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Epigenetics Volume 11, 2016 - Issue 1
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Research Paper

Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients

Efterpi KostareliDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany;Department of Otolaryngology, Head and Neck Surgery, University Hospital, Heidelberg, Heidelberg, Germany
,
Thomas HielscherDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Manuela ZucknickDivision of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany;Oslo Center for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Norway
,
Lorena BabociVeneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy;Division of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Gunnar WichmannDepartment of Otorhinolaryngology, University Hospital Leipzig, Germany
,
Dana HolzingerDivision of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Oliver MückeDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Michael PawlitaDivision of Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Annarosa Del MistroVeneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy
,
Paolo Boscolo-RizzoDepartment of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, School of Medicine, Treviso Regional Hospital, Treviso, Italy
,
Maria Cristina Da MostoDepartment of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, School of Medicine, Treviso Regional Hospital, Treviso, Italy
,
Giancarlo TirelliHead and Neck Department, Hospital of Cattinara, University of Trieste, Trieste, Italy
,
Peter PlinkertDepartment of Otolaryngology, Head and Neck Surgery, University Hospital, Heidelberg, Heidelberg, Germany
,
Andreas DietzDepartment of Otorhinolaryngology, University Hospital Leipzig, Germany
,
Christoph PlassDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Dieter WeichenhanDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
&
Jochen HessDepartment of Otolaryngology, Head and Neck Surgery, University Hospital, Heidelberg, Heidelberg, Germany;Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, GermanyCorrespondence[email protected]
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Pages 61-73 | Received 02 Dec 2015, Accepted 24 Dec 2015, Published online: 22 Feb 2016

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Ghada Barakat, Asser Elsharkawy & Yasmin Nabiel. (2021) Human leucocyte antigen – G gene polymorphism in laryngeal squamous cell carcinoma patients in Mansoura University Hospitals. Egyptian Journal of Basic and Applied Sciences 8:1, pages 214-221.
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Laura S. Rozek, Shama Virani, Emily L. Bellile, Jeremy M. G. Taylor, Maureen A. Sartor, Katie R. Zarins, A. Virani, C. Cote, Francis P. Worden, Mark E. Prince Mark, Scott A. McLean, Sonya A. Duffy, George H. Yoo, Nabil F. Saba, Dong M. Shin, Omer Kucuk & Gregory T. Wolf. (2019) Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma. Nutrition and Cancer 71:5, pages 772-780.
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Articles from other publishers (21)

Zhi Cui, Shiqun Sun, Jia Li, Jianing Li, Tong Sha, Jie He & Linjing Zuo. (2022) Inhibitor of Growth 4 (ING4) Plays a Tumor-repressing Role in Oral Squamous Cell Carcinoma via Nuclear Factor Kappa-B (NF-kB)/DNA Methyltransferase 1 (DNMT1) Axis-mediated Regulation of Aldehyde Dehydrogenase 1A2 (ALDH1A2). Current Cancer Drug Targets 22:9, pages 771-783.
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Di Zhang, Dan Zou, Yue Deng & Lihua Yang. (2021) Systematic analysis of the relationship between ovarian cancer prognosis and alternative splicing. Journal of Ovarian Research 14:1.
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Haoru Dong, Xinhua Shu, Qiang Xu, Chen Zhu, Andreas M. Kaufmann, Zhi-Ming Zheng, Andreas E. Albers & Xu Qian. (2021) Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care. Virologica Sinica 36:6, pages 1284-1302.
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Runmin Li, Guosheng Wang, ZhouJie Wu, HuaGuang Lu, Gen Li, Qi Sun & Ming Cai. (2021) Identification of 6 gene markers for survival prediction in osteosarcoma cases based on multi-omics analysis. Experimental Biology and Medicine 246:13, pages 1512-1523.
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S. Laban, M Brand, J. Ezić, J. Doescher, G. Völkel, H. A. Kestler, C. Brunner & T. K. Hoffmann. (2020) Tumorbiologie des OropharynxkarzinomsTumor biology of oropharyngeal carcinoma. HNO 69:4, pages 249-255.
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Nan Li, Kai Yu, Zhong Lin & Dingyuan Zeng. (2021) Development and Validation of a Five-immune Gene Pair Signature in Endometrial Carcinoma. Combinatorial Chemistry & High Throughput Screening 24:2, pages 233-245.
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Yaojian Jin, Lan Wang, Hongqiang Lou, Chunhan Song, Xuying He & Mingxing Ding. (2021) Development and Validation of an Individualized Immune Prognostic Signature for Recurrent Prostate Cancer. Combinatorial Chemistry & High Throughput Screening 24:1, pages 98-108.
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Fujun Zhang, Yu Liu, Yixin Yang & Kai Yang. (2020) Development and validation of a fourteen- innate immunity-related gene pairs signature for predicting prognosis head and neck squamous cell carcinoma. BMC Cancer 20:1.
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A. Dietz, G. Wichmann, T. Kuhnt & S. Wiegand. (2020) Organerhalt beim fortgeschrittenen Larynx‑/Hypopharynxkarzinom: Erfahrungen aus der DELOS-II-StudieOrgan preservation in advanced laryngeal/hypopharyngeal carcinoma: lessons from the DeLOS-II trial. HNO 68:9, pages 648-656.
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Kaifei Zhao, Lin Xu, Feng Li, Jin Ao, Guojun Jiang, Rongshu Shi, Fang Chen & Qing Luo. (2020) Identification of hepatocellular carcinoma prognostic markers based on 10-immune gene signature. Bioscience Reports 40:8.
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HongLei Wang, Li Wu & HongTao Wang. (2020) Development and verification of a personalized immune prognostic feature in breast cancer. Experimental Biology and Medicine 245:14, pages 1242-1253.
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Stefan Schmidt, Annett Linge, Marianne Grosser, Fabian Lohaus, Volker Gudziol, Alexander Nowak, Ingeborg Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Henning Schäfer, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E. Combs, David Mönnich, Daniel Zips, Gustavo B. Baretton, Frank Buchholz, Michael Baumann, Mechthild Krause & Steffen Löck. (2020) Comparison of GeneChip, nCounter, and Real-Time PCR–Based Gene Expressions Predicting Locoregional Tumor Control after Primary and Postoperative Radiochemotherapy in Head and Neck Squamous Cell Carcinoma. The Journal of Molecular Diagnostics 22:6, pages 801-810.
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Feng Xue, Lixue Yang, Binghua Dai, Hui Xue, Lei Zhang, Ruiliang Ge & Yanfu Sun. (2020) Bioinformatics profiling identifies seven immune-related risk signatures for hepatocellular carcinoma. PeerJ 8, pages e8301.
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Andreas Dietz, Susanne Wiegand, Thomas Kuhnt & Gunnar Wichmann. (2019) Laryngeal Preservation Approaches: Considerations for New Selection Criteria Based on the DeLOS-II Trial. Frontiers in Oncology 9.
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Jiabao Ma, Rui Li & Jie Wang. (2019) Characterization of a prognostic four‑gene methylation signature associated with radiotherapy for head and neck squamous cell carcinoma. Molecular Medicine Reports.
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S. Tribius, N. Würdemann, S. Laban, S. J. Sharma, S. Wagner, T. K. Hoffmann, C. Wittekindt & J. P. Klussmann. (2018) Update zu HPV-assoziierten Kopf-Hals-Karzinomen – Highlights der ASCO-Jahrestagung 2018Update on HPV-associated head and neck cancer—highlights of the 2018 ASCO Annual Meeting. HNO 66:12, pages 888-895.
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Gunnar Wichmann, Claudia Lehmann, Cindy Herchenhahn, Marlen Kolb, Mathias Hofer, Susanne Wiegand & Andreas Dietz. (2018) Development of a Human Leukocyte Antigen Score to Predict Progression-Free Survival in Head and Neck Squamous Cell Carcinoma Patients. Frontiers in Oncology 8.
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Diane Goltz, Heidrun Gevensleben, Joern Dietrich, Friederike Schroeck, Luka de Vos, Freya Droege, Glen Kristiansen, Andreas Schroeck, Jennifer Landsberg, Friedrich Bootz & Dimo Dietrich. (2017) PDCD1 ( PD-1 ) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients . Oncotarget 8:25, pages 41011-41020.
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Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz & Regine Kluge. (2017) Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: Outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET/CT. European Journal of Cancer 72, pages 144-155.
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Maria Costales, Alejandro López‐Hernández, Cristina García‐Inclán, Blanca Vivanco, Fernando López, José Luis Llorente & Mario A. Hermsen. (2016) Gene Methylation Profiling in Sinonasal Adenocarcinoma and Squamous Cell Carcinoma. Otolaryngology–Head and Neck Surgery 155:5, pages 808-815.
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