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The World Journal of Biological Psychiatry Volume 20, 2019 - Issue 7
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Original Investigations

Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients

Ulrike HeitzCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; View further author information
,
Martina PapmeyerCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; ;Rehabilitation Services and Care Unit, Swiss Paraplegic Research, Nottwil, Switzerland; View further author information
,
Erich StuderusCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; ORCID Iconhttp://orcid.org/0000-0003-4233-0182View further author information
ORCID Icon,
Laura EgloffCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; ORCID Iconhttp://orcid.org/0000-0001-7809-7541View further author information
ORCID Icon,
Sarah IttigCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; View further author information
,
Christina AndreouCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; ORCID Iconhttp://orcid.org/0000-0002-6656-9043View further author information
ORCID Icon,
Tobias VogelDepartment of Forensic Psychiatry, University of Basel Psychiatric Hospital, Basel, Switzerland; View further author information
,
Stefan BorgwardtDepartment of Psychiatry, University of Basel Psychiatric Hospital, Basel, Switzerland; ORCID Iconhttp://orcid.org/0000-0002-5792-3987View further author information
ORCID Icon,
Marc GrafDepartment of Forensic Psychiatry, University of Basel Psychiatric Hospital, Basel, Switzerland; ORCID Iconhttp://orcid.org/0000-0001-9703-4175View further author information
ORCID Icon,
Anne EckertNeurobiology Laboratory for Brain Aging and Mental Health, University of Basel Psychiatric Hospital, Basel, SwitzerlandORCID Iconhttp://orcid.org/0000-0002-9341-3669View further author information
ORCID Icon &
Anita Riecher-RösslerCenter for Gender Research and Early Detection, University of Basel Psychiatric Hospital, Basel, Switzerland; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6361-8789View further author information
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Pages 545-554 | Received 20 Dec 2017, Accepted 28 Mar 2018, Published online: 25 Jun 2018

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Ebrahim Norouzi, Reza Mohammadi, Reza Fadaei, Mohammad-Taher Moradi, Hossein Hosseini, Leeba Rezaie & Habibolah Khazaie. (2023) A systematic review and meta-analysis on the levels of brain-derived neurotrophic factor in insomnia patients with and without comorbid depression. Biological Rhythm Research 54:5-8, pages 467-478.
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Ola Shahin, Sherif M. Gohar, Walaa Ibrahim, Shirin M. El-Makawi, Walaa Fakher, Dina Badie Taher, Mai Abdel Samie, Mohamed A. Khalil & Alia A. Saleh. (2022) Brain-Derived neurotrophic factor (BDNF) plasma level increases in patients with resistant schizophrenia treated with electroconvulsive therapy (ECT). International Journal of Psychiatry in Clinical Practice 26:4, pages 370-375.
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Articles from other publishers (29)

Przemysław Zakowicz, Maria Skibińska, Filip Waśniewski, Bartosz Skulimowski & Joanna Pawlak. (2023) Plasma biomarkers in adolescents with schizophrenia‐spectrum disorder. Early Intervention in Psychiatry 17:12, pages 1154-1161.
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Guangyu Li, Cailian Lu, Shan Li, Lin Kang, Qianqian Li, Meiyan Bai & Peng Xiong. (2023) Correlation study of brain-derived neurotrophic factor, EEG γ activity and cognitive function in first-episode schizophrenia. Brain Research 1820, pages 148561.
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Anna Maria Szota, Beata Kowalewska, Małgorzata Ćwiklińska-Jurkowska & Wiktor Dróżdż. (2023) The Influence of Electroconvulsive Therapy (ECT) on Brain-Derived Neurotrophic Factor (BDNF) Plasma Level in Patients with Schizophrenia—A Systematic Review and Meta-Analysis. Journal of Clinical Medicine 12:17, pages 5728.
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Alexandre Andrade Loch, Marcel Tavares Camilo Pinto, Julio Cesar Andrade, Leonardo Peroni de Jesus, Matheus Wanderley de Medeiros, Natalia Mansur Haddad, Martinus Theodorus van de Bilt, Leda Leme Talib & Wagner Farid Gattaz. (2023) Plasma levels of neurotrophin 4/5, NGF and pro-BDNF influence transition to mental disorders in a sample of individuals at ultra-high risk for psychosis. Psychiatry Research 327, pages 115402.
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Gry Bang-Kittilsen, Jens Egeland, Thor Ueland, Eivind Andersen, Therese Torgersen Bigseth, Tom Langerud Holmen, Jon Mordal, René Holst & John Abel Engh. (2023) The relationship between the brain-derived neurotrophic factor and neurocognitive response to physical exercise in individuals with schizophrenia. Psychoneuroendocrinology, pages 106356.
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Irene Moreno, Alexander Stojanovic-Pérez, Bengisu Bulduk, Vanessa Sánchez-Gistau, María José Algora, Laura Ortega, Gerard Muntané, Elisabet Vilella, Javier Labad & Lourdes Martorell. (2023) High blood levels of brain-derived neurotrophic factor (BDNF) mRNA in early psychosis are associated with inflammatory markers. Journal of Psychiatric Research 164, pages 440-446.
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Zhenmei Zhang, Lejia Fan, Liu Yuan, Zongchang Li, Lijun Ouyang, Xiaoqian Ma, Zihao Yang, Jingyan Lv, Shuting Chen, Xiaogang Chen & Ying He. (2023) The month of walking alone and BDNF level differ between drug-naive first-episode schizophrenia patients and healthy controls. Frontiers in Molecular Neuroscience 16.
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Ewelina Palasz, Anna Wilkaniec, Luiza Stanaszek, Anna Andrzejewska & Agata Adamczyk. (2023) Glia-Neurotrophic Factor Relationships: Possible Role in Pathobiology of Neuroinflammation-Related Brain Disorders. International Journal of Molecular Sciences 24:7, pages 6321.
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Agnieszka Wawrzczak-Bargieła, Wiktor Bilecki & Marzena Maćkowiak. (2023) Epigenetic Targets in Schizophrenia Development and Therapy. Brain Sciences 13:3, pages 426.
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Yanhui Chen, Shangjin Li, Tianyi Zhang, Feng Yang & Bai Lu. (2022) Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress. iScience 25:7, pages 104609.
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Zhiwei Wu, Qinqin Liu, Yinghua Zhang, Xiaoni Guan, Meihong Xiu & Xiangyang Zhang. (2022) Superoxide Dismutase, BDNF, and Cognitive Improvement in Drug-Naive First-Episode Patients With Schizophrenia: A 12-Week Longitudinal Study. International Journal of Neuropsychopharmacology 25:2, pages 128-135.
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Ping Lin, Junyu Sun, Xiaoyan Lou, Dan Li, Yun Shi, Zhenhua Li, Peijun Ma, Ping Li, Shuzi Chen, Weifeng Jin, Shuai Liu, Qing Chen, Qiong Gao, Lili Zhu, Jie Xu, Mengyuan Zhu, Mengxia Wang, Kangyi Liang, Ling Zhao, Huabin Xu, Ke Dong, Qingtian Li, Xunjia Cheng, Jinghong Chen & Xiaokui Guo. (2022) Consensus on potential biomarkers developed for use in clinical tests for schizophrenia. General Psychiatry 35:1, pages e100685.
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Enrico Capuzzi, Alessandro Ceresa, Alice Caldiroli, Cecilia M. Esposito, Paolo Ossola & Massimiliano Buoli. (2021) The Relation between the Plasma Concentrations of Long-Acting Atypical Antipsychotics and Clinical Effectiveness in Patients Affected by Schizophrenia or Schizoaffective Disorder: A Comprehensive Overview. Current Pharmaceutical Design 27:39, pages 4070-4077.
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Peng Zhao, Xiaqiu Li, Yang Li, Jiaying Zhu, Yu Sun & Jianli Hong. (2021) Mechanism of miR-365 in regulating BDNF-TrkB signal axis of HFD/STZ induced diabetic nephropathy fibrosis and renal function. International Urology and Nephrology 53:10, pages 2177-2187.
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Yong-Mei Wang, Ya-Yun Xu, Yi Zhai, Qian-Qian Wu, Wen Huang, Yan Liang, Yan-Hong Sun & Lian-Yin Xu. (2021) Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients. Frontiers in Psychiatry 12.
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Yossi Guterman, Yochai Ataria & Steven M. Silverstein. (2021) The Imbalanced Plasticity Hypothesis of Schizophrenia-Related Psychosis: A Predictive Perspective. Cognitive, Affective, & Behavioral Neuroscience 21:4, pages 679-697.
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Qi Zhang, Hui He, Bo Cao, Rang Gao, Liping Jiang, Xiangyang Zhang & Jing Dai. (2021) Analysis of cognitive impairment in schizophrenia based on machine learning: Interaction between psychological stress and immune system. Neuroscience Letters 760, pages 136084.
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Rodrigo R. Nieto, Andrea Carrasco, Sebastian Corral, Rolando Castillo, Pablo A. Gaspar, M. Leonor Bustamante & Hernan Silva. (2021) BDNF as a Biomarker of Cognition in Schizophrenia/Psychosis: An Updated Review. Frontiers in Psychiatry 12.
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Mei Hong Xiu, Zezhi Li, Da Chun Chen, Song Chen, Maile E Curbo, Hanjing Emily Wu, Yong Sheng Tong, Shu Ping Tan & Xiang Yang Zhang. (2020) Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 46:6, pages 1498-1510.
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Can Mişel Kilciksiz, Richard Keefe, James Benoit, Dost Öngür & John Torous. (2020) Verbal memory measurement towards digital perspectives in first-episode psychosis: A review. Schizophrenia Research: Cognition 21, pages 100177.
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Renata Markiewicz & Beata Dobrowolska. (2020) Cognitive and Social Rehabilitation in Schizophrenia—From Neurophysiology to Neuromodulation. Pilot Study. International Journal of Environmental Research and Public Health 17:11, pages 4034.
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Luisa Leonie Brokmeier, Joseph Firth, Davy Vancampfort, Lee Smith, Jeroen Deenik, Simon Rosenbaum, Brendon Stubbs & Felipe Barreto Schuch. (2020) Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies. Psychiatry Research 284, pages 112675.
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Jingzhi Su, Peiqu Liu, Bangshan Liu & Yan Zhang. (2020) BDNF polymorphisms across the spectrum of psychiatric morbidity. Medicine 99:45, pages e22875.
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Mei Hong Xiu, Dong Mei Wang, Xiang Dong Du, Nan Chen, Shu Ping Tan, Yun Long Tan, Fu De Yang, Raymond Y. Cho & Xiang Yang Zhang. (2019) Interaction of BDNF and cytokines in executive dysfunction in patients with chronic schizophrenia. Psychoneuroendocrinology 108, pages 110-117.
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Tomasz Pawełczyk, Marta Grancow-Grabka, Elżbieta Trafalska, Janusz Szemraj, Natalia Żurner & Agnieszka Pawełczyk. (2019) An increase in plasma brain derived neurotrophic factor levels is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: secondary outcome analysis of the OFFER randomized clinical trial. Psychopharmacology 236:9, pages 2811-2822.
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Magdalena Miranda, Juan Facundo Morici, María Belén Zanoni & Pedro Bekinschtein. (2019) Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Frontiers in Cellular Neuroscience 13.
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Ying He, Liu Yuan, Zongchang Li, Yao Zhou, Xiaoqian Ma, Lijun Ouyang & Xiaogang Chen. (2019) Plasma protein levels of brain-derived neurotrophic factor pathways and their association with cognitive performance in patients with clinical high risk for psychosis and first episode psychosis. Schizophrenia Research 206, pages 460-461.
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Yu-Jie Chiou & Tiao-Lai Huang. (2019) Accuracy of brain-derived neurotrophic factor levels for differentiating between Taiwanese patients with major depressive disorder or schizophrenia and healthy controls. PLOS ONE 14:2, pages e0212373.
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J. I. Schweiger, E. Bilek, A. Schäfer, U. Braun, C. Moessnang, A. Harneit, P. Post, K. Otto, N. Romanczuk-Seiferth, S. Erk, C. Wackerhagen, M. Mattheisen, T. W. Mühleisen, S. Cichon, M. M. Nöthen, J. Frank, S. H. Witt, M. Rietschel, A. Heinz, H. Walter, A. Meyer-Lindenberg & H. Tost. (2018) Effects of BDNF Val66Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans. Neuropsychopharmacology 44:3, pages 590-597.
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