2,532
Views
51
CrossRef citations to date
0
Altmetric
Research Paper

Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis

, , , , , , , , , & show all
Pages 113-122 | Received 17 Oct 2016, Accepted 07 Dec 2016, Published online: 25 Jan 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Laura López-Delgado, Alvaro del Real, Carolina Sañudo, Carmen Garcia-Ibarbia, Esther Laguna, Guillermo Menendez, Belen Garcia-Montesinos, Ana Santurtun, Jesus Merino, María I Pérez-Núñez & Jose A. Riancho. (2022) Osteogenic capacity of mesenchymal stem cells from patients with osteoporotic hip fractures in vivo. Connective Tissue Research 63:3, pages 243-255.
Read now

Articles from other publishers (50)

Yuxi Gu, Yidan Song, Yihua Pan & Jun Liu. (2024) The essential roles of m6A modification in osteogenesis and common bone diseases. Genes & Diseases 11:1, pages 335-345.
Crossref
Wei Qiang Seow, Lillian Yuxian Lim, Dewei Kong & Adrian Kee Keong Teo. 2024. Epigenetics in Human Disease. Epigenetics in Human Disease 1113 1139 .
Xinyu Liang, Wei Shi, Xinglong Zhang, Ran Pang, Kai Zhang, Qian Xu, Chunlei Xu, Xin Wan, Wenhao Cui, Dong Li, Zhaohui Jiang, Zhengxuan Liu, Hui Li, Huafeng Zhang & Zhijun Li. (2023) Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study. BMC Medical Genomics 16:1.
Crossref
Daniel García-Sánchez, Alberto González-González, Itzíar Álvarez-Iglesias, Mónica del Dujo-Gutiérrez, Alfonso Bolado-Carrancio, Matilde Certo, María Isabel Pérez-Núñez, José A. Riancho, José Carlos Rodríguez-Rey, Jesús Delgado-Calle & Flor María Pérez-Campo. (2023) Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1. International Journal of Molecular Sciences 24:15, pages 12399.
Crossref
Peiguang Zhang, Bo Feng, Guangming Dai, Kecheng Niu & Lan Zhang. (2023) FOXC1 Promotes Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells via the Dnmt3b/CXCL12 Axis. Biochemical Genetics.
Crossref
Annamaria la Torre, Filomena Lo Vecchio & Antonio Greco. (2023) Epigenetic Mechanisms of Aging and Aging-Associated Diseases. Cells 12:8, pages 1163.
Crossref
Laura Doherty, Matthew Wan, Anna Peterson, Daniel W. Youngstrom, Justin S. King, Ivo Kalajzic, Kurt D. Hankenson & Archana Sanjay. (2023) Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing. Bone 169, pages 116681.
Crossref
Zhaohua Wang, Si Wen, Meiqi Zhong, Ziming Yang, Wei Xiong, Kuo Zhang, Shude Yang, Huizheng Li & Shu Guo. (2023) Epigenetics: Novel crucial approach for osteogenesis of mesenchymal stem cells. Journal of Tissue Engineering 14.
Crossref
Maciej Tarnowski, Patrycja Tomasiak, Marta Tkacz, Katarzyna Zgutka & Katarzyna Piotrowska. (2022) Epigenetic Alterations in Sports-Related Injuries. Genes 13:8, pages 1471.
Crossref
Esther Laguna, María Isabel Pérez-Núñez, Álvaro del Real, Guillermo Menéndez, José A. Sáinz-Aja, Laura López-Delgado, Carolina Sañudo, Alicia Martín, Remigio Mazorra, Diego Ferreño, Belén García-Montesinos & José A. Riancho. (2022) Effects of Systemic or Local Administration of Mesenchymal Stem Cells from Patients with Osteoporosis or Osteoarthritis on Femoral Fracture Healing in a Mouse Model. Biomolecules 12:5, pages 722.
Crossref
Elizabeth M. Curtis, Nicholas R. Fuggle, Cyrus Cooper & Nicholas C. Harvey. (2022) Epigenetic regulation of bone mass. Best Practice & Research Clinical Endocrinology & Metabolism 36:2, pages 101612.
Crossref
Jianwei Xu, Gang Liu, Xianyao Wang, Ya’nan Hu, Hongyang Luo, Lan Ye, Zhanhui Feng, Chen Li, Menglan Kuang, Lijuan Zhang, Yixia Zhou & Xiaolan Qi. (2022) hUC-MSCs: evaluation of acute and long-term routine toxicity testing in mice and rats. Cytotechnology 74:1, pages 17-29.
Crossref
Ferhat Ege. 2022. Rheumatoid Arthritis. Rheumatoid Arthritis.
Maria Tsagiopoulou, Nikolaos Pechlivanis, Maria Christina Maniou & Fotis Psomopoulos. (2022) InterTADs: integration of multi-omics data on topologically associated domains, application to chronic lymphocytic leukemia. NAR Genomics and Bioinformatics 4:1.
Crossref
Alberto González-González, Daniel García-Sánchez, Ana Alfonso-Fernández, Khawaja Husnain Haider, José C. Rodríguez-Rey & Flor M. Pérez-Campo. 2022. Handbook of Stem Cell Therapy. Handbook of Stem Cell Therapy 1123 1158 .
Alberto González-González, Daniel García-Sánchez, Ana Alfonso-Fernández, Khawaja H. Haider, José C. Rodríguez-Rey & Flor M. Pérez-Campo. 2022. Handbook of Stem Cell Therapy. Handbook of Stem Cell Therapy 1 36 .
Sébastien Riquier, Marc Mathieu, Chloé Bessiere, Anthony Boureux, Florence Ruffle, Jean-Marc Lemaitre, Farida Djouad, Nicolas Gilbert & Thérèse Commes. (2021) Long non-coding RNA exploration for mesenchymal stem cell characterisation. BMC Genomics 22:1.
Crossref
Martina Rauner, Ines Foessl, Melissa M. Formosa, Erika Kague, Vid Prijatelj, Nerea Alonso Lopez, Bodhisattwa Banerjee, Dylan Bergen, Björn Busse, Ângelo Calado, Eleni Douni, Yankel Gabet, Natalia García Giralt, Daniel Grinberg, Nika M. Lovsin, Xavier Nogues Solan, Barbara Ostanek, Nathan J. Pavlos, Fernando Rivadeneira, Ivan Soldatovic, Jeroen van de Peppel, Bram van der Eerden, Wim van Hul, Susanna Balcells, Janja Marc, Sjur Reppe, Kent Søe & David Karasik. (2021) Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques. Frontiers in Endocrinology 12.
Crossref
Daniel García-Sánchez, Alberto González-González, Patricia García-García, Ricardo Reyes, María Isabel Pérez-Núñez, José A. Riancho, Carmen Évora, José Carlos Rodríguez-Rey & Flor M. Pérez-Campo. (2021) Effective Osteogenic Priming of Mesenchymal Stem Cells through LNA-ASOs-Mediated Sfrp1 Gene Silencing. Pharmaceutics 13:8, pages 1277.
Crossref
Fei Xu, Wenhui Li, Xiao Yang, Lixin Na, Linjun Chen & Guobin Liu. (2021) The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis. Frontiers in Cell and Developmental Biology 8.
Crossref
Junbo ChenYihong TianQi ZhangDapeng RenQiang ZhangXiao YanLingzhi WangZijing HeWei ZhangTianzhen ZhangXiao Yuan. (2021) Novel Insights Into the Role of N6-Methyladenosine RNA Modification in Bone Pathophysiology. Stem Cells and Development 30:1, pages 17-28.
Crossref
Lotte E. van der Wagen, Alberto Miranda-Bedate, Anke Janssen, Febilla Fernando, Nagesha Appukudige, Sanne van Dooremalen, Kasper Westinga, Rick Admiraal, Magdalena J. Lorenowicz, Gerwin Huls, Jeroen J. W. M. Janssen, Annoek E. C. Broers, Walter J. F. M. van der Velden, Rien van Marwijk Kooy, Mette D. Hazenberg, Colin de Haar, Caroline Lindemans, Jaap Jan Boelens & Jürgen Kuball. (2020) Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile. Bone Marrow Transplantation 55:11, pages 2188-2192.
Crossref
Jing‐chao Ren, Tongshuai Wang, Hantian Wu, Guang‐hui Zhang, Daoyuan Sun, Kongrong Guo, Haibin Li, Fengquan Zhang, Weidong Wu & Zhao‐lin Xia. (2020) Promoter hypermethylation in CSF3R induces peripheral neutrophil reduction in benzene‐exposure poisoning . Environmental and Molecular Mutagenesis 61:8, pages 786-796.
Crossref
Alvaro Del RealLaura López-DelgadoCarolina SañudoCarmen García-IbarbiaEsther LagunaFlor M. Perez-CampoGuillermo MenéndezAna AlfonsoMichel FakkasBelén García-MontesinosCarmen ValeroMaria Isabel Pérez-NúñezJose A. Riancho. (2020) Long Noncoding RNAs as Bone Marrow Stem Cell Regulators in Osteoporosis. DNA and Cell Biology 39:9, pages 1691-1699.
Crossref
Chao Dong, Hong Yang, Yongkui Wang, Xu Yan, Dongzhe Li, Zhengming Cao, Yongming Ning & Chunlin Zhang. (2020) Anagliptin stimulates osteoblastic cell differentiation and mineralization. Biomedicine & Pharmacotherapy 129, pages 109796.
Crossref
Dimitrios Cakouros & Stan Gronthos. (2020) The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging. Bone 137, pages 115440.
Crossref
Benjamin Seelbinder, Adrienne K. Scott, Isabel Nelson, Stephanie E. Schneider, Kristin Calahan & Corey P. Neu. (2020) TENSCell: Imaging of Stretch-Activated Cells Reveals Divergent Nuclear Behavior and Tension. Biophysical Journal 118:11, pages 2627-2640.
Crossref
Jun Ying, Taotao Xu, Cuicui Wang, Hongting Jin, Peijian Tong, Jianjun Guan, Yousef Abu-Amer, Regis O’Keefe & Jie Shen. (2020) Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway. JCI Insight 5:3.
Crossref
Sho Mokuda, Ryo Nakamichi, Yoshiaki Ito & Hiroshi Asahara. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 641 651 .
Patricia García-García, Mario Ruiz, Ricardo Reyes, Araceli Delgado, Carmen Évora, José Antonio Riancho, José Carlos Rodríguez-Rey & Flor María Pérez-Campo. (2019) Smurf1 Silencing Using a LNA-ASOs/Lipid Nanoparticle System to Promote Bone Regeneration . Stem Cells Translational Medicine 8:12, pages 1306-1317.
Crossref
Hyunjin Lee, Sae Min, Youngmin Song, Yun‑Hee Park & Jun‑Beom Park. (2019) Bone morphogenetic protein‑7 upregulates genes associated with osteoblast differentiation, including collagen I, Sp7 and IBSP in gingiva‑derived stem cells. Experimental and Therapeutic Medicine.
Crossref
Estefanía Cortés‐Pereira, Juan Fernández‐Tajes, Mercedes Fernández‐Moreno, María E. Vázquez‐Mosquera, Sara Relaño, Paula Ramos‐Louro, Alejandro Durán‐Sotuela, Andrea Dalmao‐Fernández, Natividad Oreiro, Francisco J. Blanco & Ignacio Rego‐Pérez. (2019) Differential Association of Mitochondrial DNA Haplogroups J and H With the Methylation Status of Articular Cartilage: Potential Role in Apoptosis and Metabolic and Developmental Processes. Arthritis & Rheumatology 71:7, pages 1191-1200.
Crossref
Fjorda Koromani, Katerina Trajanoska, Fernando Rivadeneira & Ling Oei. (2019) Recent Advances in the Genetics of Fractures in Osteoporosis. Frontiers in Endocrinology 10.
Crossref
B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva & R. I. Khusainova. (2019) The role of DNA methylation in the disorders of bone metabolism. Vavilov Journal of Genetics and Breeding 23:1, pages 67-74.
Crossref
Joyce BJ van Meurs, Cindy G Boer, Laura Lopez‐Delgado & Jose A Riancho. (2019) Role of Epigenomics in Bone and Cartilage Disease. Journal of Bone and Mineral Research 34:2, pages 215-230.
Crossref
Ana Santurtún, Alvaro del Real & Jose A. Riancho. 2019. Bone Health. Bone Health 151 175 .
Tonje G. Lien, Ørnulf Borgan, Sjur Reppe, Kaare Gautvik & Ingrid Kristine Glad. (2018) Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women. BMC Medical Genomics 11:1.
Crossref
Laetitia Michou. (2018) Epigenetics of bone diseases. Joint Bone Spine 85:6, pages 701-707.
Crossref
Laëtitia Michou. (2018) Épigénétique des maladies osseuses. Revue du Rhumatisme 85:5, pages 453-459.
Crossref
Franz Jakob, Regina Ebert, Eduardo Fernandez-Rebollo, Oliver Bischof & Wolfgang Wagner. (2018) Response to Letter to the Editor: Epigenetic Aging in Osteoporosis. Journal of Bone and Mineral Research 33:10, pages 1904-1905.
Crossref
Alvaro del Real, Leyre Riancho-Zarrabeitia & Jose A Riancho. (2018) Epigenetic Aging in Osteoporosis. Journal of Bone and Mineral Research 33:10, pages 1902-1903.
Crossref
Alvaro del Real, Leyre Riancho-Zarrabeitia, Laura López-Delgado & José A. Riancho. (2018) Epigenetics of Skeletal Diseases. Current Osteoporosis Reports 16:3, pages 246-255.
Crossref
Hao Sun, Xiaoyi Zhao, Chengyun Zhang, Ziji Zhang, Jiayong Lun, Weiming Liao & Zhiqi Zhang. (2018) MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation. Cell Death & Disease 9:5.
Crossref
Joseph L. Roberts, David N. Paglia & Hicham Drissi. (2018) Transcriptional Mechanisms of Secondary Fracture Healing. Current Osteoporosis Reports 16:2, pages 146-154.
Crossref
M.J. Peffers, P. Balaskas & A. Smagul. (2018) Osteoarthritis year in review 2017: genetics and epigenetics. Osteoarthritis and Cartilage 26:3, pages 304-311.
Crossref
Eduardo Fernandez-Rebollo, Monika Eipel, Lothar Seefried, Per Hoffmann, Klaus Strathmann, Franz Jakob & Wolfgang Wagner. (2018) Primary Osteoporosis Is Not Reflected by Disease-Specific DNA Methylation or Accelerated Epigenetic Age in Blood. Journal of Bone and Mineral Research 33:2, pages 356-361.
Crossref
Cristina Ruiz-Romero, Ignacio Rego-Perez & Francisco J. Blanco. (2018) What did we learn from ‘omics’ studies in osteoarthritis. Current Opinion in Rheumatology 30:1, pages 114-120.
Crossref
Leila Larijani & Derrick E. Rancourt. 2018. Epigenetics in Human Disease. Epigenetics in Human Disease 877 902 .
Ali Husain & Matlock A. Jeffries. (2017) Epigenetics and Bone Remodeling. Current Osteoporosis Reports 15:5, pages 450-458.
Crossref
Álvaro del Real, José A. Riancho & Jesus Delgado-Calle. (2017) Epigenetic Regulation of Sost/sclerostin Expression. Current Molecular Biology Reports 3:2, pages 85-93.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.