Advanced search
Publication Cover
Epigenetics Volume 13, 2018 - Issue 10-11
Submit an article Journal homepage
1,764
Views
15
CrossRef citations to date
0
Altmetric
Research Paper

Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts

Juan Jose CarmonaDepartment of Environmental Health and Program in Quantitative Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Center for Bioethics, Harvard Medical School, Boston, MA, USA;Office of Research, Dana-Farber/Harvard Cancer Institute, Boston, MA, USAView further author information
,
Richard T. BarfieldPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USACorrespondence[email protected]
View further author information
,
Tommaso PanniInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyView further author information
,
Jamaji C. Nwanaji-EnweremDepartment of Environmental Health and Program in Quantitative Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;MD-PhD Program, Harvard Medical School, Boston, MA, USAView further author information
,
Allan C. JustPreventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USAORCID Iconhttp://orcid.org/0000-0003-4312-5957View further author information
ORCID Icon,
John N. HutchinsonDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USAView further author information
,
Elena ColicinoDepartments Environmental Medicine & Public Health, Division of Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY, USAView further author information
,
Stefan KarraschInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany;Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research, Munich, GermanyView further author information
,
Simone WahlResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyView further author information
,
Sonja KunzeInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyView further author information
,
Nadereh JafariCenter for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAView further author information
,
Yinan ZhengCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAView further author information
,
Lifang HouCenter for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USAView further author information
,
Dawn L. DeMeoChanning Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Augusto A. LitonjuaChanning Division of Network Medicine and the Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAORCID Iconhttp://orcid.org/0000-0003-0422-5875View further author information
ORCID Icon,
Pantel S. VokonasVA Normative Aging Study, Veterans Affairs Boston Healthcare System and the Department of Medicine, Boston University School of Medicine, Boston, MA, USAView further author information
,
Annette PetersOffice of Research, Dana-Farber/Harvard Cancer Institute, Boston, MA, USA;Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, GermanyView further author information
,
Xihong LinDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Statistics, Harvard University, Cambridge, MA, USAView further author information
,
Joel SchwartzOffice of Research, Dana-Farber/Harvard Cancer Institute, Boston, MA, USAView further author information
,
Holger SchulzInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany;Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research, Munich, GermanyView further author information
&
Andrea A. BaccarelliOffice of Research, Dana-Farber/Harvard Cancer Institute, Boston, MA, USA;Departments of Epidemiology and Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USAView further author information
 show all
Pages 1039-1055 | Received 06 Mar 2018, Accepted 22 Sep 2018, Published online: 21 Oct 2018

Citations (15)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Young Soon Yoon, Minhee Jin & Don D. Sin. (2019) Accelerated lung aging and chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 13:4, pages 369-380.
Read now

Articles from other publishers (14)

David J Martino, Dinh S. Bui, Shuai Li, Sabrina Idrose, Jennifer Perret, Adrian Lowe, Caroline Lodge, Gayan Bowatte, Yuben Moodley, Paul S Thomas, Graeme Zosky, Phillip M Hansbro, John Holloway, Cecile Svanse, Rosa Faner, Eugene H Walters & Shaymali C. Dharmage. (2023) Genetic and Epigenetic Associations with Pre-COPD Lung Function Trajectories. American Journal of Respiratory and Critical Care Medicine.
Crossref
Uwe Schwartz, Maria Llamazares Prada, Stephanie T Pohl, Mandy Richter, Raluca Tamas, Michael Schuler, Corinna Keller, Vedrana Mijosek, Thomas Muley, Marc A Schneider, Karsten Quast, Joschka Hey, Claus P Heußel, Arne Warth, Hauke Winter, Özdemirhan Serçin, Harry Karmouty‐Quintana, Soma SK Jyothula, Manish K Patel, Felix Herth, Ina Koch, Giuseppe Petrosino, Alexandru Titimeaua, Balca R Mardin, Dieter Weichenhan, Tomasz P Jurkowski, Charles D Imbusch, Benedikt Brors, Vladimir Benes, Birgit Jung, David Wyatt, Heiko F Stahl, Christoph Plass & Renata Z Jurkowska. (2023) High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD. The EMBO Journal 42:12.
Crossref
Yike Shen, Marianthi-Anna Kioumourtzoglou, Haotian Wu, Pantel Vokonas, Avron SpiroIIIIII, Ana Navas-Acien, Andrea A. Baccarelli & Feng Gao. (2023) Cohort Network: A Knowledge Graph toward Data Dissemination and Knowledge-Driven Discovery for Cohort Studies. Environmental Science & Technology 57:22, pages 8236-8244.
Crossref
Evangelia Legaki, Styliani Taka & Nikolaos G. Papadopoulos. (2023) The complexity in DNA methylation analysis of allergic diseases. Current Opinion in Allergy & Clinical Immunology 23:2, pages 172-178.
Crossref
Arce Domingo-Relloso, Angela L. Riffo-Campos, Martha Powers, Maria Tellez-Plaza, Karin Haack, Robert H. Brown, Jason G. Umans, M. Daniele Fallin, Shelley A. Cole, Ana Navas-Acien & Tiffany R. Sanchez. (2022) An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study. Clinical Epigenetics 14:1.
Crossref
Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Javier Perez-Garcia, Jennifer R. Elhawary, Sam S. Oh, Donglei Hu, Celeste Eng, Kevin L. Keys, Scott Huntsman, Kenneth B. Beckman, Luisa N. Borrell, Jose Rodriguez-Santana, Esteban G. Burchard & Maria Pino-Yanes. (2022) Epigenome-wide association study of lung function in Latino children and youth with asthma. Clinical Epigenetics 14:1.
Crossref
Mikyeong Lee, Tianxiao HuanDaniel L. McCartney, Geetha Chittoor, Maaike de Vries, Lies Lahousse, Jennifer N. NguyenJennifer A. Brody, Juan Castillo-Fernandez, Natalie Terzikhan, Cancan QiRoby Joehanes, Josine L. Min, Gordon J. SmilnakJessica R. Shaw, Chen Xi Yang, Elena ColicinoThanh T. Hoang, Mairead L. Bermingham, Hanfei XuAnne E. JusticeCheng-Jian Xu, Stephen S. Rich, Simon R. Cox, Judith M. Vonk, Ivana Prokić, Nona SotoodehniaPei-Chien Tsai, Joel D. Schwartz, Janice M. LeungSinjini Sikdar, Rosie M. Walker, Sarah E. Harris, Diana A. van der Plaat, David J. Van Den Berg, Traci M. BartzTim D. SpectorPantel S. VokonasRiccardo E. Marioni, Adele M. TaylorYongmei Liu, R. Graham BarrLeslie A. Lange, Andrea A. BaccarelliMa’en Obeidat, Myriam FornageTianyuan Wang, James M. Ward, Alison A. Motsinger-Reif, Gibran Hemani, Gerard H. Koppelman, Jordana T. Bell, Sina A. Gharib, Guy Brusselle, H. Marike Boezen, Kari E. North, Daniel LevyKathryn L. Evans, Josée Dupuis, Charles E. Breeze, Ani Manichaikul & Stephanie J. London. (2022) Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis. American Journal of Respiratory and Critical Care Medicine 206:3, pages 321-336.
Crossref
Christina M. Eckhardt, Haotian Wu, Diddier Prada, Pantel S. Vokonas, David Sparrow, Lifang Hou, Joel Schwartz & Andrea A. Baccarelli. (2022) Predicting risk of lung function impairment and all-cause mortality using a DNA methylation-based classifier of tobacco smoke exposure. Respiratory Medicine 200, pages 106896.
Crossref
Fumihiko Takeuchi, Kozue Takano, Masaya Yamamoto, Masato Isono, Wataru Miyake, Kotaro Mori, Hisao Hara, Yukio Hiroi & Norihiro Kato. (2022) Clinical Implication of Smoking-Related Aryl-Hydrocarbon Receptor Repressor (<i>AHRR</i>) Hypomethylation in Japanese Adults. Circulation Journal 86:6, pages 986-992.
Crossref
Giuditta Benincasa, Dawn L. DeMeo, Kimberly Glass, Edwin K. Silverman & Claudio Napoli. (2021) Epigenetics and pulmonary diseases in the horizon of precision medicine: a review. European Respiratory Journal 57:6, pages 2003406.
Crossref
Cuicui Wang, Wenli Ni, Yueli Yao, Allan Just, Jonathan Heiss, Yaguang Wei, Xu Gao, Brent A. Coull, Anna Kosheleva, Andrea A. Baccarelli, Annette Peters & Joel D. Schwartz. (2021) DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: The NAS, and KORA F4. EBioMedicine 63, pages 103151.
Crossref
Miyuki Breen, Jamaji C. Nwanaji-Enwerem, Stefan Karrasch, Claudia Flexeder, Holger Schulz, Melanie Waldenberger, Sonja Kunze, Markus Ollert, Stefan Weidinger, Elena Colicino, Xu Gao, Cuicui Wang, Jincheng Shen, Allan C. Just, Pantel Vokonas, David Sparrow, Lifang Hou, Joel D. Schwartz, Andrea A. Baccarelli, Annette Peters & Cavin K. Ward-Caviness. (2020) Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies. Aging 12:16, pages 16539-16554.
Crossref
Cuicui Wang, Allan Just, Jonathan Heiss, Brent A. Coull, Lifang Hou, Yinan Zheng, David Sparrow, Pantel S. Vokonas, Andrea Baccarelli & Joel Schwartz. (2020) Biomarkers of aging and lung function in the normative aging study. Aging 12:12, pages 11942-11966.
Crossref
Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, André F.S. Amaral, Emmanuel Schaffner, Ayoung Jeong, Anna Beckmeyer-Borowko, Sarah E. Harris, John M. Starr, Ian J. Deary, Claudia Flexeder, Melanie Waldenberger, Annette Peters, Holger Schulz, Su Chen, Shadia Khan Sunny, Wilfried J.J. Karmaus, Yu Jiang, Gertraud Erhart, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Alexander John Henderson, Yu Fu, Päivi Piirilä, Kirsi H. Pietiläinen, Miina Ollikainen, Asa Johansson, Ulf Gyllensten, Maaike de Vries, Diana A. van der Plaat, Kim de Jong, H. Marike Boezen, Ian P. Hall, Martin D. Tobin, Marjo-Riitta Jarvelin, John W. Holloway, Deborah Jarvis & Nicole M. Probst-Hensch. (2019) Epigenome-wide association study of lung function level and its change. European Respiratory Journal 54:1, pages 1900457.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.