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Manish Jagia, Salah Taqi & Mahmud Hanafi. (2011) Metformin poisoning: A complex presentation. Indian Journal of Anaesthesia 55:2, pages 190.
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Chun Wing Yeung, Ho Yin Chung, Bonnie Mei Wah Fong, Nga Wing Tsai, Wai Ming Chan, Tak Shing Siu, Sidney Tam & Sik Hon Tsui. (2011) Metformin-Associated Lactic Acidosis in Chinese Patients with Type II Diabetes. Pharmacology 88:5-6, pages 260-265.
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Anamika M. Reed, Sohail Z. Husain, Edwin Thrower, Martine Alexandre, Ahsan Shah, Fred S. Gorelick & Michael H. Nathanson. (2011) Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling. Journal of Biological Chemistry 286:3, pages 1919-1926.
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Li Huo, Yaping Luo, Taiping Zhang, Zhaohui Zhu, Fang Li & Yupei Zhao. (2010) Unexpected Primary Osseous Lymphoma as the Cause of Lactic Acidosis in a Patient Suffering From Pancreatitis. Clinical Nuclear Medicine 35:10, pages 790-793.
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George Liamis, Haralampos J. Milionis & Moses Elisaf. (2010) Pharmacologically-Induced Metabolic Acidosis. Drug Safety 33:5, pages 371-391.
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Richard M. Bergenstal, Clifford J. Bailey & David M. Kendall. (2010) Type 2 Diabetes: Assessing the Relative Risks and Benefits of Glucose-lowering Medications. The American Journal of Medicine 123:4, pages 374.e9-374.e18.
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Anna Maria Arroyo, Todd A Walroth, James B Mowry & Louise W Kao. (2010) The MALAdy of Metformin Poisoning: Is CVVH the Cure?. American Journal of Therapeutics 17:1, pages 96-100.
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Yao-Ko Wen. (2009) Impact of acute kidney injury on metformin-associated lactic acidosis. International Urology and Nephrology 41:4, pages 967-972.
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Ole‐Petter R. Hamnvik & Graham T. McMahon. (2009) Balancing Risk and Benefit with Oral Hypoglycemic Drugs. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 76:3, pages 234-243.
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Stefano Palomba, Angela Falbo, Fulvio Zullo & Francesco OrioJr.Jr.. (2009) Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review. Endocrine Reviews 30:1, pages 1-50.
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