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Epigenetics Volume 12, 2017 - Issue 6
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Research Paper

Non-linear patterns in age-related DNA methylation may reflect CD4+ T cell differentiation

Nicholas D. JohnsonDepartment of Human Genetics, Emory University, Atlanta, GA, USACorrespondence[email protected]
,
Howard W. WienerDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
,
Alicia K. SmithDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA;Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
,
Shota NishitaniDepartment of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA;Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
,
Devin M. AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA
,
Donna K. ArnettCollege of Public Health, University of Kentucky, Lexington, KY, USA
,
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
&
Karen N. ConneelyDepartment of Human Genetics, Emory University, Atlanta, GA, USA
 show all
Pages 492-503 | Received 23 Nov 2016, Accepted 28 Mar 2017, Published online: 17 May 2017

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Nicholas D. Johnson, Luoxiu Huang, Ronghua Li, Yun Li, Yuchen Yang, Hye Rim Kim, Crystal Grant, Hao Wu, Eric A. Whitsel, Douglas P. Kiel, Andrea A. Baccarelli, Peng Jin, Joanne M. Murabito & Karen N. Conneely. (2020) Age-related DNA hydroxymethylation is enriched for gene expression and immune system processes in human peripheral blood. Epigenetics 15:3, pages 294-306.
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Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano & Martin Picard. (2019) Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. Epigenetics 14:10, pages 961-976.
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Articles from other publishers (17)

Ruochen Liu, Erhu Zhao, Huijuan Yu, Chaoyu Yuan, Muhammad Nadeem Abbas & Hongjuan Cui. (2023) Methylation across the central dogma in health and diseases: new therapeutic strategies. Signal Transduction and Targeted Therapy 8:1.
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Dimitrina Miteva & Tsvetelina Velikova. (2023) EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM. Anti-Aging Eastern Europe 2:1, pages 29-35.
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Elena Bernabeu, Daniel L. McCartney, Danni A. Gadd, Robert F. Hillary, Ake T. Lu, Lee Murphy, Nicola Wrobel, Archie Campbell, Sarah E. Harris, David Liewald, Caroline Hayward, Cathie Sudlow, Simon R. Cox, Kathryn L. Evans, Steve Horvath, Andrew M. McIntosh, Matthew R. Robinson, Catalina A. Vallejos & Riccardo E. Marioni. (2023) Refining epigenetic prediction of chronological and biological age. Genome Medicine 15:1.
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Susmita Das, Zeeshan Ahmad, Amol Suryawanshi & Ashok Kumar. (2022) Innate immunity dysregulation in aging eye and therapeutic interventions. Ageing Research Reviews 82, pages 101768.
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Carlos Ruiz-Arenas, Carles Hernandez-Ferrer, Marta Vives-Usano, Sergi Marí, Ines Quintela, Dan Mason, Solène Cadiou, Maribel Casas, Sandra Andrusaityte, Kristine Bjerve Gutzkow, Marina Vafeiadi, John Wright, Johanna Lepeule, Regina Grazuleviciene, Leda Chatzi, Ángel Carracedo, Xavier Estivill, Eulàlia Marti, Geòrgia Escaramís, Martine Vrijheid, Juan R González & Mariona Bustamante. (2022) Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children’s blood. eLife 11.
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K. A. Aitbaev, I. T. Murkamilov, Zh. A. Murkamilova, I. O. Kudaibergenova & F. A. Yusupov. (2022) Regulation of the Immune System in Aging: Focus on Epigenetic Mechanisms. The Russian Archives of Internal Medicine 12:1, pages 35-44.
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Anne-Marie Galow & Shahaf Peleg. (2022) How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span. Cells 11:3, pages 468.
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Shuang Jiang & Yuchen Guo. (2020) Epigenetic Clock: DNA Methylation in Aging. Stem Cells International 2020, pages 1-9.
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Mario Saare, Liina Tserel, Liis Haljasmägi, Egon Taalberg, Nadežda Peet, Margus Eimre, Rait Vetik, Külli Kingo, Kai Saks, Riin Tamm, Lili Milani, Kai Kisand & Pärt Peterson. (2020) Monocytes present age‐related changes in phospholipid concentration and decreased energy metabolism. Aging Cell 19:4.
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Qian Zhang, Costanza L. Vallerga, Rosie M. Walker, Tian Lin, Anjali K. Henders, Grant W. Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, Martin Kennedy, Toni Pitcher, John Pearson, Glenda Halliday, John B. Kwok, Ian Hickie, Simon Lewis, Tim Anderson, Peter A. Silburn, George D. Mellick, Sarah E. Harris, Paul Redmond, Alison D. Murray, David J. Porteous, Christopher S. Haley, Kathryn L. Evans, Andrew M. McIntosh, Jian Yang, Jacob Gratten, Riccardo E. Marioni, Naomi R. Wray, Ian J. Deary, Allan F. McRae & Peter M. Visscher. (2019) Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Medicine 11:1.
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Cui-Huan Tian, Jun Dai, Wei Zhang, Yan LiuYan Yang. (2019) Expression of IL-17 and its gene promoter methylation status are associated with the progression of chronic hepatitis B virus infection. Medicine 98:23, pages e15924.
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Nicholas D. Johnson & Karen N. Conneely. (2019) The role of DNA methylation and hydroxymethylation in immunosenescence. Ageing Research Reviews 51, pages 11-23.
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Christine R. Keenan & Rhys S. Allan. (2018) Epigenomic drivers of immune dysfunction in aging. Aging Cell 18:1.
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Paul Moss. 2019. Handbook of Immunosenescence. Handbook of Immunosenescence 323 335 .
Paul Moss. 2018. Handbook of Immunosenescence. Handbook of Immunosenescence 1 13 .
Lucas T. Husquin, Maxime Rotival, Maud Fagny, Hélène Quach, Nora Zidane, Lisa M. McEwen, Julia L. MacIsaac, Michael S. Kobor, Hugues Aschard, Etienne Patin & Lluis Quintana-Murci. (2018) Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation. Genome Biology 19:1.
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Miriam G. Jasiulionis. (2018) Abnormal Epigenetic Regulation of Immune System during Aging. Frontiers in Immunology 9.
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