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Case Report

Abrupt awakening phenomenon associated with gamma-hydroxybutyrate use: A case series

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Pages 533-538 | Received 23 Jan 2006, Accepted 29 Sep 2006, Published online: 07 Oct 2008

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Filipa Raposo Pereira, Minni T. B. McMaster, YvonD. A. T. de Vries, Wim van den Brink & Guido A. van Wingen. (2020) Demographic and Clinical Characteristics of Regular GHB-Users with and without GHB-Induced Comas. Substance Use & Misuse 55:13, pages 2148-2155.
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Rebekah Brennan & Marie Claire Van Hout. (2014) Gamma-Hydroxybutyrate (GHB): A Scoping Review of Pharmacology, Toxicology, Motives for Use, and User Groups. Journal of Psychoactive Drugs 46:3, pages 243-251.
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Leo J Schep, Kai Knudsen, Robin J Slaughter, J Allister Vale & Bruno Mégarbane. (2012) The clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol. Clinical Toxicology 50:6, pages 458-470.
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Mingyu Kim, Songjin Oh, Suji Kim, Moongi Ji, Byeongchan Choi, Jung-Woo Bae, Yong Sup Lee, Man-Jeong Paik & Sooyeun Lee. (2023) Alcohol perturbed locomotor behavior, metabolism, and pharmacokinetics of gamma-hydroxybutyric acid in rats. Biomedicine & Pharmacotherapy 164, pages 114992.
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Suryun Jung, Mingyu Kim, Suji Kim & Sooyeun Lee. (2023) Interaction between γ-Hydroxybutyric Acid and Ethanol: A Review from Toxicokinetic and Toxicodynamic Perspectives. Metabolites 13:2, pages 180.
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William Lai, Jesse T Raposa & Roop Parlapalli. (2022) Treatment of Poorly Responsive Gamma-Hydroxybutyrate Withdrawal With Baclofen: A Case Report. Cureus.
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Madelaine Abid, Jana Kietzerow, Stefanie Iwersen‐Bergmann, Tino Schnitgerhans & Hilke Andresen‐Streichert. (2021) Characteristics and dose‐effect relationship of clinical gamma‐hydroxybutyrate intoxication: A case series. Journal of Forensic Sciences 67:1, pages 416-427.
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B.A.G. Dijkstra, H. Beurmanjer, A.E. Goudriaan, A.F.A. Schellekens & E.A.G. Joosten. (2021) Unity in diversity: A systematic review on the GHB using population. International Journal of Drug Policy 94, pages 103230.
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Jonathan Henssler & Felix Bermpohl. 2018. Handbuch Psychoaktive Substanzen. Handbuch Psychoaktive Substanzen 631 642 .
Zurina Hassan, Oliver G. Bosch, Darshan Singh, Suresh Narayanan, B. Vicknasingam Kasinather, Erich Seifritz, Johannes Kornhuber, Boris B. Quednow & Christian P. Müller. (2017) Novel Psychoactive Substances—Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs. Frontiers in Psychiatry 8.
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David M. Wood. 2017. Critical Care Toxicology. Critical Care Toxicology 1555 1586 .
Evangelia Liakoni, Fabio Walther, Christian H. Nickel & Matthias E. Liechti. (2016) Presentations to an urban emergency department in Switzerland due to acute γ-hydroxybutyrate toxicity. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 24:1.
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Oliver G. Bosch & Erich Seifritz. (2016) The behavioural profile of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol in humans. Brain Research Bulletin 126, pages 47-60.
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J.G.C. van Amsterdam, T.M. Brunt, M.T.B. McMaster & W. van den Brink. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 453 459 .
Jonathan Henssler & Felix Bermpohl. 2017. Handbuch Psychoaktive Substanzen. Handbuch Psychoaktive Substanzen 1 16 .
David M. Wood. 2016. Critical Care Toxicology. Critical Care Toxicology 1 32 .
John M. Corkery, Barbara Loi, Hugh Claridge, Christine Goodair, Ornella Corazza, Simon Elliott & Fabrizio Schifano. (2015) Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): A literature review with a focus on UK fatalities related to non-medical use. Neuroscience & Biobehavioral Reviews 53, pages 52-78.
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Luc Heytens, Hugo Neels, Niels Van Regenmortel, Wim van den Brink, Manu Henckes, Sofie Schouwers, Greet Dockx & Cleo L Crunelle. (2014) Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 52:2, pages 283-287.
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Ann-Sofie M. E. Ingels, Sarah M. R. Wille, Nele Samyn, Willy E. Lambert & Christophe P. Stove. (2014) Screening and confirmation methods for GHB determination in biological fluids. Analytical and Bioanalytical Chemistry 406:15, pages 3553-3577.
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J. Dave Barry & Brandon K. Wills. (2013) Neurotoxic Emergencies. Psychiatric Clinics of North America 36:2, pages 219-244.
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Naren Gunja. (2012) Teenage toxins: Recreational poisoning in the adolescent. Journal of Paediatrics and Child Health 48:7, pages 560-566.
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Oliver G Bosch, Boris B Quednow, Erich Seifritz & Thomas C Wetter. (2011) Reconsidering GHB: orphan drug or new model antidepressant?. Journal of Psychopharmacology 26:5, pages 618-628.
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Jan G.C. van Amsterdam, Tibor M. Brunt, Minni T.B. McMaster & Raymond J.M. Niesink. (2012) Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose. Neuroscience & Biobehavioral Reviews 36:4, pages 1217-1227.
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Donald G. Barceloux. 2012. Medical Toxicology of Drug Abuse. Medical Toxicology of Drug Abuse 89 109 .
Stanley M. Parsons. 2011. Forensic Chemistry Handbook. Forensic Chemistry Handbook 355 434 .
H. Andresen, B. E. Aydin, A. Mueller & S. Iwersen-Bergmann. (2011) An overview of gamma-hydroxybutyric acid: pharmacodynamics, pharmacokinetics, toxic effects, addiction, analytical methods, and interpretation of results. Drug Testing and Analysis 3:9, pages 560-568.
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J. Dave Barry & Brandon K. Wills. (2011) Neurotoxic Emergencies. Neurologic Clinics 29:3, pages 539-563.
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James Bell & Rodney Collins. (2010) Gamma‐butyrolactone (GBL) dependence and withdrawal. Addiction 106:2, pages 442-447.
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Lawrence R Kidd, David P Hepburn & Linda A Middleton. (2010) Bodybuilding — A Remarkable Recovery. Journal of the Intensive Care Society 11:4, pages 261-264.
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R. J. M. Niesink. (2009) Farmacologische en toxicologische aspecten van gammahydroxyboterzuur (GHB). Verslaving 5:4, pages 50-60.
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Laurent Karila, Johanne Novarin, Bruno Megarbane, Olivier Cottencin, Sylvain Dally, William Lowenstein & Michel Reynaud. (2009) Acide gamma-hydroxy-butyrique (GHB) : plus qu’un agent de soumission chimique, une véritable source d’addiction. La Presse Médicale 38:10, pages 1526-1538.
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Lawrence P. Carter, Daniel Pardi, Jane Gorsline & Roland R. Griffiths. (2009) Illicit gamma-hydroxybutyrate (GHB) and pharmaceutical sodium oxybate (Xyrem®): Differences in characteristics and misuse. Drug and Alcohol Dependence 104:1-2, pages 1-10.
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Petra S. van Nieuwenhuijzen & Iain S. McGregor. (2009) Sedative and hypothermic effects of γ-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: Assessment using biotelemetry. Drug and Alcohol Dependence 103:3, pages 137-147.
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Joshua T. Kantrowitz, Leslie Citrome & Daniel C. Javitt. (2009) A review of tolerability and abuse liability of γ-hydroxybutyric acid for insomnia in patients with schizophrenia. Clinical Therapeutics 31, pages 1360-1373.
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Daniel Lenz, Markus A Rothschild & Lars Kröner. (2008) Intoxications due to Ingestion of γ-Butyrolactone: Organ Distribution of γ-Hydroxybutyric Acid and γ-Butyrolactone. Therapeutic Drug Monitoring 30:6, pages 755-761.
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