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Epigenetics Volume 11, 2016 - Issue 11
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Research Paper

Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma

Benjamin GoeppertInstitute of Pathology, University Hospital Heidelberg, GermanyCorrespondence[email protected] [email protected]
,
Christina ErnstDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Constance BaerDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Stephanie RoesslerInstitute of Pathology, University Hospital Heidelberg, Germany
,
Marcus RennerInstitute of Pathology, University Hospital Heidelberg, Germany
,
Arianeb MehrabiDepartment of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Germany
,
Mohammadreza HafeziDepartment of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Germany
,
Anita PathilDepartment of Internal Medicine IV, Gastroenterology and Hepatology, University Hospital Heidelberg, Germany
,
Arne WarthInstitute of Pathology, University Hospital Heidelberg, Germany
,
Albrecht StenzingerInstitute of Pathology, University Hospital Heidelberg, Germany
,
Wilko WeichertTechnical University of Munich, University Hospital, Institute for General Pathology and Pathological Anatomy, Germany
,
Marion BährDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Rainer WillGenomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
,
Peter SchirmacherInstitute of Pathology, University Hospital Heidelberg, Germany
,
Christoph PlassDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
&
Dieter WeichenhanDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, GermanyCorrespondence[email protected] [email protected]
 show all
Pages 780-790 | Received 06 Jul 2016, Accepted 18 Aug 2016, Published online: 01 Nov 2016

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Antonio Cigliano, Xin Chen & Diego F. Calvisi. (2021) Current challenges to underpinning the genetic basis for cholangiocarcinoma. Expert Review of Gastroenterology & Hepatology 15:5, pages 511-526.
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Articles from other publishers (27)

Baiyin Zhong, Qicheng Liao, Xin Wang, Xiaonong Wang & Jianhong Zhang. (2023) The roles of epigenetic regulation in cholangiocarcinogenesis. Biomedicine & Pharmacotherapy 166, pages 115290.
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Kyung-Jun Lee, Nitya Singh, Michael Bizuneh, Nam-Hyeok Kim, Hyeong Su Kim, Youngmi Kim, Jae-Jun Lee, Jung Han Kim, Jiye Kim, Soo Young Jeong, Hye-Yon Cho & Sung Taek Park. (2023) miR-429 Suppresses Endometrial Cancer Progression and Drug Resistance via DDX53. Journal of Personalized Medicine 13:9, pages 1302.
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Mingjian Ma, Guangyan Zeng, Jinhui Li, Jiahua Liang, Li Huang, Jiancong Chen & Jiaming Lai. (2022) Expressional and prognostic value of HPCAL1 in cholangiocarcinoma via integrated bioinformatics analyses and experiments . Cancer Medicine 12:1, pages 824-836.
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Sazzad Shahrear, Maliha Afroj Zinnia, Tasnim Ahmed & Abul Bashar Mir Md. Khademul Islam. (2022) Deciphering the role of predicted miRNAs of polyomaviruses in carcinogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1868:12, pages 166537.
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Benjamin Goeppert, Damian Stichel, Reka Toth, Sarah Fritzsche, Moritz Anton Loeffler, Anna Melissa Schlitter, Olaf Neumann, Yassen Assenov, Monika Nadja Vogel, Arianeb Mehrabi, Katrin Hoffmann, Bruno Köhler, Christoph Springfeld, Dieter Weichenhan, Christoph Plass, Irene Esposito, Peter Schirmacher, Andreas von Deimling & Stephanie Roessler. (2022) Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis. Gut 71:2, pages 391-401.
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Shanshan Luo, Rujing Lin, Xiwen Liao, Daimou Li & Yuzhou Qin. (2021) Identification and verification of the molecular mechanisms and prognostic values of the cadherin gene family in gastric cancer. Scientific Reports 11:1.
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Zongxian Zhao, Shuliang Li, Shilong Li, Jun Wang, Hai Lin & Weihua Fu. (2021) High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer Cell International 21:1.
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Ali Reza Safarpour, Hassan Askari, Farshid Ejtehadi, Asaad Azarnezhad, Ehsan Raeis-Abdollahi, Amir Tajbakhsh, Mohammad Foad Abazari, Firoozeh Tarkesh, Alireza Shamsaeefar, Ramin Niknam, Gholam Reza Sivandzadeh, Kamran Bagheri Lankarani & Fardad Ejtehadi. (2021) Cholangiocarcinoma and liver transplantation: What we know so far?. World Journal of Gastrointestinal Pathophysiology 12:5, pages 84-105.
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Konstantinos Laschos, Dimitra Ioanna Lampropoulou, Gerasimos Aravantinos, Maria Piperis, Dimitrios Filippou, George Theodoropoulos & Maria Gazouli. (2020) Exosomal noncoding RNAs in cholangiocarcinoma: Laboratory noise or hope?. World Journal of Gastrointestinal Surgery 12:10, pages 407-424.
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I-Jen Chiu, Yung-Ho Hsu, Jeng-Shou Chang, Jou-Chun Yang, Hui-Wen Chiu & Yuan-Feng Lin. (2020) Lactotransferrin Downregulation Drives the Metastatic Progression in Clear Cell Renal Cell Carcinoma. Cancers 12:4, pages 847.
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Mingwen Jiao, Shanglei Ning, Jingbo Chen, Lili Chen, Meng Jiao, Zhonghui Cui, Lingyu Guo, Wentao Mu & Hui Yang. (2020) Long non‑coding RNA ZEB1‑AS1 predicts a poor prognosis and promotes cancer progression through the miR‑200a/ZEB1 signaling pathway in intrahepatic cholangiocarcinoma. International Journal of Oncology.
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Zhengming Su, Ganggang Jiang, Jinlan Chen, Xing Liu, Haibo Zhao, Zhiyuan Fang, Yongzhong He, Xianhan Jiang & Guibin Xu. (2019) MicroRNA‑429 inhibits cancer cell proliferation and migration by targeting AKT1 in renal cell carcinoma. Molecular and Clinical Oncology.
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Jingxiao Wang, Haichuan Wang, Michele Peters, Ning Ding, Silvia Ribback, Kirsten Utpatel, Antonio Cigliano, Frank Dombrowski, Meng Xu, Xinyan Chen, Xinhua Song, Li Che, Matthias Evert, Antonio Cossu, John Gordan, Yong Zeng, Xin Chen & Diego F. Calvisi. (2019) Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis. Journal of Hepatology 71:4, pages 742-752.
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Deshun Huang, Fuxi Wang, Wenzhong Wu, Cuihong Lian & Enrang Liu. (2019) MicroRNA-429 inhibits cancer cell proliferation and migration by targeting the AKT1 in melanoma. Cancer Biomarkers 26:1, pages 63-68.
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Vikrant Rai, Chandra Boosani & Devendra Agrawal. (2019) The promising role of epigenetic mediators and microRNAs in the early diagnosis of cholangiocarcinoma (Review). World Academy of Sciences Journal.
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J. Ignacio Casal & Rubén A. Bartolomé. (2019) Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis. International Journal of Molecular Sciences 20:13, pages 3373.
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Chiara Braconi, Stephanie Roessler, Beata Kruk, Frank Lammert, Marcin Krawczyk & Jesper B Andersen. (2019) Molecular perturbations in cholangiocarcinoma: Is it time for precision medicine?. Liver International 39:S1, pages 32-42.
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Maria J. Perugorria, Paula Olaizola, Ibone Labiano, Aitor Esparza-Baquer, Marco Marzioni, Jose J. G. Marin, Luis Bujanda & Jesus M. Banales. (2018) Wnt–β-catenin signalling in liver development, health and disease. Nature Reviews Gastroenterology & Hepatology 16:2, pages 121-136.
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Daniel Ortega‑Bernal, Claudia Gonz�lez‑De La Rosa, Elena Arechaga‑Ocampo, Miguel Alvarez‑Avitia, Nora Moreno & Claudia Rangel‑Escare�o. (2018) A meta‑analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma. Oncology Letters.
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Quanbo Ji, Xiaojie Xu, Qi Song, Yameng Xu, Yanhong Tai, Stuart B. Goodman, Wenzhi Bi, Meng Xu, Shunchang Jiao, William J. Maloney & Yan Wang. (2018) miR-223-3p Inhibits Human Osteosarcoma Metastasis and Progression by Directly Targeting CDH6. Molecular Therapy 26:5, pages 1299-1312.
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J. Ignacio Casal & Rubén A. Bartolomé. (2018) RGD cadherins and α2β1 integrin in cancer metastasis: A dangerous liaison. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1869:2, pages 321-332.
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P. Olaizola, P.Y. Lee-Law, A. Arbelaiz, A. Lapitz, M.J. Perugorria, L. Bujanda & J.M. Banales. (2018) MicroRNAs and extracellular vesicles in cholangiopathies. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:4, pages 1293-1307.
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Colm J. O'Rourke, Patricia Munoz-Garrido, Esmeralda L. Aguayo & Jesper B. Andersen. (2018) Epigenome dysregulation in cholangiocarcinoma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:4, pages 1423-1434.
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Hongyan Xue & Guo-Yan Tian. (2018) MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23. Archives of Biochemistry and Biophysics 637, pages 48-55.
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