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Original Articles

Effect of 2,3,5,4′-tetrahydroxystilbene-2-O-beta-d-glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells

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Pages 689-697 | Received 06 Jan 2005, Accepted 02 May 2005, Published online: 06 Oct 2011

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Hee Yul Lee, Chung Eun Hwang, Kyung Pan Hwa, Du Yong Cho, Jea Gack Jung, Min Ju Kim, Jong Bin Jeong, Mu Yeun Jang & Kye Man Cho. (2022) Comprehensive comparison of the primary and secondary metabolites and antioxidant activity of Polygoni multiflori Radix by processing methods . Journal of Applied Biological Chemistry 65:4, pages 287-298.
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Xueling He, Jiayan Liu, Guohao Long, Xin-Hua Xia & Mei Liu. (2021) 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside, a major bioactive component from Polygoni multiflori Radix (Heshouwu) suppresses DSS induced acute colitis in BALb/c mice by modulating gut microbiota. Biomedicine & Pharmacotherapy 137, pages 111420.
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Zi-Lin Li, Tung-Yung Huang, Yih Ho, Ya-Jung Shih, Yi-Ru Chen, Heng-Yuan Tang, Hung-Yun Lin, Jaqueline Whang-Peng & Kuan Wang. 2021. Fibroids. Fibroids.
Chi‐Yu Lin, Min‐Shi Tsai, Po‐Jan Kuo, Yu‐Tang Chin, I‐Tsen Weng, Yen Wu, Haw‐Ming Huang, Chao‐Nan Hsiung, Hung‐Yun Lin & Sheng‐Yang Lee. (2020) 2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐β‐ d ‐glucoside promotes the effects of dental pulp stem cells on rebuilding periodontal tissues in experimental periodontal defects . Journal of Periodontology 92:2, pages 306-316.
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Fengjiao Li, Ting Zhang, Yanran He, Wen Gu, Xingxin Yang, Ronghua Zhao & Jie Yu. (2020) Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE−/− mice. Journal of Ethnopharmacology 247, pages 112232.
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Thanh-Tam Ho, Hosakatte Niranjana Murthy, Dayanand Dalawai, Medha A. Bhat, Kee-Yoeup Paek & So-Young Park. (2019) Attributes of Polygonum multiflorum to transfigure red biotechnology. Applied Microbiology and Biotechnology 103:8, pages 3317-3326.
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Manru Zhou, Jingkai Wu, Yongjie Yu, Yajun Yang, Jin Li, Liao Cui, Weimin Yao & Yuyu Liu. (2017) Polygonum multiflorm alleviates glucocorticoid‑induced osteoporosis and Wnt signaling pathway. Molecular Medicine Reports.
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Zhaohuan Lou, Bohou Xia, Jie Su, Jingjing Yu, Meiqiu Yan, Yuefang Huang & Guiyuan Lv. (2017) Effect of a stilbene glycoside‑rich extract from Polygoni Multiflori Radix on experimental non‑alcoholic fatty liver disease based on principal component and orthogonal partial least squares discriminant analysis. Experimental and Therapeutic Medicine.
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Jingjing Wu, Wenfeng Hu, Yu Gong, Peng Wang, Lijuan Tong, Xiangfan Chen, Zhuo Chen, Xiaole Xu, Wenjuan Yao, Wei Zhang & Chao Huang. (2017) Current pharmacological developments in 2,3,4′,5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG). European Journal of Pharmacology 811, pages 21-29.
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Zhuo Chen, Chao Huang, Haiyan He & Wenbin Ding. (2017) 2, 3, 5, 4′-Tetrahydroxystilbene-2-O-β-d-glucoside prevention of lipopolysaccharide-induced depressive-like behaviors in mice involves neuroinflammation and oxido-nitrosative stress inhibition. Behavioural Pharmacology 28:5, pages 365-374.
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Xie-an Yu, Ai-hua Ge, Lu Zhang, Jin Li, Mingrui An, Jun Cao, Jun He, Xiu-mei Gao & Yan-xu Chang. (2017) Influence of different processing times on the quality of Polygoni Multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry . Journal of Separation Science 40:9, pages 1928-1941.
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Na Li, Jie Song, Liang Kong, Shao-Heng Li, Ya-Nan Jiao, Yu-Hui Yan, Ying-Jia Yao, Ya-Kun Meng, Xiao-Fei Li, Miao-Miao Tong, Nan Zhang, Kai Kang, Ting-Guo Kang & Jing-Xian Yang. (2016) Neuroprotection of TSG Against Mechanical Trauma Injury Through an Anti-inflammatory Mechanism in Human Neuroblastoma SH-SY5Y Cells. International Journal of Pharmacology 12:8, pages 789-800.
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Wenjuan Yao, Lei Huang, Qinju Sun, Lifeng Yang, Lian Tang, Guoliang Meng, Xiaole Xu & Wei Zhang. (2016) The inhibition of macrophage foam cell formation by tetrahydroxystilbene glucoside is driven by suppressing vimentin cytoskeleton. Biomedicine & Pharmacotherapy 83, pages 1132-1140.
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Chien-Liang Lin, Shu-Ling Hsieh, Wan Leung, Jiiang-Huei Jeng, Guan-Cheng Huang, Chining-Ting Lee & Chih-Chung Wu. (2016) 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside suppresses human colorectal cancer cell metastasis through inhibiting NF-κB activation. International Journal of Oncology 49:2, pages 629-638.
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Wanxia Xia, Lei Lei, Wei Zhao, Yifan Feng & Shujin Zhao. (2016) Quantitative analysis of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glycoside in wild Polygonum multiflorum and suspension cell cultures fed different precursors and elicitors. Phytochemistry Letters 15, pages 180-185.
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Wenjuan YaoQinju SunLei HuangGuoliang MengHuiming WangXiang JingWei Zhang. (2016) Tetrahydroxystilbene glucoside inhibits TNF-α-induced migration of vascular smooth muscle cells via suppression of vimentin. Canadian Journal of Physiology and Pharmacology 94:2, pages 155-160.
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Yu-Tang Chin, Meng-Ti Hsieh, Chi-Yu Lin, Po-Jan Kuo, Yu-Chen S. H. Yang, Ya-Jung Shih, Hsuan-Yu Lai, Guei-Yun Cheng, Heng-Yuan Tang, Chen-Chen Lee, Sheng-Yang Lee, Ching-Chiung Wang, Hung-Yun Lin, Earl Fu, Jacqueline Whang-Peng & Leroy F. Liu. (2016) 2,3,5,4′-Tetrahydroxystilbene-2-O- β -glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis . Mediators of Inflammation 2016, pages 1-12.
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Shuang Ling & Jin-Wen Xu. (2016) Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O- β -D-Glucoside in Antiaging and Antiaging-Related Disease Treatments . Oxidative Medicine and Cellular Longevity 2016, pages 1-14.
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Teng-Hua Wang, Jing Zhang, Xiao-Hui Qiu, Jun-Qi Bai, You-Heng Gao & Wen Xu. (2015) Application of Ultra-High-Performance Liquid Chromatography Coupled with LTQ-Orbitrap Mass Spectrometry for the Qualitative and Quantitative Analysis of Polygonum multiflorum Thumb. and Its Processed Products. Molecules 21:1, pages 40.
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Hyun Young Kim, Jun Young Kim, Eun Ju Cho, Ji Myung Choi, Chung Eun Hwang, Hee Yul Lee, Min Ju Ahn, Jin Hwan Lee, Yun-Geun Kim, Keon Hee Ko, Young-Min Goo, Kyeong Yeol Oh & Kye Man Cho. (2015) Free Radical Scavenging Effect and Oxidative Stress Protective Activity of Domestic Processed Polygoni Multiflori Radix. Journal of the Korean Society of Food Science and Nutrition 44:6, pages 809-815.
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Xiao-le Xu, Yan-juan Huang, Dan-yan Ling & Wei Zhang. (2014) Inhibitory effects of 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside on angiotensin II-induced proliferation of vascular smooth muscle cells. Chinese Journal of Integrative Medicine 21:3, pages 204-210.
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Ju Duan, Xin Han, Shuang Ling, Woting Gan, Li Sun, Rong-Zhen Ni & Jin-Wen Xu. (2015) Aortic Remodelling Is Improved by 2,3,5,4′-Tetrahydroxystilbene-2-O- β -D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-10.
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Christian Büchter, Liang Zhao, Susannah Havermann, Sebastian Honnen, Gerhard Fritz, Peter Proksch & Wim Wätjen. (2015) TSG (2,3,5,4′-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans . Oxidative Medicine and Cellular Longevity 2015, pages 1-12.
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Wenjuan Yao, Chengjing Gu, Haoran Shao, Guoliang Meng, Huiming Wang, Xiang Jing & Wei Zhang. (2015) Tetrahydroxystilbene Glucoside Improves TNF-α-Induced Endothelial Dysfunction: Involvement of TGFβ/Smad Pathway and Inhibition of Vimentin Expression. The American Journal of Chinese Medicine 43:01, pages 183-198.
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Ting Deng, Junfang Jia, Na Luo & Huijun Li. (2014) A dual-task method for the simultaneous detoxification and enrichment of stilbene glycoside from Polygonum multiflorum roots extract by macroporous resin. Chemical Engineering Journal 237, pages 138-145.
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Miao Hu, Weiwei Zeng & Brian Tomlinson. (2014) Evaluation of a Crataegus -Based Multiherb Formula for Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial . Evidence-Based Complementary and Alternative Medicine 2014, pages 1-9.
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Ling Zhang, Wen-fang Ma, Jin Li, Jun He, Peng Zhang, Fang Zheng, Bo-li Zhang, Xiu-mei Gao & Yan-xu Chang. (2013) Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC–ESI–MS/MS. Journal of Ethnopharmacology 148:1, pages 246-253.
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WenJuan Yao, WenJun Fan, Chao Huang, Hui Zhong, XiangFan Chen & Wei Zhang. (2013) Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats. Biomedicine & Pharmacotherapy 67:2, pages 140-145.
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Ying-Yong Zhao, Li Zhang, Ya-Long Feng, Dan-Qian Chen, Zhi-Hui Xi, Xiao Du, Xu Bai & Rui-Chao Lin. (2013) Pharmacokinetics of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside in rat using ultra-performance LC-quadrupole TOF-MS. Journal of Separation Science 36:5, pages 863-871.
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Xiao-le Xu, Dan-yan Ling, Qiu-yan Zhu, Wen-jun Fan & Wei Zhang. (2013) The effect of 2,3,4′,5-tetrahydroxystilbene-2-0-β-d glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms. European Journal of Pharmacology 698:1-3, pages 370-378.
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Zhitao Liang, Ngon-ngon Leung, Hubiao Chen & Zhongzhen Zhao. (2012) Quality evaluation of various commercial specifications of Polygoni Multiflori Radix and its dregs by determination of active compounds. Chemistry Central Journal 6:1.
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Xin Han, Shuang Ling, Woting Gan, Li Sun, Ju Duan & Jin-Wen Xu. (2012) 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis 225:1, pages 76-82.
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Xiao-Le Xu, Yan-Juan Huang, Xiang-Fan Chen, Dan-Yan Lin & Wei Zhang. (2012) 2,3,4′,5-Tetrahydroxystilbene-2-O-β- d -glucoside Inhibits Proliferation of Vascular Smooth Muscle Cells: Involvement of NO/cGMP/PKG Pathway . Phytotherapy Research 26:7, pages 1068-1074.
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Li Shao, Shu-Jin Zhao, Tang-Bing Cui, Zhong-Yu Liu & Wei Zhao. (2012) 2,3,5,4′- Tetrahydroxystilbene-2-O-β-D-glycoside Biosynthesis by Suspension Cells Cultures of Polygonum multiflorum Thunb and Production Enhancement by Methyl Jasmonate and Salicylic Acid. Molecules 17:2, pages 2240-2247.
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Fang-ling Sun, Lan Zhang, Ru-yi Zhang & Lin Li. (2011) Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. European Journal of Pharmacology 660:2-3, pages 283-290.
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Xiao-Le Xu, Yan-Juan Huang, Yu-Qin Wang, Xiang-Fan Chen & Wei Zhang. (2011) 2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells by regulating the cell cycle. Clinical and Experimental Pharmacology and Physiology 38:5, pages 307-313.
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Xiao-liang Ren, Gui-fang Wang, Meng Wang, Hui-zi Ou-Yang & Ai-di Qi. (2011) Kinetics and mechanism of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glycoside (THSG) degradation in aqueous solutions. Journal of Pharmaceutical and Biomedical Analysis 55:1, pages 211-215.
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Xiaobing Li, Yan Li, Jianzong Chen, Jing Sun, Xiaofeng Li, Xin Sun & Xiaogang Kang. (2010) Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. Neuroscience Letters 483:1, pages 1-5.
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Ting Wang, Jun Gu, Peng-Fei Wu, Fang Wang, Zhe Xiong, Yuan-Jian Yang, Wen-Ning Wu, Ling-Dan Dong & Jian-Guo Chen. (2009) Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation. Free Radical Biology and Medicine 47:3, pages 229-240.
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