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The World Journal of Biological Psychiatry Volume 19, 2018 - Issue 5
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Brief Report

Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression

Marco Antonio CaldieraroDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; ;Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil; Correspondence[email protected] [email protected]
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Madison McKeeDepression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA; View further author information
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Sandra Leistner-SegalMedical Genetics Service, Molecular Genetics Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil; ;Experimental Research Center, B.R.A.I.N. Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil; View further author information
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Edgar Arrua VaresPrograma de Pós-Graduação Ciências Médicas: Psiquiatria, Department of Psychiatry and Forensic Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil; View further author information
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Francyne KubaskiDepartment of Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA; ;Department of Biological Sciences, University of Delaware, Newark, DE, USA; ;Department of Research, Instituto Nacional de Genética Médica Populacional-INAGEMP, Porto Alegre, Brasil; View further author information
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Lucas SpanembergPrograma de Pós-Graduação Ciências Médicas: Psiquiatria, Department of Psychiatry and Forensic Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil; ;Department of Psychiatry, Núcleo de Formação Específica em Psiquiatria da Escola de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brasil; View further author information
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Ana Carolina Brusius-FacchinMedical Genetics Service, Molecular Genetics Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil; View further author information
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Marcelo P. FleckDepartment of Psychiatry, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil; ;Programa de Pós-Graduação Ciências Médicas: Psiquiatria, Department of Psychiatry and Forensic Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil; View further author information
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David MischoulonDepression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA; ;Department of Psychiatry, Harvard Medical School, Boston, MA, USAView further author information
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Pages 402-409 | Received 20 Apr 2017, Accepted 22 Jun 2017, Published online: 12 Jul 2017

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Matea Nikolac Perkovic, Martin Gredicak, Marina Sagud, Gordana Nedic Erjavec, Suzana Uzun & Nela Pivac. (2023) The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression. Expert Review of Molecular Diagnostics 23:4, pages 283-296.
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Articles from other publishers (24)

Anna Pisani, Fabiola Paciello, Valeria Del Vecchio, Rita Malesci, Eugenio De Corso, Elena Cantone & Anna Rita Fetoni. (2023) The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration. Journal of Personalized Medicine 13:4, pages 652.
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Dilinuer Wufuer, Haidiya Aierken, Zhenyu Liang, Jin-Ping Zheng & Li Li. (2023) Association between comorbid asthma and depression and depression-related gene SNPs. Journal of Radiation Research and Applied Sciences 16:1, pages 100496.
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Johannes Hartig & Bogdan Nemeş. (2022) BDNF-related mutations in major depressive disorder: a systematic review. Acta Neuropsychiatrica 35:1, pages 5-26.
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Daniela Piancatelli, Anna Aureli, Pierluigi Sebastiani, Alessia Colanardi, Tiziana Del Beato, Lorenza Del Cane, Patrizia Sucapane, Carmine Marini & Silvia Di Loreto. (2022) Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease. International Journal of Molecular Sciences 23:23, pages 14599.
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Gabriela Aquino Torelly, Priscila dos Santos Novak, Giovana Bristot, Felipe Barreto Schuch & Marcelo Pio de Almeida Fleck. (2022) Acute effects of mind-body practices and exercise in depressed inpatients: A randomized clinical trial. Mental Health and Physical Activity 23, pages 100479.
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Faezeh Abaj, Masoumeh Rafiee & Fariba Koohdani. (2021) Interactions of dietary insulin index and dietary insulin load with brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in relation to cardiometabolic markers in Iranian diabetic patients: a cross-sectional study. British Journal of Nutrition 128:5, pages 785-792.
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Yi Zhang, Xiaoqin Gao, Xue Bai, Shanshan Yao, Yan-Zhong Chang & Guofen Gao. (2022) The emerging role of furin in neurodegenerative and neuropsychiatric diseases. Translational Neurodegeneration 11:1.
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Nikolay Mehterov, Danail Minchev, Maria Gevezova, Victoria Sarafian & Michael Maes. (2022) Interactions Among Brain-Derived Neurotrophic Factor and Neuroimmune Pathways Are Key Components of the Major Psychiatric Disorders. Molecular Neurobiology 59:8, pages 4926-4952.
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Somnath Haldar, Suparna Roy, Santanu Sen, Anindya Dasgupta & Srijit Ghosh. (2022) Association of the Val66Met polymorphism of the BDNF gene and the deletional mutation of CYP2D6 gene with the prevalence and severity of depressive disorder in an Eastern Indian population. Indian Journal of Psychiatry 64:3, pages 269.
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Samantha J. Bayer, Gee Su Yang & Debra E. Lyon. (2022) Genetic Variation Associated With Depressive Symptoms in Breast Cancer Patients. Cancer Nursing 45:1, pages E197-E205.
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Yuanyuan Cheng, Yue Wang, Wen Zhang, Junbo Yin, Jicheng Dong & Jintong Liu. (2022) Relationship between intestinal flora, inflammation, BDNF gene polymorphism and generalized anxiety disorder: A clinical investigation. Medicine 101:29, pages e28910.
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Caroline Ferreira Fratelli, Jhon Willatan Siqueira, Bruna Rodrigues Gontijo, Maurício de Lima Santos, Calliandra Maria de Souza Silva & Izabel Cristina Rodrigues da Silva. (2021) BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder. Behavioural Neurology 2021, pages 1-16.
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Heidrun Lioba Wunram, Max Oberste, Alischa Ziemendorff, Stefanie Hamacher, Tugba Kapanci, Raoul Heller, Serjosha Blick, Wilhelm Bloch, Theresia Christina Clajus, Eckhard Schönau, Stephan Bender & Oliver Fricke. (2021) Differential effects of ergometer-cycling and Whole-Body-Vibration training on serological BDNF and IGF-1 in the treatment of adolescent depression - is there an impact of BDNFp.Val66Met variants?. Physiology & Behavior 241, pages 113596.
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Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He & Ying Jia. (2021) Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis via the BDNF/Nrf2/NF-κB pathway in 6-OHDA-induced Parkinson's disease mice . Food & Function 12:9, pages 4079-4091.
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Louise Martens, Luisa Herrmann, Lejla Colic, Meng Li, Anni Richter, Gusalija Behnisch, Oliver Stork, Constanze Seidenbecher, Björn H. Schott & Martin Walter. (2021) Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts. Scientific Reports 11:1.
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Hiroaki Hori, Mariko Itoh, Mingming Lin, Fuyuko Yoshida, Madoka Niwa, Yuko Hakamata, Mie Matsui, Hiroshi Kunugi & Yoshiharu Kim. (2021) Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype. Translational Psychiatry 11:1.
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Celia Maria de Araujo, Walter Swardfager, Andre Zugman, Hugo Cogo-Moreira, Sintia I. Belangero, Vanessa K. Ota, Leticia M. Spindola, Hakon Hakonarson, Renata Pellegrino, Ary Gadelha, Giovanni A. Salum, Pedro M. Pan, Rodrigo B. Mansur, Marcelo Hoexter, Felipe Picon, João R. Sato, Elisa Brietzke, Rodrigo Grassi-Oliveira, Luis A. P. Rohde, Euripedes C. Miguel, Rodrigo A. Bressan & Andrea P. Jackowski. (2019) Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?. CNS Spectrums 25:6, pages 790-796.
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Luca Colucci-D’Amato, Luisa Speranza & Floriana Volpicelli. (2020) Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. International Journal of Molecular Sciences 21:20, pages 7777.
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Xinyu Fang, Yan Chen, Yewei Wang, Juanjuan Ren & Chen Zhang. (2019) Depressive symptoms in schizophrenia patients: A possible relationship between SIRT1 and BDNF. Progress in Neuro-Psychopharmacology and Biological Psychiatry 95, pages 109673.
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Elisabetta Maffioletti, Massimo Gennarelli, Giulio Gainelli, Luisella Bocchio-Chiavetto, Marco Bortolomasi & Alessandra Minelli. (2019) BDNF Genotype and Baseline Serum Levels in Relation to Electroconvulsive Therapy Effectiveness in Treatment-Resistant Depressed Patients. The Journal of ECT 35:3, pages 189-194.
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Ye Yang, Yi Liu, Guodong Wang, Gangrui Hei, Xiaoyi Wang, Ranran Li, Li Li, Renrong Wu & Jingping Zhao. (2019) Brain-derived neurotrophic factor is associated with cognitive impairments in first-episode and chronic schizophrenia. Psychiatry Research 273, pages 528-536.
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Cindy K. Barha, Teresa Liu-Ambrose, John R. Best, Kristine Yaffe & Caterina Rosano. (2019) Sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults: evidence from the health ABC study. Neurobiology of Aging 74, pages 161-170.
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Ada H. Zohar. 2019. Personality and Brain Disorders. Personality and Brain Disorders 25 40 .
Yu-Jia Wang, Kai-Yun Chen, Li-Na Kuo, Wen-Chang Wang, Yu-Wen Hsu, Henry Sung-Ching Wong, Chien-Min Lin, Kuo-Hsing Liao, Yan-Feng Zhang, Yung-Hsiao Chiang & Wei-Chiao Chang. (2018) The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury. BMC Medical Genetics 19:1.
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