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Journal of Sulfur Chemistry Volume 36, 2015 - Issue 2
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Original Articles

3,4-Dimethyl-2,5-functionalized thieno[2,3-b]thiophenes: versatile precursors for novel bis-thiazoles

Osama M. SayedChemistry Department, Faculty of Science, Cairo University, Giza, Egypt
,
Ahmed E.M. MekkyChemistry Department, Faculty of Science, Cairo University, Giza, Egypt
,
Ahmad M. FaragChemistry Department, Faculty of Science, Cairo University, Giza, Egypt
&
Ahmad H.M. ElwahyChemistry Department, Faculty of Science, Cairo University, Giza, EgyptCorrespondence[email protected]
Pages 124-134 | Received 02 Sep 2014, Accepted 06 Oct 2014, Published online: 10 Nov 2014

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Huda Kamel Mahmoud, Noha Hamed Mohamed Selim, Ahmed H. M. Elwahy, Ismail A. Abdelhamid & Hadeer M. Diab. (2023) Microwave-Assisted Hantzsch-Like Synthesis of Novel Bis(Tetrahydrobenzo[4,5]Imidazo[2,1-b]Quinazolinones). Polycyclic Aromatic Compounds 43:10, pages 8772-8784.
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Ahmed H. M. Elwahy, Elshimaa M. Eid, Samir A. Abdel-Latif, Huwaida M. E. Hassaneen & Ismail A. Abdelhamid. (2023) Design, Synthesis, DFT, TD-DFT/PCM Calculations, and Molecular Docking Studies on the Anti-COVID-19, and Anti-SARS Activities of Some New Bis-Thiazoles and Bis-Thiadiazole. Polycyclic Aromatic Compounds 43:7, pages 6407-6436.
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Hadeer M. Diab, Basma Elsayed, Ahmed F. Darweesh, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2023) Synthesis of Novel Bis(Sulfanediyl)Bis(Tetrahydropyrimido[4,5-b]Quinoline-4,6-Diones) Linked to Butenyl and Butynyl Spacers via Thioether Linkages. Polycyclic Aromatic Compounds 43:5, pages 4084-4102.
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Mohamed G. Badrey, Sobhi M. Gomha, Aboubakr H. Abdelmonsef & Ahmed A. M. El-Reedy. (2023) Syntheses and Molecular Docking Analysis of Some New Thiazole and Thiazine Derivatives as Three Armed Molecules with a Triazine Ring as a Core Component: A Search for anti-Obesity Agents. Polycyclic Aromatic Compounds 0:0, pages 1-19.
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Mostafa E. Salem, Ibrahim M. Z. Fares, Said A. S. Ghozlan, Ahmed H. M. Elwahy & Ismail A. Abdelhamid. (2022) Hantzsch-like three-component synthesis of bis(1,4-dihydropyridines) and bis(fused-1,4-dihydropyridines) linked to piperazine core via 2-phenoxyethanone linkage: Novel hybrid molecules. Synthetic Communications 52:19-20, pages 1981-1997.
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Amr M. Abdelmoniem, Hadeel F. Hammad, Ahmed F. Darweesh, Mahfouz A. Abdelaziz, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2021) Hantzsch one-pot multicomponent synthesis of a novel series of bis(9,10-diarylhexahydroacridine-1,8-diones). Synthetic Communications 51:17, pages 2695-2712.
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Soad K. Salama, Ahmed F. Darweesh, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2021) p-TSA Catalyzed One-Pot Synthesis of Some Novel Bis(Hexahydroacridine-1,8-Diones) and Bis(Tetrahydrodipyrazolo[3,4-b:4′,3′-e]Pyridines) Derivatives. Polycyclic Aromatic Compounds 41:7, pages 1392-1405.
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Hadeer M. Diab, Mostafa E. Salem, Ahmed H. M. Elwahy & Ismail A. Abdelhamid. (2021) Bis(sulfanediyl)bis(6-aminopyrimidin-4-ones): Versatile precursors for novel bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) linked to aliphatic spacer via multi-component reactions. Synthetic Communications 51:13, pages 2001-2015.
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Sherif M. H. Sanad, Ahmed E. M. Mekky & Ahmed A. M. El-Reedy. (2021) Tandem synthesis and antibacterial screening of novel thieno[2,3-b]thiophene-linked bis(thiazole) hybrids. Synthetic Communications 51:13, pages 1982-1993.
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Amr M. Abdelmoniem, Mohamed G. M. Abdelrahman, Said A. S. Ghozlan, Ahmed H. M. Elwahy & Ismail A. Abdelhamid. (2021) Hantzsch reaction with bis-indole-2,3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo[3,4-b:4',3'-e]pyridine and pyrido[2,3-d:6,5-d']dipyrimidine. Synthetic Communications 51:12, pages 1814-1824.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2021) Efficient synthesis and characterization of novel bis(chromenes) and bis(benzo[f]chromenes) linked to thiazole units. Synthetic Communications 51:4, pages 611-624.
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Ali M. S. Hebishy, Mohamed Saleh Abdelfattah, Abdullah Elmorsy & Ahmed H. M. Elwahy. (2020) ZnO nanoparticles catalyzed synthesis of bis- and poly(imidazoles) as potential anticancer agents. Synthetic Communications 50:7, pages 980-996.
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Mostafa E. Salem, Ahmed F. Darweesh & Ahmed H. M. Elwahy. (2020) Synthesis of novel scaffolds based on thiazole or triazolothiadiazine linked to benzofuran or benzo[d]thiazole moieties as new hybrid molecules. Synthetic Communications 50:2, pages 256-270.
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Ahmed E. M. Mekky & Sherif M. H. Sanad. (2019) Synthesis of novel bis(chromenes) and bis(chromeno[3,4-C]pyridine) incorporating piperazine moiety. Synthetic Communications 49:11, pages 1385-1395.
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Mostafa E. Salem, Abbas H. Abdullah, Nada S. Ibrahim, Magdi E. A. Zaki, Ahmed H. M. Elwahy & Ismail A. Abdelhamid. (2023) Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy- N -arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations . ACS Omega.
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Ismail A. Abdelhamid, Mohamed R. Shaaban & Ahmed H.M. Elwahy. 2023. 135 200 .
Harshita Sachdeva, Sarita Khaturia, Mohammad Saquib, Narsingh Khatik, Abhinav Raj Khandelwal, Ravina Meena & Khushboo Sharma. (2022) Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents. Applied Biochemistry and Biotechnology 194:12, pages 6438-6467.
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Mostafa E. Salem, Ibrahim M. Z. Fares, Said A. S. Ghozlan, Marwa M. Abdel‐Aziz, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2022) Facile synthesis and antimicrobial activity of bis (fused 4 H ‐pyrans) incorporating piperazine as novel hybrid molecules: Michael's addition approach . Journal of Heterocyclic Chemistry 59:11, pages 1907-1926.
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Hadeer M. Diab, Mostafa E. Salem, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2021) Hantzsch-like synthesis of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) linked to arene or heteroarene cores utilizing bis(sulfanediyl)bis(6-aminopyrimidin-4-ones) as precursors. Monatshefte für Chemie - Chemical Monthly 152:8, pages 967-976.
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Hadeer M. Diab, Mostafa E. Salem, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2020) Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules. RSC Advances 10:72, pages 44066-44078.
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Elshimaa M Eid, Huwaida M E Hassaneen, Ahmed H M Elwahy & Ismail A Abdelhamid. (2020) Hantzsch-like synthesis of novel bis(hexahydroacridine-1,8-diones), bis(tetrahydrodipyrazolo[3,4- b :4′,3′- e ]pyridines), and bis(pyrimido[4,5- b ]quinolines) incorporating thieno[2,3- b ]thiophenes . Journal of Chemical Research 44:11-12, pages 653-659.
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Amna M. Abdella, Amr M. Abdelmoniem, Nada S. Ibrahim, Salwa M. El-Hallouty, Ismail A. Abdelhamid & Ahmed H.M. Elwahy. (2020) Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages. Mini-Reviews in Medicinal Chemistry 20:9, pages 801-816.
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Elshimaa M. Eid, Huwaida M. E. Hassaneen, Ismail A. Abdelhamid & Ahmed H. M. Elwahy. (2020) Facile one‐pot, three‐component synthesis of novel bis(heterocycles) incorporating thieno[2,3‐ b ]thiophenes via Michael addition reaction . Journal of Heterocyclic Chemistry 57:5, pages 2243-2255.
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Sherif M. H. Sanad, Ahmed A. M. Ahmed & Ahmed E. M. Mekky. (2020) Synthesis, in‐vitro and in‐silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors . Archiv der Pharmazie 353:4.
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Mohammed M. Rahman, Khalid A. Alamry, Md. Rabiul Awual & Ahmed E.M. Mekky. (2020) Efficient Hg(II) ionic probe development based on one-step synthesized diethyl thieno[2,3-b]thiophene-2,5-dicarboxylate (DETTDC2) onto glassy carbon electrode. Microchemical Journal 152, pages 104291.
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Ahmed E. M. Mekky & Sherif M. H. Sanad. (2019) Microwave‐Assisted Synthesis of Novel Bis(thiazoles) Incorporating Piperazine Moiety. Journal of Heterocyclic Chemistry 56:5, pages 1560-1566.
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Mohamed Hosny, Mostafa E. Salem, Ahmed F. Darweesh & Ahmed H. M. Elwahy. (2018) Synthesis of Novel Bis(thiazolylchromen-2-one) Derivatives Linked to Alkyl Spacer via Phenoxy Group . Journal of Heterocyclic Chemistry 55:10, pages 2342-2348.
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Soad K. Salama, Magda F. Mohamed, Ahmed F. Darweesh, Ahmed H.M. Elwahy & Ismail A. Abdelhamid. (2017) Molecular docking simulation and anticancer assessment on human breast carcinoma cell line using novel bis(1,4-dihydropyrano[2,3- c ]pyrazole-5-carbonitrile) and bis(1,4-dihydropyrazolo[4′,3′:5,6]pyrano[2,3- b ]pyridine-6-carbonitrile) derivatives. Bioorganic Chemistry 71, pages 19-29.
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Said Ahmed Soliman GHOZLAN, Muhammed Aly RAMADAN, Amr Mohamed ABDELMONIEM, Ahmed H. M. ELWAHY & Ismail Abdelshafy ABDELHAMID. (2017) Bis(indoline-2,3-diones): versatile precursors for novel bis(spirooxindoles) incorporating 4$H$-chromene-3-carbonitrile and pyrano[2,3-$d$]pyrimidine-6-carbonitrile derivatives. TURKISH JOURNAL OF CHEMISTRY 41, pages 410-419.
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Wael A.A. Arafa & Mohamed G. Badry. (2019) Facile synthesis of bis-thiosemicarbazone derivatives as key precursors for the preparation of functionalised bis-thiazoles. Journal of Chemical Research 40:7, pages 385-392.
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Refaie M. Kassab, Ahmed H. M. Elwahy & Ismail Abdelshafy Abdelhamid. (2016) 1,ω-Bis(formylphenoxy)alkane: versatile precursors for novel bis-dihydropyridine derivatives. Monatshefte für Chemie - Chemical Monthly 147:7, pages 1227-1232.
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Ahmed H. M. Elwahy, Ismail A. Abdelhamid, Sherif M. H. Sanad & Refaie M. Kassab. (2016) Microwave Assisted Multi-Component Synthesis of Novel Bis(1,4-dihydropyridines) Based Arenes or Heteroarenes. HETEROCYCLES 92:5, pages 910.
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Magda F. Mohamed, Ahmed F. Darweesh, Ahmed H. M. Elwahy & Ismail A. Abdelhamid. (2016) Synthesis, characterization and antitumor activity of novel tetrapodal 1,4-dihydropyridines: p53 induction, cell cycle arrest and low damage effect on normal cells induced by genotoxic factor H 2 O 2 . RSC Advances 6:47, pages 40900-40910.
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