1,816
Views
48
CrossRef citations to date
0
Altmetric
Research Paper

LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals

, , , , &
Pages 49-60 | Received 12 Oct 2015, Accepted 17 Dec 2015, Published online: 22 Feb 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Ulrike D.B. Krammer, Sylvia Tschida, Julia Berner, Stephanie Lilja, Olivier J. Switzeny, Berit Hippe, Petra Rust & Alexander G. Haslberger. (2022) MiRNA-based “fitness score” to assess the individual response to diet, metabolism, and exercise. Journal of the International Society of Sports Nutrition 19:1, pages 455-473.
Read now
Helene A. Fachim, Kirk Siddals, Nagaraj Malipatil, Rachelle P Donn, Gabriela YC Moreno, Caroline F Dalton, Safwaan Adam, Handrean Soran, J Martin Gibson & Adrian H Heald. (2020) Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation. Adipocyte 9:1, pages 96-107.
Read now
Lílian L. Lopes, Josefina Bressan, Maria do Carmo G. Peluzio & Helen Hermana M. Hermsdorff. (2019) LINE-1 in Obesity and Cardiometabolic Diseases: A Systematic Review. Journal of the American College of Nutrition 38:5, pages 478-484.
Read now
Laura S. Rozek, Shama Virani, Emily L. Bellile, Jeremy M. G. Taylor, Maureen A. Sartor, Katie R. Zarins, A. Virani, C. Cote, Francis P. Worden, Mark E. Prince Mark, Scott A. McLean, Sonya A. Duffy, George H. Yoo, Nabil F. Saba, Dong M. Shin, Omer Kucuk & Gregory T. Wolf. (2019) Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma. Nutrition and Cancer 71:5, pages 772-780.
Read now
David John Hunter, Lynsey James, Bethan Hussey, Alex J. Wadley, Martin R. Lindley & Sarabjit S. Mastana. (2019) Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation. Epigenetics 14:3, pages 294-309.
Read now
Bethan Hussey, Martin R. Lindley & Sarabjit S. Mastana. (2017) Omega 3 fatty acids, inflammation and DNA methylation: an overview. Clinical Lipidology 12:1, pages 24-32.
Read now

Articles from other publishers (42)

Khalil ElGendy, Fiona C. Malcomson, Sorena Afshar, Michael D. Bradburn & John C. Mathers. (2023) Effects of obesity, and of weight loss following bariatric surgery, on methylation of DNA from the rectal mucosa and in cell-free DNA from blood. International Journal of Obesity 47:12, pages 1278-1285.
Crossref
Fabio Marson, Michele Zampieri, Loredana Verdone, Maria Giulia Bacalini, Francesco Ravaioli, Luca Morandi, Salvatore Gaetano Chiarella, Valerio Vetriani, Sabrina Venditti, Micaela Caserta, Antonino Raffone, Tal Dotan Ben-Soussan & Anna Reale. (2023) Quadrato Motor Training (QMT) is associated with DNA methylation changes at DNA repeats: A pilot study. PLOS ONE 18:10, pages e0293199.
Crossref
David John Hunter, Lynsey S. James, Bethan Hussey, Richard A. Ferguson, Martin R. Lindley & Sarabjit S. Mastana. (2023) Impacts of Eccentric Resistance Exercise on DNA Methylation of Candidate Genes for Inflammatory Cytokines in Skeletal Muscle and Leukocytes of Healthy Males. Genes 14:2, pages 478.
Crossref
Amaraporn Rerkasem, Sothida Nantakool, Brooke C. Wilson, Ampica Mangklabruks, Kongsak Boonyapranai, Apiwat Mutirangura, José G. B. Derraik & Kittipan Rerkasem. (2022) Associations between maternal plasma zinc concentrations in late pregnancy and LINE-1 and Alu methylation loci in the young adult offspring. PLOS ONE 17:12, pages e0279630.
Crossref
Yusheng Cai, Wei Song, Jiaming Li, Ying Jing, Chuqian Liang, Liyuan Zhang, Xia Zhang, Wenhui Zhang, Beibei Liu, Yongpan An, Jingyi Li, Baixue Tang, Siyu Pei, Xueying Wu, Yuxuan Liu, Cheng-Le Zhuang, Yilin Ying, Xuefeng Dou, Yu Chen, Fu-Hui Xiao, Dingfeng Li, Ruici Yang, Ya Zhao, Yang Wang, Lihui Wang, Yujing Li, Shuai Ma, Si Wang, Xiaoyuan Song, Jie Ren, Liang Zhang, Jun Wang, Weiqi Zhang, Zhengwei Xie, Jing Qu, Jianwei Wang, Yichuan Xiao, Ye Tian, Gelin Wang, Ping Hu, Jing Ye, Yu Sun, Zhiyong Mao, Qing-Peng Kong, Qiang Liu, Weiguo Zou, Xiao-Li Tian, Zhi-Xiong Xiao, Yong Liu, Jun-Ping Liu, Moshi Song, Jing-Dong J. Han & Guang-Hui Liu. (2022) The landscape of aging. Science China Life Sciences 65:12, pages 2354-2454.
Crossref
Matthew A. Romero, Petey W. Mumford, Paul A. Roberson, Shelby C. Osburn, Kaelin C. Young, John M. Sedivy & Michael D. Roberts. (2022) Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle. Exercise and Sport Sciences Reviews 50:4, pages 185-193.
Crossref
Zahra Barouti, Motahar Heidari-Beni, Anahita Shabanian-Boroujeni, Morteza Mohammadzadeh, Vida Pahlevani, Parnian Poursafa, Fatemeh Mohebpour & Roya Kelishadi. (2022) Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis. Archives of Public Health 80:1.
Crossref
Laszlo Szabo, Richard Molnar, Andras Tomesz, Arpad Deutsch, Richard Darago, Timea Varjas, Zsombor Ritter, Jozsef L. Szentpeteri, Kitti Andreidesz, Domokos Mathe, Imre Hegedüs, Attila Sik, Ferenc Budan & Istvan Kiss. (2022) Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model. Nutrients 14:4, pages 908.
Crossref
Rajesh Kumar Pradhan & Wusirika Ramakrishna. (2022) Transposons: Unexpected players in cancer. Gene 808, pages 145975.
Crossref
Jörg Tost. 2022. DNA Methyltransferases - Role and Function. DNA Methyltransferases - Role and Function 395 469 .
Bethan Hussey, Richard P. Steel, Boakye Gyimah, James C. Reynolds, Ian M. Taylor, Martin R. Lindley & Sarabjit Mastana. (2021) DNA methylation of tumour necrosis factor (TNF) alpha gene is associated with specific blood fatty acid levels in a gender‐specific manner. Molecular Genetics & Genomic Medicine 9:12.
Crossref
Ibrahim Issah, John Arko-Mensah, Laura S. Rozek, Katie R. Zarins, Thomas P. Agyekum, Duah Dwomoh, Niladri Basu, Stuart Batterman, Thomas G. Robins & Julius N. Fobil. (2021) Global DNA (LINE-1) methylation is associated with lead exposure and certain job tasks performed by electronic waste workers. International Archives of Occupational and Environmental Health 94:8, pages 1931-1944.
Crossref
Mojgan Gharipour, Arya Mani, Mona Amini Baghbahadorani, Camila Kellen de Souza Cardoso, Shayesteh Jahanfar, Nizal Sarrafzadegan, Cesar de Oliveira & Erika Aparecida Silveira. (2021) How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?. International Journal of Molecular Sciences 22:18, pages 9949.
Crossref
Amaya Lopez-PascualPaul TrayhurnJ. Alfredo MartínezPedro González-Muniesa. (2021) Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance. Antioxidants & Redox Signaling 35:8, pages 642-687.
Crossref
Tihana Marić, Aleksandra Fučić & Anna Aghayanian. (2021) Environmental and occupational exposures associated with male infertility. Archives of Industrial Hygiene and Toxicology 72:2, pages 101-113.
Crossref
Zainab Awada, Liacine Bouaoun, Rihab Nasr, Arafat Tfayli, Cyrille Cuenin, Reem Akika, Rose-Mary Boustany, Joelle Makoukji, Hani Tamim, Nathalie K. Zgheib & Akram Ghantous. (2021) LINE-1 methylation mediates the inverse association between body mass index and breast cancer risk: A pilot study in the Lebanese population. Environmental Research 197, pages 111094.
Crossref
Stanislav A. Vasilyev, Anton V. Markov, Oksana Yu. Vasilyeva, Ekaterina N. Tolmacheva, Lada A. Zatula, Diana V. Sharysh, Daria I. Zhigalina, Victoria V. Demeneva & Igor N. Lebedev. (2021) Method of targeted bisulfite massive parallel sequencing of the human LINE-1 retrotransposon promoter. MethodsX 8, pages 101445.
Crossref
M.R. Lindley, B. Hussey, D.J. Hunter & S.S. Mastana. 2021. Epigenetics of Exercise and Sports. Epigenetics of Exercise and Sports 65 83 .
Diana Marcela Paredes-Céspedes, Aurora Elizabeth Rojas-García, Irma Martha Medina-Díaz, Kenneth S. Ramos, José Francisco Herrera-Moreno, Briscia Socorro Barrón-Vivanco, Cyndia Azucena González-Arias & Yael Yvette Bernal-Hernández. (2020) Environmental and socio-cultural impacts on global DNA methylation in the indigenous Huichol population of Nayarit, Mexico. Environmental Science and Pollution Research 28:4, pages 4472-4487.
Crossref
Andrea Maugeri & Martina Barchitta. (2020) How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies. Medicina 56:8, pages 374.
Crossref
Sophia D. Amenyah, Amy McMahon, Mary Ward, Jennifer Deane, Helene McNulty, Catherine F. Hughes, J.J. Strain, Geraldine Horigan, John Purvis, Colum P. Walsh & Diane J. Lees-Murdock. (2020) Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype. Biochimie 173, pages 17-26.
Crossref
Hannah Savage & Keri L. Schadler. 2020. Exercise Oncology. Exercise Oncology 61 83 .
Paul A. Roberson, Matthew A. Romero, Shelby C. Osburn, Petey W. Mumford, Christopher G. Vann, Carlton D. Fox, Danielle J. McCullough, Michael D. Brown & Michael D. Roberts. (2019) Skeletal muscle LINE-1 ORF1 mRNA is higher in older humans but decreases with endurance exercise and is negatively associated with higher physical activity. Journal of Applied Physiology 127:4, pages 895-904.
Crossref
Junfeng Xu, Chia-Wen Tsai, Wen-Shin Chang, Yuyan Han, Da-Tian Bau, Curtis A Pettaway & Jian Gu. (2019) Methylation of global DNA repeat LINE-1 and subtelomeric DNA repeats D4Z4 in leukocytes is associated with biochemical recurrence in African American prostate cancer patients. Carcinogenesis 40:9, pages 1055-1060.
Crossref
Rasmon Kalayasiri, Korakot Kraijak, Michael Maes & Apiwat Mutirangura. (2018) Methamphetamine (MA) Use Induces Specific Changes in LINE-1 Partial Methylation Patterns, Which Are Associated with MA-Induced Paranoia: a Multivariate and Neuronal Network Study. Molecular Neurobiology 56:6, pages 4258-4272.
Crossref
Ivana Babić Božović, Aleksandra Stanković, Maja Živković, Jadranka Vraneković, Vesna Mahulja-Stamenković & Bojana Brajenović-Milić. (2019) Maternal LINE-1 DNA Methylation and Congenital Heart Defects in Down Syndrome. Frontiers in Genetics 10.
Crossref
L. V. Maksimenko. (2019) Epigenetics as an evidence base of the impact of lifestyle on health and disease. Profilakticheskaya meditsina 22:2, pages 115.
Crossref
Björn L.D.M. Brücher & Ijaz S. Jamall. (2019) Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress. 4open 2, pages 14.
Crossref
Rahia Mashoodh & Frances A. Champagne. 2019. Transgenerational Epigenetics. Transgenerational Epigenetics 107 133 .
Shu-Jie Huang, Yan-Ming Xu & Andy T. Y. Lau. (2018) Epigenetic Effects of the 13 Vitamins. Current Pharmacology Reports 4:6, pages 453-467.
Crossref
Devon J. Boyne, Dylan E. O'Sullivan, Branko F. Olij, Will D. King, Christine M. Friedenreich & Darren R. Brenner. (2018) Physical Activity, Global DNA Methylation, and Breast Cancer Risk: A Systematic Literature Review and Meta-analysis. Cancer Epidemiology, Biomarkers & Prevention 27:11, pages 1320-1331.
Crossref
Maurizio Cardelli. (2018) The epigenetic alterations of endogenous retroelements in aging. Mechanisms of Ageing and Development 174, pages 30-46.
Crossref
Stella Aslibekyan, Golareh Agha, Elena Colicino, Anh N. Do, Jari Lahti, Symen Ligthart, Riccardo E. Marioni, Carola Marzi, Michael M. Mendelson, Toshiko Tanaka, Matthias Wielscher, Devin M. Absher, Luigi Ferrucci, Oscar H. Franco, Christian Gieger, Harald Grallert, Dena Hernandez, Tianxiao Huan, Stella Iurato, Roby Joehanes, Allan C. Just, Sonja Kunze, Honghuang Lin, Chunyu Liu, James B. Meigs, Joyce B. J. van Meurs, Ann Zenobia Moore, Annette Peters, Holger Prokisch, Katri Räikkönen, Wolfgang Rathmann, Michael Roden, Katharina Schramm, Joel D. Schwartz, John M. Starr, André G. Uitterlinden, Pantel Vokonas, Melanie Waldenberger, Chen Yao, Degui Zhi, Andrea A. Baccarelli, Stefania Bandinelli, Ian J. Deary, Abbas Dehghan, Johan Eriksson, Christian Herder, Marjo-Riitta Jarvelin, Daniel Levy & Donna K. Arnett. (2018) Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α. JAMA Cardiology 3:6, pages 463.
Crossref
Alma Betsaida Benitez-Trinidad, Irma Martha Medina-Díaz, Yael Yvette Bernal-Hernández, Briscia Socorro Barrón-Vivanco, Cyndia Azucena González-Arias, José Francisco Herrera-Moreno, Isabel Alvarado-Cruz, Betzabet Quintanilla-Vega & Aurora Elizabeth Rojas-García. (2018) Relationship between LINE-1 methylation pattern and pesticide exposure in urban sprayers. Food and Chemical Toxicology 113, pages 125-133.
Crossref
Robin Christensen, Berit L Heitmann, Karina Winther Andersen, Ole Haagen Nielsen, Signe Bek Sørensen, Mohamad Jawhara, Anette Bygum, Lone Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan Alexander Villadsen, Søren Geill Kjær, Jan Fallingborg, Seyed A G R Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens Frederik Dahlerup, Anders Bo Bojesen, Grith Lykke Sorensen, Steffen Thiel, Nils J Færgeman, Ivan Brandslund, Tue Bjerg Bennike, Allan Stensballe, Erik Berg Schmidt, Andre Franke, David Ellinghaus, Philip Rosenstiel, Jeroen Raes, Mette Boye, Lars Werner, Charlotte Lindgaard Nielsen, Heidi Lausten Munk, Anders Bathum Nexøe, Torkell Ellingsen, Uffe Holmskov, Jens Kjeldsen & Vibeke Andersen. (2018) Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine. BMJ Open 8:2, pages e018166.
Crossref
Francesca Pirini, Sebastian Rodriguez‑Torres, Bola Ayandibu, Mar�a Orera‑Clemente, Alberto Gonzalez‑de la Vega, Fahcina Lawson, Roland Thorpe, David Sidransky & Rafael Guerrero‑Preston. (2017) INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. Molecular Medicine Reports.
Crossref
Devon J Boyne, Christine M Friedenreich, John B McIntyre, Kerry S Courneya & Will D King. (2017) Associations between adiposity and repetitive element DNA methylation in healthy postmenopausal women. Epigenomics 9:10, pages 1267-1277.
Crossref
U. Magnet, C. Urbanek, D. Gaisberger, E. Tomeva, E. Dum, A. Pointner & A.G. Haslberger. (2017) Topical equol preparation improves structural and molecular skin parameters. International Journal of Cosmetic Science 39:5, pages 535-542.
Crossref
Nayha Chopra-Tandon, Haotian Wu, Kathleen F. Arcaro & Susan R. Sturgeon. (2017) Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors. Journal of Cancer Epidemiology 2017, pages 1-25.
Crossref
Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring & Jörn Lötsch. (2016) Disagreement between two common biomarkers of global DNA methylation. Clinical Epigenetics 8:1.
Crossref
Carmen de la Rocha, J. Eduardo Pérez-Mojica, Silvia Zenteno-De León, Braulio Cervantes-Paz, Fabiola E. Tristán-Flores, Dalia Rodríguez-Ríos, Jorge Molina-Torres, Enrique Ramírez-Chávez, Yolanda Alvarado-Caudillo, F. Javier Carmona, Manel Esteller, Rosaura Hernández-Rivas, Katarzyna Wrobel, Kazimierz Wrobel, Silvio Zaina & Gertrud Lund. (2016) Associations between whole peripheral blood fatty acids and DNA methylation in humans. Scientific Reports 6:1.
Crossref
Jörg Tost. 2016. DNA Methyltransferases - Role and Function. DNA Methyltransferases - Role and Function 343 430 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.