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Toxin Reviews Volume 38, 2019 - Issue 3
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Research Article

Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice

Heidar Heidari KhoeiDepartment of Biology and Anatomical Sciences, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; ORCID Iconhttp://orcid.org/0000-0002-7362-1698View further author information
ORCID Icon,
Sajad FakhriDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran; View further author information
,
Siavash ParvardehDepartment of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Iran; ORCID Iconhttp://orcid.org/0000-0002-5001-4633View further author information
ORCID Icon,
Zahra Shams MofaraheDepartment of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Correspondence[email protected]
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,
Zahra BaninamehSina Hospital, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, IranView further author information
&
Mina VardianiDepartment of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; ORCID Iconhttp://orcid.org/0000-0001-5341-554XView further author information
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Pages 248-254 | Received 18 Oct 2017, Accepted 11 Mar 2018, Published online: 12 Apr 2018

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Elif Ayazoglu Demir, Ahmet Mentese, Ayten Livaoglu, Nihal Turkmen Alemdar & Selim Demir. (2023) Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats. Drug and Chemical Toxicology 46:1, pages 97-103.
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Rahime Aslankoc, Ozlem Ozmen & Arzu Yalcın. (2022) Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate. Biotechnic & Histochemistry 97:5, pages 382-393.
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Heidar Heidari Khoei, Sajad Fakhri, Siavash Parvardeh, Zahra Shams Mofarahe, Hojjat Ghasemnejad-Berenji, Hamid Nazarian & Zahra Baninameh. (2019) Testicular toxicity and reproductive performance of streptozotocin-induced diabetic male rats: the ameliorating role of silymarin as an antioxidant. Toxin Reviews 38:3, pages 223-233.
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Articles from other publishers (24)

Ling-Ling Zhao, Titilope John Jayeoye, Tolulope Joshua Ashaolu & Opeyemi Joshua Olatunji. (2023) Pinostrobin, a dietary bioflavonoid exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against methotrexate-induced ovarian toxicity in rats. Tissue and Cell 85, pages 102254.
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Faezeh LorestaniAhmad Movahedianadel mohammadalipourMohammad HashemniaMohammad Hossein Aarabi. (2023) Astaxanthin prevent nephrotoxicity through Nrf2/HO-1 pathway. Canadian Journal of Physiology and Pharmacology.
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Razieh Azadian, Adel Mohammadalipour, Mohammad Reza Memarzadeh, Mohammad Hashemnia & Mohammad Hosein Aarabi. (2023) Examining hepatoprotective effects of astaxanthin against methotrexate-induced hepatotoxicity in rats through modulation of Nrf2/HO-1 pathway genes. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Katarzyna Ciapała, Ewelina Rojewska, Katarzyna Pawlik, Agata Ciechanowska & Joanna Mika. (2023) Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain. International Journal of Molecular Sciences 24:10, pages 9000.
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Mona S. Almujaydil. (2023) The Role of Dietary Nutrients in Male Infertility: A Review. Life 13:2, pages 519.
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Moustafa E. Motawee, Ahmed A. Damanhory, Hany Sakr, Mohamed Mansour Khalifa, Tarek Atia, Mohamed M. Elfiky, Muhammad Maher & Hader I. Sakr. (2022) An electron microscopic and biochemical study of the potential protective effect of ginger against Cadmium-induced testicular pathology in rats. Frontiers in Physiology 13.
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Sajad Fakhri, Fatemeh Abbaszadeh, Leila Dargahi, Ramin Pouriran & Masoumeh Jorjani. (2022) Astaxanthin ameliorates serum level and spinal expression of macrophage migration inhibitory factor following spinal cord injury. Behavioural Pharmacology 33:7, pages 505-512.
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Behçet Varışlı, Cuneyt Caglayan, Fatih Mehmet Kandemir, Cihan Gür, İbrahim Bayav & Aydın Genç. (2022) The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats. Molecular Biology Reports 49:10, pages 9641-9649.
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Taha GhantabpourMaryam Shabani NashtaeiSaeid NekoonamHossein RezaeiFardin Amidi. (2022) The Effect of Astaxanthin on Motility, Viability, Reactive Oxygen Species, Apoptosis, and Lipid Peroxidation of Human Spermatozoa During the Freezing–Thawing Process. Biopreservation and Biobanking 20:4, pages 367-373.
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Elif Didem Örs, Şenay Burçin Alkan & Abdullah Öksüz. (2022) Possible Effect of Astaxanthin on Obesity-related Increased COVID-19 Infection Morbidity and Mortality. Current Nutrition & Food Science 18:3, pages 265-273.
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Azita Afzali, Fardin Amidi, Morteza Koruji, Hassan Nazari, Mohammad Ali Sadighi Gilani & Aligholi Sobhani Sanjbad. (2021) Astaxanthin Relieves Busulfan-Induced Oxidative Apoptosis in Cultured Human Spermatogonial Stem Cells by Activating the Nrf-2/HO-1 pathway. Reproductive Sciences 29:2, pages 374-394.
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Salman Ahmed, Haroon Khan, Sajad Fakhri, Michael Aschner & Wai San Cheang. (2021) Therapeutic potential of marine peptides in cervical and ovarian cancers. Molecular and Cellular Biochemistry 477:2, pages 605-619.
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Sajad Fakhri & Mohammad Hosein Farzaei. 2022. Antioxidants Effects in Health. Antioxidants Effects in Health 819 836 .
Shan Gao, Nuo Heng, Fang Liu, Yong Guo, Yu Chen, Liang Wang, Hemin Ni, Xihui Sheng, Xiangguo Wang, Kai Xing, Longfei Xiao & Xiaolong Qi. (2021) Natural astaxanthin enhanced antioxidant capacity and improved semen quality through the MAPK/Nrf2 pathway in aging layer breeder roosters. Journal of Animal Science and Biotechnology 12:1.
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Reza Azadnasab, Hadi Kalantar, Layasadat Khorsandi, Heibatullah Kalantari & Mohammad Javad Khodayar. (2021) Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice. Human & Experimental Toxicology 40:12_suppl, pages S603-S610.
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Nicolai B. Jensen, Signe D. Justesen, Agnete Larsen, Erik Ernst & Lars H. Pedersen. (2021) A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil. Acta Obstetricia et Gynecologica Scandinavica 100:9, pages 1557-1580.
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Sajad Fakhri, Akram Yarmohammadi, Mostafa Yarmohammadi, Mohammad Hosein Farzaei & Javier Echeverria. (2021) Marine Natural Products: Promising Candidates in the Modulation of Gut-Brain Axis towards Neuroprotection. Marine Drugs 19:3, pages 165.
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Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi & Siavash Parvardeh. (2021) Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European Journal of Pharmacology 893, pages 173821.
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Lu Yuan, Peng Liang, Yunhua Qu, Tianyang An, Jianhui Wang, Xuenan Deng, Liyuan Bai, Peijun Shen & Disi Bai. (2020) Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice. Food and Chemical Toxicology 145, pages 111736.
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Sajad Fakhri, Zeinab Nouri, Seyed Zachariah Moradi & Mohammad Hosein Farzaei. (2020) Astaxanthin, COVID ‐19 and immune response: Focus on oxidative stress, apoptosis and autophagy . Phytotherapy Research 34:11, pages 2790-2792.
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Sajad Fakhri, Mirko Pesce, Antonia Patruno, Seyed Zachariah Moradi, Amin Iranpanah, Mohammad Hosein Farzaei & Eduardo Sobarzo-Sánchez. (2020) Attenuation of Nrf2/Keap1/ARE in Alzheimer’s Disease by Plant Secondary Metabolites: A Mechanistic Review. Molecules 25:21, pages 4926.
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Fatemeh Abbaszadeh, Sajad Fakhri & Haroon Khan. (2020) Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals. Pharmacological Research 160, pages 105069.
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Érique Ricardo Alves, Cintia Giselle Martins Ferreira, Maria Vanessa da Silva, Leucio Duarte Vieira Filho, Valdemiro Amaro da Silva Junior, Ismaela Maria Ferreira de Melo, Clovis José Cavalcanti Lapa Neto, Laís Caroline da Silva Santos, Álvaro Aguiar Coelho Teixeira & Valéria Wanderley Teixeira. (2020) Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels. Acta Histochemica 122:5, pages 151559.
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Iman O. Sherif, Laila A. Al-Mutabagani & Osama M. Sarhan. (2020) Ginkgo biloba Extract Attenuates Methotrexate-Induced Testicular Injury in Rats: Cross-talk Between Oxidative Stress, Inflammation, Apoptosis, and miRNA-29a Expression . Integrative Cancer Therapies 19, pages 153473542096981.
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