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Research Article

The impact of vehicle on the relative potency of skin-sensitizing chemicals in the local lymph node assay

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Pages 67-75 | Published online: 10 Oct 2008

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Read on this site (4)

David Basketter, Ian R. White, John P. McFadden & Ian Kimber. (2015) Hexyl cinnamal: consideration of skin-sensitizing properties and suitability as a positive control. Cutaneous and Ocular Toxicology 34:3, pages 227-231.
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Jakob Torp Madsen, Stefan Vogel, Jeanne Duus Johansen & Klaus Ejner Andersen. (2011) Encapsulating contact allergens in liposomes, ethosomes, and polycaprolactone may affect their sensitizing properties. Cutaneous and Ocular Toxicology 30:2, pages 116-123.
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Jakob Torp Madsen, Stefan Vogel, Jeanne Duus Johansen, Jens Ahm Sørensen, Klaus Ejner Andersen & Jesper Bo Nielsen. (2011) Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes. Cutaneous and Ocular Toxicology 30:1, pages 38-44.
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David A. Basketter. (2009) The human repeated insult patch test in the 21st century: A commentary. Cutaneous and Ocular Toxicology 28:2, pages 49-53.
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Articles from other publishers (19)

K.R. Brain, D.M. Green, A.C. Jones, K.A. Walters, A.M. Api, D. Selechnik & K. Joshi. (2022) In vitro human skin absorption of linalool: Effects of vehicle composition, evaporation and occlusion on permeation and distribution. International Journal of Pharmaceutics 622, pages 121826.
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Niamh M O’Boyle, Ida B Niklasson, David J Ponting, Miguel A Ortega, Tina Seifert, Andreas Natsch, Kristina Luthman & Ann-Therese Karlberg. (2022) Nature-derived epoxy resins: Synthesis, allergenicity, and thermosetting properties of pinoresinol diglycidyl ether. Toxicology and Industrial Health 38:5, pages 259-269.
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Mathilde Bergal, Mickaël Puginier, Cédric Gerbeix, Hervé Groux, Alicia Roso, Françoise Cottrez & Alain Milius. (2020) In vitro testing strategy for assessing the skin sensitizing potential of “difficult to test” cosmetic ingredients. Toxicology in Vitro 65, pages 104781.
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Françoise Cottrez, Elodie Boitel, Marie-Pierre Berrada-Gomez, Hanna Dalhuchyts, Catherine Bidan, Sandy Rattier, Pierre-Jacques Ferret & Hervé Groux. (2020) In vitro measurement of skin sensitization hazard of mixtures and finished products: Results obtained with the SENS-IS assays. Toxicology in Vitro 62, pages 104644.
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Joe Reynolds, Cameron MacKay, Nicola Gilmour, David Miguel-Vilumbrales & Gavin Maxwell. (2019) Probabilistic prediction of human skin sensitiser potency for use in next generation risk assessment. Computational Toxicology 9, pages 36-49.
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D.A. Basketter, A. Natsch, G. Ellis, A.M. Api, A. Irizar, B. Safford, C. Ryan & P. Kern. (2018) Interspecies assessment factors and skin sensitization risk assessment. Regulatory Toxicology and Pharmacology 97, pages 186-188.
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Steven J. Canipa, Martyn L. Chilton, Rachel Hemingway, Donna S. Macmillan, Alun Myden, Jeffrey P. Plante, Rachael E. Tennant, Jonathan D. Vessey, Thomas Steger-Hartmann, Janet Gould, Jedd Hillegass, Sylvain Etter, Benjamin P. C. Smith, Angela White, Paul Sterchele, Ann De Smedt, Devin O'Brien & Rahul Parakhia. (2017) A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure-activity alert spaces . Journal of Applied Toxicology 37:8, pages 985-995.
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Nico Watzek, Franz Berger, Susanne Noreen Kolle, Tanja Kaufmann, Matthias Becker & Bennard van Ravenzwaay. (2017) Assessment of skin sensitization under REACH: A case report on vehicle choice in the LLNA and its crucial role preventing false positive results. Regulatory Toxicology and Pharmacology 85, pages 25-32.
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David W. Roberts, Anne Marie Api & Aynur O. Aptula. (2016) Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 2. The biological variability of the murine Local Lymph Node Assay (LLNA) for skin sensitisation. Regulatory Toxicology and Pharmacology 80, pages 255-259.
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Coralie Dumont, João Barroso, Izabela Matys, Andrew Worth & Silvia Casati. (2016) Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches. Toxicology in Vitro 34, pages 220-228.
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Julia Scheel & Detlef Keller. (2012) Investigation of the Skin Sensitizing Properties of 5 Osmolytic Prodrugs in a Weight-of-Evidence Assessment, Employing In Silico, In Vivo, and Read Across Analyses. International Journal of Toxicology 31:4, pages 358-363.
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Costanza Rovida, Cindy Ryan, Serena Cinelli, David Basketter, Rebecca Dearman & Ian Kimber. (2012) The Local Lymph Node Assay (LLNA). Current Protocols in Toxicology 51:1.
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Alexandre Angers-Loustau, Luca Tosti & Silvia Casati. (2011) The regulatory use of the Local Lymph Node Assay for the notification of new chemicals in Europe. Regulatory Toxicology and Pharmacology 60:3, pages 300-307.
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Stacey E. Anderson, Paul D. Siegel & B. J. Meade. (2011) The LLNA: A Brief Review of Recent Advances and Limitations. Journal of Allergy 2011, pages 1-10.
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Carl Simonsson, Jakob Torp Madsen, Annette Graneli, Klaus E. Andersen, Ann-Therese Karlberg, Charlotte A. Jonsson & Marica B. Ericson. (2011) A study of the enhanced sensitizing capacity of a contact allergen in lipid vesicle formulations. Toxicology and Applied Pharmacology 252:3, pages 221-227.
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E.Y.M. Bonnist, J.-P. Gorce, C. Mackay, R.U. Pendlington & P.D.A. Pudney. (2011) Measuring the Penetration of a Skin Sensitizer and Its Delivery Vehicles Simultaneously with Confocal Raman Spectroscopy. Skin Pharmacology and Physiology 24:5, pages 274-283.
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Peter S. Friedmann & Christopher Pickard. (2010) Quantifying human susceptibility to contact sensitization; risk assessments now and in the future. Contact Dermatitis 63:5, pages 237-247.
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Ovanes MekenyanM. Nendza, T. Aldenberg, E. Benfenati, R. Benigni, M.T.D. Cronin, S. Escher, A. Fernandez, S. Gabbert, F. Giralt, M. Hewitt, M. Hrovat, S. Jeram, D. Kroese, J. C. Madden, I. Mangelsdorf, R. Rallo, A. Roncaglioni, E. Rorije, H. Segner, B. Simon-Hettich & T. Vermeire. 2010. In Silico Toxicology. In Silico Toxicology 59 117 .
Itai Chipinda, Stacey E. Anderson, Leon F. Butterworth, Donald Beezhold & Paul D. Siegel. (2009) Increased cell proliferation in spleen and lymph nodes peripheral to contact allergen application site. Toxicology 257:3, pages 113-116.
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